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ÇEŞİTLİ YÖNLERİ İLE PUFALAR VE PERİODONTİTİS İLE İLİŞKİLERİ

Year 2024, Volume: 2 Issue: 1, 30 - 46, 30.06.2024

Ayşegül Sunar Ali Hakan Develioğlu

Abstract

Klinik olarak periodontitis, ataşman kaybı, periodontal cep, diş eti kanaması ve kemik rezorpsiyonu ile kendini göstermektedir. Bu belirtiler radyografik olarak gözlenmekte ve potansiyel olarak diş kaybına yol açabilimektedir. Dokosaheksaenoik asit (DHA) ve eikosapentaenoik asit (EPA) gibi Omega-3 çoklu doymamış yağ asitleri (ω-3 yağ asitleri, PUFA); romatoid artrit, ülseratif kolit, ateroskleroz, kanser, kalp ve damar hastalıkları ve periodontitis üzerinde antiinflamatuar, koruyucu ve tedavi edici etkilere sahiptir. Bu yağ asitleri ince bağırsakta emilir ve kan dolaşımı yoluyla çeşitli dokulara taşınır. Yağ dokusu fazla yağ asitlerini depolar ve gerektiğinde bunları harekete geçirebilir. Bu süreç, özellikle iltihaplanmanın merkezi bir rol oynadığı periodontal sağlık bağlamında, bu yağ asitlerinin yararlı etkilerini sürdürmek için tutarlı alım gerekliliğinin altını çizmektedir. Bu derlemede, Omega 3 çoklu yağ asitlerinin periodontitis ile ilişkileri incelenmiş olup Omega 3 PUFA’ların kullanıldığı klinik ve deneysel çalışmalar değerlendirilerek bulgular sentezlenmiştir.

Keywords

Yağ Asitleri Omega-3 n-3 PUFA Periodontitis

References

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Year 2024, Volume: 2 Issue: 1, 30 - 46, 30.06.2024

Ayşegül Sunar Ali Hakan Develioğlu

Abstract

References

  • 1. Van Dyke, T. E., Bartold, P. M., & Reynolds, E. C. (2020). The Nexus Between Periodontal Inflammation and Dysbiosis. Frontiers in Immunology, 11, 511. https://doi.org/10.3389/fimmu.2020.00511
  • 2. Socransky, S. S., Haffajee, A. D., Cugini, M. A., Smith, C., & Kent, R. L., Jr (1998). Microbial complexes in subgingival plaque. Journal of Clinical Periodontology, 25(2), 134–144. https://doi.org/10.1111/j.1600-051x.1998.tb02419.x
  • 3. Sedghi, L. M., Bacino, M., & Kapila, Y. L. (2021). Periodontal Disease: The Good, The Bad, and The Unknown. Frontiers in Cellular and Infection Microbiology, 11, 766944. https://doi.org/10.3389/fcimb.2021.766944
  • 4. Genco, R. J., & Sanz, M. (2020). Clinical and public health implications of periodontal and systemic diseases: An overview. Periodontology 2000, 83(1), 7–13. https://doi.org/10.1111/prd.12344
  • 5. de Souza, A. B., Okawa, R. T., Silva, C. O., & Araújo, M. G. (2017). Short-term changes on C-reactive protein (CRP) levels after non-surgical periodontal treatment in systemically healthy individuals. Clinical Oral Investigations, 21(1), 477–484. https://doi.org/10.1007/s00784-016-1817-0
  • 6. Shimada, Y., Komatsu, Y., Ikezawa-Suzuki, I., Tai, H., Sugita, N., & Yoshie, H. (2010). The effect of periodontal treatment on serum leptin, interleukin-6, and C-reactive protein. Journal of Periodontology, 81(8), 1118–1123. https://doi.org/10.1902/jop.2010.090741
  • 7. Fullerton, J. N., & Gilroy, D. W. (2016). Resolution of inflammation: a new therapeutic frontier. Nature Reviews Drug Discovery, 15(8), 551–567. https://doi.org/10.1038/nrd.2016.39
  • 8. Van Dyke T. E. (2017). Pro-resolving mediators in the regulation of periodontal disease. Molecular Aspects of Medicine, 58, 21–36. https://doi.org/10.1016/j.mam.2017.04.006
  • 9. Chiang, N., Fredman, G., Bäckhed, F., Oh, S. F., Vickery, T., Schmidt, B. A., & Serhan, C. N. (2012). Infection regulates pro-resolving mediators that lower antibiotic requirements. Nature, 484(7395), 524–528. https://doi.org/10.1038/nature11042
  • 10. Serhan, C.N., Sulciner, M.L. (2023). Resolution medicine in cancer, infection, pain and inflammation: are we on track to address the next Pandemic?. Cancer Metastasis Rev 42, 13-17. https://doi.org/10.1007/s10555-023-10091-5
  • 11. Osorio Parra, M. M., Elangovan, S., & Lee, C. T. (2019). Specialized pro-resolving lipid mediators in experimental periodontitis: A systematic review. Oral Diseases, 25(5), 1265–1276. https://doi.org/10.1111/odi.12979
  • 12. Rakian, A., Rakian, R., Shay, A. E., Serhan, C. N., & Van Dyke, T. E. (2022). Periodontal Stem Cells Synthesize Maresin Conjugate in Tissue Regeneration 3. Journal of Dental Research, 101(10), 1205–1213. https://doi.org/10.1177/00220345221090879
  • 13. Serhan, C. N., & Chiang, N. (2023). Resolvins and cysteinyl-containing pro-resolving mediators activate resolution of infectious inflammation and tissue regeneration. Prostaglandins & Other Lipid Mediators, 166, 106718. https://doi.org/10.1016/j.prostaglandins.2023.106718
  • 14. Serhan, C. N., Chiang, N., & Dalli, J. (2015). The resolution code of acute inflammation: Novel pro-resolving lipid mediators in resolution. Seminars in Immunology, 27(3), 200–215. https://doi.org/10.1016/j.smim.2015.03.004
  • 15. Lee, C. T., Teles, R., Kantarci, A., Chen, T., McCafferty, J., Starr, J. R., Brito, L. C., Paster, B. J., & Van Dyke, T. E. (2016). Resolvin E1 Reverses Experimental Periodontitis and Dysbiosis. Journal of Immunology (Baltimore, Md.: 1950), 197(7), 2796–2806. https://doi.org/10.4049/jimmunol.1600859
  • 16. Alvarez, C., Abdalla, H., Sulliman, S., Rojas, P., Wu, Y. C., Almarhoumi, R., Huang, R. Y., Galindo, M., Vernal, R., & Kantarci, A. (2021). RvE1 Impacts the Gingival Inflammatory Infiltrate by Inhibiting the T Cell Response in Experimental Periodontitis. Frontiers in Immunology, 12, 664756. https://doi.org/10.3389/fimmu.2021.664756
  • 17. Zarrough AE, Hasturk H, Stephens DN, Dyke TEV, Kantarci A. (2023). Resolvin D1 modulates periodontal ligament fibroblast function. Journal of Periodontology, 94(5), 683–93. doi: 10.1002/JPER.22-0462
  • 18. Albuquerque-Souza, E., Schulte, F., Chen, T., Hardt, M., Hasturk, H., Van Dyke, T. E., Holzhausen, M., & Kantarci, A. (2020). Maresin-1 and Resolvin E1 Promote Regenerative Properties of Periodontal Ligament Stem Cells Under Inflammatory Conditions. Frontiers in Immunology, 11, 585530. https://doi.org/10.3389/fimmu.2020.585530
  • 19. Hasturk, H., Schulte, F., Martins, M., Sherzai, H., Floros, C., Cugini, M., Chiu, C. J., Hardt, M., & Van Dyke, T. (2021). Safety and Preliminary Efficacy of a Novel Host-Modulatory Therapy for Reducing Gingival Inflammation. Frontiers in Immunology, 12, 704163. https://doi.org/10.3389/fimmu.2021.704163
  • 20. Wang, C. W., Colas, R. A., Dalli, J., Arnardottir, H. H., Nguyen, D., Hasturk, H., Chiang, N., Van Dyke, T. E., & Serhan, C. N. (2015). Maresin 1 Biosynthesis and Proresolving Anti-infective Functions with Human-Localized Aggressive Periodontitis Leukocytes. Infection and Immunity, 84(3), 658–665.https://doi.org/10.1128/IAI.01131-15
  • 21. Van Dyke, T. E., Hasturk, H., Kantarci, A., Freire, M. O., Nguyen, D., Dalli, J., & Serhan, C. N. (2015). Proresolving nanomedicines activate bone regeneration in periodontitis. Journal of Dental Research, 94(1), 148–156. https://doi.org/10.1177/0022034514557331
  • 22. Basil, M. C., & Levy, B. D. (2016). Specialized pro-resolving mediators: endogenous regulators of infection and inflammation. Nature Reviews Immunology, 16(1), 51–67. https://doi.org/10.1038/nri.2015.4
  • 23. Wang, R. X., Colgan, S., P. (2017). Special pro-resolving mediator (SPM) actions in regulating gastro-intestinal inflammation and gut mucosal immune responses. Mol Aspects Medicine 58, 93–101. doi: 10.1016/j.mam.2017.02.002
  • 24. Spite, M., Clària, J., & Serhan, C. N. (2014). Resolvins, specialized proresolving lipid mediators, and their potential roles in metabolic diseases. Cell Metabolism, 19(1), 21–36. https://doi.org/10.1016/j.cmet.2013.10.006
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There are 52 citations in total.

Details

Primary Language Turkish
Subjects Periodontics
Journal Section Reviews
Authors

Ayşegül Sunar 0000-0002-6340-8092

Ali Hakan Develioğlu 0000-0002-2228-488X

Publication Date June 30, 2024
Submission Date February 9, 2024
Acceptance Date March 11, 2024
Published in Issue Year 2024 Volume: 2 Issue: 1

Cite

APA Sunar, A., & Develioğlu, A. H. (2024). ÇEŞİTLİ YÖNLERİ İLE PUFALAR VE PERİODONTİTİS İLE İLİŞKİLERİ. Journal of Kocaeli Health and Technology University, 2(1), 30-46.


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