Abstract
Aim: Type
2 diabetes can cause serious vascular problems. Abnormal plateletcrit (PCT)
levels were shown as a risc factor for coronary artery diseases by recent
studies. Glycosylated hemoglonin (HbA1c) is widely ysed marker for assessment
of glycemic control. This study aimed to evaluate relationship between HbA1c
and PCT.
Material and Method:
It is retrospective case control study. 65 type 2 diabetic patients’ records
were evaluated. Correlation between HbA1c and PCT, MPV was investigated.
Results:
Between HbA1c and PCT levels, statistically significant correlation was
detected (r=0,4 p<0,01). Any correlation wasn’t detected with MPV.
Conclusion: Plateletcrit
may be guide for preventing vascular complication due to poor glycemic
regulation. Therefore patients with increased plateletcrit values, should be
evaluated for higher risk of vascular complications.
Keywords
References
- 1. Angiolillo DJ, Fernandez-Ortiz A, Bernardo E, et al. Platelet function profiles in patients with Type 2 diabetes and coronary artery disease on combined aspirin and clopidogrel treatment. Diabetes. 2005; 54: 2430-5.
- 2. Skyler JS, Bergenstal R, Bonow RO, Buse J, Deedwania P, Gale EAM, et al. Erratum: Intensive glycemic control and the prevention of cardiovascular events: Implications of the ACCORD, ADVANCE, and VA Diabetes trials: a position statement of the American Diabetes Association and a scientific statement of the American College of Cardiology Foundation and the American Heart Association (Diabetes Care (2009) 32 (187-192)). Diabetes Care [Internet]. 2009;32(4):754. Available from: http://dx.doi.org/10.1016/j.jacc.2008.10.008
- 3. Ergelen M, Uyarel H. Plateletcrit: A novel prognostic marker for acute coronary syndrome. Int J Cardiol [Internet]. 2014;177(1):161. Available from: http://dx.doi.org/10.1016/j.ijcard.2014.09.054
- 4. Uğur M, Ayhan E, Bozbay M, Çiçek G, Ergelen M, Işik T, et al. The independent association of plateletcrit with long-term outcomes in patients undergoing primary percutaneous coronary intervention. J Crit Care. 2014;29(6):978–81.
- 5. Chen L, Magliano DJ, Zimmet PZ. The worldwide epidemiol- ogy of type 2 diabetes mellitus-present and future perspec- tives. Nat Rev Endocrinol 2012; 8(4): 228.
- 6. Liu J, Liu X, Li Y, et al. The association of neutrophil to lymphocyte ratio, mean platelet volume, and platelet distribution width with diabetic retinopathy and nephropathy: a meta-analysis. Biosci Rep [Internet]. 2018;38(3):BSR20180172. Available from: http://www.ncbi.nlm.nih.gov/pubmed/29581246
- 7. Rechcinski T, Jasinska A, Forys J, et al. Prognostic value of platelet indices after acute myocardial infarction treated with primary percutaneous coronary intervention. Cardiol J 2013; 20: 491-8
- 8. Jaman S. Association of Mean Platelet Volume and Platelet Distribution Width with Hba1c. J Endocrinol Diabetes [Internet]. 2017; 4 : 1–6.
- 9. Tvedten H, Lilliehöök I, Hillström A, Häggström J. Plateletcritis superior to platelet count for assessing platelet status in Cavalier King Charles Spaniels. Vet Clin Pathol; 37: 266–271
- 10. Yazgan S, Celik U, Ayar O, et al. The role of patient’s systemic characteristics and plateletcrit in developing toxic anterior segment syndrome after uneventful phaco surgery: A case–control study. Int Ophthalmol. 2018; 38: 43–52.
- 11. Alhadas KR, Santos SN, Mara Freitas MS, et al. Are platelet indices useful in the evaluation of type 2 diabetic patients? Os índices plaquetários são úteis na avaliação de pacientes diabéticos tipo 2? J Bras Patol Med Lab [Internet]. 2016; 52 :105–11.
- 12. Anandhalakshmi S, Kalaivani A, Shivashekar G, Saravanan A. Evaluation of mean platelet volume and other platelet parameters in subjects with Type-2 diabetes mellitus. Natl J Physiol Pharm Pharmacol. 2017; 7: 51–4.
- 13. Atak BM, Duman TT, Aktas G, Kocak MZ, Savli H. Platelet Distribution Width is Associated with Type 2 Diabetes Mellitus and Diabetic Nephropathy and Neuropathy. 2018; 95–8.
- 14. Havakuk O, Banai S, Halkin A, et al. HbA1cLevels and Long-Term Mortality in Patients Undergoing Coronary Angiography. Cardiol. 2016; 134: 101–6.
- 15. Schoos MM, Dangas GD, Mehran R, et al. Impact of hemoglobin a1c levels on residual platelet reactivity and outcomes after insertion of coronary drug-eluting stents (from the ADAPT-DES Study). Am J Cardiol [Internet]. 2016; 117: 192–200.
Abstract
Amaç:
Tip 2 diyabet ciddi damar hastalıklarına yol açabilen bir hastalıktır.
Plateletcrit (PCT) anormal düzeyleri yapılan çalışmalarda koroner arter
hastalıkları için risk faktörü olarak belirlenmiştir. Glikolize hemoglobin
(HbA1c), glisemik kontrolü değerlendirmek için geniş kullanıma sahip bir
belirteçtir. Bu çalışmada PCT ile HbA1c arasındaki ilişkinin değerlendirilmesi
amaçlanmıştır.
Gereç ve yöntem: Çalışma,
retrospektif vaka kontrol çalışmasıdır. Tip 2 diyabetli 65 hastanın geçmiş
kayıtları değerlendirilmiş,HbA1c ve MPV, PCT arasındaki ilişki araştırılmıştır.
Bulgular:
HbA1c ve PCT arasında anlamlı korelasyon saptandı (r=0,4 p<0,01). MPV ile
korelasyon saptanmadı.
Sonuç:
PCT, glisemik kontrolü sağlanmayan ve buna bağlı vasküler hasar gelişme
olasılığı olan hastalarda yol gösterici olabilir. Bu açıdan, anormal PCT
düzeyleri olan hastaların vasküler patolojiler açısından yakın takibi önemli
olabilir.
Keywords
References
- 1. Angiolillo DJ, Fernandez-Ortiz A, Bernardo E, et al. Platelet function profiles in patients with Type 2 diabetes and coronary artery disease on combined aspirin and clopidogrel treatment. Diabetes. 2005; 54: 2430-5.
- 2. Skyler JS, Bergenstal R, Bonow RO, Buse J, Deedwania P, Gale EAM, et al. Erratum: Intensive glycemic control and the prevention of cardiovascular events: Implications of the ACCORD, ADVANCE, and VA Diabetes trials: a position statement of the American Diabetes Association and a scientific statement of the American College of Cardiology Foundation and the American Heart Association (Diabetes Care (2009) 32 (187-192)). Diabetes Care [Internet]. 2009;32(4):754. Available from: http://dx.doi.org/10.1016/j.jacc.2008.10.008
- 3. Ergelen M, Uyarel H. Plateletcrit: A novel prognostic marker for acute coronary syndrome. Int J Cardiol [Internet]. 2014;177(1):161. Available from: http://dx.doi.org/10.1016/j.ijcard.2014.09.054
- 4. Uğur M, Ayhan E, Bozbay M, Çiçek G, Ergelen M, Işik T, et al. The independent association of plateletcrit with long-term outcomes in patients undergoing primary percutaneous coronary intervention. J Crit Care. 2014;29(6):978–81.
- 5. Chen L, Magliano DJ, Zimmet PZ. The worldwide epidemiol- ogy of type 2 diabetes mellitus-present and future perspec- tives. Nat Rev Endocrinol 2012; 8(4): 228.
- 6. Liu J, Liu X, Li Y, et al. The association of neutrophil to lymphocyte ratio, mean platelet volume, and platelet distribution width with diabetic retinopathy and nephropathy: a meta-analysis. Biosci Rep [Internet]. 2018;38(3):BSR20180172. Available from: http://www.ncbi.nlm.nih.gov/pubmed/29581246
- 7. Rechcinski T, Jasinska A, Forys J, et al. Prognostic value of platelet indices after acute myocardial infarction treated with primary percutaneous coronary intervention. Cardiol J 2013; 20: 491-8
- 8. Jaman S. Association of Mean Platelet Volume and Platelet Distribution Width with Hba1c. J Endocrinol Diabetes [Internet]. 2017; 4 : 1–6.
- 9. Tvedten H, Lilliehöök I, Hillström A, Häggström J. Plateletcritis superior to platelet count for assessing platelet status in Cavalier King Charles Spaniels. Vet Clin Pathol; 37: 266–271
- 10. Yazgan S, Celik U, Ayar O, et al. The role of patient’s systemic characteristics and plateletcrit in developing toxic anterior segment syndrome after uneventful phaco surgery: A case–control study. Int Ophthalmol. 2018; 38: 43–52.
- 11. Alhadas KR, Santos SN, Mara Freitas MS, et al. Are platelet indices useful in the evaluation of type 2 diabetic patients? Os índices plaquetários são úteis na avaliação de pacientes diabéticos tipo 2? J Bras Patol Med Lab [Internet]. 2016; 52 :105–11.
- 12. Anandhalakshmi S, Kalaivani A, Shivashekar G, Saravanan A. Evaluation of mean platelet volume and other platelet parameters in subjects with Type-2 diabetes mellitus. Natl J Physiol Pharm Pharmacol. 2017; 7: 51–4.
- 13. Atak BM, Duman TT, Aktas G, Kocak MZ, Savli H. Platelet Distribution Width is Associated with Type 2 Diabetes Mellitus and Diabetic Nephropathy and Neuropathy. 2018; 95–8.
- 14. Havakuk O, Banai S, Halkin A, et al. HbA1cLevels and Long-Term Mortality in Patients Undergoing Coronary Angiography. Cardiol. 2016; 134: 101–6.
- 15. Schoos MM, Dangas GD, Mehran R, et al. Impact of hemoglobin a1c levels on residual platelet reactivity and outcomes after insertion of coronary drug-eluting stents (from the ADAPT-DES Study). Am J Cardiol [Internet]. 2016; 117: 192–200.
Details
| Primary Language | English |
|---|---|
| Subjects | Health Care Administration |
| Journal Section | Original Article |
| Authors | |
| Publication Date | April 1, 2019 |
| Published in Issue | Year 2019 Volume: 2 Issue: 2 |
Interuniversity Board (UAK) Equivalency: Article published in Ulakbim TR Index journal [10 POINTS], and Article published in other (excuding 1a, b, c) international indexed journal (1d) [5 POINTS].
The Directories (indexes) and Platforms we are included in are at the bottom of the page.
Note: Our journal is not WOS indexed and therefore is not classified as Q.
You can download Council of Higher Education (CoHG) [Yüksek Öğretim Kurumu (YÖK)] Criteria) decisions about predatory/questionable journals and the author's clarification text and journal charge policy from your browser. https://dergipark.org.tr/tr/journal/2316/file/4905/show
The indexes of the journal are ULAKBİM TR Dizin, Index Copernicus, ICI World of Journals, DOAJ, Directory of Research Journals Indexing (DRJI), General Impact Factor, ASOS Index, WorldCat (OCLC), MIAR, EuroPub, OpenAIRE, Türkiye Citation Index, Türk Medline Index, InfoBase Index, Scilit, etc.
|
|
|
| |
|
|
|
|
The platforms of the journal are Google Scholar, CrossRef (DOI), ResearchBib, Open Access, COPE, ICMJE, NCBI, ORCID, Creative Commons, etc.
|
|
|
|
|
|
Our Journal using the DergiPark system indexed are;
Ulakbim TR Dizin, Index Copernicus, ICI World of Journals, Directory of Research Journals Indexing (DRJI), General Impact Factor, ASOS Index, OpenAIRE, MIAR, EuroPub, WorldCat (OCLC), DOAJ, Türkiye Citation Index, Türk Medline Index, InfoBase Index
Our Journal using the DergiPark system platforms are;
Journal articles are evaluated as "Double-Blind Peer Review".
Our journal has adopted the Open Access Policy and articles in JHSM are Open Access and fully comply with Open Access instructions. All articles in the system can be accessed and read without a journal user. https//dergipark.org.tr/tr/pub/jhsm/page/9535
Journal charge policy https://dergipark.org.tr/tr/pub/jhsm/page/10912
Editor List for 2022
Assoc. Prof. Alpaslan TANOĞLU (MD)
Prof. Aydın ÇİFCİ (MD)
Prof. İbrahim Celalaettin HAZNEDAROĞLU (MD)
Prof. Murat KEKİLLİ (MD)
Prof. Yavuz BEYAZIT (MD)
Prof. Ekrem ÜNAL (MD)
Prof. Ahmet EKEN (MD)
Assoc. Prof. Ercan YUVANÇ (MD)
Assoc. Prof. Bekir UÇAN (MD)
Assoc. Prof. Mehmet Sinan DAL (MD)
Our journal has been indexed in DOAJ as of May 18, 2020.
Our journal has been indexed in TR-Dizin as of March 12, 2021.
Articles published in the Journal of Health Sciences and Medicine have open access and are licensed under the Creative Commons CC BY-NC-ND 4.0 International License.