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The role of the De Ritis ratio in acute cholecystitis: a retrospective observational study

Year 2023, Volume: 13 Issue: 3, 388 - 395, 31.05.2023
https://doi.org/10.16899/jcm.1210142

Abstract

Aim
Our study aimed to evaluate the relationship between the De-Ritis ratio and prognosis and mortality in patients diagnosed with cholecystitis.
Materials and Methods
This retrospective observational study was conducted on patients diagnosed with acute cholecystitis who presented to the emergency medical clinic of XXX Hospital between June 1, 2020, and January 1, 2022. The Statistical Package for Social Sciences (SPSS) software (v.20; Chicago, IL, USA) was used for all statistical analyses. All results with p < 0.05 were considered statistically significant.
Results
In our study, 174 patients were included, and 50.6% of our patients were women. The mean age was 59.0 (43.2 to 71.8). A total of 2.29% of our patients died. No statistically significant relationship was found between AST, ALT, CRP, albumin, and the De-Ritis ratio and mortality (p=0.584, p=0.533, p=0.517, p=0.07, p=0.399, respectively). When mortality rates in operated patients were examined, no statistically significant correlation was found between AST, ALT, CRP, albumin, and De-Ritis rates and mortality (p=0.248, p=0.315, p=0.451, p=0.183, p=0.688, respectively)
Conclusion
To the best of our knowledge, no study has examined the relationship between cholecystitis and the De-Ritis ratio. De-Ritis ratio is not used as a prognostic marker in patients with cholecystitis.

References

  • 1) Gallaher JR, Charles A. Acute Cholecystitis: A Review. JAMA 2022;327(10):965-75. Doi:10.1001/jama.2022.2350.
  • 2) Yokoe M, Hata J, Takada T, et al. Tokyo Guidelines 2018: diagnostic criteria and severity grading of acute cholecystitis (with videos). J Hepatobiliary Pancreat Sci 2018;25(1):41–54. Doi:10.1002/jhbp.515.
  • 3) Özkan A. Comparison of the c-reactive protein-mean arterial pressure ratio with critical care prognostic scoring systems. Ann Clin Anal Med 2022;13(11):1257-1261. Doi: 10.4328/ACAM.21281
  • 4) Özdemir S, Eroğlu SE, Algın A, et al. Analysis of laboratory parameters in patients with COVID-19: Experiences from a pandemic hospital. Ann Clin Anal Med 2021;12(Suppl 4): S518-523. Doi: 10.4328/ACAM.20678.
  • 5) Karakaş DO, Yeşiltaş M. Validity of the Glasgow prognostic score and modified systemic inflammation score in predicting complicated cholecystitis. Hippokratia 2020;24(1):15-20.
  • 6) Cakcak İE, Kula O. Predictive evaluation of SIRI, SII, PNI, and GPS in cholecystostomy application in patients with acute cholecystitis. TJTES 2022;28:940-6. Doi: 10.14744/tjtes.2022.90249.
  • 7) Özdemir S, Altunok İ, Özkan A et al. The role of the hematological inflammatory index and systemic immuno-inflammation index in acute cholecystitis. Eur J Clin Exp Med 2022;20(3):330-5. Doi: 10.15584/ejcem.2022.3.11.
  • 8) Sato N, Kinoshita A, Imai N et al. Inflammation-based prognostic scores predict disease severity in patients with acute cholecystitis. Eur J Gastroenterol Hepatol 2018;30(4):484-9. Doi: 10.1097/MEG.0000000000001063.
  • 9) Moss DW, Henderson RA, Kachmar JF. Enzymes. In:Tietz NW editors. Fundamentals of clinical chemistry. Philadelphia: WB Saunders Company 1987.p.369-73.
  • 10) Thomas L. Alanine aminotransferase (ALT), aspartate aminotransferase (AST). In:Thomas L, editor. Clinical laboratory diagnostics. Use and assessment of clinical laboratory results. Frankfurt/Main:TH-Books. Verlagsgesellschaft;1998.p.55-65.
  • 11) De Ritis F, Coltorti M, Giusti G, An enzymic test for the diagnosis of viral hepatitis: The transaminase serum activities, Clinica Chimica. Acta1957;2(1):70-4. Doi:10.1016/0009-8981(57)90027-X.
  • 12) Botros M, Sikaris KA. The De Ritis ratio: the test of time. Clin Biochem Rev 2013;34:117-30.
  • 13) Schupp T, Weidner K, Rusnak J et al. Diagnostic and prognostic value of the AST/ALT ratio in patients with sepsis and septic shock. Scand J Gastroenterol 2022 Doi: 10.1080/00365521.2022.2131331.
  • 14) Li R, Zhu WJ, Wang F et al. AST/ALT ratio as a predictor of mortality and exacerbations of PM/DM-ILD in 1 year—a retrospective cohort study with 522 cases. Arthritis Res Ther 2020;22:202. Doi:10.1186/s13075-020-02286-w.
  • 15) Yazar H, Kayacan Y, Ozdin M. De Ritis ratio and biochemical parameters in COVID-19 patients, Arch Physiol Biochem 2022;128(6):1676-80. Doi: 10.1080/13813455.2020.1788604.
  • 16) Zinellu A, Arru F, De Vito A et al. The De Ritis ratio as prognostic biomarker of in-hospital mortality in COVID-19 patients. Eur J Clin Investig 2021;51:e13427.
  • 17) Chen W, Wang W, Zhou L et al.Elevated AST/ALT ratio is associated with all-cause mortalityand cancer incident. J Clin Lab Anal 2022;36:e24356. Doi:10.1002/jcla.24356.
  • 18) Wu J, Chen L, Wang Y, Tan W, Huang Z. Prognostic value of aspartate transaminase to alanine transaminase (De Ritis) ratio in solid tumors: a pooled analysis of 9,400 patients. Onco Targets Ther 2019;12:5201-13. Doi: 10.2147/OTT.S204403.
  • 19) Mo Q, Liu Y, Zhou Z, Li R et al. Prognostic Value of Aspartate Transaminase/Alanine Transaminase Ratio in Patients With Hepatitis B Virus-Related Hepatocellular Carcinoma Undergoing Hepatectomy. Front Oncol 2022;12:876900. Doi: 10.3389/fonc.2022.876900.
  • 20) Ghahari M, Salari A, Ghafoori M. Association Between Preoperative De Ritis (AST/ALT) Ratio and Oncological Outcomes Following Radical Cystectomy in Patients With Urothelial Bladder Cancer. Clin. Genitourin Cancer 2022;20(2):e89-e93. Doi: 10.1016/j.clgc.2021.10.007.
  • 21) Gorgel S.N., Kose, O., Koc, E.M. et al. The prognostic significance of preoperatively assessed AST/ALT (De Ritis) ratio on survival in patients underwent radical cystectomy. Int Urol Nephrol 2017;49:1577-83. Doi:10.1007/s11255-017-1648-1.
  • 22) Taştemur S, Şenel S, Kasap Y, Odabaş O. Effectiveness of de ritis (AST/ALT) ratio in predicting biochemical recurrence in patients underwent radical prostatectomy for localized prostate cancer. Eur J Ther 2022;28(1):8-13. Doi: 10.54614/eurjther.2022.0038.
  • 23) Jadhav Y, Choudhary A and Pawar A. Assessment of AST/ALT ratio as a significant predictor of the incidence risk of prostate cancer. J Pharm Negative Results 2022;1103-6. Doi: 10.47750/pnr.2022.13.S03.172.
  • 24) Haberal HBH, Sarıkaya K, Sadioğlu FE, İbiş MA, Şenocak Ç, Bozkurt ÖF. The predictive role of preoperative full blood count markers and the De-Ritis ratio in the diagnosis of testicular tumor. Ege Med J 2022; 61(2): 145-50. Doi:10.19161/etd.1125252.
  • 25) Wu J, Chen L, Wang Y, Tan W, Huang Z. Prognostic value of aspartate transaminase to alanine transaminase (De Ritis) ratio in solid tumors: a pooled analysis of 9,400 patients. Onco Targets Ther 2019;12:5201-5213. Doi: 10.2147/OTT.S204403.
  • 26) Lu Z, Ma G, Chen L. De-Ritis Ratio Is Associated with Mortality after Cardiac Arrest. Dis. Markers 2020: 8826318. Doi: 10.1155/2020/8826318.
  • 27) Ndrepepa G, Holdenrieder S, Kastrati A. Prognostic value of De Ritis ratio in patients with acute myocardial infarction. Clinica Chimica Acta 2022;535:775-81. Doi:10.1016/j.cca.2022.08.016.
  • 28) He H, He C, Zhang S et al. Predictive value of aspartate aminotransferase-to-alanine aminotransferase ratio for contrast-associated acute kidney injury in patients undergoing elective percutaneous coronary intervention. J Cardiol 2022;79(5):618-25. Doi:10.1016/j.jjcc.2021.11.009.
  • 29) Su W-T, Rau C-S, Chou S-E et al. Association between Elevated De Ritis Ratio and Mortality Outcome in Adult Patients with Thoracoabdominal Trauma. Healthcare 2022;10(10):2082. Doi:10.3390/healthcare10102082.
  • 30) Wang B, Hu L, Chen Y, Aspartate transaminase/alanine transaminase (De Ritis ratio) predicts survival in major burn patients. Burns 2022;48(4):872-9. Doi:10.1016/j.burns.2021.08.006.
  • 31) Uçar A, Doğrusöz A. The Prognostic Role of In-Hospital Mortality Predictors and De Ritis Ratio in Patients with Upper Gastrointestinal System Bleeding. Pakistan J. Med. Sci. 2022;16(6):659-62. Doi:10.53350/pjmhs22166669.

De Ritis oranının akut kolesistitteki rolü: retrospektif gözlemsel çalışma

Year 2023, Volume: 13 Issue: 3, 388 - 395, 31.05.2023
https://doi.org/10.16899/jcm.1210142

Abstract

Amaç
Çalışmamızda kolesistit tanılı hastalarda De-Ritis oranı ile prognoz ve mortalite arasındaki ilişkiyi değerlendirmeyi amaçladık.
Gereç ve Yöntem
Bu retrospektif gözlemsel çalışma, 1 Haziran 2020 ile 1 Ocak 2022 tarihleri arasında XXX Hastanesi acil servisine başvuran akut kolesistit tanısı alan hastalar üzerinde yapılmıştır. Statistical Package for Social Sciences (SPSS) yazılımı (v.20; Chicago, IL, ABD) tüm istatistiksel analizler için kullanıldı. p < 0.05 olan tüm sonuçlar istatistiksel olarak anlamlı kabul edildi.
Bulgular
Çalışmamıza 174 hasta dahil edildi ve hastalarımızın %50,6'sı kadındı. Ortalama yaş 59.0 (43.2 ila 71.8) idi. Hastalarımızın toplam %2,29'u ex oldu. AST, ALT, CRP, albumin ve De-Ritis oranı ile mortalite arasında istatistiksel olarak anlamlı bir ilişki bulunmadı (sırası ile p=0,584, p=0,533, p=0,517, p=0,07, p=0,399). Ameliyatlı hastalarda mortalite oranları incelendiğinde AST, ALT, CRP, albumin ve De-Ritis oranları ile mortalite arasında istatistiksel olarak anlamlı bir ilişki bulunmadı (sırası ile p=0,248, p=0,315, p=0,451, p=0,183, p= 0.688)
Sonuç
Bildiğimiz kadarıyla, literatürde kolesistit ile De-Ritis oranı arasındaki ilişki incelenmemiştir. De-Ritis oranı kolesistitli hastalarda prognostik bir belirteç olarak kullanılmaz.

References

  • 1) Gallaher JR, Charles A. Acute Cholecystitis: A Review. JAMA 2022;327(10):965-75. Doi:10.1001/jama.2022.2350.
  • 2) Yokoe M, Hata J, Takada T, et al. Tokyo Guidelines 2018: diagnostic criteria and severity grading of acute cholecystitis (with videos). J Hepatobiliary Pancreat Sci 2018;25(1):41–54. Doi:10.1002/jhbp.515.
  • 3) Özkan A. Comparison of the c-reactive protein-mean arterial pressure ratio with critical care prognostic scoring systems. Ann Clin Anal Med 2022;13(11):1257-1261. Doi: 10.4328/ACAM.21281
  • 4) Özdemir S, Eroğlu SE, Algın A, et al. Analysis of laboratory parameters in patients with COVID-19: Experiences from a pandemic hospital. Ann Clin Anal Med 2021;12(Suppl 4): S518-523. Doi: 10.4328/ACAM.20678.
  • 5) Karakaş DO, Yeşiltaş M. Validity of the Glasgow prognostic score and modified systemic inflammation score in predicting complicated cholecystitis. Hippokratia 2020;24(1):15-20.
  • 6) Cakcak İE, Kula O. Predictive evaluation of SIRI, SII, PNI, and GPS in cholecystostomy application in patients with acute cholecystitis. TJTES 2022;28:940-6. Doi: 10.14744/tjtes.2022.90249.
  • 7) Özdemir S, Altunok İ, Özkan A et al. The role of the hematological inflammatory index and systemic immuno-inflammation index in acute cholecystitis. Eur J Clin Exp Med 2022;20(3):330-5. Doi: 10.15584/ejcem.2022.3.11.
  • 8) Sato N, Kinoshita A, Imai N et al. Inflammation-based prognostic scores predict disease severity in patients with acute cholecystitis. Eur J Gastroenterol Hepatol 2018;30(4):484-9. Doi: 10.1097/MEG.0000000000001063.
  • 9) Moss DW, Henderson RA, Kachmar JF. Enzymes. In:Tietz NW editors. Fundamentals of clinical chemistry. Philadelphia: WB Saunders Company 1987.p.369-73.
  • 10) Thomas L. Alanine aminotransferase (ALT), aspartate aminotransferase (AST). In:Thomas L, editor. Clinical laboratory diagnostics. Use and assessment of clinical laboratory results. Frankfurt/Main:TH-Books. Verlagsgesellschaft;1998.p.55-65.
  • 11) De Ritis F, Coltorti M, Giusti G, An enzymic test for the diagnosis of viral hepatitis: The transaminase serum activities, Clinica Chimica. Acta1957;2(1):70-4. Doi:10.1016/0009-8981(57)90027-X.
  • 12) Botros M, Sikaris KA. The De Ritis ratio: the test of time. Clin Biochem Rev 2013;34:117-30.
  • 13) Schupp T, Weidner K, Rusnak J et al. Diagnostic and prognostic value of the AST/ALT ratio in patients with sepsis and septic shock. Scand J Gastroenterol 2022 Doi: 10.1080/00365521.2022.2131331.
  • 14) Li R, Zhu WJ, Wang F et al. AST/ALT ratio as a predictor of mortality and exacerbations of PM/DM-ILD in 1 year—a retrospective cohort study with 522 cases. Arthritis Res Ther 2020;22:202. Doi:10.1186/s13075-020-02286-w.
  • 15) Yazar H, Kayacan Y, Ozdin M. De Ritis ratio and biochemical parameters in COVID-19 patients, Arch Physiol Biochem 2022;128(6):1676-80. Doi: 10.1080/13813455.2020.1788604.
  • 16) Zinellu A, Arru F, De Vito A et al. The De Ritis ratio as prognostic biomarker of in-hospital mortality in COVID-19 patients. Eur J Clin Investig 2021;51:e13427.
  • 17) Chen W, Wang W, Zhou L et al.Elevated AST/ALT ratio is associated with all-cause mortalityand cancer incident. J Clin Lab Anal 2022;36:e24356. Doi:10.1002/jcla.24356.
  • 18) Wu J, Chen L, Wang Y, Tan W, Huang Z. Prognostic value of aspartate transaminase to alanine transaminase (De Ritis) ratio in solid tumors: a pooled analysis of 9,400 patients. Onco Targets Ther 2019;12:5201-13. Doi: 10.2147/OTT.S204403.
  • 19) Mo Q, Liu Y, Zhou Z, Li R et al. Prognostic Value of Aspartate Transaminase/Alanine Transaminase Ratio in Patients With Hepatitis B Virus-Related Hepatocellular Carcinoma Undergoing Hepatectomy. Front Oncol 2022;12:876900. Doi: 10.3389/fonc.2022.876900.
  • 20) Ghahari M, Salari A, Ghafoori M. Association Between Preoperative De Ritis (AST/ALT) Ratio and Oncological Outcomes Following Radical Cystectomy in Patients With Urothelial Bladder Cancer. Clin. Genitourin Cancer 2022;20(2):e89-e93. Doi: 10.1016/j.clgc.2021.10.007.
  • 21) Gorgel S.N., Kose, O., Koc, E.M. et al. The prognostic significance of preoperatively assessed AST/ALT (De Ritis) ratio on survival in patients underwent radical cystectomy. Int Urol Nephrol 2017;49:1577-83. Doi:10.1007/s11255-017-1648-1.
  • 22) Taştemur S, Şenel S, Kasap Y, Odabaş O. Effectiveness of de ritis (AST/ALT) ratio in predicting biochemical recurrence in patients underwent radical prostatectomy for localized prostate cancer. Eur J Ther 2022;28(1):8-13. Doi: 10.54614/eurjther.2022.0038.
  • 23) Jadhav Y, Choudhary A and Pawar A. Assessment of AST/ALT ratio as a significant predictor of the incidence risk of prostate cancer. J Pharm Negative Results 2022;1103-6. Doi: 10.47750/pnr.2022.13.S03.172.
  • 24) Haberal HBH, Sarıkaya K, Sadioğlu FE, İbiş MA, Şenocak Ç, Bozkurt ÖF. The predictive role of preoperative full blood count markers and the De-Ritis ratio in the diagnosis of testicular tumor. Ege Med J 2022; 61(2): 145-50. Doi:10.19161/etd.1125252.
  • 25) Wu J, Chen L, Wang Y, Tan W, Huang Z. Prognostic value of aspartate transaminase to alanine transaminase (De Ritis) ratio in solid tumors: a pooled analysis of 9,400 patients. Onco Targets Ther 2019;12:5201-5213. Doi: 10.2147/OTT.S204403.
  • 26) Lu Z, Ma G, Chen L. De-Ritis Ratio Is Associated with Mortality after Cardiac Arrest. Dis. Markers 2020: 8826318. Doi: 10.1155/2020/8826318.
  • 27) Ndrepepa G, Holdenrieder S, Kastrati A. Prognostic value of De Ritis ratio in patients with acute myocardial infarction. Clinica Chimica Acta 2022;535:775-81. Doi:10.1016/j.cca.2022.08.016.
  • 28) He H, He C, Zhang S et al. Predictive value of aspartate aminotransferase-to-alanine aminotransferase ratio for contrast-associated acute kidney injury in patients undergoing elective percutaneous coronary intervention. J Cardiol 2022;79(5):618-25. Doi:10.1016/j.jjcc.2021.11.009.
  • 29) Su W-T, Rau C-S, Chou S-E et al. Association between Elevated De Ritis Ratio and Mortality Outcome in Adult Patients with Thoracoabdominal Trauma. Healthcare 2022;10(10):2082. Doi:10.3390/healthcare10102082.
  • 30) Wang B, Hu L, Chen Y, Aspartate transaminase/alanine transaminase (De Ritis ratio) predicts survival in major burn patients. Burns 2022;48(4):872-9. Doi:10.1016/j.burns.2021.08.006.
  • 31) Uçar A, Doğrusöz A. The Prognostic Role of In-Hospital Mortality Predictors and De Ritis Ratio in Patients with Upper Gastrointestinal System Bleeding. Pakistan J. Med. Sci. 2022;16(6):659-62. Doi:10.53350/pjmhs22166669.
There are 31 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Original Research
Authors

Ercan Gürlevik 0000-0001-8891-2562

Hatice Şeyma Akça 0000-0003-2823-9577

Muhammed Tahir Akça 0000-0002-5617-6705

Hilal Akça 0000-0003-4875-9166

Publication Date May 31, 2023
Acceptance Date December 7, 2022
Published in Issue Year 2023 Volume: 13 Issue: 3

Cite

AMA Gürlevik E, Akça HŞ, Akça MT, Akça H. The role of the De Ritis ratio in acute cholecystitis: a retrospective observational study. J Contemp Med. May 2023;13(3):388-395. doi:10.16899/jcm.1210142