Abstract
Objective: We aimed to reveal possible relationships between pre-operative RDW values and clinicopathological features of gastric cancer (GC) and to evaluate its predictive impact on progression and prognosis of GC.
Material And Method: A total of 92 patients who underwent curative surgery were retrospectively included the study. GC patients were divided into two groups: high-RDW group (>14.5%, n=58) and low-RDW (<14.5%, n=34).
Results: The optimal pre-operative RDW cut-off value to predict mortality in GC patients was 14.5% (AUC=0.690, p=0.010). Increased tumor size and decreased albumin and hemoglobin values were found in the high-RDW group (p=0.036, 0.003 and <0.001, respectively). The 5-year overall survival (OS) rates were 17.6±5% in patients with high-RDW and 44.5±9% in the low-RDW group (p<0.001). Cox regression analysis showed perineural invasion, surgical margin positivity, N3 stage, leakage and high RDW were independent prognostic factors for mortality.
Conclusion: Our results indicate that RDW is associated with GC pathogenesis and tumor progression. Pre-operative RDW may be a non-invasive, easily accessible and reliable indicator to predict survival in patients with GC.
References
- Petrillo A, Smyth EC. 27 years of stomach cancer: painting a global picture. Lancet Gastroenterol Hepatol 2020; 5: 5-6.
- Thrift AP, El-Serag HB. Burden of gastric cancer. Clin Gastroenterol Hepatol 2020; 18: 534-42.
- Bhandare MS, Chaudhari V, Shrikhande SV. Surgery for Gastric Cancer: State of the Art. Indian J Surg 2020: 1-11.
- Ghidini M, Donida B, Totaro L, et al. Prognostic factors associated with survival in a large cohort of gastric cancer patients resected over a decade at a single Italian center: the Cremona experience. Clin Transl Oncol 2020; 22: 1004-12.
- Chang W-J, Du Y, Zhao X, Ma L-Y, Cao G-W. Inflammation-related factors predicting prognosis of gastric cancer. World J Gastroenterol: WJG 2014; 20: 4586-96.
- Zhou Y, Li X, Lu Z, Zhang L, Dai T. Prognostic significance of red blood cell distribution width in gastrointestinal cancers: A meta-analysis. Medicine 2020; 99: e19588.
- Wang P-F, Song S-Y, Guo H, Wang T-J, Liu N, Yan C-X. Prognostic role of pretreatment red blood cell distribution width in patients with cancer: a meta-analysis of 49 studies. J Cancer 2019; 10: 4305-17.
- Edge SB, Byrd DR, Carducci MA, Compton CC, Fritz A, Greene F. AJCC cancer staging manual: Springer New York; 2010.
- Lauren P. The two histological main types of gastric carcinoma: diffuse and so‐called intestinal‐type carcinoma: an attempt at a histo‐clinical classification. Acta Pathol Microbiol Scand 1965; 64: 31-49.
- Mantovani A, Allavena P, Sica A, Balkwill F. Cancer-related inflammation. Nature 2008; 454: 436-44.
- Wan G-X, Chen P, Cai X-J, et al. Elevated red cell distribution width contributes to a poor prognosis in patients with esophageal carcinoma. Clin Chim Acta 2016; 452: 199-203.
- Cheng S, Han F, Wang Y, et al. The red distribution width and the platelet distribution width as prognostic predictors in gastric cancer. BMC Gastroenterol 2017; 17: 1-11.
- Fu L, Li Q, Fan Q. Combination of preoperative red cell distribution width and neutrophil to lymphocyte ratio as a prognostic marker for gastric cancer patients. J Gastrointest Oncol 2021; 12: 1049-57.
- Yüksel C, Erşen O, Culcu S, Bakırarar B, Unal AE, Demirci S. Prognostic role of red distribution width (RDW) value in gastric cancer. J Coll Physicians Surg Pak 2021; 31: 21-6.
- Hu L, Li M, Ding Y, et al. Prognostic value of RDW in cancers: a systematic review and meta-analysis. Oncotarget 2017; 8: 16027-35.
- Gao L, Zhang H, Zhang B, Zhang L, Wang C. Prognostic value of combination of preoperative platelet count and mean platelet volume in patients with resectable non-small cell lung cancer. Oncotarget 2017; 8: 15632-41.
- Macciò A, Madeddu C, Gramignano G, et al. The role of inflammation, iron, and nutritional status in cancer-related anemia: results of a large, prospective, observational study. Haematologica 2015; 100: 124-32.
- Gillies RJ, Robey I, Gatenby RA. Causes and consequences of increased glucose metabolism of cancers. J Nucl Med 2008; 49: 24S-42S.
- Mcmillan DC. Systemic inflammation, nutritional status and survival in patients with cancer. Curr Opin Clin Nutr Metab Care 2009; 12: 223-6.
- Sakin A, Aydemir O, Sahin S, et al. Red blood cell distribution width as a possible predictor of diagnosis and survival in gastric cancer. EJMI 2020; 4: 289-97.
- Shota S, Saito H, Kono Y, et al. Prognostic significance of pre-and post-operative red-cell distribution width in patients with gastric cancer. J Gastrointest Surg 2020; 24: 1010-7.
- Hirahara N, Tajima Y, Fujii Y, et al. Comprehensive analysis of red blood cell distribution width as a preoperative prognostic predictor in gastric cancer. Anticancer Res 2019; 39: 3121-30.
- Yazici P, Demir U, Bozkurt E, Isil GR, Mihmanli M. The role of red cell distribution width in the prognosis of patients with gastric cancer. Cancer Biomark 2017; 18: 19-25.
Abstract
Amaç: Preoperatif RDW değerleri ile mide kanseri (MK)’nin klinikopatolojik özellikleri arasındaki olası ilişkileri ortaya koymayı ve MK’nin progresyonu ve prognozu üzerindeki prediktif etkisini değerlendirmeyi amaçladık.
Gereç ve Yöntem: Küratif cerrahi uygulanan toplam 92 hasta retrospektif olarak çalışmaya dahil edildi. MK hastaları iki gruba ayrıldı: yüksek RDW grubu (>%14,5, n=58) ve düşük RDW (<%14,5, n=34).
Bulgular: MK hastalarında mortaliteyi öngörmek için optimal preoperatif RDW eşik değeri %14,5 idi (AUC=0,690, p=0,010). Yüksek RDW grubunda tümör boyutunda artış, albümin ve hemoglobin değerlerinde azalma saptandı (sırasıyla p=0,036, 0,003 ve <0,001). Yüksek RDW’li hastalarda 5 yıllık genel sağkalım (OS) oranları %17,6±%5 ve düşük RDW grubunda %44,5±%9 idi (p<0,001). Cox regresyon analizi perinöral invazyon, cerrahi sınır pozitifliği, N3 evresi, sızıntı ve yüksek RDW değerinin mortalite için bağımsız prognostik faktörler olduğunu gösterdi.
Sonuç: Sonuçlarımız, RDW’nin MK patogenezinde ve tümör progresyonunda rol oynadığını göstermektedir. Preoperatif RDW, MK’li hastalarda sağkalımı öngörmek için invazif olmayan, kolay erişilebilir ve güvenilir bir gösterge olabilir.
References
- Petrillo A, Smyth EC. 27 years of stomach cancer: painting a global picture. Lancet Gastroenterol Hepatol 2020; 5: 5-6.
- Thrift AP, El-Serag HB. Burden of gastric cancer. Clin Gastroenterol Hepatol 2020; 18: 534-42.
- Bhandare MS, Chaudhari V, Shrikhande SV. Surgery for Gastric Cancer: State of the Art. Indian J Surg 2020: 1-11.
- Ghidini M, Donida B, Totaro L, et al. Prognostic factors associated with survival in a large cohort of gastric cancer patients resected over a decade at a single Italian center: the Cremona experience. Clin Transl Oncol 2020; 22: 1004-12.
- Chang W-J, Du Y, Zhao X, Ma L-Y, Cao G-W. Inflammation-related factors predicting prognosis of gastric cancer. World J Gastroenterol: WJG 2014; 20: 4586-96.
- Zhou Y, Li X, Lu Z, Zhang L, Dai T. Prognostic significance of red blood cell distribution width in gastrointestinal cancers: A meta-analysis. Medicine 2020; 99: e19588.
- Wang P-F, Song S-Y, Guo H, Wang T-J, Liu N, Yan C-X. Prognostic role of pretreatment red blood cell distribution width in patients with cancer: a meta-analysis of 49 studies. J Cancer 2019; 10: 4305-17.
- Edge SB, Byrd DR, Carducci MA, Compton CC, Fritz A, Greene F. AJCC cancer staging manual: Springer New York; 2010.
- Lauren P. The two histological main types of gastric carcinoma: diffuse and so‐called intestinal‐type carcinoma: an attempt at a histo‐clinical classification. Acta Pathol Microbiol Scand 1965; 64: 31-49.
- Mantovani A, Allavena P, Sica A, Balkwill F. Cancer-related inflammation. Nature 2008; 454: 436-44.
- Wan G-X, Chen P, Cai X-J, et al. Elevated red cell distribution width contributes to a poor prognosis in patients with esophageal carcinoma. Clin Chim Acta 2016; 452: 199-203.
- Cheng S, Han F, Wang Y, et al. The red distribution width and the platelet distribution width as prognostic predictors in gastric cancer. BMC Gastroenterol 2017; 17: 1-11.
- Fu L, Li Q, Fan Q. Combination of preoperative red cell distribution width and neutrophil to lymphocyte ratio as a prognostic marker for gastric cancer patients. J Gastrointest Oncol 2021; 12: 1049-57.
- Yüksel C, Erşen O, Culcu S, Bakırarar B, Unal AE, Demirci S. Prognostic role of red distribution width (RDW) value in gastric cancer. J Coll Physicians Surg Pak 2021; 31: 21-6.
- Hu L, Li M, Ding Y, et al. Prognostic value of RDW in cancers: a systematic review and meta-analysis. Oncotarget 2017; 8: 16027-35.
- Gao L, Zhang H, Zhang B, Zhang L, Wang C. Prognostic value of combination of preoperative platelet count and mean platelet volume in patients with resectable non-small cell lung cancer. Oncotarget 2017; 8: 15632-41.
- Macciò A, Madeddu C, Gramignano G, et al. The role of inflammation, iron, and nutritional status in cancer-related anemia: results of a large, prospective, observational study. Haematologica 2015; 100: 124-32.
- Gillies RJ, Robey I, Gatenby RA. Causes and consequences of increased glucose metabolism of cancers. J Nucl Med 2008; 49: 24S-42S.
- Mcmillan DC. Systemic inflammation, nutritional status and survival in patients with cancer. Curr Opin Clin Nutr Metab Care 2009; 12: 223-6.
- Sakin A, Aydemir O, Sahin S, et al. Red blood cell distribution width as a possible predictor of diagnosis and survival in gastric cancer. EJMI 2020; 4: 289-97.
- Shota S, Saito H, Kono Y, et al. Prognostic significance of pre-and post-operative red-cell distribution width in patients with gastric cancer. J Gastrointest Surg 2020; 24: 1010-7.
- Hirahara N, Tajima Y, Fujii Y, et al. Comprehensive analysis of red blood cell distribution width as a preoperative prognostic predictor in gastric cancer. Anticancer Res 2019; 39: 3121-30.
- Yazici P, Demir U, Bozkurt E, Isil GR, Mihmanli M. The role of red cell distribution width in the prognosis of patients with gastric cancer. Cancer Biomark 2017; 18: 19-25.
Details
| Primary Language | English |
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| Subjects | Health Care Administration |
| Journal Section | Research Articles [en] Araştırma Makaleleri [tr] |
| Authors | |
| Publication Date | March 24, 2022 |
| Published in Issue | Year 2022 Volume: 3 Issue: 1 |
TR DİZİN ULAKBİM and International Indexes (1d)
Interuniversity Board (UAK) Equivalency: Article published in Ulakbim TR Index journal [10 POINTS], and Article published in other (excuding 1a, b, c) international indexed journal (1d) [5 POINTS]
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