Abstract
Aim: To compare mean platelet volume (MPV) values and platelet counts of normal pregnancies and patients with missed abortions to determine whether hematological parameters such as MPV and platelet counts (PLT) can predict unsuccessful pregnancy particularly missed abortion.
Material and Methods: This retrospective case-control study investigated the hematological parameters of patients diagnosed with missed abortion and the control group. Among 476 cases, 238 participants with missed abortion were included in the study group and 238 healthy pregnant women were included in the control group. The mean age of the missed abortion group was 33.50 and the mean age of the control group was 32.
Result: Age showed a significant difference between the two groups (p = 0.01). Gestational age was higher in the missed abortion group than that in the control group (p < 0.001). Significant differences in gravida (p < 0.001) and parity (p = 0.002) were observed. Smoking was higher in the missed abortion group than that in the control group (p < 0.001). RDW-SD (p < 0.001) and hematocrit (p = 0.032) showed significant differences between groups. There was no significant correlation between MPV (p = 0.155; OR = 1.097; CI = 0.966_1.247), PDW (p = 0.695; OR = 0.991; CI = 0.947_1.037), PCT (P = 0.468) and missed abortion.
Conclusion: Hematological parameters such as MPV may not be used as a screening or diagnostic test for unsuccessful pregnancies particularly missed abortion as shown in the current study.
References
- 1. Wood SL, Brian PH. Medical management of missed abortion: a randomized clinical trial. Obstet Gynecol. 2002;99(4):563-6.
- 2. Eroglu M, Keskin U, Yildirim AI, Saygi IA, Gun I, Topuz S. Can mean platelet volume predict abortion? Med Glas (Zenica) 2013;10:283–287.
- 3. Robertson L, Wu O, Langhorne P, Twaddle S, Clark P, Lowe GD, et al. Thrombophilia in pregnancy: a systematic review. Thrombosis: Risk and Economic Assessment of Thrombophilia Screening (TREATS) Study. Br J Haematol. 2006;132(2):171-96.
- 4. Lassere M, Empson M. Treatment of antiphospholipid syndrome in a pregnancy-a systematic review of randomized therapeutic trials. Thromb Res. 2004;114(5-6):419-26. 5. Jakubowski JA, Thompson CB, Vaillancourt R, Valeri CR, Deykin D. Arachidonic acid metabolism by platelets of differing size. Br J Haematol. 1983;53:503-11.
- 6. Bath PM, Butterworth RJ. Platelet size: measurement, physiology, and vascular disease. Blood Coagul Fibrinolysis. 1996; 7:157-61.
- 7. Eldor A, Avitzour M, Or R, Hanna R, Penchas S. Prediction of haemorrhagic diathesis in thrombocytopenia by mean platelet volume. Br Med J 1982;285:397–400.
- 8. Dundar O, Yoruk P, Tutuncu L, Erikci AA, Muhcu M, Ergur AR, et al. Longitudinal study of platelet size changes in gestation and predictive power of elevated MPV in development of pre-eclampsia. Prenat Diagn 2008; 28:1052–6.
- 9. Stubbs TM, Lazarchick J, Van Dorsten JP, Cox J, Loadholt CB. Evidence of accelerated platelet production and consumption in nonthrombocytopenic preeclampsia.Am J Obstet Gynecol 1986; 155:263–5.
- 10. Kosus N, Kosus A, Yildirim M, Duran M., Turhan NO. Mean platelet volume as a marker of thrombosis in patients with missed abortion. Acta Haematol. 2011; 125:208-9.
- 11. Chu SG, Becker RC, Berger PB, Bhatt DL, Eikelboom JW, Konkle B, et al. Mean platelet volume as a predictor of cardiovascular risk: a systematic review and meta-analysis. J Thromb Haemost. 2010;8(1):148-56.
- 12. Cetin MS, Ozcan Cetin EH, Akdi A, Aras D, Topaloglu S, Temizhan A, et al. Platelet distribution width and plateletcrit: novel biomarkers of ST-elevation myocardial infarction in young patients. Kardiol Pol. 2017;75(10):1005-12.
- 13. Sever Erdem Z, Cayir Y, Kosan Z, Erdem H. Is There Any Relation Between Recurrent Miscarriage and Complete Blood Count Values? A Case-Control Study. Konuralp Medical Journal. 2020; 12(1): 39-43.
- 14. AlSheeha MA, Alaboudi RS, Alghasham MA, Iqbal J, Adam I. Platelet count and platelet indices in women with preeclampsia. Vasc Health Risk Manag. 2016;12:477-80.
- 15. Akin MN, Kasap B, Yuvaci HU, Turhan N. Association between platelet indices and first trimester miscarriage. Blood Coagul Fibrinolysis. 2016;27(5):526-30.
- 16. Lamparelli RD, Baynes RD, Atkinson P, Bezwoda WR, Mendelow BV. Platelet parameters. Platelet counts and mean platelet volume in normal and pregnant subjects. S Afr Med J. 1988;73:36–39.
- 17. Kaplanoglu M, Yuce T, Bulbul M. Decreased mean platelet volume is associated with the developing stage of fetoplacental unit in spontaneous abortion. Int J Clin Exp Med. 2015;8(7):11301-6.
- 18. Gasparyan AY, Ayvazyan L, Mikhailidis DP, Kitas GD. Mean platelet volume: a link between thrombosis and inflammation? Curr Pharm Des. 2011;17:47–58.
- 19. Rai R, Shlebak A, Cohen H, Backos M, Holmes Z, Marriott K, et al. Factor V Leiden and acquired activated protein C resistance among 1000 women with recurrent miscarriage. Hum Reprod. 2001;16:961–965.
- 20. Bıyık İ, Aslan MM, Keskin F. Association between platelet indices and missed abortion. J Surg Med. 2019;3(8):549-52.
- 21. Al-Aghbary AAR, Almorish MAW, Jaffar DWM, Kahiry WMA. Platelet indices in evaluation of patients with recurrent pregnancy loss. Asian Pacific Journal of Reproduction. 2018;8:15-8.
- 22. Tsiara S, Elisaf M, Jagroop IA, Mikhailidis DP. Platelets as predictors of vascular risk: is there a practical index of platelet activity? Clin Appl Thromb Hemost. 2003;9(3):177-90.
- 23. Bain BJ, Bates I. Basic haematological techniques. In: Lewis SM, Bain BJ, Bates I (eds). Dacie and Lewis Practical Haematology, 9th ed. Edinburgh: Churchill Livingstone; 2001:19–46.
- 24. Kara PH, Ünlüer S. Are There any Predictive Values of Mean Platelet Volume (MPV) and MPV/Platelet Count Ratio in Patients with Spontaneous Abortion? Eurasian J Emerg Med. 2017;16:57-61.
- 25. Uysal A, İncebiyik A, Hacıvelioglu S, Gencer M, Gungor A, Cosar E. Is There Any Relationship Between Platelet Functions, Red Cell Distribution Width, and Recurrent Pregnancy Loss? J Clin Anal Med. 2015;6(2):149-51.
- 26. Yilmaz M, Delibas IB, Isaoglu U, Ingec M, Borekci B,et al. Relationship between mean platelet volume and recurrent miscarriage: a preliminary study. Arch Med Sci. 2015;11(5):989-93.
- 27. Dundar O, Pektas MK, Bodur S, Bakır LV, Cetin A.Recurrent pregnancy loss is associated with increased red cell distribution width and platelet distribution width. J Obstet Gynaecol Res. 2015;41(4):551-8.
Abstract
Amaç:Çalışmamızda ortalama trombosit hacmi (MPV) ve trombosit sayısı (PLT) gibi hematolojik parametrelerin başarısız gebelikleri, özellikle gecikmiş düşüğü tahmin etmede kullanılıp kullanılmayacağını belirlemeyi amaçladık.
Gereçler ve Yöntem: Bu retrospektif vaka-kontrol çalışmasında, gecikmiş düşük tanısı almış hastaların ve kontrol grubunun hematolojik parametreleri incelendi. Gebeliği normal seyreden gebeler ile gecikmiş düşükle sonuçlanan gebelerin MPV değerleri karşılaştırıldı. Çalışma grubuna dahil edilen gecikmiş düşük tanılı 238 hasta ve kontrol grubuna dahil edilen 238 sağlıklı gebe olmak üzere toplam 476 kişi çalışmaya dahil edildi. Gecikmiş düşük tanılı grupta ortalama yaş 33.50 iken, kontrol grubunda ortalama yaş 32 yıl idi.
Bulgular: İki grup arasında yaş açısından istatistiksel anlamlı fark mevcuttu (p=0.01). Gecikmiş düşük grubunda gebelik yaşı, kontrol grubuna göre istatistiksel anlamlı daha yüksekti (p<0.001). Gebelik sayısı (p<0.001) ve canlı doğum sayısı (p=0.002) açısından istatistiksel anlamlı farklılık saptandı. Gecikmiş düşük grubunda sigara içen hasta sayısı, kontrol grubuna göre daha yüksekti (p<0.001). RDW-SD (p<0.001) ve hematokrit (p=0.032) değerleri gruplar arasında anlamlı farklılık gösterdi. MPV (p = 0.155; OR = 1.097; CI = 0.966_1.247), PDW (p = 0.695; OR = 0.991; CI = 0.947_1.037), PCT (P = 0.468) değerleri ve gecikmiş düşük arasında anlamlı bir korelasyon bulunmadı.
Sonuç: Çalışmamızda gösterildiği üzere, MPV gibi hematolojik parametrelerin gecikmiş düşük için tarama veya tanı testi olarak kullanılması uygun bulunmamıştır.
References
- 1. Wood SL, Brian PH. Medical management of missed abortion: a randomized clinical trial. Obstet Gynecol. 2002;99(4):563-6.
- 2. Eroglu M, Keskin U, Yildirim AI, Saygi IA, Gun I, Topuz S. Can mean platelet volume predict abortion? Med Glas (Zenica) 2013;10:283–287.
- 3. Robertson L, Wu O, Langhorne P, Twaddle S, Clark P, Lowe GD, et al. Thrombophilia in pregnancy: a systematic review. Thrombosis: Risk and Economic Assessment of Thrombophilia Screening (TREATS) Study. Br J Haematol. 2006;132(2):171-96.
- 4. Lassere M, Empson M. Treatment of antiphospholipid syndrome in a pregnancy-a systematic review of randomized therapeutic trials. Thromb Res. 2004;114(5-6):419-26. 5. Jakubowski JA, Thompson CB, Vaillancourt R, Valeri CR, Deykin D. Arachidonic acid metabolism by platelets of differing size. Br J Haematol. 1983;53:503-11.
- 6. Bath PM, Butterworth RJ. Platelet size: measurement, physiology, and vascular disease. Blood Coagul Fibrinolysis. 1996; 7:157-61.
- 7. Eldor A, Avitzour M, Or R, Hanna R, Penchas S. Prediction of haemorrhagic diathesis in thrombocytopenia by mean platelet volume. Br Med J 1982;285:397–400.
- 8. Dundar O, Yoruk P, Tutuncu L, Erikci AA, Muhcu M, Ergur AR, et al. Longitudinal study of platelet size changes in gestation and predictive power of elevated MPV in development of pre-eclampsia. Prenat Diagn 2008; 28:1052–6.
- 9. Stubbs TM, Lazarchick J, Van Dorsten JP, Cox J, Loadholt CB. Evidence of accelerated platelet production and consumption in nonthrombocytopenic preeclampsia.Am J Obstet Gynecol 1986; 155:263–5.
- 10. Kosus N, Kosus A, Yildirim M, Duran M., Turhan NO. Mean platelet volume as a marker of thrombosis in patients with missed abortion. Acta Haematol. 2011; 125:208-9.
- 11. Chu SG, Becker RC, Berger PB, Bhatt DL, Eikelboom JW, Konkle B, et al. Mean platelet volume as a predictor of cardiovascular risk: a systematic review and meta-analysis. J Thromb Haemost. 2010;8(1):148-56.
- 12. Cetin MS, Ozcan Cetin EH, Akdi A, Aras D, Topaloglu S, Temizhan A, et al. Platelet distribution width and plateletcrit: novel biomarkers of ST-elevation myocardial infarction in young patients. Kardiol Pol. 2017;75(10):1005-12.
- 13. Sever Erdem Z, Cayir Y, Kosan Z, Erdem H. Is There Any Relation Between Recurrent Miscarriage and Complete Blood Count Values? A Case-Control Study. Konuralp Medical Journal. 2020; 12(1): 39-43.
- 14. AlSheeha MA, Alaboudi RS, Alghasham MA, Iqbal J, Adam I. Platelet count and platelet indices in women with preeclampsia. Vasc Health Risk Manag. 2016;12:477-80.
- 15. Akin MN, Kasap B, Yuvaci HU, Turhan N. Association between platelet indices and first trimester miscarriage. Blood Coagul Fibrinolysis. 2016;27(5):526-30.
- 16. Lamparelli RD, Baynes RD, Atkinson P, Bezwoda WR, Mendelow BV. Platelet parameters. Platelet counts and mean platelet volume in normal and pregnant subjects. S Afr Med J. 1988;73:36–39.
- 17. Kaplanoglu M, Yuce T, Bulbul M. Decreased mean platelet volume is associated with the developing stage of fetoplacental unit in spontaneous abortion. Int J Clin Exp Med. 2015;8(7):11301-6.
- 18. Gasparyan AY, Ayvazyan L, Mikhailidis DP, Kitas GD. Mean platelet volume: a link between thrombosis and inflammation? Curr Pharm Des. 2011;17:47–58.
- 19. Rai R, Shlebak A, Cohen H, Backos M, Holmes Z, Marriott K, et al. Factor V Leiden and acquired activated protein C resistance among 1000 women with recurrent miscarriage. Hum Reprod. 2001;16:961–965.
- 20. Bıyık İ, Aslan MM, Keskin F. Association between platelet indices and missed abortion. J Surg Med. 2019;3(8):549-52.
- 21. Al-Aghbary AAR, Almorish MAW, Jaffar DWM, Kahiry WMA. Platelet indices in evaluation of patients with recurrent pregnancy loss. Asian Pacific Journal of Reproduction. 2018;8:15-8.
- 22. Tsiara S, Elisaf M, Jagroop IA, Mikhailidis DP. Platelets as predictors of vascular risk: is there a practical index of platelet activity? Clin Appl Thromb Hemost. 2003;9(3):177-90.
- 23. Bain BJ, Bates I. Basic haematological techniques. In: Lewis SM, Bain BJ, Bates I (eds). Dacie and Lewis Practical Haematology, 9th ed. Edinburgh: Churchill Livingstone; 2001:19–46.
- 24. Kara PH, Ünlüer S. Are There any Predictive Values of Mean Platelet Volume (MPV) and MPV/Platelet Count Ratio in Patients with Spontaneous Abortion? Eurasian J Emerg Med. 2017;16:57-61.
- 25. Uysal A, İncebiyik A, Hacıvelioglu S, Gencer M, Gungor A, Cosar E. Is There Any Relationship Between Platelet Functions, Red Cell Distribution Width, and Recurrent Pregnancy Loss? J Clin Anal Med. 2015;6(2):149-51.
- 26. Yilmaz M, Delibas IB, Isaoglu U, Ingec M, Borekci B,et al. Relationship between mean platelet volume and recurrent miscarriage: a preliminary study. Arch Med Sci. 2015;11(5):989-93.
- 27. Dundar O, Pektas MK, Bodur S, Bakır LV, Cetin A.Recurrent pregnancy loss is associated with increased red cell distribution width and platelet distribution width. J Obstet Gynaecol Res. 2015;41(4):551-8.
Details
| Primary Language | English |
|---|---|
| Subjects | Obstetrics and Gynaecology |
| Journal Section | Research Articles |
| Authors | |
| Publication Date | April 1, 2021 |
| Submission Date | June 11, 2020 |
| Acceptance Date | October 27, 2020 |
| Published in Issue | Year 2021 Volume: 18 Issue: 1 |
