Mean platelet volume and platelet distribution width as mortality predictors in ıntensive care unit

İşın Gençay; Ünase Büyükkoçak; Gökay Ateş; Osman Çağlayan

doi:10.32322/jhsm.643639

Research Article

Yoğun bakım ünitesinde ortalama platelet hacmi ve platelet dağılım hacminin mortaliteye etkisi

Year 2020, Volume: 3 Issue: 1, 51 - 55, 15.01.2020

İşın Gençay Ünase Büyükkoçak Gökay Ateş Osman Çağlayan

https://doi.org/10.32322/jhsm.643639

Cited By: 3

Abstract

Giriş/Amaç: Bu çalışmada genel Yoğun Bakım Ünitesi’ndeki (YBÜ) hasta
populasyonunda, MPV (ortalama platelet hacmi) ve PDW (platelet dağilim hacmi)
parametrelerinin mortalite ile olan ilişkisini değerlendirmeyi amaçladık.

Gereç ve
Yöntem:
Genel YBÜ’ de yatan 284 hasta retrospektif olarak
analiz edildi. Hastaların ilk yatışlarında MPV ve PDW değerleri, ölmeden veya
taburcu edilmeden önceki son MPV ve PDW değerleri, hastanede yatış süreleri ve
yaşları kaydedildi.

Bulgular: Hayatta kalan hasta grubunda MPV ve PDW değerleri arasında
anlamlı fark yoktu. Benzer şekilde, ölen hastaların grubunda PDWFirst ve
PDWLast değerleri arasında istatistiksel olarak anlamlı fark yoktu (p>
0.05). Bununla birlikte, ölen hastaların grubunda MPVLast değeri, MPVFirst
değerlerine göre anlamlı olarak arttı (p <0.05). Mortalite ile ilişkili
hastaların yaş, hastanede kalış süreleri, MPV ve PDW değerleri
karşılaştırıldığında en önemli faktör MPVLast olarak bulundu.

Sonuç: Bu çalışma,
ölen hastalarda MPV değerlerinin arttığını ve mortalite ile yakından ilişkili
olduğunu göstermiştir.

Keywords

MPV, PDW, mortalite, yoğun bakım ünitesi

Supporting Institution

Yok

Project Number

Yok

Thanks

Yok

References

1. Nurden AT. Platelets, inflammation and tissue regeneration. Thromb Haemost 2011; 105(S 06), 13-33 (PMID: 21479340).
2. McFadyen JD, Kaplan ZS. Platelets are not just for clots. Transfus Med Rev 2015; 29(2), 110-119 (PMID: 25680870)
3. Lippi G, Pavesi F, Pipitone S. Evaluation of mean platelet volume with four hematological analyzers: harmonization is still an unresolved issue. Blood Coagul Fibrinolysis 2015; 26(2), 235-237 (PMID: 25255243).
4. Budak YU, Polat M, Huysal K. The use of platelet indices, plateletcrit, mean platelet volume and platelet distribution width in emergency non-traumatic abdominal surgery: a systematic review. Biochem Med. 2016; 26(2), 178-193 (PMID: 27346963).
5. Demirin H, Ozhan H, Ucgun T, et al. Normal range of mean platelet volume in healthy subjects: Insight from a large epidemiologic study. Thromb Res 2011; 128(4), 358-360 (PMID: 21620440).
6. Larsen SB, Grove EL, Hvas AM, Kristensen SD. Platelet turnover in stable coronary artery disease—influence of thrombopoietin and low-grade inflammation. PloS one 2014; 9(1), e85566 (PMID: 24465602).
7. Thompson CB, Eaton KA, Princiotta SM, Rushin CA, Valeri CR. Size dependent platelet subpopulations: relationship of platelet volume to ultrastructure, enzymatic activity, and function. Br J Haematol 1982; 50(3), 509-519 (PMID: 7066203).
8. Bath PM, Butterworth RJ. Platelet size: measurement, physiology and vascular disease. Blood Coagul Fibrinolysis 1996; 7(2), 157-161 (PMID: 8735807).
9. Choi DH, Kang SH, Song H. Mean platelet volume: a potential biomarker of the risk and prognosis of heart disease. Korean J Intern Med 2016; 31(6), 1009-1017 (PMID: 27776204).
10. Gasparyan AY, Ayvazyan L, Mikhailidis PD, Kitas DG. Mean platelet volume: a link between thrombosis and inflammation? Curr Pharm Des 2011; 17(1), 47-58 (PMID: 21247392)
11. Beyazit Y, Sayilir A, Torun S, et al. Mean platelet volume as an indicator of disease severity in patients with acute pancreatitis. Clin Res Hepatol Gastroenterol 2012; 36(2), 162-168 (PMID: 22088974).
12. Sachdev R, Tiwari AK, Goel S, Raina V, Sethi M. Establishing biological reference intervals for novel platelet parameters (immature platelet fraction, high immature platelet fraction, platelet distribution width, platelet large cell ratio, platelet-X, plateletcrit, and platelet distribution width) and their correlations among each other. Indian J Pathol Microbiol 2014; 57(2), 231 (PMID: 24943755).
13. Maluf CB, Barreto SM, Vidigal PG. Standardization and reference intervals of platelet volume indices: Insight from the Brazilian longitudinal study of adult health (ELSA-BRASIL). Platelets 2015; 26(5), 413-420 (PMID: 25101826).
14. Vagdatli E, Gounari E, Lazaridou E, Katsibourlia E, Tsikopoulou F, Labrianou I. Platelet distribution width: a simple, practical and specific marker of activation of coagulation. Hippokratia 2010; 14(1), 28 (PMID: 20411056)
15. Rapsang AG, Shyam DC. Scoring systems in the intensive care unit: a compendium. Indian J Crit Care Med 2014; 18(4), 220 (PMID: 24872651).
16. Zimmerman, J. E., Alzola, C., & Von Rueden, K. T.. The use of benchmarking to identify top performing critical care units: a preliminary assessment of their policies and practices. J Crit Care 2003; 18(2), 76-86.
17. Maccariello, E. R., Valente, C., Nogueira, L., Ismael, M., Valença, R. V., Machado, J., Soares, M. Performance of six prognostic scores in critically ill patients receiving renal replacement therapy. Rev Bras Ter Intensiva 2008; 20(2), 115-123.
18. Uysal N, Gündogdu N, Börekçi S, Dikensoy Ö, Bayram N, Uyar M, Mutlu GM. Prognosis of Patients in a Medical Intensive Care Unit of a Tertiary Care Centre. Yogun Bakim Dergisi 2010; 1(1), 1 (PMID: 28058366)
19. Unal AU, Kostek O, Takir M, Caklili O, Uzunlulu M, Oguz A. Prognosis of patients in a medical intensive care unit. North Clin Istanb 2015; 2(3), 189 (PMID: 28058366)
20. Castella X, Artigas A, Bion J, Kari A. A comparison of severity of illness scoring systems for intensive care unit patients: Results of a multicenter, multinational study. Crit Care Med 1995; 23(8), 1327-1335(PMID: 7634802).
21. Le Gall JR, Lemeshow S, Saulnier F. A new simplified acute physiology score (SAPS II) based on a European/North American multicenter study. Jama 1993; 270(24), 2957-2963 (PMID: 8254858).
22. Martin JF, Bath PMW, Burr ML. Influence of platelet size on outcome after myocardial infarction. The Lancet 1991; 338(8780), 1409-1411(PMID: 1683417).
23. Mayda-Domaç F, Mısırlı H, Yılmaz M. Prognostic role of mean platelet volume and platelet count in ischemic and hemorrhagic stroke. J Stroke Cerebrovasc Dis 2010 19(1), 66-72 (PMID: 20123229)
24. Zhang Z, Xu X, Ni H, Deng H. Platelet indices are novel predictors of hospital mortality in intensive care unit patients. J Crit Care 2014; 29(5), 885. e 1-6 (PMID: 24895093).
25. Sezgi C, Taylan M, Kaya H, et al. Alterations in platelet count and mean platelet volume as predictors of patient outcome in the respiratory intensive care unit. Clin Respir J 2015; 9(4), 403-408 (PMID: 24725778)
26. Khandekar MM, Khurana AS, Deshmukh SD, Kakrani AL, Katdare AD, Inamdar AK. Platelet volume indices in patients with coronary artery disease and acute myocardial infarction: an Indian scenario. J Clin Pathol 2006; 59(2), 146-149 (PMID: 16443728).
27. Lee JH, Park M, Han S, Hwang JJ, Park SH, Park SY. An increase in mean platelet volume during admission can predict the prognoses of patients with pneumonia in the intensive care unit: A retrospective study. PLoS one 2018; 11;13(12) (PMID: 30533065).

Mean platelet volume and platelet distribution width as mortality predictors in ıntensive care unit

Year 2020, Volume: 3 Issue: 1, 51 - 55, 15.01.2020

İşın Gençay Ünase Büyükkoçak Gökay Ateş Osman Çağlayan

https://doi.org/10.32322/jhsm.643639

Cited By: 3

Abstract

Background
and Aim: This study aimed to determine the mean platelet volume (MPV) and
platelet distribution width (PDW) values of intensive care patients, and show
the relationship between these parameters and mortality.

Material and Method: In the present study, 284 patients who were hospitalized in the intensive
care unit were retrospectively analyzed. MPV and PDW values of the patients
when they first hospitalized, their last MPV and PDW values before they died or
were discharged, their ages and duration of hospitalization were recorded.

Results: There was
no significant difference between the MPV and PDW values in the group of the
patients who survived. Similarly, there was no statistically significant
difference between PDWFirst and PDWLast values in the group of the patients who
died (p> 0.05). However, MPVLast value increased significantly compared to
MPVFirst values (p <0.05) in the group of the patients who died. MPVLast was
found to be the most important factor when the age, hospitalization period, MPV
and PDW values of the patients, which are associated with mortality, were
compared.

Conclusion: This
study showed that MPV values increased in the patients who died and that they
were closely related to mortality.

Keywords

: MPV, PDW, mortality, intensive care unit

Project Number

Yok

References

1. Nurden AT. Platelets, inflammation and tissue regeneration. Thromb Haemost 2011; 105(S 06), 13-33 (PMID: 21479340).
2. McFadyen JD, Kaplan ZS. Platelets are not just for clots. Transfus Med Rev 2015; 29(2), 110-119 (PMID: 25680870)
3. Lippi G, Pavesi F, Pipitone S. Evaluation of mean platelet volume with four hematological analyzers: harmonization is still an unresolved issue. Blood Coagul Fibrinolysis 2015; 26(2), 235-237 (PMID: 25255243).
4. Budak YU, Polat M, Huysal K. The use of platelet indices, plateletcrit, mean platelet volume and platelet distribution width in emergency non-traumatic abdominal surgery: a systematic review. Biochem Med. 2016; 26(2), 178-193 (PMID: 27346963).
5. Demirin H, Ozhan H, Ucgun T, et al. Normal range of mean platelet volume in healthy subjects: Insight from a large epidemiologic study. Thromb Res 2011; 128(4), 358-360 (PMID: 21620440).
6. Larsen SB, Grove EL, Hvas AM, Kristensen SD. Platelet turnover in stable coronary artery disease—influence of thrombopoietin and low-grade inflammation. PloS one 2014; 9(1), e85566 (PMID: 24465602).
7. Thompson CB, Eaton KA, Princiotta SM, Rushin CA, Valeri CR. Size dependent platelet subpopulations: relationship of platelet volume to ultrastructure, enzymatic activity, and function. Br J Haematol 1982; 50(3), 509-519 (PMID: 7066203).
8. Bath PM, Butterworth RJ. Platelet size: measurement, physiology and vascular disease. Blood Coagul Fibrinolysis 1996; 7(2), 157-161 (PMID: 8735807).
9. Choi DH, Kang SH, Song H. Mean platelet volume: a potential biomarker of the risk and prognosis of heart disease. Korean J Intern Med 2016; 31(6), 1009-1017 (PMID: 27776204).
10. Gasparyan AY, Ayvazyan L, Mikhailidis PD, Kitas DG. Mean platelet volume: a link between thrombosis and inflammation? Curr Pharm Des 2011; 17(1), 47-58 (PMID: 21247392)
11. Beyazit Y, Sayilir A, Torun S, et al. Mean platelet volume as an indicator of disease severity in patients with acute pancreatitis. Clin Res Hepatol Gastroenterol 2012; 36(2), 162-168 (PMID: 22088974).
12. Sachdev R, Tiwari AK, Goel S, Raina V, Sethi M. Establishing biological reference intervals for novel platelet parameters (immature platelet fraction, high immature platelet fraction, platelet distribution width, platelet large cell ratio, platelet-X, plateletcrit, and platelet distribution width) and their correlations among each other. Indian J Pathol Microbiol 2014; 57(2), 231 (PMID: 24943755).
13. Maluf CB, Barreto SM, Vidigal PG. Standardization and reference intervals of platelet volume indices: Insight from the Brazilian longitudinal study of adult health (ELSA-BRASIL). Platelets 2015; 26(5), 413-420 (PMID: 25101826).
14. Vagdatli E, Gounari E, Lazaridou E, Katsibourlia E, Tsikopoulou F, Labrianou I. Platelet distribution width: a simple, practical and specific marker of activation of coagulation. Hippokratia 2010; 14(1), 28 (PMID: 20411056)
15. Rapsang AG, Shyam DC. Scoring systems in the intensive care unit: a compendium. Indian J Crit Care Med 2014; 18(4), 220 (PMID: 24872651).
16. Zimmerman, J. E., Alzola, C., & Von Rueden, K. T.. The use of benchmarking to identify top performing critical care units: a preliminary assessment of their policies and practices. J Crit Care 2003; 18(2), 76-86.
17. Maccariello, E. R., Valente, C., Nogueira, L., Ismael, M., Valença, R. V., Machado, J., Soares, M. Performance of six prognostic scores in critically ill patients receiving renal replacement therapy. Rev Bras Ter Intensiva 2008; 20(2), 115-123.
18. Uysal N, Gündogdu N, Börekçi S, Dikensoy Ö, Bayram N, Uyar M, Mutlu GM. Prognosis of Patients in a Medical Intensive Care Unit of a Tertiary Care Centre. Yogun Bakim Dergisi 2010; 1(1), 1 (PMID: 28058366)
19. Unal AU, Kostek O, Takir M, Caklili O, Uzunlulu M, Oguz A. Prognosis of patients in a medical intensive care unit. North Clin Istanb 2015; 2(3), 189 (PMID: 28058366)
20. Castella X, Artigas A, Bion J, Kari A. A comparison of severity of illness scoring systems for intensive care unit patients: Results of a multicenter, multinational study. Crit Care Med 1995; 23(8), 1327-1335(PMID: 7634802).
21. Le Gall JR, Lemeshow S, Saulnier F. A new simplified acute physiology score (SAPS II) based on a European/North American multicenter study. Jama 1993; 270(24), 2957-2963 (PMID: 8254858).
22. Martin JF, Bath PMW, Burr ML. Influence of platelet size on outcome after myocardial infarction. The Lancet 1991; 338(8780), 1409-1411(PMID: 1683417).
23. Mayda-Domaç F, Mısırlı H, Yılmaz M. Prognostic role of mean platelet volume and platelet count in ischemic and hemorrhagic stroke. J Stroke Cerebrovasc Dis 2010 19(1), 66-72 (PMID: 20123229)
24. Zhang Z, Xu X, Ni H, Deng H. Platelet indices are novel predictors of hospital mortality in intensive care unit patients. J Crit Care 2014; 29(5), 885. e 1-6 (PMID: 24895093).
25. Sezgi C, Taylan M, Kaya H, et al. Alterations in platelet count and mean platelet volume as predictors of patient outcome in the respiratory intensive care unit. Clin Respir J 2015; 9(4), 403-408 (PMID: 24725778)
26. Khandekar MM, Khurana AS, Deshmukh SD, Kakrani AL, Katdare AD, Inamdar AK. Platelet volume indices in patients with coronary artery disease and acute myocardial infarction: an Indian scenario. J Clin Pathol 2006; 59(2), 146-149 (PMID: 16443728).
27. Lee JH, Park M, Han S, Hwang JJ, Park SH, Park SY. An increase in mean platelet volume during admission can predict the prognoses of patients with pneumonia in the intensive care unit: A retrospective study. PLoS one 2018; 11;13(12) (PMID: 30533065).

There are 27 citations in total.

Details

Primary Language	English
Subjects	Health Care Administration
Journal Section	Original Article
Authors	İşın Gençay 0000-0001-5279-9975 Ünase Büyükkoçak 0000-0001-8472-6041 Gökay Ateş 0000-0002-3718-2827 Osman Çağlayan 0000-0003-3727-0277
Project Number	Yok
Publication Date	January 15, 2020
Published in Issue	Year 2020 Volume: 3 Issue: 1

Cite

AMA	Gençay İ, Büyükkoçak Ü, Ateş G, Çağlayan O. Mean platelet volume and platelet distribution width as mortality predictors in ıntensive care unit. J Health Sci Med / JHSM. January 2020;3(1):51-55. doi:10.32322/jhsm.643639

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