Abstract
Aim. Coronary artery ectasia (CAE) is defined as localized or generalized aneurysmal dilatation of the coronary arteries. Plasma viscosity is determined by various macromolecules, eg, fibrinogen, immunoglobulins, and lipoproteins. It may therefore reflect several aspects involved in cardiovascular diseases, including the effects of classic risk factors, hemostatic disturbances, and inflammation.In this study we aimed to observe plasma viscosity of the patients with coronary artery ectasy, which is a important risk factor in coronary artery disease (CAD). In our study, viscosity of the plasma has been calculated. Method. 24 coronary artery ectasy patients and 24 coronary artery disease patients have included the study. Age, sex, cardiovascular risk factors such as existence of hypertension, smoking history and previous medication have been investigated. Plasma viscosity of all patients have been measured. Results. Plasma viscosity of coronary artery disease patients group was measured as 1.19 ± 0.7 mPa·s, coronary artery ectasy patients group was measured as 1.18 ± 0.8 mPa·s. There was no statistically significant difference between two groups (p>0.05). Conclusion. However plasma viscosity is a good known cardiovascular risk factor, one can say it does not play causal role in coronary artery ectasy. As expected there is no diffrence on fibrinogen levels between the groups, this result supports our findings on the viscosity values.
References
- Yetkin E, Waltenberger J. Novel insights into an old controversy: is coronary artery ectasia a variant of coronary atherosclerosis? Clin Res Cardiol 2007; 96: 331Swaye PS, Fisher LD, Litwin P, Vignola PA, Judkins MP, Kemp HG, Mudd JG, Gosselin AJ. Aneurysmal coronary artery disease. Circulation 1983; 67: 134-8.
- Falsetti HL, Carroll RJ. Coronary artery aneurysm. A review of the literature with a report of 11 new cases. Chest 1976; 69: 630-6.
- Markis JE, Joffe CD, Cohn PF, Feen DJ, Herman MV, Gorlin R. Clinical significance of coronary arterial ectasia. Am J Cardiol 1976; 37: 217-22.
- Maehara A, Mintz GS, Ahmed JM, Fuchs S, Castagna MT, Pichard AD, Satler LF, Waksman R, Suddath WO, Kent KM, Weissman NJ. An intravascular ultrasound classification of angiographic coronary artery aneurysms. Am J Cardiol 2001; 88: 365-70.
- Türkiye Kalp Raporu 2000, Türk Kardiyoloji Derneği, Yenilik Basımevi, İstanbul 2000; 11-25.
- Befeler B, Aranda MJ, Embi A, Mullin FL, El-Sherif N, Lazzara R. Coronary artery aneurysms: Study of their etiology, clinical course and effect on left ventricular function and prognosis. Am J Med 1977; 62: 597-607.
- Oliveros RA, Falsetti HL, Carroll RJ, Heinle RA, Ryan GF. Atherosclerotic coronary artery aneurysm: report of five cases and review of literature. Arch Intern Med 1974; 134: 1072-6.
- Hartnell GG, Parnell BM, Pridie RB. Coronary artery ectasia. Its prevalence and clinical significance in 4993 patients. Br Heart J 1985; 54: 392-5.
- Demir E. Koroner yavaş akımlı hastaların hemoreolojik parametrelerinin değerlendirilmesi. Pamukkale Üniversitesi Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Uzmanlık Tezi, Denizli 2011.
- Dikmenoğlu N. Kardiyovasküler hastalıklarda sigara ve kolesterol kadar önemli bir risk faktörü: kan akışkanlığı. Hacettepe Tıp Dergisi 2006; 37: 93-7.
- Yolcu M, Bilgili H, Küçükdurmaz Z, Karapınar H, Dokumacı B. Koroner arter hastalığı yaygınlığı ile plazma vizkositesi ve fibrinojen düzeyleri arasındaki ilişki. Türk Göğüs Kalp Damar Cerrahisi Dergisi 2012; 16: 15-9.
- Gapinska, AM, Jaroszyk, F, Elikowski W, Kubisz, L. The effect of acetylsalicylic acid and acenocoumarin on rheological properties of blood studied on patients after myocardial infarction. Current Topics in Biophysics 2004; 28: 3-8.
- Reinhart, WH. Hemorheology: blood flow hematology. Schweiz Med Woochenschr 1995; 125: 387-95.
- Baskurt OK. Rheologic properties of blood. Doğa-Tr.J.of Medical Sciences 1990; 14: 433-7.
- Altıparmak İH, Kaya Z, Sezen H, Aydın MS, Demirbağ R, Aksoy N. Serum paraoksonaz-1 aktivitesinin izole koroner arter ektazisi ile ilişkisi: Gözlemsel bir çalışma. Anadolu Kardiyoloji Dergisi 2012; 12: 307-12.
- Baskurt OK, Boynard M, Cokelet GC, Connes P, Cooke BM, Forconi S, Liao F, Hardeman MR, Friedrich Jung F, Meiselman HJ, Nash G, Nemeth N, Neu B, Sandhagen B, Shin S, Thurston G, Wautier JL. New guidelines for hemorheological laboratory techniques. Clin Hemorheol Microcirc 2009; 42: 75
- Leonhardt H, Bungert HJ. Plasma viskositat und portale hypertension bei bercirrhosekranken. Klın Wschr 1973; 51: 1043-49.
- Ernst E, Matrai A, Schmölzl CH, Magyarosy I. Dose-effect relationship between smoking and blood rheology. Br J Haematol 1987; 65: 485-7.
- Ernst E, Schmid WM, Baumann M, Matrai A. Cardiovascular risk factors and hemoreology. Atherosclerosis 1986; 59: 263-9.
- Solerto SB, Fioravanti M, Patti AL, Fedele P, Ferrari E. Incresed plasmaapolipoprotein B levels and blood hyperviscosity in noninsülin dependent diabetic patients: Role in the occurence of arterial hypertension. Acta Diabetol Lal 1987; 24: 341-9.
- Kensey KR. The mechanistic relationships between hemorheological characteristics and cardiovascular disease. Curr Med Res Opin 2003; 19: 587-96. Lee AJ, Mowbray PI, Lowe GDO, Rumley A, Fowkes FGR, Allan PL. Blood viscosity and elevated carotid intima-media thickness in men and women:the Edinburgh Artery Study. Circulation 1998; 97: 1467-73.
- Chrissoheris MP, Donohue TJ, Young RS, Ghantous A. Coronary Artery Aneurysms. Cardiol in Rev 2008; 16: 116-23.
- Papadakis MC, Manginas A, Cotileas P, Demopoulos V, Voudris V, Pavlides G, Foussas SG, Cokkinos DV. Documentation of slow coronary flow by the TIMI frame count in patients with coronary ectasia. Am J Cardiol 2001; 88: 1030-2.
Abstract
Özet
Amaç. Koroner arter ektazisi (CAE) koroner arterlerdeki lokalize veya yaygın anevrizmatik genişlemeler olarak tanımlanır. Plazma viskozitesi fibrinojen, immünoglobülinler ve lipoproteinler gibi çeşitli makromoleküller tarafından belirlenir. Bu nedenle kardiyovasküler hastalıklarda klasik risk faktörleri, hemostatik bozukluklar ve enflamasyon etkilerini çeşitli açılardan yansıtabilir. Çalışmada koroner arter hastalığında (KAH) risk faktörü olarak kabul edilen plazma viskozitesinin, koroner arter ektazili hastalarda bir farklılık gösterip göstermediğini incelemeyi amaçladık. Yöntem. Çalışmaya rutin koroner anjiyografiler sırasında koroner arter ektazisi (24 hasta) ve koroner arter hastalığı (24 hasta) tespit edilen hastalar alındı. Hastaların yaş, cinsiyet, diyabet varlığı, hipertansiyon, tütün içiciliği gibi kardiyovasküler risk faktörleri ve aldığı tedaviler sorgulandı. Tüm hastaların plazma viskozite düzeyleri ölçüldü ve istatistiksel olarak karşılaştırıldı. Bulgular. Plazma viskozitesi KAH’lı grupta 1,19 ± 0,70 mPa·s, KAE’li grupta 1,18 ± 0,80 mPa·s olarak ölçüldü. Her iki grup arasında istatistiksel olarak anlamlı fark bulunamadı (p>0,05). Sonuç. Plazma viskozitesinin kardiyovasküler risk faktörü olmakla birlikte, KAE hastalığı fizyopatolojisinde, nedensel bir rol oynamadığı söylenebilir. Fibrinojen seviyelerinde gruplar arası değişiklik saptanmaması viskozite değerleri bulgularımızı desteklemektedir.
Anahtar sözcükler: Koroner arter ektazisi, koroner arter hastalığı, plazma viskozitesi
Abstract
Aim. Coronary artery ectasia (CAE) is defined as localized or generalized aneurysmal dilatation of the coronary arteries. Plasma viscosity is determined by various macromolecules, eg, fibrinogen, immunoglobulins, and lipoproteins. It may therefore reflect several aspects involved in cardiovascular diseases, including the effects of classic risk factors, hemostatic disturbances, and inflammation.In this study we aimed to observe plasma viscosity of the patients with coronary artery ectasy, which is a important risk factor in coronary artery disease (CAD). In our study, viscosity of the plasma has been calculated. Method. 24 coronary artery ectasy patients and 24 coronary artery disease patients have included the study. Age, sex, cardiovascular risk factors such as existence of hypertension, smoking history and previous medication have been investigated. Plasma viscosity of all patients have been measured. Results. Plasma viscosity of coronary artery disease patients group was measured as 1.19 ± 0.7 mPa·s, coronary artery ectasy patients group was measured as 1.18 ± 0.8 mPa·s. There was no statistically significant difference between two groups (p>0.05). Conclusion. However plasma viscosity is a good known cardiovascular risk factor, one can say it does not play causal role in coronary artery ectasy. As expected there is no diffrence on fibrinogen levels between the groups, this result supports our findings on the viscosity values.
Keywords: Coronary artery ectasy, coronary artery disease, plasma viscosity
References
- Yetkin E, Waltenberger J. Novel insights into an old controversy: is coronary artery ectasia a variant of coronary atherosclerosis? Clin Res Cardiol 2007; 96: 331Swaye PS, Fisher LD, Litwin P, Vignola PA, Judkins MP, Kemp HG, Mudd JG, Gosselin AJ. Aneurysmal coronary artery disease. Circulation 1983; 67: 134-8.
- Falsetti HL, Carroll RJ. Coronary artery aneurysm. A review of the literature with a report of 11 new cases. Chest 1976; 69: 630-6.
- Markis JE, Joffe CD, Cohn PF, Feen DJ, Herman MV, Gorlin R. Clinical significance of coronary arterial ectasia. Am J Cardiol 1976; 37: 217-22.
- Maehara A, Mintz GS, Ahmed JM, Fuchs S, Castagna MT, Pichard AD, Satler LF, Waksman R, Suddath WO, Kent KM, Weissman NJ. An intravascular ultrasound classification of angiographic coronary artery aneurysms. Am J Cardiol 2001; 88: 365-70.
- Türkiye Kalp Raporu 2000, Türk Kardiyoloji Derneği, Yenilik Basımevi, İstanbul 2000; 11-25.
- Befeler B, Aranda MJ, Embi A, Mullin FL, El-Sherif N, Lazzara R. Coronary artery aneurysms: Study of their etiology, clinical course and effect on left ventricular function and prognosis. Am J Med 1977; 62: 597-607.
- Oliveros RA, Falsetti HL, Carroll RJ, Heinle RA, Ryan GF. Atherosclerotic coronary artery aneurysm: report of five cases and review of literature. Arch Intern Med 1974; 134: 1072-6.
- Hartnell GG, Parnell BM, Pridie RB. Coronary artery ectasia. Its prevalence and clinical significance in 4993 patients. Br Heart J 1985; 54: 392-5.
- Demir E. Koroner yavaş akımlı hastaların hemoreolojik parametrelerinin değerlendirilmesi. Pamukkale Üniversitesi Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Uzmanlık Tezi, Denizli 2011.
- Dikmenoğlu N. Kardiyovasküler hastalıklarda sigara ve kolesterol kadar önemli bir risk faktörü: kan akışkanlığı. Hacettepe Tıp Dergisi 2006; 37: 93-7.
- Yolcu M, Bilgili H, Küçükdurmaz Z, Karapınar H, Dokumacı B. Koroner arter hastalığı yaygınlığı ile plazma vizkositesi ve fibrinojen düzeyleri arasındaki ilişki. Türk Göğüs Kalp Damar Cerrahisi Dergisi 2012; 16: 15-9.
- Gapinska, AM, Jaroszyk, F, Elikowski W, Kubisz, L. The effect of acetylsalicylic acid and acenocoumarin on rheological properties of blood studied on patients after myocardial infarction. Current Topics in Biophysics 2004; 28: 3-8.
- Reinhart, WH. Hemorheology: blood flow hematology. Schweiz Med Woochenschr 1995; 125: 387-95.
- Baskurt OK. Rheologic properties of blood. Doğa-Tr.J.of Medical Sciences 1990; 14: 433-7.
- Altıparmak İH, Kaya Z, Sezen H, Aydın MS, Demirbağ R, Aksoy N. Serum paraoksonaz-1 aktivitesinin izole koroner arter ektazisi ile ilişkisi: Gözlemsel bir çalışma. Anadolu Kardiyoloji Dergisi 2012; 12: 307-12.
- Baskurt OK, Boynard M, Cokelet GC, Connes P, Cooke BM, Forconi S, Liao F, Hardeman MR, Friedrich Jung F, Meiselman HJ, Nash G, Nemeth N, Neu B, Sandhagen B, Shin S, Thurston G, Wautier JL. New guidelines for hemorheological laboratory techniques. Clin Hemorheol Microcirc 2009; 42: 75
- Leonhardt H, Bungert HJ. Plasma viskositat und portale hypertension bei bercirrhosekranken. Klın Wschr 1973; 51: 1043-49.
- Ernst E, Matrai A, Schmölzl CH, Magyarosy I. Dose-effect relationship between smoking and blood rheology. Br J Haematol 1987; 65: 485-7.
- Ernst E, Schmid WM, Baumann M, Matrai A. Cardiovascular risk factors and hemoreology. Atherosclerosis 1986; 59: 263-9.
- Solerto SB, Fioravanti M, Patti AL, Fedele P, Ferrari E. Incresed plasmaapolipoprotein B levels and blood hyperviscosity in noninsülin dependent diabetic patients: Role in the occurence of arterial hypertension. Acta Diabetol Lal 1987; 24: 341-9.
- Kensey KR. The mechanistic relationships between hemorheological characteristics and cardiovascular disease. Curr Med Res Opin 2003; 19: 587-96. Lee AJ, Mowbray PI, Lowe GDO, Rumley A, Fowkes FGR, Allan PL. Blood viscosity and elevated carotid intima-media thickness in men and women:the Edinburgh Artery Study. Circulation 1998; 97: 1467-73.
- Chrissoheris MP, Donohue TJ, Young RS, Ghantous A. Coronary Artery Aneurysms. Cardiol in Rev 2008; 16: 116-23.
- Papadakis MC, Manginas A, Cotileas P, Demopoulos V, Voudris V, Pavlides G, Foussas SG, Cokkinos DV. Documentation of slow coronary flow by the TIMI frame count in patients with coronary ectasia. Am J Cardiol 2001; 88: 1030-2.
Details
| Primary Language | Turkish |
|---|---|
| Journal Section | Surgical Science Research Articles |
| Authors | |
| Publication Date | September 30, 2014 |
| Published in Issue | Year 2014Volume: 36 Issue: 3 |