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Year 2009, Volume: 22 Issue: 1, 34 - 44, 04.05.2015

Hale Toklu Mustafa Deniz Meral Yüksel Meral Keyer-uysal Göksel Şener

Abstract

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Keywords

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References

  • 1. Matsuo Y, Onodera H, Shiga Y, et al. Role of cell adhesion molecules in brain injury after transient middle cerebral artery occlusion in the rat. Brain Res 1994;656:344-352.
  • 2. Tan DX, Manchester LC, Reiter RJ, et al. Significance of melatonin in antioxidative defense system: reactions and products. Biol Signals Recept 2000;9:137-159.
  • 3. Chauvin G, Vannier G, Gilad E, et al. Melatonin is a scavenger of peroxynitrite. Life Sci 1997;60:169-174.
  • 4. Tan DX, Manchester LC, Terron MP, Flores LJ, Reiter RJ. One molecule, many derivatives: a never-ending interaction of melatonin with reactive oxygen and nitrogen species? J Pineal Res 2007;42:28-42.
  • 5. Manda K, Ueno M, Anzai K. AFMK, a melatonin metabolite, attenuates X-ray-induced oxidative damage to DNA, proteins and lipids in mice. J Pineal Res 2007;42:386-393.
  • 6. Reiter RJ, Tan DX, Manchester LC, Qi W. Biochemical reactivity of melatonin with reactive oxygen and nitrogen species. A review of the evidence. Cell Biochem Biophys 2001;34:237-256.
  • 7. Yoshii T, Iwai M, Li Z, et al. Regression of atherosclerosis by amlodipine via anti-inflammatory and anti-oxidative stress actions. Hypertens Res 2006;29:457-466.
  • 8. Liu LL, Li QX, Xia L, Li J, Shao L. Differential effects of dihydropyridine calcium antagonists on doxorubicininduced nephrotoxicity in rats. Toxicology 2007;231:81- 90.
  • 9. Yamagata K, Ichinose S, Tagami M. Amlodipine and carvedilol prevent cytotoxicity in cortical neurons isolated from stroke-prone spontaneously hypertensive rats. Hypertens Res 2004;27:271-282.
  • 10. Hirooka Y, Kimura Y, Nozoe M, et al. Amlodipineinduced reduction of oxidative stress in the brain is associated with sympatho-inhibitory effects in strokeprone spontaneously hypertensive rats. Hypertens Res 2006;29:49-56.
  • 11. Mogi M, Iwai M, Chen R, et al. Amlodipine treatment reduces stroke size in apolipoprotein E-deficient mice. Am J Hypertens 2006;19:1144-1149.
  • 12. Toklu HZ, Keyer Uysal M, Kabasakal L, et al. The effects of riluzole on neurological, biochemical and histological changes in early and late term of sepsis in rats. J Surg Res 2008; Doi:10.1016/j.jss.2008.03.013.
  • 13. Bederson JB, Pitts LH, Tsuji M, Nishimura MC, Davis RL. Rat middle cerebral artery occlusion: Evaluation of the model and development of a neurological examination. Stroke 1986;17:472-476.
  • 14. Beuge JA, Aust SD. Microsomal lipid peroxidation. Methods Enzymol 1978;52:302–311.
  • 15. Beutler E. Glutathione in red blood cell metabolism. A Manuel of Biochemical Methods, Grune and Stratton, New York, NY: 1975:112–114.
  • 16. Hillegass LM, Griswold DE, Brickson B, AlbrightsonWinslow C. Assessment of myeloperoxidase activity in whole rat kidney. J Pharmacol Methods 1990; 24: 285- 295.
  • 17. Reading HW, Isbir T. The role of cation activated ATPase in transmitter release from the art iris. Q J Exp Physiol Cogn Med Sci 1980;65:105-116.
  • 18. Lowry OH, Rosenbrough NJ, Farr AL, Randall RJ. Protein measurements with the folin phenol reagent. J Biol Chem 1951;193:265-75.
  • 19. Ohara Y, Peterson TE, Harrison DG. Hypercholesterolemia increases endothelial superoxide anion production. J Clin Invest 1993;92:2546-2551.
  • 20. Davies GR, Simmonds NJ, Stevens TR, et al. Helicobacter pylori stimulates antral mucosal reactive oxygen metabolite production in vivo. Gut 1994;35:179–185.
  • 21. Read JS, Hirano T, Davis SM, Donnan GA. Limiting neurological damage after stroke. Drugs Aging 1999;14:11–39.
  • 22. Candelario-Jalil E, Alvarez D, Merino N, León OS. Delayed treatment with nimesulide reduces measures of oxidative stress following global ischemic brain injury in gerbils. Neurosci Res 2003;47:245-253.
  • 23. Ozkul A, Akyol A, Yenisey C, et al. Oxidative stress in acute ischemic stroke. J Clin Neurosci 2007;14:1062- 1066.
  • 24. Ross D. Glutathione, free radicals and chemotherapeutic agents. Pharmacol Ther 1988;37:231-249.
  • 25. Gilgun-Sherki Y, Melamed E, Offen D. Oxidative stress induced-neurodegenerative diseases: the need for antioxidants that penetrate the blood brain barrier. Neuropharmacol 2001;40:959-975.
  • 26. Wu G, Fang YZ, Yang S, Lupton JR, Turner ND. Glutathione metabolism and its implications for health. J Nutr 2004;134:489-492.
  • 27. Hendriks JJ, Teunissen CE, de Vries HE, Dijkstra CD. Macrophages and neurodegeneration. Brain Res Rev 2005;48:185-195.
  • 28. Homi HM, Freitas JJ, Curi R, Velasco IT, Junior BA. Changes in superoxide dismutase and catalase activities of rat brain regions during early global transient ischemia/reperfusion. Neurosci Lett 2002;333:37-40.
  • 29. Kim GW, Kondo T, Noshita N, Chan PH. Manganese superoxide dismutase deficiency exacerbates cerebral infarction after focal cerebral ischemia/reperfusion in mice: implications for the production and role of superoxide radicals. Stroke 2002;33:809-815.
  • 30. Koner BC, Banerjee BD, Ray A. Organochlorine pesticide-induced oxidative stress and immune suppression in rats. Ind J Exp Biol 1998;36:395-398.
  • 31. Tuna M, Polat S, Erman T, et al. Effect of anti-rat interleukin-6 antibody after spinal cord injury in the rat: inducible nitric oxide synthase expression, sodium- and potassium-activated, magnesium-dependent adenosine- 5\'-triphosphatase and superoxide dismutase activation, and ultrastructural changes. J Neurosurg 2001;95:64-73.
  • 32. Mrsic-Pelcic J, Pelcic G, Vitezic D, et al. Hyperbaric oxygen treatment: the influence on the hippocampal superoxide dismutase and Na+,K+-ATPase activities in global cerebral ischemia-exposed rats. Neurochem Int 2004;44:585-594.
  • 33. Kempski O. Cerebral edema. Semin Nephrol 2001; 21: 303-307.
  • 34. Unterberg AW, Stover J, Kress B, Kiening KL. Edema and brain trauma. Neuroscience 2004;129:1021-1029.
  • 35. Kaptanoglu E, Okutan O, Akbiyik F, et al. Correlation of injury severity and tissue Evans blue content, lipid peroxidation and clinical evaluation in acute spinal cord injury in rats. J Clin Neurosci 2004;11:879-885.
  • 36. Mason RP, Walter MF, Trumbore MW, Olmstead Jr. EG, Mason PE. Membrane antioxidant effects of the charged dihydropyridine calcium antagonist amlodipine. J Mol Cell Cardiol 1999;31:275–281.
  • 37. Uchida S, Yamada S, Nagai K, Deguchi Y, Kimura R. Brain pharmacokinetics and in vivo receptor binding of 1,4-dihydropyridine calcium channel antagonists. Life Sci 1997;61:2083-2090.
  • 38. Reiter RJ. Oxidative damage in the central nervous system: protection by melatonin. Prog Neurobiol 1998;56:359–384.

SEREBRAL İSKEMİ/REPERFÜZYONA BAĞLI OKSİDAN BEYİN HASARINA KARŞI MELATONİN VE AMLODİPİNİN KORUYUCU ETKİLERİ

Year 2009, Volume: 22 Issue: 1, 34 - 44, 04.05.2015

Hale Toklu Mustafa Deniz Meral Yüksel Meral Keyer-uysal Göksel Şener

Abstract

Amaç: Bu çalışmada melatonin ve amlodipinin iskemi/reperfüzyon (İ/R) ile oluşan beyin hasarına karşı olası koruyucu etkileri araştırıldı. Yöntem: Wistar Albino sıçanlar 15 dakika bilateral carotid arter oklüzyonunu takiben 24 saat süreyle reperfüzyona bırakıldı. Melatonin ve amlodipin 10mg/kg ip veya 50µg/sıçan icv dozlarında reperfüzyondan hemen önce uygulandı. Nörolojik tayin sonrası hayvanlar dekapite edildi. Beyin dokularında malondialdehit (MDA) ve glutatyon (GSH) düzeyleri ile myeloperoxidaz (MPO) ve Na+-K+-ATPaz aktiviteleri tayin edildi. Dokuda serbest radikal oluşumu luminol ve lusigenin kemiluminesans (KL) yöntemi ile ölçüldü. Beyin ödemi yaş/kuru ağırlık üzerinden, kan beyin bariyer (KBB) geçirgenliği de Evans Mavisi (EM) extravazasyonu ile değerlendirilidi. Bulgular: Çözücü uygulanan grup ile karşılaştırıldığında nörolojik bozuklukların melatonin ve amlodipin gruplarında düzeldiği belirlendi. İskemi/reperfüzyon beyinde GSH ve Na+-K+-ATPaz aktivitesinde azalma ve bununla birlikte MDA, MPO ve KL düzeylerinde artışa neden oldu. Buna karşılık melatonin ve amlodipin tedavileri tüm incelenen biyokimyasal parametrelerdeki değişimi ve İ/R nin neden olduğu beyin ödemini geri çevirdi. Sonuç: Bu bulgulara göre gerek melatonin ve gerekse amlodipin muhtemelen antioksidan özellikleri aracılığı ile global iskemiye bağlı olarak meydana gelen nörokimyasal ve davranışsal değişikleri module edebileceği düşünülmektedir.

Anahtar Kelimeler: melatonin, amlodipin, beyin, iskemi / reperfüzyon, lipid peroksidasyonu

Keywords

melatonin amlodipin beyin iskemi / reperfüzyon lipid peroksidasyonu

References

  • 1. Matsuo Y, Onodera H, Shiga Y, et al. Role of cell adhesion molecules in brain injury after transient middle cerebral artery occlusion in the rat. Brain Res 1994;656:344-352.
  • 2. Tan DX, Manchester LC, Reiter RJ, et al. Significance of melatonin in antioxidative defense system: reactions and products. Biol Signals Recept 2000;9:137-159.
  • 3. Chauvin G, Vannier G, Gilad E, et al. Melatonin is a scavenger of peroxynitrite. Life Sci 1997;60:169-174.
  • 4. Tan DX, Manchester LC, Terron MP, Flores LJ, Reiter RJ. One molecule, many derivatives: a never-ending interaction of melatonin with reactive oxygen and nitrogen species? J Pineal Res 2007;42:28-42.
  • 5. Manda K, Ueno M, Anzai K. AFMK, a melatonin metabolite, attenuates X-ray-induced oxidative damage to DNA, proteins and lipids in mice. J Pineal Res 2007;42:386-393.
  • 6. Reiter RJ, Tan DX, Manchester LC, Qi W. Biochemical reactivity of melatonin with reactive oxygen and nitrogen species. A review of the evidence. Cell Biochem Biophys 2001;34:237-256.
  • 7. Yoshii T, Iwai M, Li Z, et al. Regression of atherosclerosis by amlodipine via anti-inflammatory and anti-oxidative stress actions. Hypertens Res 2006;29:457-466.
  • 8. Liu LL, Li QX, Xia L, Li J, Shao L. Differential effects of dihydropyridine calcium antagonists on doxorubicininduced nephrotoxicity in rats. Toxicology 2007;231:81- 90.
  • 9. Yamagata K, Ichinose S, Tagami M. Amlodipine and carvedilol prevent cytotoxicity in cortical neurons isolated from stroke-prone spontaneously hypertensive rats. Hypertens Res 2004;27:271-282.
  • 10. Hirooka Y, Kimura Y, Nozoe M, et al. Amlodipineinduced reduction of oxidative stress in the brain is associated with sympatho-inhibitory effects in strokeprone spontaneously hypertensive rats. Hypertens Res 2006;29:49-56.
  • 11. Mogi M, Iwai M, Chen R, et al. Amlodipine treatment reduces stroke size in apolipoprotein E-deficient mice. Am J Hypertens 2006;19:1144-1149.
  • 12. Toklu HZ, Keyer Uysal M, Kabasakal L, et al. The effects of riluzole on neurological, biochemical and histological changes in early and late term of sepsis in rats. J Surg Res 2008; Doi:10.1016/j.jss.2008.03.013.
  • 13. Bederson JB, Pitts LH, Tsuji M, Nishimura MC, Davis RL. Rat middle cerebral artery occlusion: Evaluation of the model and development of a neurological examination. Stroke 1986;17:472-476.
  • 14. Beuge JA, Aust SD. Microsomal lipid peroxidation. Methods Enzymol 1978;52:302–311.
  • 15. Beutler E. Glutathione in red blood cell metabolism. A Manuel of Biochemical Methods, Grune and Stratton, New York, NY: 1975:112–114.
  • 16. Hillegass LM, Griswold DE, Brickson B, AlbrightsonWinslow C. Assessment of myeloperoxidase activity in whole rat kidney. J Pharmacol Methods 1990; 24: 285- 295.
  • 17. Reading HW, Isbir T. The role of cation activated ATPase in transmitter release from the art iris. Q J Exp Physiol Cogn Med Sci 1980;65:105-116.
  • 18. Lowry OH, Rosenbrough NJ, Farr AL, Randall RJ. Protein measurements with the folin phenol reagent. J Biol Chem 1951;193:265-75.
  • 19. Ohara Y, Peterson TE, Harrison DG. Hypercholesterolemia increases endothelial superoxide anion production. J Clin Invest 1993;92:2546-2551.
  • 20. Davies GR, Simmonds NJ, Stevens TR, et al. Helicobacter pylori stimulates antral mucosal reactive oxygen metabolite production in vivo. Gut 1994;35:179–185.
  • 21. Read JS, Hirano T, Davis SM, Donnan GA. Limiting neurological damage after stroke. Drugs Aging 1999;14:11–39.
  • 22. Candelario-Jalil E, Alvarez D, Merino N, León OS. Delayed treatment with nimesulide reduces measures of oxidative stress following global ischemic brain injury in gerbils. Neurosci Res 2003;47:245-253.
  • 23. Ozkul A, Akyol A, Yenisey C, et al. Oxidative stress in acute ischemic stroke. J Clin Neurosci 2007;14:1062- 1066.
  • 24. Ross D. Glutathione, free radicals and chemotherapeutic agents. Pharmacol Ther 1988;37:231-249.
  • 25. Gilgun-Sherki Y, Melamed E, Offen D. Oxidative stress induced-neurodegenerative diseases: the need for antioxidants that penetrate the blood brain barrier. Neuropharmacol 2001;40:959-975.
  • 26. Wu G, Fang YZ, Yang S, Lupton JR, Turner ND. Glutathione metabolism and its implications for health. J Nutr 2004;134:489-492.
  • 27. Hendriks JJ, Teunissen CE, de Vries HE, Dijkstra CD. Macrophages and neurodegeneration. Brain Res Rev 2005;48:185-195.
  • 28. Homi HM, Freitas JJ, Curi R, Velasco IT, Junior BA. Changes in superoxide dismutase and catalase activities of rat brain regions during early global transient ischemia/reperfusion. Neurosci Lett 2002;333:37-40.
  • 29. Kim GW, Kondo T, Noshita N, Chan PH. Manganese superoxide dismutase deficiency exacerbates cerebral infarction after focal cerebral ischemia/reperfusion in mice: implications for the production and role of superoxide radicals. Stroke 2002;33:809-815.
  • 30. Koner BC, Banerjee BD, Ray A. Organochlorine pesticide-induced oxidative stress and immune suppression in rats. Ind J Exp Biol 1998;36:395-398.
  • 31. Tuna M, Polat S, Erman T, et al. Effect of anti-rat interleukin-6 antibody after spinal cord injury in the rat: inducible nitric oxide synthase expression, sodium- and potassium-activated, magnesium-dependent adenosine- 5\'-triphosphatase and superoxide dismutase activation, and ultrastructural changes. J Neurosurg 2001;95:64-73.
  • 32. Mrsic-Pelcic J, Pelcic G, Vitezic D, et al. Hyperbaric oxygen treatment: the influence on the hippocampal superoxide dismutase and Na+,K+-ATPase activities in global cerebral ischemia-exposed rats. Neurochem Int 2004;44:585-594.
  • 33. Kempski O. Cerebral edema. Semin Nephrol 2001; 21: 303-307.
  • 34. Unterberg AW, Stover J, Kress B, Kiening KL. Edema and brain trauma. Neuroscience 2004;129:1021-1029.
  • 35. Kaptanoglu E, Okutan O, Akbiyik F, et al. Correlation of injury severity and tissue Evans blue content, lipid peroxidation and clinical evaluation in acute spinal cord injury in rats. J Clin Neurosci 2004;11:879-885.
  • 36. Mason RP, Walter MF, Trumbore MW, Olmstead Jr. EG, Mason PE. Membrane antioxidant effects of the charged dihydropyridine calcium antagonist amlodipine. J Mol Cell Cardiol 1999;31:275–281.
  • 37. Uchida S, Yamada S, Nagai K, Deguchi Y, Kimura R. Brain pharmacokinetics and in vivo receptor binding of 1,4-dihydropyridine calcium channel antagonists. Life Sci 1997;61:2083-2090.
  • 38. Reiter RJ. Oxidative damage in the central nervous system: protection by melatonin. Prog Neurobiol 1998;56:359–384.
There are 38 citations in total.

Details

Primary Language Turkish
Journal Section Articles
Authors

Hale Toklu This is me

Mustafa Deniz This is me

Meral Yüksel This is me

Meral Keyer-uysal This is me

Göksel Şener

Publication Date May 4, 2015
Published in Issue Year 2009 Volume: 22 Issue: 1

Cite

APA Toklu, H., Deniz, M., Yüksel, M., Keyer-uysal, M., et al. (2015). SEREBRAL İSKEMİ/REPERFÜZYONA BAĞLI OKSİDAN BEYİN HASARINA KARŞI MELATONİN VE AMLODİPİNİN KORUYUCU ETKİLERİ. Marmara Medical Journal, 22(1), 34-44.
AMA Toklu H, Deniz M, Yüksel M, Keyer-uysal M, Şener G. SEREBRAL İSKEMİ/REPERFÜZYONA BAĞLI OKSİDAN BEYİN HASARINA KARŞI MELATONİN VE AMLODİPİNİN KORUYUCU ETKİLERİ. Marmara Med J. August 2015;22(1):34-44.
Chicago Toklu, Hale, Mustafa Deniz, Meral Yüksel, Meral Keyer-uysal, and Göksel Şener. “SEREBRAL İSKEMİ/REPERFÜZYONA BAĞLI OKSİDAN BEYİN HASARINA KARŞI MELATONİN VE AMLODİPİNİN KORUYUCU ETKİLERİ”. Marmara Medical Journal 22, no. 1 (August 2015): 34-44.
EndNote Toklu H, Deniz M, Yüksel M, Keyer-uysal M, Şener G (August 1, 2015) SEREBRAL İSKEMİ/REPERFÜZYONA BAĞLI OKSİDAN BEYİN HASARINA KARŞI MELATONİN VE AMLODİPİNİN KORUYUCU ETKİLERİ. Marmara Medical Journal 22 1 34–44.
IEEE H. Toklu, M. Deniz, M. Yüksel, M. Keyer-uysal, and G. Şener, “SEREBRAL İSKEMİ/REPERFÜZYONA BAĞLI OKSİDAN BEYİN HASARINA KARŞI MELATONİN VE AMLODİPİNİN KORUYUCU ETKİLERİ”, Marmara Med J, vol. 22, no. 1, pp. 34–44, 2015.
ISNAD Toklu, Hale et al. “SEREBRAL İSKEMİ/REPERFÜZYONA BAĞLI OKSİDAN BEYİN HASARINA KARŞI MELATONİN VE AMLODİPİNİN KORUYUCU ETKİLERİ”. Marmara Medical Journal 22/1 (August 2015), 34-44.
JAMA Toklu H, Deniz M, Yüksel M, Keyer-uysal M, Şener G. SEREBRAL İSKEMİ/REPERFÜZYONA BAĞLI OKSİDAN BEYİN HASARINA KARŞI MELATONİN VE AMLODİPİNİN KORUYUCU ETKİLERİ. Marmara Med J. 2015;22:34–44.
MLA Toklu, Hale et al. “SEREBRAL İSKEMİ/REPERFÜZYONA BAĞLI OKSİDAN BEYİN HASARINA KARŞI MELATONİN VE AMLODİPİNİN KORUYUCU ETKİLERİ”. Marmara Medical Journal, vol. 22, no. 1, 2015, pp. 34-44.
Vancouver Toklu H, Deniz M, Yüksel M, Keyer-uysal M, Şener G. SEREBRAL İSKEMİ/REPERFÜZYONA BAĞLI OKSİDAN BEYİN HASARINA KARŞI MELATONİN VE AMLODİPİNİN KORUYUCU ETKİLERİ. Marmara Med J. 2015;22(1):34-4.