Genetic and Epigenetic Changes of CDKN2A in Gastric Cancer

Malik Ejder Yıldırım

doi:10.7197/cmj.1443256

TR EN

Gastrik Kanserde CDKN2A’nın Genetik ve Epigenetik Değişiklikleri

Öz

Mide kanseri, farklı moleküler özelliklere sahip çeşitli alt grupları içeren multifaktöriyel, heterojen bir hastalıktır ve dünya çapında kanser ölümlerinin önde gelen nedenlerinden biridir. Gastrik kanserde beslenme koşulları (kızarmış, yağlı ve tuzlu yiyecekler), tütün ve alkol tüketimi ve bazı gastrointestinal enfeksiyonlar önemli olmasına rağmen hastalığın gelişimi karmaşıktır. Tümör baskılayıcı genlerin ve proto-onkogenlerin mide kanserinin oluşumunda önemli bir etkiye sahip olduğu açıktır. CDKN2A, iki farklı proteini kodlayan tümör supresör bir gendir ve bu genin metilasyonu, delesyonu ve diğer mutasyonları mide kanserinin hem gelişiminde hem de prognozunda etkilidir. CDKN2A hipermetilasyonu, H. Pylori ve EBV enfeksiyonlarıyla ilişkili mide kanserinde yaygındır. Mide kanserinin metastazları ile bu tümör baskılayıcı genin kayıpları (delesyonlar) arasında sıklıkla bir bağlantı kurulmaktadır. Bu bağlamda, mide kanserinin tedavi ve takibinde biyobelirteç olarak CDKN2A genindeki olası değişiklikler göz önüne alınmalıdır.

Anahtar Kelimeler

Genetic and Epigenetic Changes of CDKN2A in Gastric Cancer

Abstract

Gastric cancer is a multifactorial heterogeneous disease involving various subgroups with different molecular features and it is one of the leading causes of cancer deaths worldwide. Although dietary conditions (fried, fatty and salty foods), tobacco and alcohol consumption, and some gastrointestinal infections are important in gastric cancer, the development of the disease is complex. It is clear that tumor suppressor genes and proto-oncogenes have a significant impact on the formation of gastric cancer. CDKN2A is a tumor suppressor gene that encodes two different proteins, and methylation, deletion and other mutations of this gene are effective in both the development and prognosis of gastric cancer. CDKN2A hypermethylation is common in gastric cancer related with H. Pylori and EBV infections. A connection is often established between metastases of gastric cancer and losses of this tumor suppressor gene (deletions). In this context, possible changes in the CDKN2A gene should be taken into consideration as a biomarker in the treatment and follow-up of gastric cancer.

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Details

Primary Language

English

Subjects

Multimorbidity

Journal Section

Review

Authors

Malik Ejder Yıldırım ^*
0000-0003-4386-1583
Türkiye

Publication Date

June 29, 2024

Submission Date

February 26, 2024

Acceptance Date

April 22, 2024

Published in Issue

Year 2024 Volume: 46 Number: 2

DOI

https://doi.org/10.7197/cmj.1443256

IZ

https://izlik.org/JA54XK88LT

Cite

RIS / Bibtex

AMA

1.Yıldırım ME. Genetic and Epigenetic Changes of CDKN2A in Gastric Cancer. CMJ. 2024;46(2):99-103. doi:10.7197/cmj.1443256