Evaluation of neutrophyl/lymphocyte ratio, platelet/lymphocyte ratio and mean platelet volume according to the disease activity index in patients of ankylosing spondylitis
Abstract
Objective: To determine the relationship between neutrophil/lymphocyte ratio (NLR), platelet/ lymphocyte ratio (PLR) and mean platelet volume (MPV) with acute phase reactants in patients with ankylosing spondylitis (AS) and to show the usability of these parameters in the activation periods and follow-up of the disease.
Material and Method: The demographic data (age, gender) and Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) score of 70 patients who had been followed regularly for at least 1 year and whose diagnosis of AS was definite were recorded. The control group consists of 70 people who do not have any disease. Among the laboratory parameters, neutrophil, platelet, lymphocyte count, C-reactive protein(CRP), erythrocyte sedimentation rate(ESR), NLR, PLR and MPV values were retrospectively checked and recorded.
Results: In our study, a statistically significant difference was found between the AS patients and the control group in MPV, NLR and PLR values. In addition, these values were found to be statistically significantly different between the groups with low disease activity and high disease activity in the AS patient group. There was a weak negative correlation between MPV value and BASDAI, ESR and CRP values. There was no statistically significant correlation between NLR value and ESR and CRP. There was no correlation between PLR value and ESR and CRP.
Conclusion: As a result of our study, NLR, PLR and MPV values are seen as simple, easy and inexpensive markers that can be used to determine disease activity in AS patients.
Keywords
References
- Braun J, Sieper J. Ankylosing spondylitis. The Lancet 2007; 369: 1379-90.
- Zhu W, He X, Cheng K, et al. Ankylosing spondylitis: etiology, pathogenesis, and treatments. Bone Res 2019; 7: 1-16.
- Dougados M, Baeten D. Spondyloarthritis. Lancet 2011; 377: 2127-37.
- Reveille J. Clinical Features of Ankylosing Spondylitis. In: Hochberg MC, Silman AJ, Smolen JS, Weinblatt ME, Weisman MH. Rheumatology (4th ed) Elsevier Publishers; 2008: 1109-14.
- Raychaudhuri SP, Deodhar A. The classification and diagnostic criteria of ankylosing spondylitis. J Autoimmun 2014; 48: 128-33.
- Elyan M, Khan MA. Diagnosing ankylosing spondylitis. J Rheumatol Supp 2006; 78: 12-23.
- Spoorenberg A, van der Heijde D, de Klerk E, et al. Relative value of erythrocyte sedimentation rate and C-reactive protein in assessment of disease activity in ankylosing spondylitis. J Rheumatol 1999; 26: 980-4.
- Zochling J. Measures of symptoms and disease status in ankylosing spondylitis: Ankylosing Spondylitis Disease Activity Score, Ankylosing Spondylitis Quality of Life Scale, Bath Ankylosing Spondylitis Disease Activity Index, Bath Ankylosing Spondylitis Functional Index, Bath Ankylosing Spondylitis Global Score, Bath Ankylosing Spondylitis Metrology Index, Dougados Functional Index, and Health Assessment Questionnaire for the Spondylarthropathies. Arthritis Care Res (Hoboken). 2011; 63: S47-S58.
- Abd-Elazeem MI, Mohamed RA. Neutrophil-lymphocyte and platelet-lymphocyte ratios in rheumatoid arthritis patients: Relation to disease activity. Egypt Rheumatol 2018; 40(4): 227-31
- Schmoeller D, Picarelli MM, Paz Munhoz T, Poli de Figueiredo CE, Staub HL. Mean platelet volume and immature platelet fraction in autoimmune disorders. Front Med 2017; 4: 146.
- Mercan R, Bitik B, Tufan A, et al. The association between neutrophil/lymphocyte ratio and disease activity in rheumatoid arthritis and ankylosing spondylitis. J Clin Lab Anal 2016; 30: 597-601.
- Şahin A, Yetişgin A, Şahin M, Durmaz Y, Cengiz AK. Can mean platelet volume be a surrogate marker of inflammation in rheumatic diseases? West Indian Med J 2016; 65: 165-9.
- Sen BB, Rifaioglu EN, Ekiz O, Inan MU, Sen T, Sen N. Neutrophil to lymphocyte ratio as a measure of systemic inflammation in psoriasis. Cutan Ocul Toxicol 2014; 33: 223-7.
- Seng JJB, Kwan YH, Low LL, Thumboo J, Fong WSW. Role of neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR) and mean platelet volume (MPV) in assessing disease control in Asian patients with axial spondyloarthritis. Biomarkers 2018; 23: 335-8.
- Song GG, Lee YH. Red cell distribution width, platelet-to-lymphocyte ratio, and mean platelet volume in ankylosing spondylitis and their correlations with inflammation: A meta-analysis. Modern Rheumatol 2019: 1-6.
- Gökmen F, Akbal A, Reşorlu H, et al. Neutrophil–lymphocyte ratio connected to treatment options and inflammation markers of ankylosing spondylitis. J Clin Lab Anal 2015; 29: 294-8.
- Aşkın A. Ankilozan spondilit hastalarında nötrofil/lenfosit oranı, trombosit/lenfosit oranı ve ortalama trombosit hacminin değerlendirilmesi. Cukurova Med J 2016; 41: 479-84.
- Boyraz İ, Koç B, Boyacı A, Tutoğlu A, Sarman H, Özkan H. Ratio of neutrophil/lymphocyte and platelet/lymphocyte in patient with ankylosing spondylitis that are treating with anti-TNF. International journal of clinical and experimental medicine 2014; 7: 2912
- Templeton AJ, Ace O, McNamara MG, et al. Prognostic role of platelet to lymphocyte ratio in solid tumors: a systematic review and meta-analysis. Cancer Epidemiol Biomarkers Prev 2014; 23: 1204-12.
- Bozan N, Alpaycı M, Aslan M, et al. Mean platelet volume, red cell distribution width, platelet-to-lymphocyte and neutrophil-to- lymphocyte ratios in patients with ankylosing spondylitis and their relationships with high-frequency hearing thresholds. Eur Arch Oto-Rhino-Laryngol 2016; 273: 3663-72.
Abstract
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References
- Braun J, Sieper J. Ankylosing spondylitis. The Lancet 2007; 369: 1379-90.
- Zhu W, He X, Cheng K, et al. Ankylosing spondylitis: etiology, pathogenesis, and treatments. Bone Res 2019; 7: 1-16.
- Dougados M, Baeten D. Spondyloarthritis. Lancet 2011; 377: 2127-37.
- Reveille J. Clinical Features of Ankylosing Spondylitis. In: Hochberg MC, Silman AJ, Smolen JS, Weinblatt ME, Weisman MH. Rheumatology (4th ed) Elsevier Publishers; 2008: 1109-14.
- Raychaudhuri SP, Deodhar A. The classification and diagnostic criteria of ankylosing spondylitis. J Autoimmun 2014; 48: 128-33.
- Elyan M, Khan MA. Diagnosing ankylosing spondylitis. J Rheumatol Supp 2006; 78: 12-23.
- Spoorenberg A, van der Heijde D, de Klerk E, et al. Relative value of erythrocyte sedimentation rate and C-reactive protein in assessment of disease activity in ankylosing spondylitis. J Rheumatol 1999; 26: 980-4.
- Zochling J. Measures of symptoms and disease status in ankylosing spondylitis: Ankylosing Spondylitis Disease Activity Score, Ankylosing Spondylitis Quality of Life Scale, Bath Ankylosing Spondylitis Disease Activity Index, Bath Ankylosing Spondylitis Functional Index, Bath Ankylosing Spondylitis Global Score, Bath Ankylosing Spondylitis Metrology Index, Dougados Functional Index, and Health Assessment Questionnaire for the Spondylarthropathies. Arthritis Care Res (Hoboken). 2011; 63: S47-S58.
- Abd-Elazeem MI, Mohamed RA. Neutrophil-lymphocyte and platelet-lymphocyte ratios in rheumatoid arthritis patients: Relation to disease activity. Egypt Rheumatol 2018; 40(4): 227-31
- Schmoeller D, Picarelli MM, Paz Munhoz T, Poli de Figueiredo CE, Staub HL. Mean platelet volume and immature platelet fraction in autoimmune disorders. Front Med 2017; 4: 146.
- Mercan R, Bitik B, Tufan A, et al. The association between neutrophil/lymphocyte ratio and disease activity in rheumatoid arthritis and ankylosing spondylitis. J Clin Lab Anal 2016; 30: 597-601.
- Şahin A, Yetişgin A, Şahin M, Durmaz Y, Cengiz AK. Can mean platelet volume be a surrogate marker of inflammation in rheumatic diseases? West Indian Med J 2016; 65: 165-9.
- Sen BB, Rifaioglu EN, Ekiz O, Inan MU, Sen T, Sen N. Neutrophil to lymphocyte ratio as a measure of systemic inflammation in psoriasis. Cutan Ocul Toxicol 2014; 33: 223-7.
- Seng JJB, Kwan YH, Low LL, Thumboo J, Fong WSW. Role of neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR) and mean platelet volume (MPV) in assessing disease control in Asian patients with axial spondyloarthritis. Biomarkers 2018; 23: 335-8.
- Song GG, Lee YH. Red cell distribution width, platelet-to-lymphocyte ratio, and mean platelet volume in ankylosing spondylitis and their correlations with inflammation: A meta-analysis. Modern Rheumatol 2019: 1-6.
- Gökmen F, Akbal A, Reşorlu H, et al. Neutrophil–lymphocyte ratio connected to treatment options and inflammation markers of ankylosing spondylitis. J Clin Lab Anal 2015; 29: 294-8.
- Aşkın A. Ankilozan spondilit hastalarında nötrofil/lenfosit oranı, trombosit/lenfosit oranı ve ortalama trombosit hacminin değerlendirilmesi. Cukurova Med J 2016; 41: 479-84.
- Boyraz İ, Koç B, Boyacı A, Tutoğlu A, Sarman H, Özkan H. Ratio of neutrophil/lymphocyte and platelet/lymphocyte in patient with ankylosing spondylitis that are treating with anti-TNF. International journal of clinical and experimental medicine 2014; 7: 2912
- Templeton AJ, Ace O, McNamara MG, et al. Prognostic role of platelet to lymphocyte ratio in solid tumors: a systematic review and meta-analysis. Cancer Epidemiol Biomarkers Prev 2014; 23: 1204-12.
- Bozan N, Alpaycı M, Aslan M, et al. Mean platelet volume, red cell distribution width, platelet-to-lymphocyte and neutrophil-to- lymphocyte ratios in patients with ankylosing spondylitis and their relationships with high-frequency hearing thresholds. Eur Arch Oto-Rhino-Laryngol 2016; 273: 3663-72.
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| Primary Language | English |
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| Subjects | Health Care Administration |
| Journal Section | Original Article |
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| Publication Date | January 17, 2022 |
| Published in Issue | Year 2022 Volume: 5 Issue: 1 |
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