Meta-analysis of odds ratios for the COMT Gene rs737865 SNP for schizophrenia

Gulden Hakverdi; Harika Gözükara Bağ

doi:10.7197/cmj.1606628

TR EN

Şizofreni için COMT Geni rs737865 SNP odds oranlarının meta analizi

Öz

Özet Amaç: İlgilenilen konuda yapılan birden çok bağımsız çalışmanın bulgularını uygun istatistiksel metotlarla birleştirmeyi sağlayan metotlar topluluğuna meta analizi adı verilir. Şizofreni, birçok çevresel ve genetik faktörle bağlantılı karmaşık bir psikiyatrik hastalıktır ve dünya nüfusunun %1'ini etkilemektedir. Katekol-O-Metiltransferaz (COMT) geni şizofreniye yatkınlık için aday bir gen olarak görülmektedir. Bu çalışmada, şizofreni için COMT geninin rs737865 SNP’ne (tek nükleotit polimorfizmi) göre farklı çalışmalardan elde edilen odds oranlarının meta analizi ile birleştirilmesi amaçlanmıştır. Materyal ve Metot: Yazım dili İngilizce olan yayınlar "COMT ve şizofreni" anahtar kelimeleri ile Ekim 2024 tarihine kadar Web of Science, Pubmed ve Google Akademik veri tabanlarında ile taranmıştır. Dâhil olma kriterlerini sağlayan 17 çalışma ve ayrıca ırka göre Asyalı ve Beyaz ırklar için sırasıyla 8 ve 4 çalışma için farklı genetik modeller altında, uygun meta analitik yöntemler yardımıyla ortak odds oranı kestirimleri elde edillmiştir. Tüm analizlerde STATA 14.0 programı kullanılmıştır. Bulgular: On yedi çalışmaya uygulanan farklı genetik modeller altında, sadece CC genotipine sahip olanların T (TT+CT) alleli taşıyıcılarına göre şizofreni için risk taşıdığı bulunmuştur [OR=1,133 (%95 G.A.=1,008 – 1,273)]. Irka göre yapılan alt grup analizlerinde ise Asyalı ırk için bir riskten söz edemezken Beyaz ırk için C (CC+CT) alleli taşıyıcılarının TT genotipine sahip olanlara göre şizofreni riskini arttırdığı bulunmuştur [OR=1,586 (%95 G.A.=1,349 – 1,865)]. Sonuç: Uygulanan meta-analitik yöntemler yardımıyla bağımsız çalışmalardan elde edilen odds oranları (OR) için farklı genetik modeller altında tümel kestirimler elde edilmiştir. Bununla birlikte, etnik köken açısından homojen daha büyük gruplarda yapılan çalışmalar ile COMT geni rs737865 SNP’i ile şizofreni arasındaki bağın incelenmesi gerektiği düşünülmektedir.

Anahtar Kelimeler

Meta-analysis of odds ratios for the COMT Gene rs737865 SNP for schizophrenia

Abstract

ABSTRACT Meta-analysis of COMT Gene rs737865 SNP odds ratios for schizophrenia Background: The collection of methods that enable combining the findings of several independent studies on the topic of interest with appropriate statistical methods is called meta-analysis. Schizophrenia is a complex psychiatric disease linked to many environmental and genetic factors and affects up to 1% of the world's population. A candidate gene for schizophrenia susceptibility is the catechol-O-methyltransferase (COMT) gene. This study aimed to combine the odds ratios obtained from different studies according to the rs737865 SNP (single nucleotide polymorphism) of the COMT gene for schizophrenia by meta-analysis. Material and Method: Publications written in English were scanned with the keywords "COMT and schizophrenia" in Web of Science, Pubmed, and Google Scholar databases until October 2024. Common odds ratio estimates were obtained with the help of appropriate meta-analytic methods under different genetic models for 17 studies that met the inclusion criteria, as well as 8 and 4 studies for Asians and Caucasians, respectively, by race. STATA 14 program was used for all analyses. Results: Under different genetic models applied to seventeen studies, only carriers of the CC genotype were found to have a higher risk for schizophrenia than carriers of the T (TT+CT) allele [OR=1.133 (95% CI=1.008 - 1.273)]. In subgroup analyses according to race, no risk was found for Asians. In contrast, for Caucasians, it was found that carriers of the C (CC+CT) allele had an increased risk of schizophrenia compared to those with TT genotype [OR=1.586 (95% CI=1.349 - 1.865)]. Conclusion: With the help of applied meta-analytic methods, overall estimates were obtained for odds ratios (OR) obtained from independent studies under different genetic models. However, it is thought that the association between COMT gene rs737865 SNP and schizophrenia should be examined with studies conducted in larger groups homogeneous in terms of ethnicity. Keywords: Meta-analysis, COMT, odds ratio, schizophrenia.

Keywords

Supporting Institution

İnönü Üniversitesi Bilimsel Araştırma Projeleri (BAP) birimi

Project Number

BAP 2016/149

Ethical Statement

Meta analiz çalışması olup etk kurul gerekmemektedir.

Thanks

İnönü Üniversitesi Bilimsel Araştırma Projeleri (BAP) birimi

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Details

Primary Language

English

Subjects

Health Informatics and Information Systems , Implementation Science and Evaluation

Journal Section

Systematic Reviews and Meta Analysis

Authors

Gulden Hakverdi ^*
0000-0002-8078-0451
Türkiye

Harika Gözükara Bağ
0000-0003-1208-4072
Türkiye

Publication Date

December 31, 2024

Submission Date

December 24, 2024

Acceptance Date

December 28, 2024

Published in Issue

Year 2024 Volume: 46 Number: 4

DOI

https://doi.org/10.7197/cmj.1606628

IZ

https://izlik.org/JA33YE64TC

Cite

RIS / Bibtex

AMA

1.Hakverdi G, Gözükara Bağ H. Meta-analysis of odds ratios for the COMT Gene rs737865 SNP for schizophrenia. CMJ. 2024;46(4):300-307. doi:10.7197/cmj.1606628