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Konya Yöresinde Yetiştirilen Sarı Kantaron (H. Perforatum) Bitkisinin Fitokimyasal Analizi

Year 2020, Volume: 2 Issue: 2, 1 - 7, 25.08.2020

Hayriye Baltaoğlu Alp

Abstract

GİRİŞ
HypericumPerforatum (sarı kantaron, StJohn’swort olarak da bilinen) bitki yaklaşık 200 yıldır tıbbi bitki olarak kabul edilmektedir. Bitki aynı zamanda geleneksel olarak medikal amaçla yara iyileşmesinde, inflamasyon giderici, yanıkta, kas ağrıları ve hematom tedavisinde kullanılmaktadır. John'swort (SJW) hafif ve orta şiddette depresyon tedavisinde kullanılan yaygın bir şifalı bitkidir. SJW'nin ana bileşenlerinden biri olan hiperforin, sitokrom P450 enzimlerinin (CYP) ve P-glikoprotein taşıyıcıların (P-gp) indüksiyonunnda önemli bir rol oynar ve bu nedenle çeşitli ilaçların farmakokinetiğini etkiler. Bu çalışmamızda yöremizde yetiştirilen sarı kantaron bitkisinin fitokimyasal analizini yapmak ve antidepresan etkiden sorumlu bileşen miktarının yeterince olup olmadığını tespit etmektir.
METOD
Konya-Akyokuş yöresinde (Temmuz Organik Çiftliği)yetişen numunenin Hiperisin, Hiperforin, Pseudohiperisin, uçucu yağ miktarları ile kırılma indisi, yoğunluk tayini yapılmıştır. Analizler Batı Akdeniz Tarım Orman Bölge Müdürlüğü Tıbbi ve Aromatik Bitkiler Enstitüsünde yapılmıştır. Numune analizi için gerekli izinler alınmıştır.
BULGULAR
Numunemizde hiperforin miktarı 8,53mg/l olarak bulunmuştur.
SONUÇ
Hiperforin, SJW'nin CYP ve P-gp indükleyici aktivitesinden sorumlu ana bileşen gibi görünmektedir; Bu nedenle, hiperforin içermeyen ürünler ilaç etkileşimini azaltmak için gelecekte önem kazanmaktadır

Keywords

Hypericum perforatum fitoterapi

Thanks

TEMMUZ ORGANİK ÇİFTLİĞİNE TEŞEKKÜR EDERİZ

References

  • 1.Istikoglou CI, Mavreas V, Geroulanos G. Historyandtherapeuticproperties of Hypericum perforatum from antiquity until today. Psychiatriki. 2010 Oct-Dec; 21(4):332-8.
  • 2.Moffat B. Archaeological Sources for the History of Herbal Medicine Practice: The case study of StJohn’swort with valerian at Soutra medieval hospital. In Francia S.,Stobart A. (eds) Critical Approach esto the History of Western Herbal Medicine: From Classical Antiquity to the Early Modern Period. Bloomsbury, London, UK, pp. 253–270 (2014).
  • 3.Chatterjee SS, Bhattacharya SK, Wonnemann M, Singer A, Müller WE. Hyperforin as a possible antidepressant component of hypericum extracts. Life Sci. 1998; 63(6):499-510.
  • 4.Soleymani S, Bahramsoltani R, Rahimi R, Abdollahi M. Clinicalrisks of StJohn'sWort (Hypericumperforatum) co-administration. ExpertOpinDrugMetabToxicol. 2017 Oct;13(10):1047-1062.
  • 5.Zeybek A.U. Özgüç S. İlaç ve bitki metabolizması. Modern ve Rasyonel Fitoterapi-1. 1.baskı Güneş Tıp Kitapevi.2019.p:38.
  • 6. TS ISO 280, Eteri yağlar- Kırılma İndisi Tayini.
  • 7.Committee on HerbalMedicinalProducts (HMPC). Assessment Report on HypericumPerforatum L.,Herba. EuropeanMedicinesAgency: London, UK (2009).
  • 8.Barnes J, Anderson LA, Phillipson JD. Review. StJohn'swort (Hypericumperforatum L.): a review of its chemistry, pharmacology and clinical properties. J PharmPharmacol. 2001 May; 53(5):583-600.
  • 9.Kim HL, Streltzer J, Goebert D. St. John'swort for depression: a meta-analysis of well-defined clinical trials. J NervMentDis. 1999 Sep; 187(9):532-8.
  • 10.Brenner R, Azbel V, Madhusoodanan S, Pawlowska M. Comparison of an extract of hypericum (LI 160) andsertraline in thetreatment of depression: a double-blind, randomized pilot study. ClinTher. 2000 Apr; 22(4):411-9.
  • 11.Ng QX1, Venkatanarayanan N2, Ho CY3. Clinicaluse of Hypericumperforatum (StJohn'swort) in depression: A meta-analysis. J AffectDisord. (2017) Mar 1;210:211-221.
  • 12. Kumar V, Khanna VK, Seth PK, Singh PN, Bhattacharya SK. Brain neurotransmitter receptor binding and nootropic studies on Indian Hypericum perforatum Linn. PhytotherRes. 2002 May; 16(3):210-6.
  • 13.Greeson JM, Sanford B, Monti DA. Review St. John'swort (Hypericumperforatum): a review of the current pharmacological, toxicological, and clinical literature. Psychopharmacology (Berl). 2001 Feb; 153(4):402-14.
  • 14.Nathan PJ. Review Hypericum perforatum (StJohn'sWort): a non-selective reuptake inhibitor? A review of the recent advances in its pharmacology. J Psychopharmacol. 2001 Mar; 15(1):47-54.
  • 15.Butterweck V, Böckers T, Korte B, Wittkowski W, Winterhoff H. Long-termeffects of St. John'swort and hypericin on mono amine levels in rat hypothalamus and hippocampus. Brain Res. 2002 Mar 15; 930(1-2):21-9.
  • 16.Bongiorno P. &LoGiudice P. Hypericum for depression. Nat. Med. J. 2, 3–9 (2010).
  • 17. Ben-Eliezer D, Yechiam E. Hypericum perforatum as a cognitive enhancer in rodents: A meta-analysis. SciRep. 2016 Oct 20;6:35700.
  • 18. Kessler RC, Soukup J, Davis RB, Foster DF, Wilkey SA, Van Rompay MI, et al. Theuse of complementary and alternative therapies to treat anxiety and depression in the United States. Am J Psychiatry. 2001 Feb; 158(2):289-94.

Year 2020, Volume: 2 Issue: 2, 1 - 7, 25.08.2020

Hayriye Baltaoğlu Alp

Abstract

References

  • 1.Istikoglou CI, Mavreas V, Geroulanos G. Historyandtherapeuticproperties of Hypericum perforatum from antiquity until today. Psychiatriki. 2010 Oct-Dec; 21(4):332-8.
  • 2.Moffat B. Archaeological Sources for the History of Herbal Medicine Practice: The case study of StJohn’swort with valerian at Soutra medieval hospital. In Francia S.,Stobart A. (eds) Critical Approach esto the History of Western Herbal Medicine: From Classical Antiquity to the Early Modern Period. Bloomsbury, London, UK, pp. 253–270 (2014).
  • 3.Chatterjee SS, Bhattacharya SK, Wonnemann M, Singer A, Müller WE. Hyperforin as a possible antidepressant component of hypericum extracts. Life Sci. 1998; 63(6):499-510.
  • 4.Soleymani S, Bahramsoltani R, Rahimi R, Abdollahi M. Clinicalrisks of StJohn'sWort (Hypericumperforatum) co-administration. ExpertOpinDrugMetabToxicol. 2017 Oct;13(10):1047-1062.
  • 5.Zeybek A.U. Özgüç S. İlaç ve bitki metabolizması. Modern ve Rasyonel Fitoterapi-1. 1.baskı Güneş Tıp Kitapevi.2019.p:38.
  • 6. TS ISO 280, Eteri yağlar- Kırılma İndisi Tayini.
  • 7.Committee on HerbalMedicinalProducts (HMPC). Assessment Report on HypericumPerforatum L.,Herba. EuropeanMedicinesAgency: London, UK (2009).
  • 8.Barnes J, Anderson LA, Phillipson JD. Review. StJohn'swort (Hypericumperforatum L.): a review of its chemistry, pharmacology and clinical properties. J PharmPharmacol. 2001 May; 53(5):583-600.
  • 9.Kim HL, Streltzer J, Goebert D. St. John'swort for depression: a meta-analysis of well-defined clinical trials. J NervMentDis. 1999 Sep; 187(9):532-8.
  • 10.Brenner R, Azbel V, Madhusoodanan S, Pawlowska M. Comparison of an extract of hypericum (LI 160) andsertraline in thetreatment of depression: a double-blind, randomized pilot study. ClinTher. 2000 Apr; 22(4):411-9.
  • 11.Ng QX1, Venkatanarayanan N2, Ho CY3. Clinicaluse of Hypericumperforatum (StJohn'swort) in depression: A meta-analysis. J AffectDisord. (2017) Mar 1;210:211-221.
  • 12. Kumar V, Khanna VK, Seth PK, Singh PN, Bhattacharya SK. Brain neurotransmitter receptor binding and nootropic studies on Indian Hypericum perforatum Linn. PhytotherRes. 2002 May; 16(3):210-6.
  • 13.Greeson JM, Sanford B, Monti DA. Review St. John'swort (Hypericumperforatum): a review of the current pharmacological, toxicological, and clinical literature. Psychopharmacology (Berl). 2001 Feb; 153(4):402-14.
  • 14.Nathan PJ. Review Hypericum perforatum (StJohn'sWort): a non-selective reuptake inhibitor? A review of the recent advances in its pharmacology. J Psychopharmacol. 2001 Mar; 15(1):47-54.
  • 15.Butterweck V, Böckers T, Korte B, Wittkowski W, Winterhoff H. Long-termeffects of St. John'swort and hypericin on mono amine levels in rat hypothalamus and hippocampus. Brain Res. 2002 Mar 15; 930(1-2):21-9.
  • 16.Bongiorno P. &LoGiudice P. Hypericum for depression. Nat. Med. J. 2, 3–9 (2010).
  • 17. Ben-Eliezer D, Yechiam E. Hypericum perforatum as a cognitive enhancer in rodents: A meta-analysis. SciRep. 2016 Oct 20;6:35700.
  • 18. Kessler RC, Soukup J, Davis RB, Foster DF, Wilkey SA, Van Rompay MI, et al. Theuse of complementary and alternative therapies to treat anxiety and depression in the United States. Am J Psychiatry. 2001 Feb; 158(2):289-94.
There are 18 citations in total.

Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Research Articles
Authors

Hayriye Baltaoğlu Alp 0000-0002-7262-2234

Publication Date August 25, 2020
Submission Date January 2, 2020
Acceptance Date April 23, 2020
Published in Issue Year 2020 Volume: 2 Issue: 2

Cite

APA Baltaoğlu Alp, H. (2020). Konya Yöresinde Yetiştirilen Sarı Kantaron (H. Perforatum) Bitkisinin Fitokimyasal Analizi. Genel Sağlık Bilimleri Dergisi, 2(2), 1-7.
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