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Çocuklarda Primer Enürezis Nokturna ile Alerjik ve Solunumsal Hastalıkların Birlikteliği

Year 2021, Volume: 16 Issue: 1, 79 - 88, 08.02.2021

Gamze Aydın Sanem Nemmezi Karaca Seda Aybüke Sarı

https://doi.org/10.17517/ksutfd.767987

Abstract

Amaç: Enürezis; çocukluk çağında alerjik hastalıklardan sonra en sık görülen kronik hastalık olup, ciddi psikososyal sorunlara yol açabilmektedir. Az sayıda çalışmada, alerjik hastalıklar ve uykuda solunum bozukluğu ile ilişkili olabileceğine dikkat çekilmiştir. Bu çalışmada; hastaneye başvuran enüretik çocuklarda, primer enürezis nokturna (PEN) ile alerjik hastalıklar ve uykuda solunum bozukluğu ilişkisinin araştırılması amaçlandı.
Gereç ve yöntemler: Vaka kontrol tipinde dizayn edilen bu çalışmada, PEN tanısı ile hastaneye girişi yapılmış 150 çocuk vaka grubuna dahil edildi. Ardından aile hekimliği ile çocuk ve ergen ruh sağlığı ve hastalıkları polikliniklerine çeşitli nedenlerle başvuran ve herhangi bir üriner şikâyeti olmayan benzer yaştaki 150 çocuk kontrol grubu olarak alındı. International Study of Asthma and Allergies in Childhood (ISAAC), Uykuda Solunum Bozukluğu anketi ve sosyodemografik verileri sorgulayan veri toplama formu araştırmacı tarafından aileler ve çocuklarla yüz yüze görüşülerek dolduruldu. Veriler SPSS 22.0 programına yüklendi ve yanılma düzeyi 0.05 kabul edildi.
Bulgular: Çalışmadaki çocukların %52.3’ü erkek, %47.7’si kızdı ve yaş ortalamaları 10.3 ± 3.3 yıldı. PEN’li olguların %28.0’ine astımın, %33.3’üne alerjik rinitin ve %18.7’sine uykuda solunum bozukluğunun eşlik ettiği saptandı. Enüretik olmayan çocuklarda bu oranlar daha seyrek olup sırasıyla %12, %16.7 ve %1.3 idi (p<0.001).
Sonuç: Bu çalışmada PEN’li çocuklarda, alerjik hastalıklar ve uykuda solunum bozuklukları, enüretik olmayanlara kıyasla istatistiksel açıdan anlamlı derecede daha sık gözlendi.

Keywords

çocuk primer enürezis nokturna alerjik hastalıklar uykuda solunum bozukluğu

Supporting Institution

Cumhuriyet Üniversitesi Bilimsel Araştırma Projeleri (CÜBAP)

Project Number

T-803

Thanks

Değerli bilimsel ve teknik katkılarından dolayı Prof. Dr. Levent Cankorkmaz’a teşekkür ediyoruz.

References

  • Referans 1. Türkiye Enürezis Çalışma Grubu, 2. Baskı, Aralık 2010. (Erişim Tarihi: Mart 2019) (https://www.tuseb.gov.tr/enstitu/tacese/yuklemeler/ekitap/kilavuzlar/enuresis kilavuzu.pdf).
  • Referans 2. Amerikan Psikiyatri Birliği, Ruhsal Bozuklukların Tanısal ve Sayımsal Elkitabı, Beşinci Baskı (DSM-5), Tanı Ölçütleri Başvuru El Kitabı'ndan, çev. yay. yön. Köroğlu E, Hekimler Yayın Birliği, Ankara, 2014; 479.
  • Referans 3. Birdal S, Dogangun B. Behavioural problems in children with enuresis. Türk Pediatr Arşivi. 2016;51(3):142-47.
  • Referans 4. Ramakrıshnan K. Evaluation and Treatment of Enuresis. Am Fam Physician. 2008;78(4):489-96.
  • Referans 5. Mungan NA, Seckiner I, Yeşilli C, Akduman B, Tekin IO. Nocturnal enuresis and allergy. Scand J Urol Nephrol. 2005;39(3):237–41.
  • Referans 6. Gür E, Turhan P, Can G, Akkus S, Sever L, Güzelöz S, Cifçili S, Arvas A. Enuresis: prevalence, risk factors and urinary pathology among school children in Istanbul, Turkey. Pediatr Int. 2004;46(1):58-63.
  • Referans 7. Abou-Khadra MK, Amin OR, Ahmed D. Association between sleep and behavioural problems among children with enuresis. J Paediatr Child Health. 2013;49(2):E160-66. (doi: 10.1111/jpc.12017.)
  • Referans 8. Asher MI, Keil U, Anderson HR, Beasley R, Crane J, Martinez F, Mitchell EA, et al. International study of asthma and allergies in childhood (ISAAC): rationale and methods. Eur Respir J. 1995;8:483-91.
  • Referans 9. Talay F, Kurt B, Tug T, Yilmaz F, Goksugur N. Prevalence and risk factors of asthma and allergic diseases among schoolchildren in Bolu, Turkey. Acta Paediatr. 2008;97(4):459-62.
  • Referans 10. Öner P, Barut Y, et al. Çocuklarda Uyku Ölçeği’nin Geçerlik ve Güvenirliği. Klinik Psikofarmakol Bulteni. 2009;19(4):382-95.
  • Referans 11. Goin RP. Nocturnal enuresis in children. Child Care Health Dev. 1998;24:277-88.
  • Referans 12. Lee SD, Sohn DW, Lee JZ, Park NC, Chung MK. An epidemiological study of enuresis in Korean children. BJU Int. 2000;85(7):869-73.
  • Referans 13. Safarinejad MR. Prevalence of nocturnal enuresis, risk factors, associated familial factors and urinary pathology among school children in Iran. J Pediatr Urol. 2007;3(6):443-52.
  • Referans 14. Serel TA, Akhan 0, Koyuncuoğlu HR, Öztürk A, Doğruer K, Ünal S, Çelik K. Epidemiology of enuresis in Turkish children. Scand J Urol Nephrol. 1997;31:537-39.
  • Referans 15. Özden C, Özdal OL, et al. Prevalence and Associated Factors of Enuresis in Turkish Children. Int Braz J Urol. 2007;33(2):216-22.
  • Referans 16. Mahmoodzadeh H, Amestejani M, Karamyar M, Nikibakhsh A. Prevalence of Nocturnal Enuresis in School Aged Children. The Role of Personal and Parents Related Socio-Economic and Educational Factors. Iran J Pediatr. 2013;23(1):59–64.
  • Referans 17. Von Gontard A, Eiberg H, Hollmann E, Ritting S, Lehmkuhl G. Molecular genetics of nocturnal enuresis; clinical genetic heterogenity. Acta Pediatr. 1998;87:571-78.
  • Referans 18. Arnell H, Hjalmas K, et al. The genetics of primary nocturnal enuresis: inheritance and suggestion of a second major gene on chromosome 12q. J Med Genet. 1997;34:360-65.
  • Referans 19. Eilberg H. Total genome scan analysis in a single extended family for primary nocturnal enuresis: evidence for a new locus (ENUR3) for primary nocturnal enuresis on chromosome 22q11. Eur Urol. 1998;33(3):34-36.
  • Referans 20. Fergusson DM, Horwood LJ. Nocturnal enuresis and behavioral problems in adolescence: a 15 year longitudinal study. Pediatrics. 1994;94(5):662-68.
  • Referans 21. Çarman KB, Nuhoğlu Ç, Ceran Ö. İstanbul ili Ümraniye ilçesinde bir grup okul çocuğun da enürezis nokturna prevalansı. Türk Pediatri Arşivi. 2003;38:153-59.
  • Referans 22. Bozlu M, Çayan S, Doruk E, Canpolat B, Akbay E. The Epıdemıology of Nocturnal and Diurnal Enuresıs in Chıldhood and Adolescence. Türk Üroloji Dergisi. 2002;28(1):70-75.
  • Referans 23. Devlin JB. Prevalence and risk factors for childhood nocturnal enuresis. Ir Med J. 1992;84:118-20.
  • Referans 24. Bixler EO, Vgontzas AN, Lin HM, et al. Sleep disordered breathing in children in a general population sample: prevalence and risk factors. Sleep. 2009;32(6):731–36.
  • Referans 25. Li AM, So HK, Au CT, et al. Epidemiology of obstructive sleep apnoea syndrome in Chinese children: a two-phase community study. Thorax. 2010;65(11):991–97.
  • Referans 26. Barone JG, Hanson C, DaJusta DG, Gioia K, England SJ, Schneider D. Nocturnal enuresis and overweight are associated with obstructive sleep apnea. Pediatrics. 2009;124(1):e53–e59.
  • Referans 27. Brooks LJ, Topol H. Enuresis in children with sleep apnea. J Pediatr. 2003;142:515–18.
  • Referans 28. Lehmann KJ, Nelson R, Maclellan D, Anderson P, Romao RLP. The role of adenotonsillectomy in the treatment of primary nocturnal enuresis in children: A systematic review. J Pediatr Urol. 2018;14:53.
  • Referans 29. Sönmez F, Başak S, Tosun A, Ünüvar T, Yıldız M, The role of adenoid vegetations in the pathogenesis of in children with Enuresis Nocturna. Ege Pediatri Bülteni. 2006;13(2):79-83.
  • Referans 30. Uzun Çiçek A, Bora A, Altuntaş EE. Adenoid hypertrophy and nocturnal enuresis are associated with sleep disturbances. ENT Updates, 2020, Accepted Research.
  • Referans 31. Norgaard JP, Djurhuus JC, Watanabe H, Lettbeng B. Experi¬ence and current status of research into pathophysiology of nocturnal enuresis. Br J Urol. 1997;79:825-35.
  • Referans 32. Cohen-Zrubavel V, Kushnir B, Kushnir J, Sadeh A. Sleep and sleepiness in children with nocturnal enuresis. Sleep. 2011;34(2):191-94.
  • Referans 33. Alexopoulos EI, Kostadima E, Pagonari I. Association between primary nocturnal enuresis and habitual snoring in children. Urology. 2006;68(2):406-9.
  • Referans 34. Ertan P, Gönülal D, Söğüt A, Yılmaz Ö, Bozgül A, Yüksel H. Monosemptomatik nokturnal enürezisi olan çocuklarda dikkat eksikliği ve hiperaktivite bulguları. Türk Ped Arş. 2010;45(1):37-40.
  • Referans 35. Bray GW. Enuresis of allergic origin. Arch Dis Child. 1931;6:251-53.
  • Referans 36. Zaleski A, Shokeir MK, Gerrard JW. Enuresis: familial incidence and relationship to allergic disorders. Can Med Assoc J. 1972;106(1):30-31.
  • Referans 37. GERRARD JW, LuBos MC, HARDY LW, Ct al: Clinical picture and familial incidence. Can Med Assoc J. 1967;97:780.
  • Referans 38. Ozkaya E, Aydın SC, Yazıcı M, Dundaröz R. Enuresis Nocturna in children with asthma: prevalence and associated risk factors. Ital J Pediatr. 2016;42(1):59. (doi: 10.1186/s13052-016-0266-3).
  • Referans 39. Rawashdeh F, Hvistendahl GM, Kamperis K, Hansen MN, Djurhuus JC. Demographic of enuresis patients attending a referral centre. Scand J Urol Nephrol. 2002;36(5):348-53.
  • Referans 40. Tsai J, Chen H, Ku M, et al. Association between allergic disease, sleep-disordered breathing, and childhood nocturnal enuresis: a population-based case-control study. Pediatr Nephrol. 2017;32: 2293–301. (https://doi.org/10.1007/s00467-017-3750-0).
  • Referans 41. Kurt E, Metintas S, Basyigit I, et al; PARFAIT Study of T urkish Thoracic Society Asthma-Allergy Working Group. Prevalence and risk factors of allergies in Turkey: Results of a multicentric cross-sectional study in children. Pediatr Allergy Immunol. 2007;18:566-574.

Year 2021, Volume: 16 Issue: 1, 79 - 88, 08.02.2021

Gamze Aydın Sanem Nemmezi Karaca Seda Aybüke Sarı

https://doi.org/10.17517/ksutfd.767987

Abstract

Project Number

T-803

References

  • Referans 1. Türkiye Enürezis Çalışma Grubu, 2. Baskı, Aralık 2010. (Erişim Tarihi: Mart 2019) (https://www.tuseb.gov.tr/enstitu/tacese/yuklemeler/ekitap/kilavuzlar/enuresis kilavuzu.pdf).
  • Referans 2. Amerikan Psikiyatri Birliği, Ruhsal Bozuklukların Tanısal ve Sayımsal Elkitabı, Beşinci Baskı (DSM-5), Tanı Ölçütleri Başvuru El Kitabı'ndan, çev. yay. yön. Köroğlu E, Hekimler Yayın Birliği, Ankara, 2014; 479.
  • Referans 3. Birdal S, Dogangun B. Behavioural problems in children with enuresis. Türk Pediatr Arşivi. 2016;51(3):142-47.
  • Referans 4. Ramakrıshnan K. Evaluation and Treatment of Enuresis. Am Fam Physician. 2008;78(4):489-96.
  • Referans 5. Mungan NA, Seckiner I, Yeşilli C, Akduman B, Tekin IO. Nocturnal enuresis and allergy. Scand J Urol Nephrol. 2005;39(3):237–41.
  • Referans 6. Gür E, Turhan P, Can G, Akkus S, Sever L, Güzelöz S, Cifçili S, Arvas A. Enuresis: prevalence, risk factors and urinary pathology among school children in Istanbul, Turkey. Pediatr Int. 2004;46(1):58-63.
  • Referans 7. Abou-Khadra MK, Amin OR, Ahmed D. Association between sleep and behavioural problems among children with enuresis. J Paediatr Child Health. 2013;49(2):E160-66. (doi: 10.1111/jpc.12017.)
  • Referans 8. Asher MI, Keil U, Anderson HR, Beasley R, Crane J, Martinez F, Mitchell EA, et al. International study of asthma and allergies in childhood (ISAAC): rationale and methods. Eur Respir J. 1995;8:483-91.
  • Referans 9. Talay F, Kurt B, Tug T, Yilmaz F, Goksugur N. Prevalence and risk factors of asthma and allergic diseases among schoolchildren in Bolu, Turkey. Acta Paediatr. 2008;97(4):459-62.
  • Referans 10. Öner P, Barut Y, et al. Çocuklarda Uyku Ölçeği’nin Geçerlik ve Güvenirliği. Klinik Psikofarmakol Bulteni. 2009;19(4):382-95.
  • Referans 11. Goin RP. Nocturnal enuresis in children. Child Care Health Dev. 1998;24:277-88.
  • Referans 12. Lee SD, Sohn DW, Lee JZ, Park NC, Chung MK. An epidemiological study of enuresis in Korean children. BJU Int. 2000;85(7):869-73.
  • Referans 13. Safarinejad MR. Prevalence of nocturnal enuresis, risk factors, associated familial factors and urinary pathology among school children in Iran. J Pediatr Urol. 2007;3(6):443-52.
  • Referans 14. Serel TA, Akhan 0, Koyuncuoğlu HR, Öztürk A, Doğruer K, Ünal S, Çelik K. Epidemiology of enuresis in Turkish children. Scand J Urol Nephrol. 1997;31:537-39.
  • Referans 15. Özden C, Özdal OL, et al. Prevalence and Associated Factors of Enuresis in Turkish Children. Int Braz J Urol. 2007;33(2):216-22.
  • Referans 16. Mahmoodzadeh H, Amestejani M, Karamyar M, Nikibakhsh A. Prevalence of Nocturnal Enuresis in School Aged Children. The Role of Personal and Parents Related Socio-Economic and Educational Factors. Iran J Pediatr. 2013;23(1):59–64.
  • Referans 17. Von Gontard A, Eiberg H, Hollmann E, Ritting S, Lehmkuhl G. Molecular genetics of nocturnal enuresis; clinical genetic heterogenity. Acta Pediatr. 1998;87:571-78.
  • Referans 18. Arnell H, Hjalmas K, et al. The genetics of primary nocturnal enuresis: inheritance and suggestion of a second major gene on chromosome 12q. J Med Genet. 1997;34:360-65.
  • Referans 19. Eilberg H. Total genome scan analysis in a single extended family for primary nocturnal enuresis: evidence for a new locus (ENUR3) for primary nocturnal enuresis on chromosome 22q11. Eur Urol. 1998;33(3):34-36.
  • Referans 20. Fergusson DM, Horwood LJ. Nocturnal enuresis and behavioral problems in adolescence: a 15 year longitudinal study. Pediatrics. 1994;94(5):662-68.
  • Referans 21. Çarman KB, Nuhoğlu Ç, Ceran Ö. İstanbul ili Ümraniye ilçesinde bir grup okul çocuğun da enürezis nokturna prevalansı. Türk Pediatri Arşivi. 2003;38:153-59.
  • Referans 22. Bozlu M, Çayan S, Doruk E, Canpolat B, Akbay E. The Epıdemıology of Nocturnal and Diurnal Enuresıs in Chıldhood and Adolescence. Türk Üroloji Dergisi. 2002;28(1):70-75.
  • Referans 23. Devlin JB. Prevalence and risk factors for childhood nocturnal enuresis. Ir Med J. 1992;84:118-20.
  • Referans 24. Bixler EO, Vgontzas AN, Lin HM, et al. Sleep disordered breathing in children in a general population sample: prevalence and risk factors. Sleep. 2009;32(6):731–36.
  • Referans 25. Li AM, So HK, Au CT, et al. Epidemiology of obstructive sleep apnoea syndrome in Chinese children: a two-phase community study. Thorax. 2010;65(11):991–97.
  • Referans 26. Barone JG, Hanson C, DaJusta DG, Gioia K, England SJ, Schneider D. Nocturnal enuresis and overweight are associated with obstructive sleep apnea. Pediatrics. 2009;124(1):e53–e59.
  • Referans 27. Brooks LJ, Topol H. Enuresis in children with sleep apnea. J Pediatr. 2003;142:515–18.
  • Referans 28. Lehmann KJ, Nelson R, Maclellan D, Anderson P, Romao RLP. The role of adenotonsillectomy in the treatment of primary nocturnal enuresis in children: A systematic review. J Pediatr Urol. 2018;14:53.
  • Referans 29. Sönmez F, Başak S, Tosun A, Ünüvar T, Yıldız M, The role of adenoid vegetations in the pathogenesis of in children with Enuresis Nocturna. Ege Pediatri Bülteni. 2006;13(2):79-83.
  • Referans 30. Uzun Çiçek A, Bora A, Altuntaş EE. Adenoid hypertrophy and nocturnal enuresis are associated with sleep disturbances. ENT Updates, 2020, Accepted Research.
  • Referans 31. Norgaard JP, Djurhuus JC, Watanabe H, Lettbeng B. Experi¬ence and current status of research into pathophysiology of nocturnal enuresis. Br J Urol. 1997;79:825-35.
  • Referans 32. Cohen-Zrubavel V, Kushnir B, Kushnir J, Sadeh A. Sleep and sleepiness in children with nocturnal enuresis. Sleep. 2011;34(2):191-94.
  • Referans 33. Alexopoulos EI, Kostadima E, Pagonari I. Association between primary nocturnal enuresis and habitual snoring in children. Urology. 2006;68(2):406-9.
  • Referans 34. Ertan P, Gönülal D, Söğüt A, Yılmaz Ö, Bozgül A, Yüksel H. Monosemptomatik nokturnal enürezisi olan çocuklarda dikkat eksikliği ve hiperaktivite bulguları. Türk Ped Arş. 2010;45(1):37-40.
  • Referans 35. Bray GW. Enuresis of allergic origin. Arch Dis Child. 1931;6:251-53.
  • Referans 36. Zaleski A, Shokeir MK, Gerrard JW. Enuresis: familial incidence and relationship to allergic disorders. Can Med Assoc J. 1972;106(1):30-31.
  • Referans 37. GERRARD JW, LuBos MC, HARDY LW, Ct al: Clinical picture and familial incidence. Can Med Assoc J. 1967;97:780.
  • Referans 38. Ozkaya E, Aydın SC, Yazıcı M, Dundaröz R. Enuresis Nocturna in children with asthma: prevalence and associated risk factors. Ital J Pediatr. 2016;42(1):59. (doi: 10.1186/s13052-016-0266-3).
  • Referans 39. Rawashdeh F, Hvistendahl GM, Kamperis K, Hansen MN, Djurhuus JC. Demographic of enuresis patients attending a referral centre. Scand J Urol Nephrol. 2002;36(5):348-53.
  • Referans 40. Tsai J, Chen H, Ku M, et al. Association between allergic disease, sleep-disordered breathing, and childhood nocturnal enuresis: a population-based case-control study. Pediatr Nephrol. 2017;32: 2293–301. (https://doi.org/10.1007/s00467-017-3750-0).
  • Referans 41. Kurt E, Metintas S, Basyigit I, et al; PARFAIT Study of T urkish Thoracic Society Asthma-Allergy Working Group. Prevalence and risk factors of allergies in Turkey: Results of a multicentric cross-sectional study in children. Pediatr Allergy Immunol. 2007;18:566-574.
There are 41 citations in total.

Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Araştırma Makaleleri
Authors

Gamze Aydın This is me 0000-0003-2708-5297

Sanem Nemmezi Karaca 0000-0002-4853-8366

Seda Aybüke Sarı 0000-0003-4793-0662

Project Number T-803
Publication Date February 8, 2021
Submission Date July 11, 2020
Acceptance Date September 28, 2020
Published in Issue Year 2021 Volume: 16 Issue: 1

Cite

AMA Aydın G, Nemmezi Karaca S, Sarı SA. Çocuklarda Primer Enürezis Nokturna ile Alerjik ve Solunumsal Hastalıkların Birlikteliği. KSU Medical Journal. February 2021;16(1):79-88. doi:10.17517/ksutfd.767987
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