Research Article
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Year 2021, Volume: 5 Issue: 3, 149 - 155, 20.09.2021

Alkim Gulsah Sahingoz Yildirim Barış Sever Hakan Gölbaşı İbrahim Ömeroğlu Zübeyde Emiralioğlu Çakır Mehmet Ozer Ceren Golbasi Atalay Ekin Halil Gürsoy Pala Mehmet Özeren

https://doi.org/10.30621/jbachs.955838

Abstract

References

  • References 1. G.A. Mensah, D.W. Brown.An overview of cardiovascular disease burden in the United States Health Affairs, 26 (2007), pp. 38-48.
  • 2. Bull C. Current and potential impact of fetal diagnosis on prevalence and spectrum of serious congenital heart disease at term in the UK. British Paediatric Cardiac Association. Lancet 1999; 354: 1242–47.
  • 3. Hawkins JA, Doty DB. Aortic atresia: morphologic characteristics aff ecting survival and operative palliation. J Thorac Cardiovasc Surg 1984; 88: 620–26.
  • 4. Morris CD, Outcalt J, Menashe VD. Hypoplastic left heart syndrome: natural history in a geographically defined population. Pediatrics 1990; 85: 977–83.
  • 5. Allan LD, Sharland GK, Milburn A, et al. Prospective diagnosis of 1,006 consecutive cases of congenital heart disease in the fetus. J Am Coll Cardiol 1994; 23: 1452–58.
  • 6. Raymond FL, Simpson JM, Sharland GK, Ogilvie Mackie CM. Fetal echocardiography as a predictor of chromosomal abnormality. Lancet 1997; 350: 930.
  • 7. Grossfeld PD, Mattina T, Lai Z, et al. The 11q terminal deletion disorder: a prospective study of 110 cases. Am J Med Genet 2004; 129A: 51–61.
  • 8. Barron DJ., Kilby MD., Davies B., Wright JGC., Jones TJ., Brawn WJ. Hypoplastic left heart syndrome. Lancet 2009; 374: 551–64.
  • 9. Tchervenkov CI, Jacobs ML, Tahta SA. Congenital heart surgery nomenclature and database project: hypoplastic left heart syndrome. Ann Thorac Surg 2000; 69: S170–S179.
  • 10. van Velzen CL, Clur SA, Rijlaarsdam ME, et al. Prenatal detection of congenital heart disease–results of a national screening programme. (BJOG 2016; 123: 400–407.
  • 11. Rasiah SV, Publicover M, Ewer AK, Khan KS, Kilby MD, Zamora J. A systematic review of the accuracy of first-trimester ultrasound examination for detecting major congenital heart disease. Ultrasound Obstet Gynecol 2006; 28: 110–16.
  • 12. Hess DB, Flaker G, Aggarwal KB, Buchheit LC, Hess LW. Fetal cardiac imaging. In Fetal Echocardiography, Hess DB, Hess LW (eds). Appleton & Lange: Stamford, CT, 1999; 149–194. 15.
  • 13. Rychik J, Ayres N, Cuneo B, Gotteiner N, Hornberger L, Spevak PJ, Van Der Veld M. American Society of Echocardiography guidelines and standards for performance of the fetal echocardiogram. J Am Soc Echocardiogr 2004; 17: 803–810.
  • 14. Rychik J. Hypoplastic left heart syndrome: from in-utero diagnosis to school age. Semin Fetal Neonatal Med. 2005;10:553-566.
  • 15. Jenkins PC, Chinnock RE, Jenkins KJ, et al. Decreased exercise performance with age in children with hypoplastic left heart syndrome. J Pediatr. 2008;152(4):507-512.
  • 16. Sun L, Macgowan CK, Sled JG, et al. Reduced fetal cerebral oxygen consumption is associated with smaller brain size in fetuses with congenital heart disease. Circulation 2015; 131: 1313–1323.
  • 17. Limperopoulos C, Tworetzky W, McElhinney DB, et al. Brain volume and metabolism in fetuses with congenital heart disease: Evaluation with quantitative magnetic resonance imaging and spectroscopy. Circulation 2010; 121: 26–33.
  • 18. Jones HN, Olbrych SK, Smith KL, et al. Hypoplastic left heart syndrome is associated with structural and vascular placental abnormalities and leptin dysregulation. Placenta 2015; 36: 1078–1086.
  • 19. Williams RV, Ravishankar C, Zak V, et al. Birth weight and prematurity in infants with single ventricle physiology: Pediatric heart network infant single ventricle trial screened population. Congenit Heart Dis 2010; 5: 96–103.
  • 20. Rychik J, Szwast A, Natarajan S, et al. Perinatal and early surgical outcome for the fetus with hypoplastic left heart syndrome: a 5-year single institutional experience. Ultrasound Obstet Gynecol 2010; 36: 465–470.
  • 21. Allen RH, Benson CB, Haug LW. Pregnancy outcome of fetuses with a diagnosis of hypoplastic left ventricle on prenatal sonography. J Ultrasound Med 2005; 24: 1199–1203.
  • 22. Donofrio MT, Moon-Grady AJ, Hornberger LK, et al. Diagnosis and treatment of fetal cardiac disease: a scientific statement from the American heart association. Circulation 2014; 129: 2183–2242.
  • 23. Roeleveld PP, Axelrod DM, Klugman D, Jones MB, Chanani NK, Rossano JW, Costello JM. (2018) Hypoplastic left heart syndrome: from fetus to fontan. Cardiology in the Young 28: 1275–1288.
  • 24. Ellinger MK., Rempel GR. Parental Decision Making Regarding Treatment of Hypoplastic Left Heart Syndrome. Advances in Neonatal Care.Vol. 10, No. 6.pp. 316-322.
  • 25. Atallah J, Dinu IR, Joffe AR, et al. Two-year survival and mental and psychomotor outcomes after the Norwood procedure: an analysis of the modified BlalockTaussig shunt and right ventricle-to-pulmonary artery shunt surgical eras. Circulation. 2008;118:1410-1418.
  • 26. Norwood WI, Lang P, Hansen DD. Physiologic repair of aortic atresia-hypoplastic left heart syndrome. N Engl J Med 1983; 308: 23–26.
  • 27. Tibballs J, Kawahira Y, Carter BG, Donath S, Brizard C, Wilkinson J. Outcomes of surgical treatment of infants with hypoplastic left heart syndrome: an institutional experience 1983-2004. J Paediatr Child Health. 2007;43(11):746-751.
  • 28. Jacobs JP, O’Brien SM, Chai PJ, Morell VO, Lindberg HL, Quintessenza JA. Management of 239 patients with hypoplastic left heart syndrome and related malformations from 1993 to 2007. Ann Thorac Surg. 2008;85:1691-1697.
  • 29. Pizarro C, Derby CD, Baffa JM, Murdison KA, Radtke WA. Improving the outcome of high risk neonates with hypoplastic left heart syndrome: hybrid procedure or conventional surgical palliation? Eur J Cardiothorac Surg. 2008;33:613-618.
  • 30. Jenkins KJ, Gauvreau K, Newburger JW, Spray TL, Moller JH, Iezzoni LI. Consensus-based method for risk adjustment for surgery for congenital heart disease. J Thorac Cardiovasc Surg 2002; 123: 110–18.
  • 31. Sharland GK, Allan LD. Screening for congenital heart disease prenatally. Results of a 2 1/2 year study in the South East Thames Region. Br J Obstet Gynaecol 1992; 99: 220–225.
  • 32. Nikkila A, Bj ¨ orkhem G, K ¨ all ¨ en B. Prenatal diagnosis of congen- ´ ital heart defects – a population based study. Acta Paediatrica 2007; 96: 49–52.
  • 33. Rychik J, Rome JJ, Collins MH, et al. The hypoplastic left heart syndrome with intact atrial septum: atrial morphology, pulmonary vascular histopathology and outcome. J Am Coll Cardiol 1999;34:554–60.
  • 34. Brackley KJ, Kilby MD, Wright JG, et al. Outcome after prenatal diagnosis of hypoplastic left-heart syndrome: a case series. Lancet 2000; 356: 1143–47.
  • 35. Yagel S, Weissman A, Rotstein Z, et al. Congenital heart defects: natural course and in utero development. Circulation 1997; 96: 550–55.

Perinatal results of antenatally detected hypoplastic left heart syndrome in a single tertiary center: experience of 5 years time

Year 2021, Volume: 5 Issue: 3, 149 - 155, 20.09.2021

Alkim Gulsah Sahingoz Yildirim Barış Sever Hakan Gölbaşı İbrahim Ömeroğlu Zübeyde Emiralioğlu Çakır Mehmet Ozer Ceren Golbasi Atalay Ekin Halil Gürsoy Pala Mehmet Özeren

https://doi.org/10.30621/jbachs.955838

Abstract

Abstract
Aim: Our aim is to investigate Hypoplastic Left Heart Syndrome diagnosed pregnancies that were followed up in Tepecik Education and Research Hospital- Perinatology Unit between 2015-2020, retrospectively.
Matherials and Methods: The archieves were scanned retrospectively. Maternal features such as age, gravidy, parity, teratogen exposure, concominant disease existence, karyotyping rejection and decision for the pregnancies future and delivery type was noted. Also fetal features like gestational age at diagnosis, fetal growth, perinatal complications (eg: intrauterin growth retardation, additional anomaly, preterm delivery) and postnatal condition was noted.
Results: 9 of the 41 patients met the criteria. One of them had termination of the pregnancy. %37.5 of the rest had preterm delivery. 3 of the 8 patients (%37,5) had intrauterin growth retardation with estimated fetal weight below 10 persentile. There were no gender difference among infants. 75 percent of delivered infants, were operated postnataly. 2 of the infants were died before operation due to prematurity complications.
Discussion: Hypoplastic Left Heart Syndrome is a very rare condition highly detectable in the antenatal period with high morbidity and mortality rates. These fetuses must be followed up in tertiary centers both because of antenatal problems’ management and postnatal management.
Keywords: Hypoplastic Left Heart Syndrome, fetal echocardiography

Keywords

Hypoplastic Left Heart Syndrome fetal echocardiography. congenital heart defects

References

  • References 1. G.A. Mensah, D.W. Brown.An overview of cardiovascular disease burden in the United States Health Affairs, 26 (2007), pp. 38-48.
  • 2. Bull C. Current and potential impact of fetal diagnosis on prevalence and spectrum of serious congenital heart disease at term in the UK. British Paediatric Cardiac Association. Lancet 1999; 354: 1242–47.
  • 3. Hawkins JA, Doty DB. Aortic atresia: morphologic characteristics aff ecting survival and operative palliation. J Thorac Cardiovasc Surg 1984; 88: 620–26.
  • 4. Morris CD, Outcalt J, Menashe VD. Hypoplastic left heart syndrome: natural history in a geographically defined population. Pediatrics 1990; 85: 977–83.
  • 5. Allan LD, Sharland GK, Milburn A, et al. Prospective diagnosis of 1,006 consecutive cases of congenital heart disease in the fetus. J Am Coll Cardiol 1994; 23: 1452–58.
  • 6. Raymond FL, Simpson JM, Sharland GK, Ogilvie Mackie CM. Fetal echocardiography as a predictor of chromosomal abnormality. Lancet 1997; 350: 930.
  • 7. Grossfeld PD, Mattina T, Lai Z, et al. The 11q terminal deletion disorder: a prospective study of 110 cases. Am J Med Genet 2004; 129A: 51–61.
  • 8. Barron DJ., Kilby MD., Davies B., Wright JGC., Jones TJ., Brawn WJ. Hypoplastic left heart syndrome. Lancet 2009; 374: 551–64.
  • 9. Tchervenkov CI, Jacobs ML, Tahta SA. Congenital heart surgery nomenclature and database project: hypoplastic left heart syndrome. Ann Thorac Surg 2000; 69: S170–S179.
  • 10. van Velzen CL, Clur SA, Rijlaarsdam ME, et al. Prenatal detection of congenital heart disease–results of a national screening programme. (BJOG 2016; 123: 400–407.
  • 11. Rasiah SV, Publicover M, Ewer AK, Khan KS, Kilby MD, Zamora J. A systematic review of the accuracy of first-trimester ultrasound examination for detecting major congenital heart disease. Ultrasound Obstet Gynecol 2006; 28: 110–16.
  • 12. Hess DB, Flaker G, Aggarwal KB, Buchheit LC, Hess LW. Fetal cardiac imaging. In Fetal Echocardiography, Hess DB, Hess LW (eds). Appleton & Lange: Stamford, CT, 1999; 149–194. 15.
  • 13. Rychik J, Ayres N, Cuneo B, Gotteiner N, Hornberger L, Spevak PJ, Van Der Veld M. American Society of Echocardiography guidelines and standards for performance of the fetal echocardiogram. J Am Soc Echocardiogr 2004; 17: 803–810.
  • 14. Rychik J. Hypoplastic left heart syndrome: from in-utero diagnosis to school age. Semin Fetal Neonatal Med. 2005;10:553-566.
  • 15. Jenkins PC, Chinnock RE, Jenkins KJ, et al. Decreased exercise performance with age in children with hypoplastic left heart syndrome. J Pediatr. 2008;152(4):507-512.
  • 16. Sun L, Macgowan CK, Sled JG, et al. Reduced fetal cerebral oxygen consumption is associated with smaller brain size in fetuses with congenital heart disease. Circulation 2015; 131: 1313–1323.
  • 17. Limperopoulos C, Tworetzky W, McElhinney DB, et al. Brain volume and metabolism in fetuses with congenital heart disease: Evaluation with quantitative magnetic resonance imaging and spectroscopy. Circulation 2010; 121: 26–33.
  • 18. Jones HN, Olbrych SK, Smith KL, et al. Hypoplastic left heart syndrome is associated with structural and vascular placental abnormalities and leptin dysregulation. Placenta 2015; 36: 1078–1086.
  • 19. Williams RV, Ravishankar C, Zak V, et al. Birth weight and prematurity in infants with single ventricle physiology: Pediatric heart network infant single ventricle trial screened population. Congenit Heart Dis 2010; 5: 96–103.
  • 20. Rychik J, Szwast A, Natarajan S, et al. Perinatal and early surgical outcome for the fetus with hypoplastic left heart syndrome: a 5-year single institutional experience. Ultrasound Obstet Gynecol 2010; 36: 465–470.
  • 21. Allen RH, Benson CB, Haug LW. Pregnancy outcome of fetuses with a diagnosis of hypoplastic left ventricle on prenatal sonography. J Ultrasound Med 2005; 24: 1199–1203.
  • 22. Donofrio MT, Moon-Grady AJ, Hornberger LK, et al. Diagnosis and treatment of fetal cardiac disease: a scientific statement from the American heart association. Circulation 2014; 129: 2183–2242.
  • 23. Roeleveld PP, Axelrod DM, Klugman D, Jones MB, Chanani NK, Rossano JW, Costello JM. (2018) Hypoplastic left heart syndrome: from fetus to fontan. Cardiology in the Young 28: 1275–1288.
  • 24. Ellinger MK., Rempel GR. Parental Decision Making Regarding Treatment of Hypoplastic Left Heart Syndrome. Advances in Neonatal Care.Vol. 10, No. 6.pp. 316-322.
  • 25. Atallah J, Dinu IR, Joffe AR, et al. Two-year survival and mental and psychomotor outcomes after the Norwood procedure: an analysis of the modified BlalockTaussig shunt and right ventricle-to-pulmonary artery shunt surgical eras. Circulation. 2008;118:1410-1418.
  • 26. Norwood WI, Lang P, Hansen DD. Physiologic repair of aortic atresia-hypoplastic left heart syndrome. N Engl J Med 1983; 308: 23–26.
  • 27. Tibballs J, Kawahira Y, Carter BG, Donath S, Brizard C, Wilkinson J. Outcomes of surgical treatment of infants with hypoplastic left heart syndrome: an institutional experience 1983-2004. J Paediatr Child Health. 2007;43(11):746-751.
  • 28. Jacobs JP, O’Brien SM, Chai PJ, Morell VO, Lindberg HL, Quintessenza JA. Management of 239 patients with hypoplastic left heart syndrome and related malformations from 1993 to 2007. Ann Thorac Surg. 2008;85:1691-1697.
  • 29. Pizarro C, Derby CD, Baffa JM, Murdison KA, Radtke WA. Improving the outcome of high risk neonates with hypoplastic left heart syndrome: hybrid procedure or conventional surgical palliation? Eur J Cardiothorac Surg. 2008;33:613-618.
  • 30. Jenkins KJ, Gauvreau K, Newburger JW, Spray TL, Moller JH, Iezzoni LI. Consensus-based method for risk adjustment for surgery for congenital heart disease. J Thorac Cardiovasc Surg 2002; 123: 110–18.
  • 31. Sharland GK, Allan LD. Screening for congenital heart disease prenatally. Results of a 2 1/2 year study in the South East Thames Region. Br J Obstet Gynaecol 1992; 99: 220–225.
  • 32. Nikkila A, Bj ¨ orkhem G, K ¨ all ¨ en B. Prenatal diagnosis of congen- ´ ital heart defects – a population based study. Acta Paediatrica 2007; 96: 49–52.
  • 33. Rychik J, Rome JJ, Collins MH, et al. The hypoplastic left heart syndrome with intact atrial septum: atrial morphology, pulmonary vascular histopathology and outcome. J Am Coll Cardiol 1999;34:554–60.
  • 34. Brackley KJ, Kilby MD, Wright JG, et al. Outcome after prenatal diagnosis of hypoplastic left-heart syndrome: a case series. Lancet 2000; 356: 1143–47.
  • 35. Yagel S, Weissman A, Rotstein Z, et al. Congenital heart defects: natural course and in utero development. Circulation 1997; 96: 550–55.
There are 35 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Research Article
Authors

Alkim Gulsah Sahingoz Yildirim 0000-0001-8707-8086

Barış Sever 0000-0002-9690-8819

Hakan Gölbaşı 0000-0001-8682-5537

İbrahim Ömeroğlu 0000-0001-9200-0208

Zübeyde Emiralioğlu Çakır 0000-0001-8298-8363

Mehmet Ozer This is me 0000-0003-0683-0710

Ceren Golbasi This is me 0000-0002-1844-1782

Atalay Ekin 0000-0002-4712-3927

Halil Gürsoy Pala 0000-0003-1569-4474

Mehmet Özeren 0000-0002-4552-9042

Publication Date September 20, 2021
Submission Date June 28, 2021
Published in Issue Year 2021 Volume: 5 Issue: 3

Cite

APA Sahingoz Yildirim, A. G., Sever, B., Gölbaşı, H., Ömeroğlu, İ., et al. (2021). Perinatal results of antenatally detected hypoplastic left heart syndrome in a single tertiary center: experience of 5 years time. Journal of Basic and Clinical Health Sciences, 5(3), 149-155. https://doi.org/10.30621/jbachs.955838
AMA Sahingoz Yildirim AG, Sever B, Gölbaşı H, Ömeroğlu İ, Emiralioğlu Çakır Z, Ozer M, Golbasi C, Ekin A, Pala HG, Özeren M. Perinatal results of antenatally detected hypoplastic left heart syndrome in a single tertiary center: experience of 5 years time. JBACHS. September 2021;5(3):149-155. doi:10.30621/jbachs.955838
Chicago Sahingoz Yildirim, Alkim Gulsah, Barış Sever, Hakan Gölbaşı, İbrahim Ömeroğlu, Zübeyde Emiralioğlu Çakır, Mehmet Ozer, Ceren Golbasi, Atalay Ekin, Halil Gürsoy Pala, and Mehmet Özeren. “Perinatal Results of Antenatally Detected Hypoplastic Left Heart Syndrome in a Single Tertiary Center: Experience of 5 Years Time”. Journal of Basic and Clinical Health Sciences 5, no. 3 (September 2021): 149-55. https://doi.org/10.30621/jbachs.955838.
EndNote Sahingoz Yildirim AG, Sever B, Gölbaşı H, Ömeroğlu İ, Emiralioğlu Çakır Z, Ozer M, Golbasi C, Ekin A, Pala HG, Özeren M (September 1, 2021) Perinatal results of antenatally detected hypoplastic left heart syndrome in a single tertiary center: experience of 5 years time. Journal of Basic and Clinical Health Sciences 5 3 149–155.
IEEE A. G. Sahingoz Yildirim, “Perinatal results of antenatally detected hypoplastic left heart syndrome in a single tertiary center: experience of 5 years time”, JBACHS, vol. 5, no. 3, pp. 149–155, 2021, doi: 10.30621/jbachs.955838.
ISNAD Sahingoz Yildirim, Alkim Gulsah et al. “Perinatal Results of Antenatally Detected Hypoplastic Left Heart Syndrome in a Single Tertiary Center: Experience of 5 Years Time”. Journal of Basic and Clinical Health Sciences 5/3 (September 2021), 149-155. https://doi.org/10.30621/jbachs.955838.
JAMA Sahingoz Yildirim AG, Sever B, Gölbaşı H, Ömeroğlu İ, Emiralioğlu Çakır Z, Ozer M, Golbasi C, Ekin A, Pala HG, Özeren M. Perinatal results of antenatally detected hypoplastic left heart syndrome in a single tertiary center: experience of 5 years time. JBACHS. 2021;5:149–155.
MLA Sahingoz Yildirim, Alkim Gulsah et al. “Perinatal Results of Antenatally Detected Hypoplastic Left Heart Syndrome in a Single Tertiary Center: Experience of 5 Years Time”. Journal of Basic and Clinical Health Sciences, vol. 5, no. 3, 2021, pp. 149-55, doi:10.30621/jbachs.955838.
Vancouver Sahingoz Yildirim AG, Sever B, Gölbaşı H, Ömeroğlu İ, Emiralioğlu Çakır Z, Ozer M, Golbasi C, Ekin A, Pala HG, Özeren M. Perinatal results of antenatally detected hypoplastic left heart syndrome in a single tertiary center: experience of 5 years time. JBACHS. 2021;5(3):149-55.
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