Abstract
Objective: The aim of this study is to evaluate the demographic data, clinical features and laboratory findings of patients followed up with methanol poisoning in our internal medicine clinic. In addition, to examine the data of the patients followed in our intensive care unit and to contribute to the literature in this direction.
Material and Method: In this study, 21 patients diagnosed with methanol intoxication who were hospitalized in the internal medicine clinic of our hospital between 01.01.2019 and 01.04.2022 were included. Demographic information of the patients, initial complaints, accompanying symptoms, laboratory results, blood gas values, intensive care unit requirements, mechanical ventilation needs, length of hospital stay and whether they received hemodialysis treatment were recorded from the hospital automation system.
Results: 21 patients were included in the study. The mean time for patients to apply to the hospital after drinking alcohol was calculated as 31.42±4.27 hours. The mean hospital stay was 3.0±1.02 days. While 12 patients were followed up in the intensive care unit, it was found that 6 patients needed mechanical ventilation and 9 patients needed hemodialysis. Glucose, creatinine, acetyl aminotransferase (AST), partial carbon dioxide pressure (PaCO2), lactate, anion gap and base gap were found to be statistically significantly higher in the group treated in the intensive care unit (p<0.05). When the blood gas parameters at the time of admission were compared between the groups who received and did not receive hemodialysis treatment of the patients who presented with methanol intoxication, pH, lactate, anion gap and base deficit were found to be statistically significantly higher (p=0.001).
Conclusion: Hyperglycemia, increased serum creatinine value and metabolic acidosis were found to be significantly different in patients hospitalized in the intensive care unit
Keywords
References
- Oguz AB, Gunalp M, Polat O, Genc S, Gurler S. Transdermal methanol intoxication. Arch Iran Med 2019; 22: 671-2.
- Jammalamadaka D, Raissi S. Ethylene glycol, methanol and isopropyl alcohol intoxication. Am J Med Sci 2010; 339: 276-81.
- McMartin K, Jacobsen D, Hovda KE. Antidotes for poisoning by alcohols that form toxic metabolites. British J Clin Pharmacol 2016; 81: 505-15.
- Hovda KE, Hunderi OH, Tafjord AB, Dunlop O, Rudberg N, Jacobsen D. Methanol outbreak in Norway 2002–2004: epidemiology, clinical features and prognostic signs. J Intern Med 2005; 258: 181–90.
- Paasma R, Hovda KE, Tikkerberi A, Jacobsen D. Methanol mass poisoning in Estonia: Outbreak in 154 patients. Clin Toxicol (Phila) 2007; 45: 152–7.
- Zakharov S, Pelclova D, Urban P, et al. Czech mass methanol outbreak 2012: Epidemiology, challenges and clinical features. Clin Toxicol (Phila) 2014; 52: 1013–24.
- Levy P, Hexdall A, Gordon P, Boeriu C, Heller M, Nelson L. Methanol contamination of Romanian home‐distilled alcohol. J Toxicol Clin Toxicol 2003; 41: 23–8.
- Hassanian‐Moghaddam H, Nikfarjam A, Mirafzal A, et al. Methanol mass poisoning in Iran: role of case finding in outbreak management. J Public Health (Oxf) 2015; 37: 354–9.
- AbdulRahim FAA, Shiekh AA. Substance abuse and homeless: mass methanol poisoning in Khartoum. Sudan Med J 2012; 48: 1–5.
- Md Noor J, Hawari R, Mokhtar et al. Methanol outbreak: a Malaysian tertiary hospital experience. Int J Emerg Med 2020; 13: 6.
- Lee CY, Chang EK, Lin JL, et al. Risk factors for mortality in Asian Taiwanese patients with methanol poisoning. Ther Clin Risk Management 2014; 10: 61-7.
- Ahmed F, Khan NU, Ali N, Feroze A. Methanol poisoning: 27 experience at a tertiary care hospital. J Pak Med Assoc 2017;67: 1751–2.
- Kurtas O, Imre KY, Ozer E, et al. The evaluation of deaths due to methyl alcohol intoxication. Biomed Res 2017; 28: 3680–7.
- Kraut JA. Approach to the treatment of methanol intoxication. Am J Kidney Dis 2016; 68: 161–7.
- Diagne MH, Nyumbandogo EK, Vincent P, Muschart X. Methanol intoxication. Louv Med 2019; 138: 207–12.
- Rulisek J, Waldauf P, Belohlavek J, et al. Health-related quality of life determinants in survivors of a mass methanol poisoning outbreak: six-year prospective cohort study. Clin Toxicol 2020; 58: 870–80.
- Kaewput W, Thongprayoon C, Petnak T, et al. Inpatient burden and mortality of methanol intoxication in the United States. Am J Med Sci 2021; 361: 69–74.
- Sharif AF, AlAmeer MR, AlSubaie DS, et al. Predictors of poor outcomes among patients of acute methanol intoxication with particular reference to Sequential Organ Failure Assessment (SOFA) score. Environ Sci Pollut Res Int 2021; 28: 60511-25.
- Chang ST, Wang YT, Hou YC, et al. Acute kidney injury and the risk of mortality in patients with methanol intoxication. BMC Nephrol 2019; 20: 1–8.
- Sanaei-Zadeh H, Kazemi Esfeh S, Zamani N, Jamshidi F, Shadnia S. Hyperglycemia is a strong prognostic factor of lethality in methanol poisoning. J Med Toxicol 2011; 7: 189-94.
- Liu JJ, Daya MR, Carrasquillo O, Kales SN. Prognostic factors in patients with methanol poisoning. J Toxicol Clin Toxicol 1998; 36: 175–81.
- Meyer RJ, Beard ME, Ardagh MW, Henderson S. Methanol poisoning. N Z Med J 2000; 113: 11–3.
- Coulter CV, Farquhar SE, McSherry CM, Isbister GK, Duffull SB. Methanol and ethylene glycol acute poisonings – predictors of mortality. Clin Toxicol (Phila) 2011; 49: 900–6.
- Palatnick W, Redman L, Sitar D, Tenenbein M. Methanol half-life during ethanol administration: ımplicationsfor management of methanol poisoning from the departments of emergency medicine. Ann Emerg Med 1995; 26: 202-7.
- Roberts DM, Yates C, Megarbane B, et. al. Recommendations for the role of extracorporeal treatments in the management of acute methanol poisoning: a systematic review and consensus statement. Crit Care Med 2015; 43: 461-72.
Abstract
References
- Oguz AB, Gunalp M, Polat O, Genc S, Gurler S. Transdermal methanol intoxication. Arch Iran Med 2019; 22: 671-2.
- Jammalamadaka D, Raissi S. Ethylene glycol, methanol and isopropyl alcohol intoxication. Am J Med Sci 2010; 339: 276-81.
- McMartin K, Jacobsen D, Hovda KE. Antidotes for poisoning by alcohols that form toxic metabolites. British J Clin Pharmacol 2016; 81: 505-15.
- Hovda KE, Hunderi OH, Tafjord AB, Dunlop O, Rudberg N, Jacobsen D. Methanol outbreak in Norway 2002–2004: epidemiology, clinical features and prognostic signs. J Intern Med 2005; 258: 181–90.
- Paasma R, Hovda KE, Tikkerberi A, Jacobsen D. Methanol mass poisoning in Estonia: Outbreak in 154 patients. Clin Toxicol (Phila) 2007; 45: 152–7.
- Zakharov S, Pelclova D, Urban P, et al. Czech mass methanol outbreak 2012: Epidemiology, challenges and clinical features. Clin Toxicol (Phila) 2014; 52: 1013–24.
- Levy P, Hexdall A, Gordon P, Boeriu C, Heller M, Nelson L. Methanol contamination of Romanian home‐distilled alcohol. J Toxicol Clin Toxicol 2003; 41: 23–8.
- Hassanian‐Moghaddam H, Nikfarjam A, Mirafzal A, et al. Methanol mass poisoning in Iran: role of case finding in outbreak management. J Public Health (Oxf) 2015; 37: 354–9.
- AbdulRahim FAA, Shiekh AA. Substance abuse and homeless: mass methanol poisoning in Khartoum. Sudan Med J 2012; 48: 1–5.
- Md Noor J, Hawari R, Mokhtar et al. Methanol outbreak: a Malaysian tertiary hospital experience. Int J Emerg Med 2020; 13: 6.
- Lee CY, Chang EK, Lin JL, et al. Risk factors for mortality in Asian Taiwanese patients with methanol poisoning. Ther Clin Risk Management 2014; 10: 61-7.
- Ahmed F, Khan NU, Ali N, Feroze A. Methanol poisoning: 27 experience at a tertiary care hospital. J Pak Med Assoc 2017;67: 1751–2.
- Kurtas O, Imre KY, Ozer E, et al. The evaluation of deaths due to methyl alcohol intoxication. Biomed Res 2017; 28: 3680–7.
- Kraut JA. Approach to the treatment of methanol intoxication. Am J Kidney Dis 2016; 68: 161–7.
- Diagne MH, Nyumbandogo EK, Vincent P, Muschart X. Methanol intoxication. Louv Med 2019; 138: 207–12.
- Rulisek J, Waldauf P, Belohlavek J, et al. Health-related quality of life determinants in survivors of a mass methanol poisoning outbreak: six-year prospective cohort study. Clin Toxicol 2020; 58: 870–80.
- Kaewput W, Thongprayoon C, Petnak T, et al. Inpatient burden and mortality of methanol intoxication in the United States. Am J Med Sci 2021; 361: 69–74.
- Sharif AF, AlAmeer MR, AlSubaie DS, et al. Predictors of poor outcomes among patients of acute methanol intoxication with particular reference to Sequential Organ Failure Assessment (SOFA) score. Environ Sci Pollut Res Int 2021; 28: 60511-25.
- Chang ST, Wang YT, Hou YC, et al. Acute kidney injury and the risk of mortality in patients with methanol intoxication. BMC Nephrol 2019; 20: 1–8.
- Sanaei-Zadeh H, Kazemi Esfeh S, Zamani N, Jamshidi F, Shadnia S. Hyperglycemia is a strong prognostic factor of lethality in methanol poisoning. J Med Toxicol 2011; 7: 189-94.
- Liu JJ, Daya MR, Carrasquillo O, Kales SN. Prognostic factors in patients with methanol poisoning. J Toxicol Clin Toxicol 1998; 36: 175–81.
- Meyer RJ, Beard ME, Ardagh MW, Henderson S. Methanol poisoning. N Z Med J 2000; 113: 11–3.
- Coulter CV, Farquhar SE, McSherry CM, Isbister GK, Duffull SB. Methanol and ethylene glycol acute poisonings – predictors of mortality. Clin Toxicol (Phila) 2011; 49: 900–6.
- Palatnick W, Redman L, Sitar D, Tenenbein M. Methanol half-life during ethanol administration: ımplicationsfor management of methanol poisoning from the departments of emergency medicine. Ann Emerg Med 1995; 26: 202-7.
- Roberts DM, Yates C, Megarbane B, et. al. Recommendations for the role of extracorporeal treatments in the management of acute methanol poisoning: a systematic review and consensus statement. Crit Care Med 2015; 43: 461-72.
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| Primary Language | English |
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| Subjects | Health Care Administration |
| Journal Section | Original Article |
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| Publication Date | May 30, 2022 |
| Published in Issue | Year 2022 Volume: 5 Issue: 3 |
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