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Evaluatıon Of Neutrophil/Lymphocyte Ratıo And Mean Platelet Volume In Patıents Wıth Acute And Chronıc Subdural Hemorrhage

Year 2013, Volume: 4 Issue: 14, 23 - 30, 03.03.2015

Abstract

Aim: neutrophil/lymphocyte (N/R) ratio and mean platelet volume (MPV) values in patients with acute and chronic subdural hemorrhage. Material and methods: A total of 114 patients underwent surgery due to acute and chronic subdural hemorrhage, and patients admitted to the hospital for routine visit between 01.01.2009 and 31.12.2012 at Mustafa Kemal University Research Hospital were investigated retrospectively. The patients divided in to 3 groups. These groups were group K (control group, n=37), group ASD (acute subdural hemorrhage, n=30) and group KDS (chronic subdural hemorrhage =37). Groups were compared to each other in terms of neutrophil, lymphocyte, N/L ratio and MPV values. Results: Neutrophil values were found as follows ; Group K 3.76 (range 1.77-8.09)×103/µL, Group ASD 13.10 (range 2.15-32.90)×103/µL and Group KSD 5.27 (range 0.90-13.30)×103/µL. There was a significant difference in neutrophil values between groups K, ASD and KSD (p values; Group KASD=0.0001, Group K-KSD=0.0001, Group ASDKSD=0.0001). N/L ratio values were found as follows; Group K 2 (range 0.80-3.77), Group ASD 6.24 (range 0.31-49.25) and Group KSD 2.79 (range 0.16-23.33). There was a significant difference in N/L ratio values between groups K, ASD and KSD (p values; Group K-ASD=0.0001, Group K-KSD=0.0001, Group ASD-KSD=0.040). There were no statistically significant differences in MPV and lymphocyte count values between groups (p ˃ 0.05). Conclusion:The highest N/L ratio was found in ASD group. However, N/L ratio in KSD was higher than control group and MPV values were similar in all 3 groups. Key neutrophil/lymphocyte ratio, mean platelet volume, anesthesia

References

  • 1- Yıldırım H, Öztürk T, Esen M. Akut subdural hematomun spontan rezolüsyon ve redüstirbüsyonu: BT ve MR bulguları. Fırat Tıp Dergisi. 2011; 16: 137-140.
  • 2- Camel M, Grubb RL Jr. Treatment of chronic subdural hematoma by twist-drill craniotomy with continuous catheter drainage. J Neurosurg. 1986; 65: 183- 7.
  • 3- Gibson PH, Cuthbertson BH, Croal BL, Rae D, El-Shafei H, Gibson G, Jeffrey RR, Buchan KG, Hillis GS. Usefulness of neutrophil/lymphocyte ratio as predictor of newonset atrial fibrillation after coronary artery bypass grafting. Am J Cardiol. 2010; 105: 186-91.
  • 4- Yamanaka T, Matsumoto S, Teramukai S, Ishiwata R, Nagai Y, Fukushima M. The baseline ratio of neutrophils to lymphocytes is associated with patient prognosis in advanced gastric cancer. Oncology. 2007; 73: 215-20.
  • 5- Ziai WC, Torbey MT, Kickler TS, Oh S, Bhardwaj A, Wityk RJ. Platelet count and function in spontaneous intracerebral hemorrhage. J Stroke Cerebrovasc Dis. 2003; 12: 201-6.
  • 6- Arıkanoğlu A, Çevik MU, Uzar E, Acar A, Akıl E, Ekici F, Taşdemir N. İntraserebral kanamalı hastalarda ortalama trombosit hacminin artışı. Türk Nöroloji Dergisi. 2012; 18: 54-6.
  • 7- Keçik Y. Nöroanestezi. Tüzüner F, editör. Anestezi yoğun bakım ağrı. Ankara: NM Medikal & Nobel Tıp Kitabevi; 2010. sayfa. 947-71.
  • 8- Baechli H, Nordmann A, Bucher HC, Gratzl O. Demographics and prevalent risk factors of chronic subdural haematoma: results of a large single-center cohort study. Neurosurg Rev. 2004; 27: 263-6.
  • 9- Tuğcu B, Tanrıverdi O, Baydın S, Günaldı Ö, Ofluoğlu E, Demirgil BT. Tekrarlayan kronik subdural hematomlar önceden öngörülebilir mi? 136 olgunun retrospektif analizi. Düşünen Adam Psikiyatri ve Nörolojik Bilimler Dergisi. 2010; 23: 44-9.
  • 10- Kamışlı S, Kamışlı Ö, Gönüllü S, Kaplan Y, Özcan C. Erken lökosit ve nötrofil yüksekliğinin serebral venöz trombozda prognostik önemi. Türk Beyin Damar Hastalıkları Dergisi. 2012; 18: 39-42.
  • 11- Buck BH, Liebeskind DS, Saver JL, Bang OY, Yun SW, Starkman S, Ali LK, Villablanca JP, Salamon N, Razinia T, Ovbiagele B. Early neutrophilia is associated with volume of ischemic tissue in acute stroke. Stroke. 2008; 39: 355-60.
  • 12- Cho KH, Jeong MH, Ahmed K, Hachinohe D, Choi HS, Chang SY, Kim MC, Hwang SH, Park KH, Lee MG, Ko JS, Sim DS, Yoon NS, Yoon HJ, Hong YJ, Kim KH, Kim JH, Ahn Y, Cho JG, Park JC, Kang JC. Value of early risk stratification using hemoglobin level and neutrophil-to-lymphocyte ratio in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention. Am J Cardiol. 2011; 107: 849-56.
  • 13- Stewart GJ. Neutrophils and deep venous thrombosis. Haemostasis. 1993; 23 Suppl 1: 127-40.
  • 14- Korkmaz Dilmen Ö, Tunalı Y, Yentür E. Kafa travmalarında yoğun bakım tedavisi. Şahinoğlu AH, editör. Yoğun bakım sorunları ve tedavileri. İstanbul: Nobel Tıp Kitabevleri; 2011. sayfa. 691-700.
  • 5- Traynor C, Hall GM. Endocrine and metabolic changes during surgery: anaesthetic implications. Br J Anaesth. 1981; 53: 153-60.
  • 16- Lin E, Calvano SE, Lowry SS. Systemic responce to injury and metabolic support. In: Brunicardi C, Andersen DK, Billiar TR, Dunn DL, Hunter JG, Pollock RE, editors. Schwartz’s Principles of Surgery. 8 th ed. The McGraw-Hill Companies Inc; 2005. p. 3- 41.
  • 17- Endler G, Klimesch A, Sunder-Plassmann H, Schillinger M, Exner M, Mannhalter C, et al. Mean platelet volume is an independent risk factor for myocardial infarction but for coronary artery disease. Br J Haematol 2002;117:399-404.
  • 18- Greisenegger S, Endler G, Hsieh K, Tentschert S, Mannhalter C, Lalouschek W. Is elevated mean platelet volume associated with a worse outcome in patients with acute ischemic cerebrovascular events? Stroke 2004;34:1688-91.
  • 19- Gasparyan AY, Ayvazyan L, Mikhailidis DP, Kitas GD. Mean platelet volume: a link between thrombosis and inflammation? Curr Pharm Des. 2011; 17: 47-58. 20- Yüksel O, Helvaci K, Başar O, Köklü S, Caner S, Helvaci N, Abayli E, Altiparmak E. An overlooked indicator of disease activity in ulcerative colitis: mean platelet volume. Platelets. 2009; 20: 277-81.
  • 21- Mulley GP, Heptinstall S, Taylor PM, Mitchell JR. ADP-induced platelet release reaction in acute stroke. Thromb Haemost. 1983; 50: 524-6.
  • 22- Mayda-Domac F, Misirli H, Yilmaz M. Prognostic role of mean platelet volume and platelet count in ischemic and hemorrhagic stroke. J Stroke and Cerebrovasc Dis. 2010; 19: 66-72.

AKUT VE KRONİK SUBDURAL KANAMALI HASTALARDA NÖTROFİL/LENFOSİT ORANI VE ORTALAMA TROMBOSİT HACMİNİN DEĞERLENDİRİLMESİ

Year 2013, Volume: 4 Issue: 14, 23 - 30, 03.03.2015

Abstract

Amaç: Bu çalışmada genel anestezi uygulanan akut
ve kronik subdural kanamalı hastalarda
nötrofil/lenfosit (N/L) oranı ve ortalama trombosit
hacmi (MPV) değerlerinin karşılaştırılması
amaçlanmıştır.
Gereç ve Yöntem: Mustafa Kemal Üniversitesi Tıp
Fakültesi hastanesinde 01/01/2009 – 31/12/2012
tarihleri arasında opere olan akut subdural, kronik
subdural kanamalı hastalar ile hiç bir şikayeti
olmayan toplam 114 hasta retrospektif olarak
incelendi. Hastalar Grup K (Kontrol grubu, n=37),
Grup ASD (Akut subdural kanamalı hastalar,
n=30), Grup KSD (Kronik subdural kanamalı
hastalar, n=37) olarak 3 gruba ayrıldı. Gruplardaki
bireyler nötrofil, lenfosit, N/L oranı ve MPV
değerleri açısından karşılaştırıldı.

Bulgular: Gruplardaki nötrofil değerleri Grup K’da
3.76 (dağılım 1.77-8.09)×103/μL, Grup ASD’de
13.10 (dağılım 2.15-32.90)×103/μL, Grup KSD’de
5.27 (dağılım 0.90-13.30)×103/μL idi. Her üç
grupta da nötrofil değerleri açısından farklılık
istatistiksel olarak anlamlıydı (p değerleri sırasıyla;
Grup K-ASD=0.0001, Grup K-KSD=0.0001, Grup
ASD-KSD=0.0001).
Gruplardaki N/L oranı değerleri Grup K’da 2
(dağılım 0.80-3.77), Grup ASD’de 6.24 (dağılım
0.31-49.25), Grup KSD’de 2.79 (dağılım 0.16-
23.33) idi. Her üç grupta da N/L oranı değerleri
açısından farklılık istatistiksel olarak anlamlıydı (p
değerleri sırasıyla; Grup K-ASD=0.0001, Grup KKSD=
0.0001, Grup ASD-KSD=0.040). MPV ve
lenfosit değerleri açısından ise gruplar arasında
istatistiksel olarak anlamlı bir fark yoktu (p ˃ 0.05).
Sonuç: Sonuç olarak N/L oranının ASD grubunda
daha yüksek olmakla birlikte KSD grubunda da
kontrol grubuna göre arttığı ve MPV değerinin her
üç grupta da benzer olduğu görüldü.
Anahtar kelimeler: Subdural kanama,
nötrofil/lenfosit oranı, ortalama trombosit hacmi,
anestezi

References

  • 1- Yıldırım H, Öztürk T, Esen M. Akut subdural hematomun spontan rezolüsyon ve redüstirbüsyonu: BT ve MR bulguları. Fırat Tıp Dergisi. 2011; 16: 137-140.
  • 2- Camel M, Grubb RL Jr. Treatment of chronic subdural hematoma by twist-drill craniotomy with continuous catheter drainage. J Neurosurg. 1986; 65: 183- 7.
  • 3- Gibson PH, Cuthbertson BH, Croal BL, Rae D, El-Shafei H, Gibson G, Jeffrey RR, Buchan KG, Hillis GS. Usefulness of neutrophil/lymphocyte ratio as predictor of newonset atrial fibrillation after coronary artery bypass grafting. Am J Cardiol. 2010; 105: 186-91.
  • 4- Yamanaka T, Matsumoto S, Teramukai S, Ishiwata R, Nagai Y, Fukushima M. The baseline ratio of neutrophils to lymphocytes is associated with patient prognosis in advanced gastric cancer. Oncology. 2007; 73: 215-20.
  • 5- Ziai WC, Torbey MT, Kickler TS, Oh S, Bhardwaj A, Wityk RJ. Platelet count and function in spontaneous intracerebral hemorrhage. J Stroke Cerebrovasc Dis. 2003; 12: 201-6.
  • 6- Arıkanoğlu A, Çevik MU, Uzar E, Acar A, Akıl E, Ekici F, Taşdemir N. İntraserebral kanamalı hastalarda ortalama trombosit hacminin artışı. Türk Nöroloji Dergisi. 2012; 18: 54-6.
  • 7- Keçik Y. Nöroanestezi. Tüzüner F, editör. Anestezi yoğun bakım ağrı. Ankara: NM Medikal & Nobel Tıp Kitabevi; 2010. sayfa. 947-71.
  • 8- Baechli H, Nordmann A, Bucher HC, Gratzl O. Demographics and prevalent risk factors of chronic subdural haematoma: results of a large single-center cohort study. Neurosurg Rev. 2004; 27: 263-6.
  • 9- Tuğcu B, Tanrıverdi O, Baydın S, Günaldı Ö, Ofluoğlu E, Demirgil BT. Tekrarlayan kronik subdural hematomlar önceden öngörülebilir mi? 136 olgunun retrospektif analizi. Düşünen Adam Psikiyatri ve Nörolojik Bilimler Dergisi. 2010; 23: 44-9.
  • 10- Kamışlı S, Kamışlı Ö, Gönüllü S, Kaplan Y, Özcan C. Erken lökosit ve nötrofil yüksekliğinin serebral venöz trombozda prognostik önemi. Türk Beyin Damar Hastalıkları Dergisi. 2012; 18: 39-42.
  • 11- Buck BH, Liebeskind DS, Saver JL, Bang OY, Yun SW, Starkman S, Ali LK, Villablanca JP, Salamon N, Razinia T, Ovbiagele B. Early neutrophilia is associated with volume of ischemic tissue in acute stroke. Stroke. 2008; 39: 355-60.
  • 12- Cho KH, Jeong MH, Ahmed K, Hachinohe D, Choi HS, Chang SY, Kim MC, Hwang SH, Park KH, Lee MG, Ko JS, Sim DS, Yoon NS, Yoon HJ, Hong YJ, Kim KH, Kim JH, Ahn Y, Cho JG, Park JC, Kang JC. Value of early risk stratification using hemoglobin level and neutrophil-to-lymphocyte ratio in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention. Am J Cardiol. 2011; 107: 849-56.
  • 13- Stewart GJ. Neutrophils and deep venous thrombosis. Haemostasis. 1993; 23 Suppl 1: 127-40.
  • 14- Korkmaz Dilmen Ö, Tunalı Y, Yentür E. Kafa travmalarında yoğun bakım tedavisi. Şahinoğlu AH, editör. Yoğun bakım sorunları ve tedavileri. İstanbul: Nobel Tıp Kitabevleri; 2011. sayfa. 691-700.
  • 5- Traynor C, Hall GM. Endocrine and metabolic changes during surgery: anaesthetic implications. Br J Anaesth. 1981; 53: 153-60.
  • 16- Lin E, Calvano SE, Lowry SS. Systemic responce to injury and metabolic support. In: Brunicardi C, Andersen DK, Billiar TR, Dunn DL, Hunter JG, Pollock RE, editors. Schwartz’s Principles of Surgery. 8 th ed. The McGraw-Hill Companies Inc; 2005. p. 3- 41.
  • 17- Endler G, Klimesch A, Sunder-Plassmann H, Schillinger M, Exner M, Mannhalter C, et al. Mean platelet volume is an independent risk factor for myocardial infarction but for coronary artery disease. Br J Haematol 2002;117:399-404.
  • 18- Greisenegger S, Endler G, Hsieh K, Tentschert S, Mannhalter C, Lalouschek W. Is elevated mean platelet volume associated with a worse outcome in patients with acute ischemic cerebrovascular events? Stroke 2004;34:1688-91.
  • 19- Gasparyan AY, Ayvazyan L, Mikhailidis DP, Kitas GD. Mean platelet volume: a link between thrombosis and inflammation? Curr Pharm Des. 2011; 17: 47-58. 20- Yüksel O, Helvaci K, Başar O, Köklü S, Caner S, Helvaci N, Abayli E, Altiparmak E. An overlooked indicator of disease activity in ulcerative colitis: mean platelet volume. Platelets. 2009; 20: 277-81.
  • 21- Mulley GP, Heptinstall S, Taylor PM, Mitchell JR. ADP-induced platelet release reaction in acute stroke. Thromb Haemost. 1983; 50: 524-6.
  • 22- Mayda-Domac F, Misirli H, Yilmaz M. Prognostic role of mean platelet volume and platelet count in ischemic and hemorrhagic stroke. J Stroke and Cerebrovasc Dis. 2010; 19: 66-72.
There are 21 citations in total.

Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Original Articles
Authors

Kasım Tuzcu

İşıl Davarcı This is me

Sedat Hakimoğlu This is me

Erhan Yengil This is me

Mustafa Aras This is me

Ali Sarı This is me

Leyla Kekeç This is me

İsmail Dikey This is me

Publication Date March 3, 2015
Submission Date March 1, 2015
Published in Issue Year 2013 Volume: 4 Issue: 14

Cite

Vancouver Tuzcu K, Davarcı İ, Hakimoğlu S, Yengil E, Aras M, Sarı A, Kekeç L, Dikey İ. AKUT VE KRONİK SUBDURAL KANAMALI HASTALARDA NÖTROFİL/LENFOSİT ORANI VE ORTALAMA TROMBOSİT HACMİNİN DEĞERLENDİRİLMESİ. mkutfd. 2015;4(14):23-30.