İkinci ve üçüncü trimester gebelerde artırılmış derinlik optik koherens tomografi ile koroid kalınlık ölçümü
Abstract
Amaç: Gebelerde ikinci ve üçüncü trimesterde artırılmış derinlik görüntüleme (Enhanced Depth İmaging –EDİ) Optik Koherens Tomografi (OKT) kullanarak koroid kalınlıgı belirlemek.
Yöntemler: Bu calısmada 40 gebe ile gebe olmayan (kontrol) 40 sağlıklı kadının her iki gözü EDİ-OKT kullanarak subfoveal, 2 mm nazal, 2 mm temporal koroidal kalınlıkları değerlendirildi. Gebelerden 20’ si 16-24. haftalar arası (ikinci trimester), 20’ si 24-39. haftalar arası (üçüncü trimester) olarak 2 gruba ayrıldi. Yaş ortalaması gebelerde 27.4±5.8, kontrol grubunda 26.9±7.1 olarak hesaplandı.
Bulgular: Gebelerde koroid kalınlıkları EDİ-OKT ile sağ gözde subfoveal 295.3±51.8μm, 2 mm nazal 242.4±49.2μm (p=0.032); 2 mm temporal 252.3±52.9μm (p=0.001) iken sol göz ölçümlerinde subfoveal 298.4±66.7μm, 2 mm nazal 251.5±54.7μm, 2 mm temporal 263.6±64.3μm (p=0.044) olarak kaydedildi. Kontrol grubunda sağ göz subfoveal 307.8±64.5μm, 2 mm nazal 267.6±54.2μm, 2 mm temporal 292.9±50.9μm, sol göz subfoveal 295.3±71.3μm, 2 mm nazal 269.6±63.7μm, 2 mm temporal 292.0±59.5μm olarak ölçüldü. Gebe grubu ile kontrol grubu koroid kalınlığı karşılaştırıldığında sağ göz 2 mm nazal (p=0.032) ve 2 mm temporal (p=0.001) alanlar ile sol göz 2 mm temporal (p=0.044) alanda kalınlık kontrol grubunda daha yüksek olup istatistiksel olarak anlamlı fark saptanmıştır. Diğer bölgelerde fark bulunmamıştır (p>0.05).
Sonuç: Bu çalışmada gebe hastalarda benzer yaş grubu ile kıyaslandığında EDİ OKT ile yapılan koroid kalınlık ölçümünün daha ince olduğu tespit edilmiştir.
References
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- 3. Macdonald-Wallis C, Tilling K, Fraser A, Nelson SM, Lawlor DA. Established pre-eclampsia risk factors are related to patterns of blood pressure change in normal term pregnancy: findings from the Avon Longitudinal Study of Parents and Children (ALSPAC). J Hypertens. 2011; 29:1703-11. doi: 10.1097/HJH.0b013e328349eec6
- 4. Cankaya C, Bozkurt M, Ulutas O. Total macular volume and foveal retinal thickness alterations in healthy pregnant women. Semin Ophthalmol. 2013; 28:103-5. doi:10.3109/08820538.2012.760628
- 5. Cioffi GA, Granstam C,Alm A. Ocular circulation. In:Kaufman PL,Alm A, editors.Ader’s physiology of the eye: clinical application. 10th edSt. Louis: Mosby . P.2003;747-84
- 6. Errera M-H, Kohly RP, DA Cruz L.Pregnancy-associated retinal diseases and their management. Surv Ophthalmol.2013; 58:127–42. doi: 10.1016/j.survophthal.2012.08.001
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- 11. Spaide RF, Koizumi H, Pozonni MC Enhanced depth imaging spectral-domain optical coherence tomography. Am J Ophthalmol2008;146:496–500. doi: 10.1016/j.ajo.2008.05.032.
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- 13. Savaş HB, Köse SA, Güler M, Gültekin F. [The relationship between the second trimester screening biochemical markers and complications and anomalies in pregnant women.] Acta Med. Alanya 2017;1(1):7-10. Turkish Doi: 10.30565/medalanya.265994
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- 20. Nakai K, Gomi F, Ikuno Y, Yasuno Y, Nouchi T,Ohguro N et al Choroidal observations in Vogt-Koyanagi-harada disease using high-penetration optical coherence tomography. Graefes Arch clin Exp Ophthalmol.2012; 2:1089-1095 doi: 10.1007/s00417-011-1910-7
- 21. Esmaeelpour M, Povazay B, Hernann B,Hofer B, Kajie V, Hale SL et al Mapping choroidal and retinal thickness variation in type 2 diabetes using three-dimensional 1060-nm optical coherence tomography. İnvest Ophthalmol Vis Sci. 2011;52:5311-5316 doi: 10.1167/iovs.10-6875
- 22. Kara N, Sayin N, Pirhan D, Vural AD, Araz-Ersan HB, Tekirdag AI et al Evaluation of subfoveal choroidal thickness in pregnant women using enhanced depth imaging optical coherence tomography. Curr Eye Res.2014; 39:642-7 doi: 10.3109/02713683.2013.855236
- 23. Sayin N, Kara N, Pirhan D, Vural A, Araz Ersan HB, Tekirdag AI et al Subfoveal choroidal thickness in pre-eclampsia: comparison with normal pregnant and nonpregnant women. Semin Ophthalmol.2014; 29:11–17. doi: 10.3109/08820538.2013.839813
- 24. Takahashi J, Kado M, Mizumoto K, Igarashi S, Kojo T. Choroidal thickness in pregnant women measured by enhanced depth imaging optical coherence tomography. Jpn J Ophthalmol.2013; 57:435–9 doi: 10.1007/s10384-013-0265-5
- 25. Ulusoy MD, Duru N, Atas M, Altinkaynak H, Duru Z, Acmaz G. Measurement of choroidal thickness abd macular thickness during and after pregnancy İnt J Ophthalmol. 2015; 8:312-325 doi: 10.3980/j.issn.2222-3959.2015.02.19
Choroid thickness measurement in second and third trimester pregnancies by enhanced depth imaging optical coherence tomography
Abstract
Aim: Evaluation of choroid thickness in 2nd and 3rd trimester pregnancies by Enhanced Depth Imaging –EDI Optic Coherence Tomography (OCT).
Patients and Methods: In this study, the subfoveal, 2 mm nasal, 2 mm temporal choroidal thicknesses of both eyes in 40 pregnant and 40 non-pregnant (control) women were evaluated. The pregnant women were categorized in 2 groups, 20 being 16-24 weeks pregnant (second trimester) and 20 being 24-39 weeks pregnant (third trimester). The average age of the pregnant women and non-pregnant women was calculated as 27.4±5.8 and 26.9±7.1, respectively.
Results: The choroid thicknesses in the pregnant women were recorded by EDI-OCT as follows; right eye subfoveal 295.3±51.8μm, 2 mm nasal 242.4±49.2μm, 2 mm temporal 252.3±52.9μm and left eye subfoveal 298.4±66.7μm, 2 mm nasal 251.5±54.7μm, 2 mm temporal 263.6±64.3μm. The control group was recorded as follows; right eye subfoveal 307.8±64.5μm, 2 mm nasal 267.6±54.2μm, 2 mm temporal 292.9±50.9μm and left eye subfoveal 295.3±71.3μm, 2 mm nasal 269.6±63.7μm, 2 mm temporal 292.0±59.5μm. The comparison of the choroid thicknesses in the pregnant subjects and the control group shows that the thickness in the 2 mm nasal (p=0.032) and 2 mm temporal (p=0.001) areas of the right eye and 2 mm temporal (p=0.044) area of the left eye is significantly different. No significant difference was observed in the other areas (p>0.05)
Conclusions: In this study, choroidal thickness measurement with EDI OCT was found to be thinner in pregnant patients compared to similar age group.
References
- 1. Chapman AB, Abraham WT, Zamudio S, Coffin C, Merouani A, Young D et al Temporal relationships between hormonal and hemodynamic changes in early human pregnancy. Kidney Int. 1998; 54:2056–63 doi:10.1046/j.1523-1755.1998.00217.x
- 2. Moutquin JM, Rainville C, Giroux L, Raynauld P, Amyot G, Bilodeau R et al A prospective study of blood pressure in pregnancy: prediction of preeclampsia. Am J Obstet Gynecol.1985;151:191-6 doi:10.1016/0002-9378(85)90010-9
- 3. Macdonald-Wallis C, Tilling K, Fraser A, Nelson SM, Lawlor DA. Established pre-eclampsia risk factors are related to patterns of blood pressure change in normal term pregnancy: findings from the Avon Longitudinal Study of Parents and Children (ALSPAC). J Hypertens. 2011; 29:1703-11. doi: 10.1097/HJH.0b013e328349eec6
- 4. Cankaya C, Bozkurt M, Ulutas O. Total macular volume and foveal retinal thickness alterations in healthy pregnant women. Semin Ophthalmol. 2013; 28:103-5. doi:10.3109/08820538.2012.760628
- 5. Cioffi GA, Granstam C,Alm A. Ocular circulation. In:Kaufman PL,Alm A, editors.Ader’s physiology of the eye: clinical application. 10th edSt. Louis: Mosby . P.2003;747-84
- 6. Errera M-H, Kohly RP, DA Cruz L.Pregnancy-associated retinal diseases and their management. Surv Ophthalmol.2013; 58:127–42. doi: 10.1016/j.survophthal.2012.08.001
- 7. Ataş M, Duru N, Ulusoy DM, Altınkaynak H, Duru Z, Açmaz G et al Evaluation of anterior segment parameters during and after pregnancy. Contact Lens Anterior Eye. 2014;37:447–50. doi: 10.1016/j.clae.2014.07.013
- 8. Haimovici R,Koh S, Gagnon DR, Lehrfeld T, Wellik S. Risk factors for central serous chorioretinopathy: a case-control study. Ophthalmology 2004;111:244–9 doi: 10.1016/j.ophtha.2003.09.024
- 9. Tsuiki E, Suzuma K, Ueki R, Maekawa Y, Kitaoka T. Enhanced depth imaging optical coherence tomography of the choroid in central retinal vein occlusion. Am J Ophthalmol.2013;156:543–7. doi: 10.1016/j.ajo.2013.04.008.
- 10. Imamura Y, Fujiwara T, Margolis R, Spaide RF. Enhanced depth imaging optical coherence tomography of the choroid in central serous chorioretinopathy. Retina Phila Pa. 2009; 29:1469–73 doi: 10.1097/IAE.0b013e3181be0a83
- 11. Spaide RF, Koizumi H, Pozonni MC Enhanced depth imaging spectral-domain optical coherence tomography. Am J Ophthalmol2008;146:496–500. doi: 10.1016/j.ajo.2008.05.032.
- 12. Margolis R, Spaide R. A pilot study of enhanced depth imaging optical coherence tomography of the choroid in normal eyes. AmJ Ophthalmol.2009; 147:811–5. doi: 10.1016/j.ajo.2008.12.008
- 13. Savaş HB, Köse SA, Güler M, Gültekin F. [The relationship between the second trimester screening biochemical markers and complications and anomalies in pregnant women.] Acta Med. Alanya 2017;1(1):7-10. Turkish Doi: 10.30565/medalanya.265994
- 14. Lareiprele G, Valensise H, Vasapollo B, Altomare F, Sorge R, Casalino B et al Body composition during normel pregnancy: refernce range. Acta Diabctol.2003; 40:225 -232 doi:10.1007/s00592-003-0072-4
- 15. Nickla DL, Wallman J. The multifunctional choroid. Prog Retin Eye Res. 2010; 29:144 -168 doi: 10.1016/j.preteyeres.2009.12.002
- 16. Goldich Y, Cooper M, Barkana Y, Tovbin J, Lee Ovadia K, Avni I et al Ocular anterior segment changes in pregnancy. J Cataract Refract Surg.2014; 40:1868 –71 doi: 10.1016/j.jcrs.2014.02.042
- 17. Manjunath V, Gren J, Fujimoto JG, Duker JS. Analysis of choroidal thickness in age-related macular degeneration using spectral-domain optical coherence tomography. Am J Ophthalmol.2011; 152:663-668 doi: 10.1016/j.ajo.2011.03.008
- 18. Kim SW, Oh J, Kwon SS, Yoo J, Huh K. Comparision of choroidal thickness among patients with healthy eyes, early age-related maculopathy, neovascular age-related macular degeneration, central serous chorioretinopathy and polyypoidal choroidal vacsulopathy. Retina 2011; 31:1904-1911 doi: 10.1097/IAE.0b013e31821801c5
- 19. Harada T, Machida S, Fujiwara T, Nishida Y, Kurusaka D. Choroidal findings in idiopathic uveal effusion syndrome. Clin Ophthalmol.2011; 5:1599-1601 doi: 10.2147/OPTH.S26324
- 20. Nakai K, Gomi F, Ikuno Y, Yasuno Y, Nouchi T,Ohguro N et al Choroidal observations in Vogt-Koyanagi-harada disease using high-penetration optical coherence tomography. Graefes Arch clin Exp Ophthalmol.2012; 2:1089-1095 doi: 10.1007/s00417-011-1910-7
- 21. Esmaeelpour M, Povazay B, Hernann B,Hofer B, Kajie V, Hale SL et al Mapping choroidal and retinal thickness variation in type 2 diabetes using three-dimensional 1060-nm optical coherence tomography. İnvest Ophthalmol Vis Sci. 2011;52:5311-5316 doi: 10.1167/iovs.10-6875
- 22. Kara N, Sayin N, Pirhan D, Vural AD, Araz-Ersan HB, Tekirdag AI et al Evaluation of subfoveal choroidal thickness in pregnant women using enhanced depth imaging optical coherence tomography. Curr Eye Res.2014; 39:642-7 doi: 10.3109/02713683.2013.855236
- 23. Sayin N, Kara N, Pirhan D, Vural A, Araz Ersan HB, Tekirdag AI et al Subfoveal choroidal thickness in pre-eclampsia: comparison with normal pregnant and nonpregnant women. Semin Ophthalmol.2014; 29:11–17. doi: 10.3109/08820538.2013.839813
- 24. Takahashi J, Kado M, Mizumoto K, Igarashi S, Kojo T. Choroidal thickness in pregnant women measured by enhanced depth imaging optical coherence tomography. Jpn J Ophthalmol.2013; 57:435–9 doi: 10.1007/s10384-013-0265-5
- 25. Ulusoy MD, Duru N, Atas M, Altinkaynak H, Duru Z, Acmaz G. Measurement of choroidal thickness abd macular thickness during and after pregnancy İnt J Ophthalmol. 2015; 8:312-325 doi: 10.3980/j.issn.2222-3959.2015.02.19
Details
| Primary Language | English |
|---|---|
| Subjects | Surgery |
| Journal Section | Research Article |
| Authors | |
| Publication Date | August 23, 2019 |
| Submission Date | April 7, 2019 |
| Acceptance Date | May 21, 2019 |
| Published in Issue | Year 2019 Volume: 3 Issue: 2 |
This Journal is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.