Investigation of Thyroid Hormones and Prolactin Levels in Fertile and Infertile Women

Arzu Şahin; Feyyaz Önder

doi:10.19127/mbsjohs.63680

Investigation of Thyroid Hormones and Prolactin Levels in Fertile and Infertile Women

Year 2016, Volume: 2 Issue: 1, 1 - 6, 27.04.2016

Arzu Şahin Feyyaz Önder

https://doi.org/10.19127/mbsjohs.63680

Cited By: 1

Abstract

Objective: This study was conducted to investigate thyroid hormones and prolactin levels in fertile and infertile women.

Materials and Methods: The study enrolled a total of 84 women, 40 infertile and 44 fertile, aged between 15-45 years and applied to Kars Maternity and Child Hospital, Obstetrics Clinic and Artvin State Hospital, Obstetrics and Gynecology Clinic. The study population was divided into 3 groups: Group P (n=30, women having primary infertility), Group S (n=10, women having secondary infertility) and Group F (N=44, fertile women). Blood samples were obtained in early follicular phase and serum thyrotropin (TSH), free triiodothyronine (FT₃₎, free thyroxine (FT₄) and prolactin levels were determined by Microparticle Enzyme Immunoasay (MEIA) method.

Results: Serum TSH levels were 1.70±0.40, 1.60±0.20 and 0.80±0.20 µIU/ml for the groups F, P and S, respectively (p> 0.05). FT₃ levels were 2.36±0.06, 2.46±0.09 and 2.35±0.2 pg/ml while FT₄ levels were 0.98±0.02, 0.94±0.04 and 1.00±0.03 ng/dl for the groups F, P and S, respectively. There was a significant negative correlation between TSH and FT₄ (p=0.012, r = -0.275) and a significant positive correlation between FT₃ and FT₄ (p=0.002, r = 0.330). Serum prolactin levels were measured as 16.70±2.60, 21.10± 2.10 and 16.00±1.90 ng/ml respectively for the groups F, P and S and no significant difference was detected between the groups with respect to prolactin levels (p >0.05).

Conclusion: As a result, there was no difference between the groups in terms of TSH, FT₃, FT₄ and prolactin levels. Hormone levels were generally within normal limits and therefore we determine no significant relationship between infertility and investigated parameters in this study.

Keywords

TSH, FT3, FT4, Prolactin, Infertility, Fertilty

References

Bagis T, Kıllıcadag E, Tarım E, Gokçel A, Haydardedeoglu B. Clinical evaluation of infertile patients. Turkish Fertile J 2001; 9(3): 215-25.
Bercovici JP. Menstrual irregularities and thyroid diseases. Feuill Biol 2000; 74: 1063–70.
Binita G, Suprava P, Mainak C, Koner BC, Alpana S. Correlation of prolactin and thyroid hormone concentration with menstrual patterns in infertile women. J Reprod Infertil 2009; 10(3): 207-12.
Boyar Hİ. Female infertility and endocrinological diseases. Dicle Med J 2013; 40(4): 700-3.
Buyru F, Serdaroglu H, Kovanci E, Baysal B. Thyroid dysfunction and infertility. Turkish Fertile J 1996; 4(1): 21-25.
Cramer DW, Sluss PM, Powers RD, McShane P, Ginsburgs ES, Hornstein MD, et al. Serum prolactin and TSH in an in vitro fertilization population: is there a link between fertilization and thyroid function? J Assist Report Genet 2003; 20(6): 210-5.
Davis LB, Lathi RB, Dahan MH. The effect of infertility medication on thyroid function in hypothyroid women who conceive. Thyroid 2007; 17: 773–7.
Doufas AG, Mastorakos G. The hypothalamicpituitary-thyroid axis and the female reproductive system. Ann N Y Acad Sci 2000; 900: 65-76.
Elahi S, Tasneem A, Nazir I, Nagra SA, Hyder SW. Thyroid dysfunction in infertile women. Coll Physicians Surg Pak 2007; 17(4): 191-4.
Jaffe SB. The basic infertility investigation. Fertil Steril 1991; 61: 599.
Joshi JV, Bhandarkar SD, Chadha M, Balaiah D, Shah R. Menstrual irregularities and lactation failure may precede thyroid dysfunction or goitre. J Postgrad Med 1993; 39: 137-41.
Krassas GE, Poppe K, Glinoer D. Thyroid function and human reproductive health. Endocr Rev 2010; 31(5): 702-55.
Lisa H, Fish MD, Cary N. Hyperprolactinemia, infertility and hypothyroidism. Arch Intern Med 1988; 148: 709-11.
Menken J, Trussel J, Larsen U. Age and infertility. Sci 1986; 233: 1389-93.
Poppe K, Velkeniers B. Thyroid disorders in infertile women. Ann Endocrinol (Paris) 2003; 64 (1):45-50.
Poppe K, Velkeniers B, Glinoer D. Thyroid disease and female reproduction. Clin Endocrinol (Oxf) 2007; 66(3): 309-21.
Shalev E, Eliyahu S, Ziw M, Ben-Ami M. Routine thyroid function tests in infertile women : Are they necessary? Am J Obstet Gynecol 1994; 11 (91): 171.
Sharma N, Baliarsingh S, Kaushik GG. Biochemical association of hyperprolac-tinemia with hypothyroidism in infertile women. Clin Lab 2012; 58(7-8): 805-10.
Songur S, Cetin M. Ovulatory and anovulatory infertile women in routine thyroid function tests. Turkish Fertile Journal 1996; 4 (4): 355-7.
Thonneau P, Marchand S, Tallec A, et al. Incidence and main causes of infertility in a resident population of three French regions. Hum Reprod 1991; 6: 811-6.
Turankar S, Sonone K, Turankar A. Hyperprolactinaemia and Iİts Comparision with Hypothyroidism in Primary Infertile Women. J Clin Diagn Res 2013; 7(5): 794-6.
Unuane D, Tournaye H, Velkeniers B, Poppe K. Endocrine disorders & female infertility. Best Pract Res Clin Endocrinol Metab 2011; 25(6): 861-73.
Williams C, Giannopoulos T, Sherriff EA. Investigation of infertility with the emphasis on laboratory testing and with reference to radiological imaging. J Clin Pathol 2003; 56: 261-7.
Vaquero E, Lazzarin CD, Valensise H, Moretti C, Ramanini C. Mild thyroid abnormalities and recurrent spontaneous abortion: Diagnostic and therapeutic approach. Am J Reprod Immunol 2000; 43: 204–8.
Vayena E, Rowe P, Griffin P. Current Practices and Contro¬versies in Assisted Reprudiction. Report of a meeting on Medical, Ethical and Social Aspets of Assisted Reprodic¬tion held at WHO Headquarters; September, 17-21; Geneva – Switzerland: 2001. P.2002.

Year 2016, Volume: 2 Issue: 1, 1 - 6, 27.04.2016

Arzu Şahin Feyyaz Önder

https://doi.org/10.19127/mbsjohs.63680

Cited By: 1

Abstract

References

Bagis T, Kıllıcadag E, Tarım E, Gokçel A, Haydardedeoglu B. Clinical evaluation of infertile patients. Turkish Fertile J 2001; 9(3): 215-25.
Bercovici JP. Menstrual irregularities and thyroid diseases. Feuill Biol 2000; 74: 1063–70.
Binita G, Suprava P, Mainak C, Koner BC, Alpana S. Correlation of prolactin and thyroid hormone concentration with menstrual patterns in infertile women. J Reprod Infertil 2009; 10(3): 207-12.
Boyar Hİ. Female infertility and endocrinological diseases. Dicle Med J 2013; 40(4): 700-3.
Buyru F, Serdaroglu H, Kovanci E, Baysal B. Thyroid dysfunction and infertility. Turkish Fertile J 1996; 4(1): 21-25.
Cramer DW, Sluss PM, Powers RD, McShane P, Ginsburgs ES, Hornstein MD, et al. Serum prolactin and TSH in an in vitro fertilization population: is there a link between fertilization and thyroid function? J Assist Report Genet 2003; 20(6): 210-5.
Davis LB, Lathi RB, Dahan MH. The effect of infertility medication on thyroid function in hypothyroid women who conceive. Thyroid 2007; 17: 773–7.
Doufas AG, Mastorakos G. The hypothalamicpituitary-thyroid axis and the female reproductive system. Ann N Y Acad Sci 2000; 900: 65-76.
Elahi S, Tasneem A, Nazir I, Nagra SA, Hyder SW. Thyroid dysfunction in infertile women. Coll Physicians Surg Pak 2007; 17(4): 191-4.
Jaffe SB. The basic infertility investigation. Fertil Steril 1991; 61: 599.
Joshi JV, Bhandarkar SD, Chadha M, Balaiah D, Shah R. Menstrual irregularities and lactation failure may precede thyroid dysfunction or goitre. J Postgrad Med 1993; 39: 137-41.
Krassas GE, Poppe K, Glinoer D. Thyroid function and human reproductive health. Endocr Rev 2010; 31(5): 702-55.
Lisa H, Fish MD, Cary N. Hyperprolactinemia, infertility and hypothyroidism. Arch Intern Med 1988; 148: 709-11.
Menken J, Trussel J, Larsen U. Age and infertility. Sci 1986; 233: 1389-93.
Poppe K, Velkeniers B. Thyroid disorders in infertile women. Ann Endocrinol (Paris) 2003; 64 (1):45-50.
Poppe K, Velkeniers B, Glinoer D. Thyroid disease and female reproduction. Clin Endocrinol (Oxf) 2007; 66(3): 309-21.
Shalev E, Eliyahu S, Ziw M, Ben-Ami M. Routine thyroid function tests in infertile women : Are they necessary? Am J Obstet Gynecol 1994; 11 (91): 171.
Sharma N, Baliarsingh S, Kaushik GG. Biochemical association of hyperprolac-tinemia with hypothyroidism in infertile women. Clin Lab 2012; 58(7-8): 805-10.
Songur S, Cetin M. Ovulatory and anovulatory infertile women in routine thyroid function tests. Turkish Fertile Journal 1996; 4 (4): 355-7.
Thonneau P, Marchand S, Tallec A, et al. Incidence and main causes of infertility in a resident population of three French regions. Hum Reprod 1991; 6: 811-6.
Turankar S, Sonone K, Turankar A. Hyperprolactinaemia and Iİts Comparision with Hypothyroidism in Primary Infertile Women. J Clin Diagn Res 2013; 7(5): 794-6.
Unuane D, Tournaye H, Velkeniers B, Poppe K. Endocrine disorders & female infertility. Best Pract Res Clin Endocrinol Metab 2011; 25(6): 861-73.
Williams C, Giannopoulos T, Sherriff EA. Investigation of infertility with the emphasis on laboratory testing and with reference to radiological imaging. J Clin Pathol 2003; 56: 261-7.
Vaquero E, Lazzarin CD, Valensise H, Moretti C, Ramanini C. Mild thyroid abnormalities and recurrent spontaneous abortion: Diagnostic and therapeutic approach. Am J Reprod Immunol 2000; 43: 204–8.
Vayena E, Rowe P, Griffin P. Current Practices and Contro¬versies in Assisted Reprudiction. Report of a meeting on Medical, Ethical and Social Aspets of Assisted Reprodic¬tion held at WHO Headquarters; September, 17-21; Geneva – Switzerland: 2001. P.2002.

There are 25 citations in total.

Details

Primary Language	English
Journal Section	Research articles
Authors	Arzu Şahin Feyyaz Önder
Publication Date	April 27, 2016
Published in Issue	Year 2016 Volume: 2 Issue: 1

Cite

Vancouver	Şahin A, Önder F. Investigation of Thyroid Hormones and Prolactin Levels in Fertile and Infertile Women. Mid Blac Sea J Health Sci. 2016;2(1):1-6.