Research Article
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The Healing Effect of Resveratrol and Platelet Rich Plasma in Corrosive Esophagitis Model in Rats

Year 2022, Volume 44, Issue 3, 282 - 287, 01.10.2022
https://doi.org/10.7197/cmj.1149750

Abstract

Background: Corrosive esophageal burns have high morbidity and mortality. The effective treatment is controversial. In our study, we aimed to examine the effects of resveratrol (RSV) and platelet rich plasma (PRP) on healing in the corrosive esophagitis model in rats.
Material and methods: A total of 24 rats were randomly divided into 4 groups each as esophagitis, control, PRP and RSV groups. No treatment was administered to the control group. The esophagitis model was induced in the esophagitis and treatment groups. The esophagitis group was not treated. PRP group was treated with PRP, RSV group was treated with RSV. Pathological and biochemical examinations were performed from distal esophagitis.
Results: The highest tissue IL-1, IL-6, and TNF-α levels were observed in the esophagitis group. The lowest tissue IL-1, IL-6, and TNF-α levels were noted in the control group. The highest tissue TAS levels were observed in the control group. The lowest tissue TAS levels were noted in the esophagitis group. The other groups had significantly lower mean tissue TOS and OSI levels than the esophagitis group (P<0.05).
Conclusions: PRP and RSV have a healing effect on esophagitis. We are of the opinion that it may be included in clinical practice over time if the dose and duration of treatment can be adjusted better for RSV. 

References

  • Senturk E, Sen S, Pabuccu E, et al. New experimental corrosive esophagitis model in rats. Pediatr Surg Int. 2010;26(3): 257-261.
  • Anderson KD, Rouse TM, Randoph JG. A controlled trial of corticosteroids in children with corrosive injury of the esophagus. N Engl J Med. 1990;323(10):637-640.
  • Günel E, Çaǧlayan F, Çaǧlayan O, et al. Reactive oxygen radical levels in caustic esophageal burns. J Pediatr Surg.:1999;34 (3)405-407.
  • Gehanno P, Guedon C. Inhibition of experimental esophageal lye strictures by penicillamine. Arch Otolaryngol. 1981;107(3):145-147.
  • Franco D, Franco T, Schettino AM, et al. Protocol for obtaining platelet-rich plasma (PRP), platelet-poor plasma (PPP), and thrombin for autologous use. Aesthetic Plast Surg. 2012;36(5):1254-1259.
  • Karaca G, Aydin O, Pehlivanli F, et al. Effectiveness of thymoquinone, zeolite, and platelet-rich plasma in model of corrosive oesophagitis induced in rats. Ann Surg Treat Res.2017;92(6):396-401.
  • Dolezelova E, Prasnicka A, Cermanova J, et al. Resveratrol modifies biliary secretion of cholephilic compounds in sham-operated and cholestatic rats. World J Gastroenterol. 2017;23(43):7678-7692.
  • Ozden H, Şahin Y, Kilitçi A, et al. Comparison of the healing effects of mesazaline and Ganoderma lucidum in acetic acid-induced colitis in rats. Annals of Surgical Treatment and Research. 2022:102(1):29-35.
  • Lakshmi C, Vijayahari R, Kate V, et al. A hospital-based epidemiological study of corrosive alimentary injuries with particular reference to the Indian experience. Natl Med J India. 2013;26(1):31-36.
  • Bustamante TF, Lourenção PLTdA, Higa KL, et al. The use of mitomycin C in caustic esophagitis in rats. Acta Cir. Bras. 2013;28(2):136-141.
  • Miller CK, Rutter MJ, von Allmen D, et al. Swallowing dynamics status post caustic ingestion in a pediatric patient: A multidisciplinary case report. Int J Pediatr Otorhinolaryngol. 2016;86:4-8.
  • Ayesh K, Sultan M. Caustic ingestions in pediatric patients. J Gastric Disord Ther. 2017;3 (2): 1-4.
  • Park KS: Evaluation and management of caustic injuries from ingestion of acid or alkaline substances. Clin Endosc, 2014;47(4):301-307.
  • Çalışkan C, Bölükbaşı H, Fırat Ö, et al. Deneysel koroziv özofajit modelinde pentoksifilin ve trimetazidinin striktür oluşumunu önleyici etkileri. Akademik Gastroenteroloji Dergisi. 2009;8(1):6-11.
  • Yetim TD, Yetim İ, Duru M. Korozif özofajit tedavisinde N-Asetil Sistein kullanımının erken dönemde striktur gelişimini engellemedeki etkinliği. Akademik Acil Tıp Dergisi. 2011;10(2):73-75.
  • Özden H, Karaca G, Bulut H, et al. The healing effects of the topical mesenchymal stem cells application on colonic anastomosis subjected to ischemia reperfusion injury. Kafkas Univ Vet Fak Derg. 2021;27(5):595-600.
  • Cömert HSY, Ötgün İ, Temiz A, et al. Ratlarda oluşturulan korozif özofajitin tedavisinde mezenkimal kök hücre kullanımı. Çocuk Cerrahisi Dergisi. 2014;28(1):1-8.
  • Tanrıkulu CŞ, Tanrıkulu Y, Kılınç F, et al. The protective and anti-inflammatory effect of methylene blue in corrosive esophageal burns: An experimental study. Ulus Travma Acil Cerrahi Derg, 25 (4): 317-323, 2019. DOI: 10.5505/tjtes.2018.58506
  • Ozbayoglu A, Sonmez K, Karabulut R, et al. Effect of polaprezinc on experimental corrosive esophageal burns in rats. Dis Esophagus. 2017;30(11):1-6.
  • Tanrıkulu CŞ, Tanrikulu Y, Kılınç F, et al. Beneficial effects of garlic (Allium sativum) oil in experimental corrosive esophageal burns effects of garlic oil in esophageal burns. Ulus Travma Acil Cerrahi Derg. 2017;23(3):181-187.
  • Oztan MO, Oztan S, Duzenli N, et al. The effect of platelet-rich plasma on motility changes in experimental caustic esophageal burn. Esophagus. 2018;15(3):198-204.
  • Cevik M, Demir T, Karadag CA, et al. Preliminary study of efficacy of hyaluronic acid on caustic esophageal burns in an experimental rat model. J Pediatr Surg. 2013;48(4):716-723.
  • Erel O. A new automated colorimetric method for measuring total oxidant status. Clin Biochem. 2005;38(12):1103-1111.
  • Homan CS, Maitra SR, Lane BP, et al. Effective treatment for acute alkali injury to the esophagus using weak-acid neutralization therapy: an ex-vivo study. Acad Emerg Med. 1995;2(11):952-958.
  • Homan CS, Maitra SR, Lane BP, et al. Effective treatment of acute alkali injury of the rat esophagus with early saline dilution therapy. Ann Emerg Med. 1993;22(2):178-182.
  • Malanga GA, Goldin M. PRP: review of the current evidence for musculoskeletal conditions. Curr Phys Med Rehabil Rep. 2014;2(1):1-15.
  • Wu PI, Diaz R, Borg-Stein J. Platelet-Rich Plasma. Phys Med Rehabil Clin N Am. 2016;27(4):825-853.
  • Oztan MO, Arslan FD, Oztan S, et al. Effects of topical application of platelet-rich plasma on esophageal stricture and oxidative stress after caustic burn in rats: Is autologous treatment possible? J Pediatr Surg. 2019;54(7):1397-1404.
  • Kim S, Ryu H-W, Lee K-S, et al. Application of platelet-rich plasma accelerates the wound healing process in acute and chronic ulcers through rapid migration and upregulation of cyclin A and CDK4 in HaCaT cells. Mol Med Rep. 2013;7(2):476-480.
  • Galiniak S, Aebisher D, Bartusik-Aebisher D. Health benefits of resveratrol administration. Acta Biochim Pol. 2019;66(1):13-21.
  • Savouret JF, Quesne M. Resveratrol and cancer: a review. Biomed Pharmacother, 2002;56(2):84-87.

Year 2022, Volume 44, Issue 3, 282 - 287, 01.10.2022
https://doi.org/10.7197/cmj.1149750

Abstract

References

  • Senturk E, Sen S, Pabuccu E, et al. New experimental corrosive esophagitis model in rats. Pediatr Surg Int. 2010;26(3): 257-261.
  • Anderson KD, Rouse TM, Randoph JG. A controlled trial of corticosteroids in children with corrosive injury of the esophagus. N Engl J Med. 1990;323(10):637-640.
  • Günel E, Çaǧlayan F, Çaǧlayan O, et al. Reactive oxygen radical levels in caustic esophageal burns. J Pediatr Surg.:1999;34 (3)405-407.
  • Gehanno P, Guedon C. Inhibition of experimental esophageal lye strictures by penicillamine. Arch Otolaryngol. 1981;107(3):145-147.
  • Franco D, Franco T, Schettino AM, et al. Protocol for obtaining platelet-rich plasma (PRP), platelet-poor plasma (PPP), and thrombin for autologous use. Aesthetic Plast Surg. 2012;36(5):1254-1259.
  • Karaca G, Aydin O, Pehlivanli F, et al. Effectiveness of thymoquinone, zeolite, and platelet-rich plasma in model of corrosive oesophagitis induced in rats. Ann Surg Treat Res.2017;92(6):396-401.
  • Dolezelova E, Prasnicka A, Cermanova J, et al. Resveratrol modifies biliary secretion of cholephilic compounds in sham-operated and cholestatic rats. World J Gastroenterol. 2017;23(43):7678-7692.
  • Ozden H, Şahin Y, Kilitçi A, et al. Comparison of the healing effects of mesazaline and Ganoderma lucidum in acetic acid-induced colitis in rats. Annals of Surgical Treatment and Research. 2022:102(1):29-35.
  • Lakshmi C, Vijayahari R, Kate V, et al. A hospital-based epidemiological study of corrosive alimentary injuries with particular reference to the Indian experience. Natl Med J India. 2013;26(1):31-36.
  • Bustamante TF, Lourenção PLTdA, Higa KL, et al. The use of mitomycin C in caustic esophagitis in rats. Acta Cir. Bras. 2013;28(2):136-141.
  • Miller CK, Rutter MJ, von Allmen D, et al. Swallowing dynamics status post caustic ingestion in a pediatric patient: A multidisciplinary case report. Int J Pediatr Otorhinolaryngol. 2016;86:4-8.
  • Ayesh K, Sultan M. Caustic ingestions in pediatric patients. J Gastric Disord Ther. 2017;3 (2): 1-4.
  • Park KS: Evaluation and management of caustic injuries from ingestion of acid or alkaline substances. Clin Endosc, 2014;47(4):301-307.
  • Çalışkan C, Bölükbaşı H, Fırat Ö, et al. Deneysel koroziv özofajit modelinde pentoksifilin ve trimetazidinin striktür oluşumunu önleyici etkileri. Akademik Gastroenteroloji Dergisi. 2009;8(1):6-11.
  • Yetim TD, Yetim İ, Duru M. Korozif özofajit tedavisinde N-Asetil Sistein kullanımının erken dönemde striktur gelişimini engellemedeki etkinliği. Akademik Acil Tıp Dergisi. 2011;10(2):73-75.
  • Özden H, Karaca G, Bulut H, et al. The healing effects of the topical mesenchymal stem cells application on colonic anastomosis subjected to ischemia reperfusion injury. Kafkas Univ Vet Fak Derg. 2021;27(5):595-600.
  • Cömert HSY, Ötgün İ, Temiz A, et al. Ratlarda oluşturulan korozif özofajitin tedavisinde mezenkimal kök hücre kullanımı. Çocuk Cerrahisi Dergisi. 2014;28(1):1-8.
  • Tanrıkulu CŞ, Tanrıkulu Y, Kılınç F, et al. The protective and anti-inflammatory effect of methylene blue in corrosive esophageal burns: An experimental study. Ulus Travma Acil Cerrahi Derg, 25 (4): 317-323, 2019. DOI: 10.5505/tjtes.2018.58506
  • Ozbayoglu A, Sonmez K, Karabulut R, et al. Effect of polaprezinc on experimental corrosive esophageal burns in rats. Dis Esophagus. 2017;30(11):1-6.
  • Tanrıkulu CŞ, Tanrikulu Y, Kılınç F, et al. Beneficial effects of garlic (Allium sativum) oil in experimental corrosive esophageal burns effects of garlic oil in esophageal burns. Ulus Travma Acil Cerrahi Derg. 2017;23(3):181-187.
  • Oztan MO, Oztan S, Duzenli N, et al. The effect of platelet-rich plasma on motility changes in experimental caustic esophageal burn. Esophagus. 2018;15(3):198-204.
  • Cevik M, Demir T, Karadag CA, et al. Preliminary study of efficacy of hyaluronic acid on caustic esophageal burns in an experimental rat model. J Pediatr Surg. 2013;48(4):716-723.
  • Erel O. A new automated colorimetric method for measuring total oxidant status. Clin Biochem. 2005;38(12):1103-1111.
  • Homan CS, Maitra SR, Lane BP, et al. Effective treatment for acute alkali injury to the esophagus using weak-acid neutralization therapy: an ex-vivo study. Acad Emerg Med. 1995;2(11):952-958.
  • Homan CS, Maitra SR, Lane BP, et al. Effective treatment of acute alkali injury of the rat esophagus with early saline dilution therapy. Ann Emerg Med. 1993;22(2):178-182.
  • Malanga GA, Goldin M. PRP: review of the current evidence for musculoskeletal conditions. Curr Phys Med Rehabil Rep. 2014;2(1):1-15.
  • Wu PI, Diaz R, Borg-Stein J. Platelet-Rich Plasma. Phys Med Rehabil Clin N Am. 2016;27(4):825-853.
  • Oztan MO, Arslan FD, Oztan S, et al. Effects of topical application of platelet-rich plasma on esophageal stricture and oxidative stress after caustic burn in rats: Is autologous treatment possible? J Pediatr Surg. 2019;54(7):1397-1404.
  • Kim S, Ryu H-W, Lee K-S, et al. Application of platelet-rich plasma accelerates the wound healing process in acute and chronic ulcers through rapid migration and upregulation of cyclin A and CDK4 in HaCaT cells. Mol Med Rep. 2013;7(2):476-480.
  • Galiniak S, Aebisher D, Bartusik-Aebisher D. Health benefits of resveratrol administration. Acta Biochim Pol. 2019;66(1):13-21.
  • Savouret JF, Quesne M. Resveratrol and cancer: a review. Biomed Pharmacother, 2002;56(2):84-87.

Details

Primary Language English
Subjects Health Care Sciences and Services
Journal Section Surgical Science Research Articles
Authors

Hüseyin ÖZDEN> (Primary Author)
SİVAS CUMHURİYET ÜNİVERSİTESİ, TIP FAKÜLTESİ, CERRAHİ TIP BİLİMLERİ BÖLÜMÜ, GENEL CERRAHİ ANABİLİM DALI
0000-0002-2786-3805
Türkiye


Muhammed GÖMEÇ>
SİVAS CUMHURİYET ÜNİVERSİTESİ, TIP FAKÜLTESİ, CERRAHİ TIP BİLİMLERİ BÖLÜMÜ, GENEL CERRAHİ ANABİLİM DALI
0000-0002-9127-3201
Türkiye


Yaşar ŞAHİN>
KIRIKKALE ÜNİVERSİTESİ, SAĞLIK BİLİMLERİ ENSTİTÜSÜ, FARMAKOLOJİ VE TOKSİKOLOJİ (VETERİNER) (DR) (ANKARA ÜN.)
0000-0001-5936-4210
Türkiye


Gökhan KARACA>
KIRŞEHİR AHİ EVRAN ÜNİVERSİTESİ, TIP FAKÜLTESİ, CERRAHİ TIP BİLİMLERİ BÖLÜMÜ, GENEL CERRAHİ ANABİLİM DALI
0000-0002-5107-5999
Türkiye


Huri BULUT>
İSTİNYE ÜNİVERSİTESİ, TIP FAKÜLTESİ, TEMEL TIP BİLİMLERİ BÖLÜMÜ, TIBBİ BİYOKİMYA ANABİLİM DALI
0000-0003-2706-9625
Türkiye


Asuman KİLİTCİ>
KIRŞEHİR AHİ EVRAN ÜNİVERSİTESİ, TIP FAKÜLTESİ, CERRAHİ TIP BİLİMLERİ BÖLÜMÜ, TIBBİ PATOLOJİ ANABİLİM DALI
0000-0002-5489-2222
Türkiye

Publication Date October 1, 2022
Published in Issue Year 2022, Volume 44, Issue 3

Cite

APA Özden, H. , Gömeç, M. , Şahin, Y. , Karaca, G. , Bulut, H. & Kilitci, A. (2022). The Healing Effect of Resveratrol and Platelet Rich Plasma in Corrosive Esophagitis Model in Rats . Cumhuriyet Medical Journal , 44 (3) , 282-287 . DOI: 10.7197/cmj.1149750