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AYDIN'DA, MİYADINDA DOĞAN YENİDOĞANLARIN KRANİYOFASİYAL ÖLÇÜMLERİ, LEPTİN VE IGF-1 İLE OLAN İLİŞKİLERİ

Year 2012, Volume: 13 Issue: 2, 1 - 9, 01.08.2012

Abstract

AMAÇ: Bu çalışma ile Aydın'da ilinde miyadında doğan yenidoğanların, kraniofasiyal ölçümleri için veritabanı oluşturma ve kraniyofasiyal ölçümler ile Leptin, IGF-1 arasındaki ilişkiyi araştırma amaçlanmıştır.GEREÇ ve YÖNTEM: Sağlıklı, miyadında 152 yenidoğan (78 erkek, 74 kız) çalışmayı oluşturdu. Bunlardan 39'u (23 erkek ve 16 kız) 3000 gr'dan daha az doğum ağırlığına sahipti. Kraniofasiyal ölçümler; baş çevresi, kafa uzunluğu (g-op), baş genişliği (eu-eu), alın genişliği (ft-ft), baş yüksekliği (v-n), dış kantal mesafe (ex-ex), içkantal mesafe (en-en), palpebral fissür uzunluğu (en-ex), burun genişliği (al-al), intercommissural mesafe (chch), yüz yüksekliği (n-gn), alın yüksekliği (n-tr), yüz genişliği (zy -zy), kulak uzunluğu (sa-sba)'dan oluşmaktaydı. Ayrıca göbek kordonundan alınan kanda leptin ve IGF-1 analizleri yapıldı.BULGULAR: Verimizin tümünü kapsayan yenidoğanların cinsiyetlere göre ölçümler arası farklılıklarına bakıldığında, sadece kulak uzunluğu ve leptin sonuçlarında anlamlı farklılık saptandı. Doğum ağırlıkları 3000 gr üzerinde olan yenidoğanlarla, 3000 gr 'ın altında doğum ağırlığına sahip olan yenidoğanların ölçümleri arasında sırasıyla boy, ağırlık, baş çevresi, baş uzunluğu (g-op), baş yüksekliği (v-n), alın genişliği (ft-ft), yüz yüksekliği (n-gn), yüz genişliği (zy-zy) ölçümlerinde anlamlı farklılık görüldü. Ağırlığı 3000 gr ve üzeri olan yenidoğanlarda cinsler arasında baş genişliği, alın genişliği, yüz genişliği ve leptin yönünden farklılık görülürken IGF-1 yönünden farklılık saptanmadı. Leptin değerleri kızlarda daha yüksekti. Doğum ağırlıkları 3000 gr'dan daha az olan yenidoğanların cinslere karşılaştırmalarında hiçbir parametrede farklılığa rastlanmadı. Gerek 3000 gr üzeri, gerekse 3000 gr'ın altında ağırlığı olan yenidoğanlarda leptin ve IGF-1 ile kraniyofasiyal ölçümler arasında korelasyon görüldü.SONUÇ: Çalışma, Aydın'da doğan bebeklerin kraniyofasiyal parametreleri için bir standart oluşturabilir. Potansiyel bazı sendromlar için erken tanı sağlamaya yardımcı olabilir. Leptin ve IGF-1'in kraniyofasiyal ölçümler üzerine de etkisinin olduğunu göstermesi bakımından önemli bir veri olacağı kanısındayız

References

  • Nati
  • onal Health And Nutrition Examination Survey III. Body Measurements (Anthropometry). Westat Inc, Rockville,1988:1-1.
  • Zweig BE. Esthetic analysis of the cervicofacial region. Atlas Oral Maxillofac Surg Clin North Am 2000; 8(2):1-11.
  • Colleen MacLachlan, Howard C. Howland. Normal values and standard
  • interpupillary distance in subjects aged 1 month to 19 years. Ophthalmic Physiol Opt 2002;22(3):175-82.
  • Merlob P, Sivan Y, Reisner SH. Anthropometric measurements of the newborn infant (27 to 41 gestational weeks). Birth Defects Orig Artic Ser 1984;20:1-52.
  • Jones KY. Smith's recognizable patterns of human malformation. 6th ed. Philadelphia: WB Saunders, 2006:897-9.
  • Fok TF, Hon KL, So HK, Ng PC, Wong E, Lee AK, Chang A. Auricular anthropometry of Hong Kong Chinese babies. Orthod Craniofac Res 2004 Feb;7(1):10-4.
  • El Shanti H, Al Lahham M, Batieha A. Craniofacial anthropometric measurements in a population of normal Jordanian newborns. Leb Med J 2000 48:23-8.
  • Malas MA, Sulak O, Aler A, Öktem F. Prematüre yenidoğanlarda kranyofasiyal morfoloji. Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi 1998;5(1) :25-31.
  • Malas MA, Çetin A, Kaya H, Salbacak A, Aler A, Sulak O. Normal spontan veya sezaryenle doğan yenidoğanlarda kraniofasiyal morfometrik boyutların karşılaştırılması. Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi 1999;6(1):47-51
  • The merck manual of diagnosis and therapy. In: th
  • Berkow R,editor. Hematology and oncology, 15 ed. Merck Sharp and Dohme Research Laboratories, Division of Merck & Co. Inc., Rahway, N.J., 1987:1098
  • Fok TF, Hon KL, So HK, Wong E, Hg PC, Lee AK, deviations for pupil diameter and Chang A. Facial anthropometry of Hong Kong Chinese babies. Orthod Craniofac Res 2003;6(3):164-72.
  • Agnihotri G, Singh D. Craniofacial anthropometry in 4.
  • newborns and infants. Iranian J Pediatr 2007;17(4): 332-8.
  • Golalipour MJ, Haidari K, Jahanshahi M, Farahani RM. The shapes of head and face in normal male 5.
  • newborns in South-East Of Caspian Sea (Iran-Gorgan). J Anat Soc India 2003;52 (1):28-31.
  • Pivnick EK, Rivas ML, Tolley EA, Smith SD, Presbury 6.
  • GJ. Interpupillary distance in a normal black population. Clin Genet 1999;55(3):182-91.
  • Omotade OO. Facial measurements in the newborn (towards syndrome delineation). J Medical Genet 7. 1990;27:358-62.
  • Wu KH, Tsai FJ, Li TC, Tsai CH, Peng CT, Wang TR. Normal values of inner canthal distance, interpupillary 8.
  • distance and palpebral fissure length in normal Chinese children in Taiwan Acta Paediatr Taiwan 2000; 41(1):22.
  • Madjarova LM, Madzharov MM, Farkas LG, Katic 9.
  • MJ. Anthropometry of soft-tissue orbits in Bulgarian newborns: norms for intercanthal and biocular widths and length of palpebral fissures in 100 boys and 100 girls. Cleft Palate Craniofac J 1999;36(2):123-6.
  • Özkağnıcı A, Büyükmumcu M, Zengin N, Gündüz K, 10. Nakano Y, Itabashi K, Nagahara K, Sakurai M, Aizawa Koç H. Ocular and periorbital anthropometric measurements in term Turkish newborns. Surg Radiol Anat 2001;23(5):321-4.
  • index gain. Pediatr Int 2012;54(1):76-80.
  • Leung AK, Ma KC, Siu TO, Robson WL. Palpebral 11. Hoggard N, Haggarty P, Thomas L, Lea RG. Leptin fissure length. In Chinese newborn infants. Comparison with other ethnic groups. Clin Pediatr (Phila) 1990; 29(3):172-4.
  • Transactions 2001;29 (Pt 2):57-63.
  • Le TT, Farkas LG, Ngim RC, Levin LS, Forrest CR. 12. Mantzoros CS, Rifas-Shiman SL, Williams CJ, Proportionality in Asian and North American Caucasian faces using neoclassical facial canons as criteria. Aesthetic Plast Surg 2002;26(1):64-9.
  • children at 3 years of age: a prospective cohort study. Pediatrics 2009;123(2): 682-9.
  • Shah M, Verma IC, Mahadevan S, Puri RK. Facial anthropometry in newborns in Pondicherry. Indian J Pediatr 1991;58:259-63.
  • E, Kogevinas M. Leptin levels in cord blood and anthropometric measures at birth: a systematic review and meta-analysis. Paediatr Perinat Epidemiol 2011;25(2):150-63
  • Colorado M, Costa TP, Perez SV, Gomez PM. Interorbital distance in the skull of the newborn infant. An Esp Pediatr 1988; 28(2):108-10
  • Chou CT, Tseng YC, Tsai FJ, Lin CC, Liu CS, Peng CT, 14. Kratzsch J, Schubring C, Stitzel B, Böttner A, Berthold Tsai CH. Measurement of ear length in neonates, infants and preschool children in Taiwan. Acta Paediatr Taiwan. 2002;43(1):40-2.
  • neonates: relations to anthropometric data. J. Clin Endocrinol Metab 2005;90(4):2212-7.
  • Kalcioglu MT, Toplu Y, Ozturan O, Yakici C. Anthropometric growth study of auricle of healthy preterm and term newborns. Int J Pediatr Otorhinolaryngol 2006; 70: 121-7.
  • University Pres, 1989.
  • Lian WB, Cheng MS, Tiong IH, Yeo CL. Auricular 16. Farkas LG, Hreczko TM, Katic MJ, Forrest CR. anthropometry of newborns at the Singapore General Hospital. Ann Acad Med Singapore 2008;37:383-9.
  • Petridou E, Mantzoros CS, Belechri M, Skalkidou A, 5 years of age. J Craniofac Surg 2003; 14(1):13-28.
  • Dessypris N, Papathoma E, Salvanos H, Lee JH, Kedikoglou S, Chrousos G, Trichopoulos D. Female gender, birth length, IGF-I levels and formula feeding. Clin Endocrinol (Oxf) 2005; 62(3): 366-71.
  • Lakho GR, Haq Z, Chundrigar T, Nazir K, Qureshi MA. Cord blood leptin levels in Pakistani newborns: relationship with birth weight, length and occipitofrontal circumference. J Coll Physicians Surg Pak 2006;16(6):393-5.
  • Savino F, Liguori SA, Oggero R, Silvestro L, Miniero R. Maternal BMI and serum leptin concentration of infants in the first year of life. Acta Paediatr 2006; 95(4): 414-8
  • Yeung LP, Wong AC, Wang X, Birmingham CL, Lewicka S, Chanoine JP. Different relationship between anthropometric markers and umbilical cord plasma leptin in Asian and Caucasian neonates Pediatr Res 2003; 53(6):1019-24.
  • Akcurin S, Velipasaoglu S, Akcurin G, Guntekin M. Leptin profile in neonatal gonadotropin surge and relationship between leptin and body mass index in early infancy. J Pediatr Endocrinol Metab 2005;18(2):189-95.
  • Savino F, Fissore MF, Grassino EC, Nanni GE, Oggero R, Silvestro L. Ghrelin, leptin and IGF-I levels in breast-fed and formula-fed infants in the first years of life Acta Paediatr 2005; 94(5): 531-7.
  • Itoh I, Ikeda M, Sueno K, Sugiura M, Suzuki S, Kida A. Anthropometric study on normal human auricle in Japan (Japanes). Nippon Jibinkoka Gakkai Kaiho 2001;104(2):165-74. YAZIŞMA ADRESİ
  • Uzm.Dr Ayfer Metin TELLİOĞLU
  • Adnan Menderes Üniversitesi Tıp Fakültesi,
  • Anatomi Anabilim Dalı, AYDIN, TÜRKİYE E-Posta
  • : ayfertellioglu@yahoo.com Geliş Tarihi Kabul Tarihi : 31.07.2012

Craniofacial Measurements of Newborns Born in Term in Aydın and Relations with Leptin and IGF-1

Year 2012, Volume: 13 Issue: 2, 1 - 9, 01.08.2012

Abstract

OBJECTIVE: We aimed to provide a database for the craniofacial measurements of newborn infants in Aydın, Turkey as well as to investigate the relation between craniofacial measurements and leptin/IGF-1 levels. MATERIALS and METHODS: A total of 152 healthy full-term infants (78 males, 74 females) were taken into study, which 23 male ve 16 female infants were weighting less than 3000 gr. The anthropometric measurements applied included head circumference, head length (g-op), head width (eu-eu), forehead width (ft-ft), head height (v-n), outer canthal distance (ex-ex), intercanthal distance (en-en), palpebral fissure length (en-ex), nasal width (al-al), intercommissural distance (ch-ch), facial height (n-gn), forehead height (n-tr), facial width (zy-zy), ear length (sa-sba). Also, leptin and IGF-1 levels were determined in umblical cord blood. RESULTS: Significant differences between the sexes, were found only in the length of ear and leptin results (p<0.05). In comparison of higher and lower than 3000 gr newborn infants, significant differences were observed in height, weight, head circumference, head length (g-op), head height (vn), head width (eu-eu), face width (ft -ft), face height (n-gn), face width (zy-zy) measurements. In higher than 3000 gr newborn infants, while there were significant differences between the sexes in terms of head width, forehead width, facial width and leptin levels, but there was no difference for IGF-1 levels. Leptin levels were higher in girls in the same group. No parameters were significant between the sexes in lower than 3000 gr newborn infants. A correlation was observed between leptin/IGF-1 levels and craniofacial measurements in higher and lower than 3000 gr groups. CONCLUSION: This study may establish the full-term newborn infants' standard of craniofacial parameters for newborn babies in Aydın, potentially enabling early syndromal diagnosis. We believe that these results could be a valuable data in the future because it shows that leptin and IGF-1 may have an effect on the craniofacial measurements.

References

  • Nati
  • onal Health And Nutrition Examination Survey III. Body Measurements (Anthropometry). Westat Inc, Rockville,1988:1-1.
  • Zweig BE. Esthetic analysis of the cervicofacial region. Atlas Oral Maxillofac Surg Clin North Am 2000; 8(2):1-11.
  • Colleen MacLachlan, Howard C. Howland. Normal values and standard
  • interpupillary distance in subjects aged 1 month to 19 years. Ophthalmic Physiol Opt 2002;22(3):175-82.
  • Merlob P, Sivan Y, Reisner SH. Anthropometric measurements of the newborn infant (27 to 41 gestational weeks). Birth Defects Orig Artic Ser 1984;20:1-52.
  • Jones KY. Smith's recognizable patterns of human malformation. 6th ed. Philadelphia: WB Saunders, 2006:897-9.
  • Fok TF, Hon KL, So HK, Ng PC, Wong E, Lee AK, Chang A. Auricular anthropometry of Hong Kong Chinese babies. Orthod Craniofac Res 2004 Feb;7(1):10-4.
  • El Shanti H, Al Lahham M, Batieha A. Craniofacial anthropometric measurements in a population of normal Jordanian newborns. Leb Med J 2000 48:23-8.
  • Malas MA, Sulak O, Aler A, Öktem F. Prematüre yenidoğanlarda kranyofasiyal morfoloji. Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi 1998;5(1) :25-31.
  • Malas MA, Çetin A, Kaya H, Salbacak A, Aler A, Sulak O. Normal spontan veya sezaryenle doğan yenidoğanlarda kraniofasiyal morfometrik boyutların karşılaştırılması. Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi 1999;6(1):47-51
  • The merck manual of diagnosis and therapy. In: th
  • Berkow R,editor. Hematology and oncology, 15 ed. Merck Sharp and Dohme Research Laboratories, Division of Merck & Co. Inc., Rahway, N.J., 1987:1098
  • Fok TF, Hon KL, So HK, Wong E, Hg PC, Lee AK, deviations for pupil diameter and Chang A. Facial anthropometry of Hong Kong Chinese babies. Orthod Craniofac Res 2003;6(3):164-72.
  • Agnihotri G, Singh D. Craniofacial anthropometry in 4.
  • newborns and infants. Iranian J Pediatr 2007;17(4): 332-8.
  • Golalipour MJ, Haidari K, Jahanshahi M, Farahani RM. The shapes of head and face in normal male 5.
  • newborns in South-East Of Caspian Sea (Iran-Gorgan). J Anat Soc India 2003;52 (1):28-31.
  • Pivnick EK, Rivas ML, Tolley EA, Smith SD, Presbury 6.
  • GJ. Interpupillary distance in a normal black population. Clin Genet 1999;55(3):182-91.
  • Omotade OO. Facial measurements in the newborn (towards syndrome delineation). J Medical Genet 7. 1990;27:358-62.
  • Wu KH, Tsai FJ, Li TC, Tsai CH, Peng CT, Wang TR. Normal values of inner canthal distance, interpupillary 8.
  • distance and palpebral fissure length in normal Chinese children in Taiwan Acta Paediatr Taiwan 2000; 41(1):22.
  • Madjarova LM, Madzharov MM, Farkas LG, Katic 9.
  • MJ. Anthropometry of soft-tissue orbits in Bulgarian newborns: norms for intercanthal and biocular widths and length of palpebral fissures in 100 boys and 100 girls. Cleft Palate Craniofac J 1999;36(2):123-6.
  • Özkağnıcı A, Büyükmumcu M, Zengin N, Gündüz K, 10. Nakano Y, Itabashi K, Nagahara K, Sakurai M, Aizawa Koç H. Ocular and periorbital anthropometric measurements in term Turkish newborns. Surg Radiol Anat 2001;23(5):321-4.
  • index gain. Pediatr Int 2012;54(1):76-80.
  • Leung AK, Ma KC, Siu TO, Robson WL. Palpebral 11. Hoggard N, Haggarty P, Thomas L, Lea RG. Leptin fissure length. In Chinese newborn infants. Comparison with other ethnic groups. Clin Pediatr (Phila) 1990; 29(3):172-4.
  • Transactions 2001;29 (Pt 2):57-63.
  • Le TT, Farkas LG, Ngim RC, Levin LS, Forrest CR. 12. Mantzoros CS, Rifas-Shiman SL, Williams CJ, Proportionality in Asian and North American Caucasian faces using neoclassical facial canons as criteria. Aesthetic Plast Surg 2002;26(1):64-9.
  • children at 3 years of age: a prospective cohort study. Pediatrics 2009;123(2): 682-9.
  • Shah M, Verma IC, Mahadevan S, Puri RK. Facial anthropometry in newborns in Pondicherry. Indian J Pediatr 1991;58:259-63.
  • E, Kogevinas M. Leptin levels in cord blood and anthropometric measures at birth: a systematic review and meta-analysis. Paediatr Perinat Epidemiol 2011;25(2):150-63
  • Colorado M, Costa TP, Perez SV, Gomez PM. Interorbital distance in the skull of the newborn infant. An Esp Pediatr 1988; 28(2):108-10
  • Chou CT, Tseng YC, Tsai FJ, Lin CC, Liu CS, Peng CT, 14. Kratzsch J, Schubring C, Stitzel B, Böttner A, Berthold Tsai CH. Measurement of ear length in neonates, infants and preschool children in Taiwan. Acta Paediatr Taiwan. 2002;43(1):40-2.
  • neonates: relations to anthropometric data. J. Clin Endocrinol Metab 2005;90(4):2212-7.
  • Kalcioglu MT, Toplu Y, Ozturan O, Yakici C. Anthropometric growth study of auricle of healthy preterm and term newborns. Int J Pediatr Otorhinolaryngol 2006; 70: 121-7.
  • University Pres, 1989.
  • Lian WB, Cheng MS, Tiong IH, Yeo CL. Auricular 16. Farkas LG, Hreczko TM, Katic MJ, Forrest CR. anthropometry of newborns at the Singapore General Hospital. Ann Acad Med Singapore 2008;37:383-9.
  • Petridou E, Mantzoros CS, Belechri M, Skalkidou A, 5 years of age. J Craniofac Surg 2003; 14(1):13-28.
  • Dessypris N, Papathoma E, Salvanos H, Lee JH, Kedikoglou S, Chrousos G, Trichopoulos D. Female gender, birth length, IGF-I levels and formula feeding. Clin Endocrinol (Oxf) 2005; 62(3): 366-71.
  • Lakho GR, Haq Z, Chundrigar T, Nazir K, Qureshi MA. Cord blood leptin levels in Pakistani newborns: relationship with birth weight, length and occipitofrontal circumference. J Coll Physicians Surg Pak 2006;16(6):393-5.
  • Savino F, Liguori SA, Oggero R, Silvestro L, Miniero R. Maternal BMI and serum leptin concentration of infants in the first year of life. Acta Paediatr 2006; 95(4): 414-8
  • Yeung LP, Wong AC, Wang X, Birmingham CL, Lewicka S, Chanoine JP. Different relationship between anthropometric markers and umbilical cord plasma leptin in Asian and Caucasian neonates Pediatr Res 2003; 53(6):1019-24.
  • Akcurin S, Velipasaoglu S, Akcurin G, Guntekin M. Leptin profile in neonatal gonadotropin surge and relationship between leptin and body mass index in early infancy. J Pediatr Endocrinol Metab 2005;18(2):189-95.
  • Savino F, Fissore MF, Grassino EC, Nanni GE, Oggero R, Silvestro L. Ghrelin, leptin and IGF-I levels in breast-fed and formula-fed infants in the first years of life Acta Paediatr 2005; 94(5): 531-7.
  • Itoh I, Ikeda M, Sueno K, Sugiura M, Suzuki S, Kida A. Anthropometric study on normal human auricle in Japan (Japanes). Nippon Jibinkoka Gakkai Kaiho 2001;104(2):165-74. YAZIŞMA ADRESİ
  • Uzm.Dr Ayfer Metin TELLİOĞLU
  • Adnan Menderes Üniversitesi Tıp Fakültesi,
  • Anatomi Anabilim Dalı, AYDIN, TÜRKİYE E-Posta
  • : ayfertellioglu@yahoo.com Geliş Tarihi Kabul Tarihi : 31.07.2012
There are 51 citations in total.

Details

Other ID JA42VP25YR
Journal Section Research Article
Authors

Sacide Karakaş This is me

Aslıhan Karul This is me

Mustafa Altınışık This is me

Münevver Kaynak Türkmen This is me

Ayfer Metin Tellioğlu This is me

Döndü Kurnaz Aslan

Publication Date August 1, 2012
Published in Issue Year 2012 Volume: 13 Issue: 2

Cite

EndNote Karakaş S, Karul A, Altınışık M, Türkmen MK, Tellioğlu AM, Aslan DK (August 1, 2012) Craniofacial Measurements of Newborns Born in Term in Aydın and Relations with Leptin and IGF-1. Meandros Medical And Dental Journal 13 2 1–9.