Research Article
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The Relationship of Serum Lipid Profile With Preeklampsia Prediction and Newborn Result

Year 2021, Volume: 5 Issue: 3, 347 - 352, 25.12.2021
https://doi.org/10.29058/mjwbs.871805

Abstract

Aim: To investigate the benefit of first trimester lipid profile in predicting preeclampsia and its relationship
with neonatal outcomes.
Material and Methods: Plasma concentrations of cholesterol, triglyceride, HDL, LDL were meausred in
121 women with preeclampsia (PE) and in 99 healthy pregnant women in the first trimester (<12 weeks).There was a comparison between groups with and without PE. The relationship between lipid profile of each group and neonatal outcomes
was evaluated.
Results: There was no significant difference between the groups in gravida and parity numbers. Differences were found between age, body
mass index (BMI) measurements, birth weeks, birth weights, and NICU acceptance values. Babies in the PE group had lower mean birth
weeks, birth weight and APGAR scores. Babies in the PE group had a higher rate of cesarean delivery. When the laboratory results are
examined among the groups; All lipid measurements in the PE group were found to be significantly lower.
Conclusion: The serum lipid profile in the first trimester was found to be lower in the PE group compared to the control group. Although
low HDL is an expected finding, the others are not expected. This suggests that the serum lipid profile may be insufficient to predict the
development of PE.

References

  • 1. American College of Obstetricians and Gynecologists; Task Force on Hypertension in Pregnancy. Hypertension in pregnancy. Report of the American College of Obstetricians and Gynecologists’ Task Force on Hypertension in Pregnancy. Obstet Gynecol 2013;122:1122–31.
  • 2.Ecemis T, Simsir C, Ecemis SS, Kinci OS, Gelisen O. Lipoprotein (a) and preeclampsia Is Serum Lipoprotein (A) Level Elevated in Preeclampsia Patients? Gazi Medical J. 2020;31:184-7.
  • 3. Bonetti PO, Lerman LO, Lerman A. Endothelial dysfunction: a marker of atherosclerotic risk. Arterioscler Thromb Vasc Biol. 2003;23(2):168-75.
  • 4. Lima VJD, Andrade CRD, Ruschi GE, Sass N. Serum lipid levels in pregnancies complicated by preeclampsia. Sao Paulo Medical Journal. 2011;129(2), 73-6.
  • 5. Paudel KR, Panth N, Kim DW. Circulating endothelial microparticles: a key hallmark of atherosclerosis progression. Scientifica. 2016;2016:8514056.
  • 6. Ohashi R, Mu H, Yao Q, Chen C. Atherosclerosis: immunopathogenesis and immunotherapy. Med Sci Monit. 2004;10(11):RA255-60.
  • 7.F. D. H. Olalere, B. O. Okusanya & B. A. Oye-Adeniran. Maternal serum lipid in women with preeclampsia in Lagos: a case control study. The Journal of Maternal-Fetal & Neonatal Medicine 2020;33:5,794-798
  • 8.Yeboah FA, Ngala RA, Bawah AT. Et al (2017). Adiposity and hyperleptinemia during the first trimester among pregnant women with preeclampsia. International Journal of Women'sHealth. 2017;9: 449-54
  • 9. Baker AM., Klein RL., Moss KL., Haeri S, Boggess K. Maternal serum dyslipidemia occurs early in pregnancy in women with mild but not severe preeclampsia. American Journal of Obstetrics and Gynecology. 2009;201.3:293.e1
  • 10. Llurba E., Elena Casals E., Domínguez C. et al. Atherogenic lipoprotein subfraction profile in preeclamptic women with and without high triglycerides: different pathophysiologic subsets in preeclampsia, Metabolism. 2005;54.11:1504-9
  • 11. Enquobahrie DA., Williams MA., Butler CL., O. Frederick IO., Miller RS., Luthy DA.. Maternal plasma lipid concentrations in early pregnancy and risk of preeclampsia, American Journal of Hypertension. 2004;17.7:574-81
  • 12. Ray JG, Diamond P, Singh G, Bell CM. Brief overview of maternal triglycerides as a risk factor for pre-eclampsia. BJOG. 2006;113(4):379-86.
  • 13. Nabih I. El Khouly, Zakaria F. Sanad, Said A. Saleh, Ayman A. Shabana, Alaa F. Elhalaby&Eman E. Badr (2016) Value of first-trimester serum lipid profile in early prediction of preeclampsia and its severity: A prospective cohort study, Hypertension in Pregnancy. 2016;35.1:73-81.
  • 14. Ware-Jaureguim S., Sanchez S. E, Zhang C., Laraburre G., King B. I., Williams M. A.. Plasma lipid concentrations in preeclamptic and normotensive Peruvian women. Int J Gynecol Obstet. 1999;67:147–55.
  • 15. Williams MA, Godfrey BW, Irena BK, Laura J, Kassam M. Plasmacarotenoids, retinol, tocopherols, and lipoproteins in preeclamptic and normotensive pregnant Zimbabwe an women. Am J Hypertens 2003;16:665–72.
  • 16. Parlakgumus HA, Aytac PC, Kalaycı H, Tarim E. First trimester maternal lipid levels and serum markers of small- and large-for-gestational age infants. J Matern Fetal Neonatal Med. 2014;27(1):48-51.
  • 17. Jiang S., Jiang J., Xu H. et al. Maternal dyslipidemia during pregnancy may increase the risk of preterm birth: A meta-analysis. Taiwanese Journal of Obstetrics and Gynecology. 2017;56.1:9-15.

Serum Lipid Profilinin Preeklampsi Öngörüsü ve Yenidoğan Sonuçları ile İlişkisi

Year 2021, Volume: 5 Issue: 3, 347 - 352, 25.12.2021
https://doi.org/10.29058/mjwbs.871805

Abstract

Amaç: İlk trimester lipid profilinin preeklampsi öngörüsünde faydasını ve yenidoğan sonuçlarıyla olan
ilişkisini araştırmaktır.
Gereç ve Yöntemler: Çalışmaya preeklampsi (PE) tanısı almış 121 hasta ve 99 sağlıklı gebe kadın
dahil edildi. Çalışma retrospektif olarak dizayn edilmiştir. Hastaların yaş, gravida, parite, vücut kütle
indeksi (VKI), doğum şekli, doğum kilosu, APGAR skoru, yenidoğan yoğun bakım ünitesi (YYBÜ) kabulü
ve doğum haftası kaydedildi. Laboratuvar analizlerinde ilk trimester (<12 hafta) kolesterol, trigliserid,
HDL, LDL düzeyleri tespit edildi. PE’li ve PE’siz iki grup oluşturularak karşılaştırma yapıldı. Her grubun
lipid profili ile yenidoğan sonuçları arasındaki ilişki değerlendirildi.
Bulgular: Gruplar arasında gravida ve parite sayıları arasında anlamlı fark yoktu. Yaş, VKI ölçümleri,
doğum haftaları, doğum kiloları, YYBÜ kabulü değerleri arasında farklılık saptanmadı. PE grubundaki
bebeklerin ortalama doğum haftaları, doğum kiloları ve APGAR skorları daha düşüktü. PE grubundaki
bebeklerin sezaryan olma oranı daha yüksekti. Grupları arasında laboratuvar sonuçları incelendiğinde;
PE grubundaki tüm lipid ölçümleri anlamlı olarak daha düşüktür bulundu. Her iki grupta yenidoğan APGAR
skoru ve YYBÜ ihtiyacı ile laboratuvar sonuçları arasında anlamlı bir ilişki saptanmadı (p<0.05).
Sonuç: İlk trimesterde bakılan serum lipid profilindeki parametreler PE grubunda kontrol grubuna göre
daha düşük bulundu. HDL düşüklüğü beklenen bir bulgu olmakla beraber kolesterol, trigliserid ve LDL
düşüklüğü beklenti dışındadır. Sonuçlarımız serum lipid profilinin PE gelişmesini öngörmede yetersiz
kalabileceğini düşündürmektedir.

References

  • 1. American College of Obstetricians and Gynecologists; Task Force on Hypertension in Pregnancy. Hypertension in pregnancy. Report of the American College of Obstetricians and Gynecologists’ Task Force on Hypertension in Pregnancy. Obstet Gynecol 2013;122:1122–31.
  • 2.Ecemis T, Simsir C, Ecemis SS, Kinci OS, Gelisen O. Lipoprotein (a) and preeclampsia Is Serum Lipoprotein (A) Level Elevated in Preeclampsia Patients? Gazi Medical J. 2020;31:184-7.
  • 3. Bonetti PO, Lerman LO, Lerman A. Endothelial dysfunction: a marker of atherosclerotic risk. Arterioscler Thromb Vasc Biol. 2003;23(2):168-75.
  • 4. Lima VJD, Andrade CRD, Ruschi GE, Sass N. Serum lipid levels in pregnancies complicated by preeclampsia. Sao Paulo Medical Journal. 2011;129(2), 73-6.
  • 5. Paudel KR, Panth N, Kim DW. Circulating endothelial microparticles: a key hallmark of atherosclerosis progression. Scientifica. 2016;2016:8514056.
  • 6. Ohashi R, Mu H, Yao Q, Chen C. Atherosclerosis: immunopathogenesis and immunotherapy. Med Sci Monit. 2004;10(11):RA255-60.
  • 7.F. D. H. Olalere, B. O. Okusanya & B. A. Oye-Adeniran. Maternal serum lipid in women with preeclampsia in Lagos: a case control study. The Journal of Maternal-Fetal & Neonatal Medicine 2020;33:5,794-798
  • 8.Yeboah FA, Ngala RA, Bawah AT. Et al (2017). Adiposity and hyperleptinemia during the first trimester among pregnant women with preeclampsia. International Journal of Women'sHealth. 2017;9: 449-54
  • 9. Baker AM., Klein RL., Moss KL., Haeri S, Boggess K. Maternal serum dyslipidemia occurs early in pregnancy in women with mild but not severe preeclampsia. American Journal of Obstetrics and Gynecology. 2009;201.3:293.e1
  • 10. Llurba E., Elena Casals E., Domínguez C. et al. Atherogenic lipoprotein subfraction profile in preeclamptic women with and without high triglycerides: different pathophysiologic subsets in preeclampsia, Metabolism. 2005;54.11:1504-9
  • 11. Enquobahrie DA., Williams MA., Butler CL., O. Frederick IO., Miller RS., Luthy DA.. Maternal plasma lipid concentrations in early pregnancy and risk of preeclampsia, American Journal of Hypertension. 2004;17.7:574-81
  • 12. Ray JG, Diamond P, Singh G, Bell CM. Brief overview of maternal triglycerides as a risk factor for pre-eclampsia. BJOG. 2006;113(4):379-86.
  • 13. Nabih I. El Khouly, Zakaria F. Sanad, Said A. Saleh, Ayman A. Shabana, Alaa F. Elhalaby&Eman E. Badr (2016) Value of first-trimester serum lipid profile in early prediction of preeclampsia and its severity: A prospective cohort study, Hypertension in Pregnancy. 2016;35.1:73-81.
  • 14. Ware-Jaureguim S., Sanchez S. E, Zhang C., Laraburre G., King B. I., Williams M. A.. Plasma lipid concentrations in preeclamptic and normotensive Peruvian women. Int J Gynecol Obstet. 1999;67:147–55.
  • 15. Williams MA, Godfrey BW, Irena BK, Laura J, Kassam M. Plasmacarotenoids, retinol, tocopherols, and lipoproteins in preeclamptic and normotensive pregnant Zimbabwe an women. Am J Hypertens 2003;16:665–72.
  • 16. Parlakgumus HA, Aytac PC, Kalaycı H, Tarim E. First trimester maternal lipid levels and serum markers of small- and large-for-gestational age infants. J Matern Fetal Neonatal Med. 2014;27(1):48-51.
  • 17. Jiang S., Jiang J., Xu H. et al. Maternal dyslipidemia during pregnancy may increase the risk of preterm birth: A meta-analysis. Taiwanese Journal of Obstetrics and Gynecology. 2017;56.1:9-15.
There are 17 citations in total.

Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Research Article
Authors

Selim Gülücü 0000-0001-7494-4045

Mehmet Güçlü 0000-0002-8295-0629

Sebahattin Çelik 0000-0002-2631-1603

İlkin Seda Can 0000-0002-2029-7281

Canan Soyer Çalışkan 0000-0002-9889-5249

Samettin Çelik 0000-0002-6407-1129

Publication Date December 25, 2021
Acceptance Date June 11, 2021
Published in Issue Year 2021 Volume: 5 Issue: 3

Cite

Vancouver Gülücü S, Güçlü M, Çelik S, Can İS, Soyer Çalışkan C, Çelik S. Serum Lipid Profilinin Preeklampsi Öngörüsü ve Yenidoğan Sonuçları ile İlişkisi. Med J West Black Sea. 2021;5(3):347-52.

Medical Journal of Western Black Sea is a scientific publication of Zonguldak Bulent Ecevit University Faculty of Medicine.

This is a refereed journal, which aims at achieving free knowledge to the national and international organizations and individuals related to medical sciences in publishedand electronic forms.

This journal is published three annually in April, August and December.
The publication language of the journal is Turkish and English.