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Choroidal Thickness And Ocular Hemodynamics In Idiopathic Sudden Sensorineural Hearing Loss

Year 2022, Volume: 1 Issue: 1, 18 - 23, 25.06.2022

Abstract

Aim: Hypotheses about idiopathic sudden sensorineural hearing loss (ISSNHL) have focused on inflammation and vascular etiopathogenesis. We evaluated the relationship between ISSNHL and choroidal thickness (CT), ocular pulse amplitude (OPA), and intraocular pressure (IOP) to reveal the generality of inflammation and vascular pathology.
Materials and Methods: This study was conducted on 34 ISSNHL patients who were admitted within 5 days and were considered idiopathic with no etiological cause and 34 healthy controls. The ISSNHL group and the control group were assessed in terms of CT, OPA and IOP and ISSNHL groups on both affected (ipsilateral) and non-affected (contralateral) sides. Mild-moderate hearing loss group (n=20) and severe-profound hearing loss group (n=14) were also investigated and ocular parameters were compared.
Results: CT values were increased statistically significantly in the ISSHNL group (p=0.03), but there was no significant difference between groups in terms of OPA and IOP. When the ipsilateral and contralateral sides of ISSHNL patients were compared, no statistical difference was found between the CT, OPA and IOP values (p>0.05). Choroid thickness was found to be higher in severe-profound group rather than the mild-moderate group, but it was not statistically significant.
Conclusion: Increase in CT values of the ISSNHL group supports the relationship between sudden hearing loss and inflammatory processes. The bilateral nature of the findings support that systemic inflammation rather than a local inflammatory response.

Thanks

We wish to thank Assoc. Prof. Aydin Keskinruzgar for his assistance with the statistics used in this study.

References

  • 1. Stachler RJ, Chandrasekhar SS, Archer SM, Rosenfeld RM, Schwartz SR, Barrs DM et al. Clinical practice guideline: sudden hearing loss. Otolaryngol Head Neck Surg. 2012;146(3 Suppl):S1-35.
  • 2. Chau JK, Lin JR, Atashband S, Irvine RA, Westerberg BD. Systematic review of the evidence for the etiology of adult sudden sensorineural hearing loss. Laryngoscope. 2010;120:1011-21.
  • 3. Dziedzic T. Systemic inflammation as a therapeutic target in acute ischemic stroke. Expert Rev Neurother. 2015;15:523-31.
  • 4. Quaranta N, De Ceglie V, D'Elia A. Endothelial dysfunction in idiopathic sudden sensorineural hearing loss: A Review. Audiol Res. 2016;6:151.
  • 5. Mosnier I, Stepanian A, Baron G, Bodenez C, Robier A, Meyer B et al. Cardiovascular and thromboembolic risk factors in idiopathic sudden sensorineural hearing loss: a case-control study. Audiol Neurootol. 2011;16:55-66.
  • 6. Ocal R, Akın Ocal FC, Gulluev M, Alatas N. Is the C-reactive protein/albumin ratio a prognostic and predictive factor in sudden hearing loss? Braz J Otorhinolaryngol. 2020;86:180-4.
  • 7. Seo YJ, Jeong JH, Choi JY, Moon IS. Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio: novel markers for diagnosis and prognosis in patients with idiopathic sudden sensorineural hearing loss. Dis Markers. 2014;2014:702807.
  • 8. Masuda M, Kanzaki S, Minami S, Kikuchi J, Kanzaki J, Sato H et al. Correlations of inflammatory biomarkers with the onset and prognosis of idiopathic sudden sensorineural hearing loss. Otol Neurotol. 2012;33:1142-50.
  • 9. Bill A, Sperber GO. Control of retinal and choroidal blood flow. Eye (Lond). 1990;4:319-25.
  • 10. Ehrlich R, Harris A, Wentz SM, Moore NA, Siesky B A. Anatomy and regulation of the optic nerve blood flow. 2017, https://doi.org/10.1016/ B978-0-12- 809324-5.01301-8.
  • 11. Williamson TH, Harris A. Ocular blood flow measurement. Br J Ophthalmol. 1994;78:939-45.
  • 12. Stalmans I, Harris A, Fieuws S, Zeyen T, Vanbellinghen V, McCranor L et al. Color Doppler imaging and ocular pulse amplitude in glaucomatous and healthy eyes. Eur J Ophthalmol. 2009;19:580-7.
  • 13. Çalışkan S, Acar M, Gürdal C. Choroidal Thickness in Patients with Graves' Ophthalmopathy. Curr Eye Res. 2017;42:484-90.
  • 14. Türkcü FM, Şahin A, Yüksel H, Akkurt M, Uçmak D, Çınar Y et al. Evaluation of choroidal thickness in psoriasis using optical coherence tomography. Int Ophthalmol. 2016;36:851-4.
  • 15. Karadag AS, Bilgin B, Soylu MB. Comparison of optical coherence tomographic findings between Behcet disease patients with and without ocular involvement and healthy subjects. Arq Bras Oftalmol. 2017;80(2):69-73.
  • 16. Onal IK, Yuksel E, Bayrakceken K, Demir MM, Karaca EE, Ibis M, et al. Measurement and clinical implications of choroidal thickness in patients with inflammatory bowel disease. Arq Bras Oftalmol. 2015;78:278-82.
  • 17. Report of the informal working group on prevention of deafness and hearing impairment programme planning, Geneva, 18-21 June 1991. Geneva: World Health Organization; 1991. Available from: http://www.who.int/iris/handle/10665/58839
  • 18. Hiramatsu M, Teranishi M, Uchida Y, Nishio N, Suzuki H, Kato K et al. Polymorphisms in genes involved in inflammatory pathways in patients with sudden sensorineural hearing loss. J Neurogenet. 2012;26:387-96.
  • 19. Crane RA, Camilon M, Nguyen S, Meyer TA. Steroids for treatment of sudden sensorineural hearing loss: a meta-analysis of randomized controlled trials. Laryngoscope. 2015;125:209-17.
  • 20.Arslan Y, Arslan İB, Aydin H, Yağiz Ö, Tokuçoğlu F, Çukurova İ. The etiological relationship between migraine and sudden hearing Loss. Otol Neurotol. 2017;38:1411-4.
  • 21.Hsu HT, Chen JY, Weng SF, Huang KH, Lin YS. Increased risk of erectile dysfunction in patients with sudden sensorineural hearing loss: a nationwide, population-based cohort study. Otol Neurotol. 2013;34:862-7.
  • 22. Alm A. Ocular circulation. In: Hart W, ed. Adler's Physiology of the Eye: Clinical Application. St. Louis, MO: Mosby-Year Book, Inc. 1992: 199–227.
  • 23.Mei X, Atturo F, Wadin K, Larsson S, Agrawal S, Ladak HM et al. Human inner ear blood supply revisited: the Uppsala collection of temporal bone-an international resource of education and collaboration. Ups J Med Sci. 2018;123:131-42.
  • 24. Yoon TH, Paparella MM, Schachern PA, Alleva M. Histopathology of sudden hearing loss. Laryngoscope. 1990;100:707-15.
  • 25. Dervisogullari MS, Totan Y, Gençler OS. Choroid thickness and ocular pulse amplitude in migraine during attack. Eye (Lond). 2015;29:371-5.
  • 26. Dervişoğulları MS, Totan Y, Yüce A, Kulak AE. Acute effects of caffeine on choroidal thickness and ocular pulse amplitude. Cutan Ocul Toxicol. 2016;35:281-6.
  • 27. Doğan S, Şimşek A, Bayraktar C, Yazıcı H, Sarıkaya Y, Karataş M et al. Ocular blood flow alterations during inferior turbinate radiofrequency reduction under local anesthesia. Am J Rhinol Allergy. 2016;30:185-8.
  • 28. Steiner M, Esteban-Ortega MDM, Muñoz-Fernández S. Choroidal and retinal thickness in systemic autoimmune and inflammatory diseases: A review. Surv Ophthalmol. 2019;64:757-69.

İdiyopatik Ani Sensörinöral İşitme Kaybında Koroid Kalınlığı ve Oküler Hemodinami

Year 2022, Volume: 1 Issue: 1, 18 - 23, 25.06.2022

Abstract

Amaç: Ani idiyopatik sensörinöral işitme kaybı (AİSNİK) ile ilgili hipotezler, inflamasyon ve vasküler etiyopatogenez üzerine odaklanmıştır. Biz bu çalışmada AİSNİK ile koroid kalınlığı (KK), oküler pulsamplitüdü (OPA) ve göz içi basıncı (GİB) arasındaki ilişkiyi değerlendirerek, inflamasyon ve vasküler patolojilerin hastalıktaki rolünü ortaya koymayı amaçladık. Gereç ve Yöntemler: Ani işitme kaybı şikayetiyle beş gün içinde başvuran ve etiyolojik bir neden bulunma yarak idiyopatik kabul edilen 34 AİSNİK hastası ve 34 sağlıklı gönüllü çalışmaya dahil edildi. AİSNİK grubu ile kontrol grubu ve kendi içinde AİSNİK grubunun etkilenen (ipsilateral) ve etkilenmeyen (kontralateral) tarafları KK, OPA ve GİB açısından karşılaştırıldı. Ayrıca hafif-orta işitme kayıplı grup (n=20) ve ileri-çok ileri işitme kayıplı gruplar (n=14) arasındaki oküler parametreler karşılaştırıldı. Bulgular: Koroid kalınlığı, AİSNİK grubunda istatistiksel olarak anlamlı düzeyde artmış bulundu (p=0,03). Ancak OPA ve GİB açısından gruplar arasında anlamlı bir fark görülmedi. AİSNİK hastalarının, aynı taraf ve karşı tarafları karşılaştırıldığında KK, OPA ve GİB değerleri arasında istatistiksel olarak fark bulunmadı (p>0.05). Koroid kalınlığı, ileri-çok ileri işitme kaybı izlenen grupta, hafif-orta işitme kaybı izlenen gruba göre, artmıştı ancak istatistiksel olarak anlamlı değildi. Sonuç: AİSNİK grubunun KK değerlerindeki artış, ani işitme kaybı ile inflamatuar süreçler arasındaki ilişkiyi  desteklemektedir. Bulguların bilateral olması, lokal bir inflamatuar yanıttan çok sistemik inflamasyonu desteklemektedir.

References

  • 1. Stachler RJ, Chandrasekhar SS, Archer SM, Rosenfeld RM, Schwartz SR, Barrs DM et al. Clinical practice guideline: sudden hearing loss. Otolaryngol Head Neck Surg. 2012;146(3 Suppl):S1-35.
  • 2. Chau JK, Lin JR, Atashband S, Irvine RA, Westerberg BD. Systematic review of the evidence for the etiology of adult sudden sensorineural hearing loss. Laryngoscope. 2010;120:1011-21.
  • 3. Dziedzic T. Systemic inflammation as a therapeutic target in acute ischemic stroke. Expert Rev Neurother. 2015;15:523-31.
  • 4. Quaranta N, De Ceglie V, D'Elia A. Endothelial dysfunction in idiopathic sudden sensorineural hearing loss: A Review. Audiol Res. 2016;6:151.
  • 5. Mosnier I, Stepanian A, Baron G, Bodenez C, Robier A, Meyer B et al. Cardiovascular and thromboembolic risk factors in idiopathic sudden sensorineural hearing loss: a case-control study. Audiol Neurootol. 2011;16:55-66.
  • 6. Ocal R, Akın Ocal FC, Gulluev M, Alatas N. Is the C-reactive protein/albumin ratio a prognostic and predictive factor in sudden hearing loss? Braz J Otorhinolaryngol. 2020;86:180-4.
  • 7. Seo YJ, Jeong JH, Choi JY, Moon IS. Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio: novel markers for diagnosis and prognosis in patients with idiopathic sudden sensorineural hearing loss. Dis Markers. 2014;2014:702807.
  • 8. Masuda M, Kanzaki S, Minami S, Kikuchi J, Kanzaki J, Sato H et al. Correlations of inflammatory biomarkers with the onset and prognosis of idiopathic sudden sensorineural hearing loss. Otol Neurotol. 2012;33:1142-50.
  • 9. Bill A, Sperber GO. Control of retinal and choroidal blood flow. Eye (Lond). 1990;4:319-25.
  • 10. Ehrlich R, Harris A, Wentz SM, Moore NA, Siesky B A. Anatomy and regulation of the optic nerve blood flow. 2017, https://doi.org/10.1016/ B978-0-12- 809324-5.01301-8.
  • 11. Williamson TH, Harris A. Ocular blood flow measurement. Br J Ophthalmol. 1994;78:939-45.
  • 12. Stalmans I, Harris A, Fieuws S, Zeyen T, Vanbellinghen V, McCranor L et al. Color Doppler imaging and ocular pulse amplitude in glaucomatous and healthy eyes. Eur J Ophthalmol. 2009;19:580-7.
  • 13. Çalışkan S, Acar M, Gürdal C. Choroidal Thickness in Patients with Graves' Ophthalmopathy. Curr Eye Res. 2017;42:484-90.
  • 14. Türkcü FM, Şahin A, Yüksel H, Akkurt M, Uçmak D, Çınar Y et al. Evaluation of choroidal thickness in psoriasis using optical coherence tomography. Int Ophthalmol. 2016;36:851-4.
  • 15. Karadag AS, Bilgin B, Soylu MB. Comparison of optical coherence tomographic findings between Behcet disease patients with and without ocular involvement and healthy subjects. Arq Bras Oftalmol. 2017;80(2):69-73.
  • 16. Onal IK, Yuksel E, Bayrakceken K, Demir MM, Karaca EE, Ibis M, et al. Measurement and clinical implications of choroidal thickness in patients with inflammatory bowel disease. Arq Bras Oftalmol. 2015;78:278-82.
  • 17. Report of the informal working group on prevention of deafness and hearing impairment programme planning, Geneva, 18-21 June 1991. Geneva: World Health Organization; 1991. Available from: http://www.who.int/iris/handle/10665/58839
  • 18. Hiramatsu M, Teranishi M, Uchida Y, Nishio N, Suzuki H, Kato K et al. Polymorphisms in genes involved in inflammatory pathways in patients with sudden sensorineural hearing loss. J Neurogenet. 2012;26:387-96.
  • 19. Crane RA, Camilon M, Nguyen S, Meyer TA. Steroids for treatment of sudden sensorineural hearing loss: a meta-analysis of randomized controlled trials. Laryngoscope. 2015;125:209-17.
  • 20.Arslan Y, Arslan İB, Aydin H, Yağiz Ö, Tokuçoğlu F, Çukurova İ. The etiological relationship between migraine and sudden hearing Loss. Otol Neurotol. 2017;38:1411-4.
  • 21.Hsu HT, Chen JY, Weng SF, Huang KH, Lin YS. Increased risk of erectile dysfunction in patients with sudden sensorineural hearing loss: a nationwide, population-based cohort study. Otol Neurotol. 2013;34:862-7.
  • 22. Alm A. Ocular circulation. In: Hart W, ed. Adler's Physiology of the Eye: Clinical Application. St. Louis, MO: Mosby-Year Book, Inc. 1992: 199–227.
  • 23.Mei X, Atturo F, Wadin K, Larsson S, Agrawal S, Ladak HM et al. Human inner ear blood supply revisited: the Uppsala collection of temporal bone-an international resource of education and collaboration. Ups J Med Sci. 2018;123:131-42.
  • 24. Yoon TH, Paparella MM, Schachern PA, Alleva M. Histopathology of sudden hearing loss. Laryngoscope. 1990;100:707-15.
  • 25. Dervisogullari MS, Totan Y, Gençler OS. Choroid thickness and ocular pulse amplitude in migraine during attack. Eye (Lond). 2015;29:371-5.
  • 26. Dervişoğulları MS, Totan Y, Yüce A, Kulak AE. Acute effects of caffeine on choroidal thickness and ocular pulse amplitude. Cutan Ocul Toxicol. 2016;35:281-6.
  • 27. Doğan S, Şimşek A, Bayraktar C, Yazıcı H, Sarıkaya Y, Karataş M et al. Ocular blood flow alterations during inferior turbinate radiofrequency reduction under local anesthesia. Am J Rhinol Allergy. 2016;30:185-8.
  • 28. Steiner M, Esteban-Ortega MDM, Muñoz-Fernández S. Choroidal and retinal thickness in systemic autoimmune and inflammatory diseases: A review. Surv Ophthalmol. 2019;64:757-69.
There are 28 citations in total.

Details

Primary Language English
Subjects Clinical Sciences
Journal Section Research Articles
Authors

Ozlem Yagiz Aghayarov 0000-0002-8455-4400

Ayşe Sevgi Karadağ 0000-0002-7662-6531

İlker Burak Arslan 0000-0001-6987-3887

Sinan Uluyol 0000-0002-6027-2062

Ejder Ciğer 0000-0003-3310-938X

İbrahim Çukurova 0000-0002-2398-3391

Publication Date June 25, 2022
Submission Date May 12, 2022
Published in Issue Year 2022 Volume: 1 Issue: 1

Cite

APA Yagiz Aghayarov, O., Karadağ, A. S., Arslan, İ. B., Uluyol, S., et al. (2022). Choroidal Thickness And Ocular Hemodynamics In Idiopathic Sudden Sensorineural Hearing Loss. İzmir Tıp Fakültesi Dergisi, 1(1), 18-23.
AMA Yagiz Aghayarov O, Karadağ AS, Arslan İB, Uluyol S, Ciğer E, Çukurova İ. Choroidal Thickness And Ocular Hemodynamics In Idiopathic Sudden Sensorineural Hearing Loss. İzmir Tıp Fak. Derg. June 2022;1(1):18-23.
Chicago Yagiz Aghayarov, Ozlem, Ayşe Sevgi Karadağ, İlker Burak Arslan, Sinan Uluyol, Ejder Ciğer, and İbrahim Çukurova. “Choroidal Thickness And Ocular Hemodynamics In Idiopathic Sudden Sensorineural Hearing Loss”. İzmir Tıp Fakültesi Dergisi 1, no. 1 (June 2022): 18-23.
EndNote Yagiz Aghayarov O, Karadağ AS, Arslan İB, Uluyol S, Ciğer E, Çukurova İ (June 1, 2022) Choroidal Thickness And Ocular Hemodynamics In Idiopathic Sudden Sensorineural Hearing Loss. İzmir Tıp Fakültesi Dergisi 1 1 18–23.
IEEE O. Yagiz Aghayarov, A. S. Karadağ, İ. B. Arslan, S. Uluyol, E. Ciğer, and İ. Çukurova, “Choroidal Thickness And Ocular Hemodynamics In Idiopathic Sudden Sensorineural Hearing Loss”, İzmir Tıp Fak. Derg., vol. 1, no. 1, pp. 18–23, 2022.
ISNAD Yagiz Aghayarov, Ozlem et al. “Choroidal Thickness And Ocular Hemodynamics In Idiopathic Sudden Sensorineural Hearing Loss”. İzmir Tıp Fakültesi Dergisi 1/1 (June 2022), 18-23.
JAMA Yagiz Aghayarov O, Karadağ AS, Arslan İB, Uluyol S, Ciğer E, Çukurova İ. Choroidal Thickness And Ocular Hemodynamics In Idiopathic Sudden Sensorineural Hearing Loss. İzmir Tıp Fak. Derg. 2022;1:18–23.
MLA Yagiz Aghayarov, Ozlem et al. “Choroidal Thickness And Ocular Hemodynamics In Idiopathic Sudden Sensorineural Hearing Loss”. İzmir Tıp Fakültesi Dergisi, vol. 1, no. 1, 2022, pp. 18-23.
Vancouver Yagiz Aghayarov O, Karadağ AS, Arslan İB, Uluyol S, Ciğer E, Çukurova İ. Choroidal Thickness And Ocular Hemodynamics In Idiopathic Sudden Sensorineural Hearing Loss. İzmir Tıp Fak. Derg. 2022;1(1):18-23.