Abstract
References
- Referans 1. 1-Martin GS et al. The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med 2003 348:1546-1553 Referans 2. Angus DC et al. Epidemiology of sepsis in the United States analysis of incidence, outcome and associated cost of care. Crit Care Med 2001 29:1303-1311 Referans 3. Bone RC, Balk RA, Cerra FB, Dellinger RP, Fein AM, Knaus WA, et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/ SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest 1992;101:1644–55.
Abstract
Aim: Today, sepsis is the most common cause of death in intensive care units. In this study, we aimed to compare presepsin with procalcitonin (PCT) and C-reactive protein (CRP) which are commonly used in the early diagnosis and treatment of sepsis.
Material and Method: One hundred-eighty three patients who were hospitalized in the Intensive Care Unit were included in the study. While 138 of these patients were followed with the diagnosis of sepsis, 45 were hospitalized in the intensive care unit for reasons other than sepsis. Blood, urine, stool and tracheal aspirate cultures were obtained from these patients. Simultaneous procalcitonin, CRP and presepsin levels were measured. Quick Sequential Organ Failure Assesment (QSOFA) and Acute Physiology and Chronic Health Assessment-II (APACHE-II) scores were calculated. The data obtained were analyzed statistically by SPSS (Statistical Package for Social Sciences) 20.0 package program.
Results: 45.5% of the patients were female and the mean age of the patients was 75.74 ± 11.35. Patients had concomitant chronic diseases, 14% of patients had diabetes mellitus, 45% had hypertension, 54% had renal failure and 26% had chronic obstructive pulmonary disease. No significant relationship was found between the levels of presepsin and the patients with septic and non-septic patients (p>0.05). However, a strong positive correlation was found between elevated presepsin levels and CRP levels (r=0.853; p<0.001).
Conclusion: As a result of the study, no significant difference was found between presepsin levels of patients with and without sepsis, while presepsin was a valuable biomarker for early diagnosis of sepsis in culture positive septic patients. It also showed a strong correlation with CRP and PCT, thus it may used in the daily clinical practice of septic patients.
Keywords
References
- Referans 1. 1-Martin GS et al. The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med 2003 348:1546-1553 Referans 2. Angus DC et al. Epidemiology of sepsis in the United States analysis of incidence, outcome and associated cost of care. Crit Care Med 2001 29:1303-1311 Referans 3. Bone RC, Balk RA, Cerra FB, Dellinger RP, Fein AM, Knaus WA, et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/ SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest 1992;101:1644–55.
Details
| Primary Language | English |
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| Subjects | Health Care Administration |
| Journal Section | Research Articles [en] Araştırma Makaleleri [tr] |
| Authors | |
| Publication Date | June 28, 2020 |
| Published in Issue | Year 2020 Volume: 1 Issue: 2 |
TR DİZİN ULAKBİM and International Indexes (1d)
Interuniversity Board (UAK) Equivalency: Article published in Ulakbim TR Index journal [10 POINTS], and Article published in other (excuding 1a, b, c) international indexed journal (1d) [5 POINTS]
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