Abstract
References
- Abass RM, Hamdan HZ, Elhassan EM, Hamdan SZ, Ali NI, Adam I. Zinc and copper levels in low birth weight deliveries in Medani Hospital, Sudan. BMC Res Notes 2014; 7: 386.
- Kot K, Kosik-Bogacka D, Łanocha-Arendarczyk N, et al. Interactions between 14 Elements in the Human Placenta, Fetal Membrane and Umbilical Cord. Int J Environ Res Public Health 2019; 16: 1615.
- Turan E, Turksoy VA. Selenium, Zinc, and Copper Status in Euthyroid Nodular Goiter: A Cross-Sectional Study. Int J Prev Med 2021; 12: 46.
- Turksoy VA, Yalvac ES, Simsek OT, et al. Impact of zinc on birth and placental weight in cadmium and lead exposure during pregnancy. Indian J Forensic Med Pathol 2019; 12: 246–54.
- Roels HA, Bowler RM, Kim Y, et al. Manganese exposure and cognitive deficits: a growing concern for manganese neurotoxicity. Neurotoxicology 2012; 33: 872-80.
- Wu G, Morris SM Jr. Arginine metabolism: nitric oxide and beyond. Biochem J. 1998; 336: 1-17.
- Wu G, Bazer FW, Satterfield MC, et al. Impacts of arginine nutrition on embryonic and fetal development in mammals. Amino Acids 2013; 45: 241-56.
- Hsu CN, Tain YL. Impact of arginine nutrition and metabolism during pregnancy on offspring outcomes. Nutrients 2019; 11: 1–15.
- Wu G, Bazer FW, Davis TA, et al. Arginine metabolism and nutrition in growth, health and disease. Amino Acids 2009; 37: 153-68.
- Zhao X, Lu X, Feng Q. Deficiency in endothelial nitric oxide synthase impairs myocardial angiogenesis. Am J Physiol Heart Circ Physiol 2002; 283: H2371-H2378.
- Gao K, Jiang Z, Lin Y, et al. Dietary L-arginine supplementation enhances placental growth and reproductive performance in sows. Amino Acids 2012; 42: 2207-14.
- Tutkun L, Gunduzoz M, Turksoy VA, et al. Assessment of Endothelial Dysfunction with Methylated Arginines and L-arginine in Cadmium-Exposed People: a Pilot Study. Clin Lab 2019; 65: 10.7754/Clin.Lab.2019.181249.
- Fickling SA, Williams D, Vallance P, Nussey SS, Whitley GS. Plasma concentrations of endogenous inhibitor of nitric oxide synthesis in normal pregnancy and pre-eclampsia. Lancet. 1993; 342: 242-3.
- Emrich IE, Zawada AM, Martens-Lobenhoffer J, et al. Symmetric dimethylarginine (SDMA) outperforms asymmetric dimethylarginine (ADMA) and other methylarginines as predictor of renal and cardiovascular outcome in non-dialysis chronic kidney disease. Clin Res Cardiol 2018; 107: 201-13.
- Martens-Lobenhoffer J, Bode-Böger SM. Amino acid N-acetylation: metabolic elimination of symmetric dimethylarginine as symmetric N(α)-acetyldimethylarginine, determined in human plasma and urine by LC-MS/MS. J Chromatogr B Analyt Technol Biomed Life Sci 2015; 975: 59-64.
- Griffioen AW, Molema G. Angiogenesis: potentials for pharmacologic intervention in the treatment of cancer, cardiovascular diseases, and chronic inflammation. Pharmacol Rev 2000; 52: 237-268.
- Wada K, Inoue K, Hagiwara M. Identification of methylated proteins by protein arginine N-methyltransferase 1, PRMT1, with a new expression cloning strategy. Biochim Biophys Acta 2002; 1591: 1-10.
- Zoccali C, Bode-Böger S, Mallamaci F, et al. Plasma concentration of asymmetrical dimethylarginine and mortality in patients with end-stage renal disease: a prospective study. Lancet 2001; 358: 2113-7.
- Shao J, Hou L, Liu J, et al. Indoleamine 2,3-Dioxygenase 1 Inhibitor-Loaded Nanosheets Enhance CAR-T Cell Function in Esophageal Squamous Cell Carcinoma. Front Immunol 2021; 12: 661357.
- Lassala A, Bazer FW, Cudd TA, et al. Intravenous administration of L-citrulline to pregnant ewes is more effective than L-arginine for increasing arginine availability in the fetus. J Nutr 2009; 139: 660-5.
- Tsikas D, Bollenbach A, Savvidou MD. Inverse correlation between maternal plasma asymmetric dimethylarginine (ADMA) and birthweight percentile in women with impaired placental perfusion: circulating ADMA as an NO-independent indicator of fetal growth restriction?. Amino Acids 2018; 50: 341-51.
- Ozdemir U, Gulturk S, Aker A, Guvenal T, Imir G, Erselcan T. Correlation between birth weight, leptin, zinc and copper levels in maternal and cord blood. J Physiol Biochem 2007; 63: 121-8.
- The Potential Role of Arginine/Glutamine/Zinc/Copper as Supplemental Immuno-Enhancing Nutrients in Suspected/Infected Sars-Cov-2 Patients. Iar J Med Sci 2020; 1: 20-25.
- Tapiero H, Townsend DM, Tew KD. Trace elements in human physiology and pathology. Copper. Biomed Pharmacother 2003; 57: 386-98.
- Groß F, Rudolf EE, Thiele B, Durner J, Astier J. Copper amine oxidase 8 regulates arginine-dependent nitric oxide production in Arabidopsis thaliana. J Exp Bot 2017; 68: 2149-62.
Abstract
Aim: Environmental exposure and maternal nutrition are vital for placental and fetal development during pregnancy. Essential elements such as Zinc (Zn), Copper (Cu) and Selenium (Se) are important elements that are needed for human growth and development. Research indicates that methylated arginines play a key role in pregnancy and offspring outcomes. The aim of the study was to compare the placental tissue levels of trace elements and methylated arginines. In addition, to evaluate this placental trace elements and methylated arginine levels in terms of placental and birth weight.
Material and Methods: This is a case-control study with 133 pregnant women. Two groups were formed: women with higher risk of exposure to chemicals (working in chemistry, metal and other industrial sectors) and those with no risk of exposure to hazardous chemicals (house wives and working in other non-hazardous workplaces). Placenta Zn, Cu, Se, ADMA, SDMA, arginine, citrulline, homoarginine and L-NMMA levels were investigated.
Results: There was a positive correlation between birth weight with Cu, L-NMMA, total methylarginines; there was a negative relationship between birth weight and ADMA, SDMA, arginine, citrulline. However, no statistically significant relationship was found between trace elements such as Zn, Cu and Se with methylated arginines, except for L-NMMA (r=0.178; p<0.05).
Conclusions: Cu, Zn and Se levels are not related to processes that reduce birth weight and vascular factors.
References
- Abass RM, Hamdan HZ, Elhassan EM, Hamdan SZ, Ali NI, Adam I. Zinc and copper levels in low birth weight deliveries in Medani Hospital, Sudan. BMC Res Notes 2014; 7: 386.
- Kot K, Kosik-Bogacka D, Łanocha-Arendarczyk N, et al. Interactions between 14 Elements in the Human Placenta, Fetal Membrane and Umbilical Cord. Int J Environ Res Public Health 2019; 16: 1615.
- Turan E, Turksoy VA. Selenium, Zinc, and Copper Status in Euthyroid Nodular Goiter: A Cross-Sectional Study. Int J Prev Med 2021; 12: 46.
- Turksoy VA, Yalvac ES, Simsek OT, et al. Impact of zinc on birth and placental weight in cadmium and lead exposure during pregnancy. Indian J Forensic Med Pathol 2019; 12: 246–54.
- Roels HA, Bowler RM, Kim Y, et al. Manganese exposure and cognitive deficits: a growing concern for manganese neurotoxicity. Neurotoxicology 2012; 33: 872-80.
- Wu G, Morris SM Jr. Arginine metabolism: nitric oxide and beyond. Biochem J. 1998; 336: 1-17.
- Wu G, Bazer FW, Satterfield MC, et al. Impacts of arginine nutrition on embryonic and fetal development in mammals. Amino Acids 2013; 45: 241-56.
- Hsu CN, Tain YL. Impact of arginine nutrition and metabolism during pregnancy on offspring outcomes. Nutrients 2019; 11: 1–15.
- Wu G, Bazer FW, Davis TA, et al. Arginine metabolism and nutrition in growth, health and disease. Amino Acids 2009; 37: 153-68.
- Zhao X, Lu X, Feng Q. Deficiency in endothelial nitric oxide synthase impairs myocardial angiogenesis. Am J Physiol Heart Circ Physiol 2002; 283: H2371-H2378.
- Gao K, Jiang Z, Lin Y, et al. Dietary L-arginine supplementation enhances placental growth and reproductive performance in sows. Amino Acids 2012; 42: 2207-14.
- Tutkun L, Gunduzoz M, Turksoy VA, et al. Assessment of Endothelial Dysfunction with Methylated Arginines and L-arginine in Cadmium-Exposed People: a Pilot Study. Clin Lab 2019; 65: 10.7754/Clin.Lab.2019.181249.
- Fickling SA, Williams D, Vallance P, Nussey SS, Whitley GS. Plasma concentrations of endogenous inhibitor of nitric oxide synthesis in normal pregnancy and pre-eclampsia. Lancet. 1993; 342: 242-3.
- Emrich IE, Zawada AM, Martens-Lobenhoffer J, et al. Symmetric dimethylarginine (SDMA) outperforms asymmetric dimethylarginine (ADMA) and other methylarginines as predictor of renal and cardiovascular outcome in non-dialysis chronic kidney disease. Clin Res Cardiol 2018; 107: 201-13.
- Martens-Lobenhoffer J, Bode-Böger SM. Amino acid N-acetylation: metabolic elimination of symmetric dimethylarginine as symmetric N(α)-acetyldimethylarginine, determined in human plasma and urine by LC-MS/MS. J Chromatogr B Analyt Technol Biomed Life Sci 2015; 975: 59-64.
- Griffioen AW, Molema G. Angiogenesis: potentials for pharmacologic intervention in the treatment of cancer, cardiovascular diseases, and chronic inflammation. Pharmacol Rev 2000; 52: 237-268.
- Wada K, Inoue K, Hagiwara M. Identification of methylated proteins by protein arginine N-methyltransferase 1, PRMT1, with a new expression cloning strategy. Biochim Biophys Acta 2002; 1591: 1-10.
- Zoccali C, Bode-Böger S, Mallamaci F, et al. Plasma concentration of asymmetrical dimethylarginine and mortality in patients with end-stage renal disease: a prospective study. Lancet 2001; 358: 2113-7.
- Shao J, Hou L, Liu J, et al. Indoleamine 2,3-Dioxygenase 1 Inhibitor-Loaded Nanosheets Enhance CAR-T Cell Function in Esophageal Squamous Cell Carcinoma. Front Immunol 2021; 12: 661357.
- Lassala A, Bazer FW, Cudd TA, et al. Intravenous administration of L-citrulline to pregnant ewes is more effective than L-arginine for increasing arginine availability in the fetus. J Nutr 2009; 139: 660-5.
- Tsikas D, Bollenbach A, Savvidou MD. Inverse correlation between maternal plasma asymmetric dimethylarginine (ADMA) and birthweight percentile in women with impaired placental perfusion: circulating ADMA as an NO-independent indicator of fetal growth restriction?. Amino Acids 2018; 50: 341-51.
- Ozdemir U, Gulturk S, Aker A, Guvenal T, Imir G, Erselcan T. Correlation between birth weight, leptin, zinc and copper levels in maternal and cord blood. J Physiol Biochem 2007; 63: 121-8.
- The Potential Role of Arginine/Glutamine/Zinc/Copper as Supplemental Immuno-Enhancing Nutrients in Suspected/Infected Sars-Cov-2 Patients. Iar J Med Sci 2020; 1: 20-25.
- Tapiero H, Townsend DM, Tew KD. Trace elements in human physiology and pathology. Copper. Biomed Pharmacother 2003; 57: 386-98.
- Groß F, Rudolf EE, Thiele B, Durner J, Astier J. Copper amine oxidase 8 regulates arginine-dependent nitric oxide production in Arabidopsis thaliana. J Exp Bot 2017; 68: 2149-62.
Details
| Primary Language | English |
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| Subjects | Health Care Administration |
| Journal Section | Original Article |
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| Publication Date | September 5, 2021 |
| Published in Issue | Year 2021 Volume: 4 Issue: 5 |
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