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Kanser Tedavisinde Yeni Bir Yaklaşım “Proteoliz Hedefli Kimera”

Year 2023, Volume: 6 Issue: 2, 1611 - 1640, 05.07.2023

Seher Saruhan Can Ali Agca

Abstract

Gelişmekte olan terapötik bir strateji olarak Proteoliz Hedefli Kimera (PROTAC), belirli bir hedef protein aktivitesinin inhibisyonundan ziyade, degredasyonuna yol açan iki işlevli bir moleküldür. PROTAC molekülleri, bir hedef protein ligandı, E3 ligaz ve bir bağlayıcı olmak üzere üç kısımdan oluşmakta ve farklı hedef proteinleri parçalamak için hücredeki ubikutin proteozom sistemini kullanmaktadır. PROTAC teknolojisi, son yirmi yılda önemli ölçüde ilerlemiş ve günümüzde de dikkatleri üzerinde toplayarak kanser tedavisinde çığır açabilecek bir dönüm noktası haline gelmiştir. PROTAC yaklaşımı aynı zamanda ilaç keşif çalışmalarında yıkıcı bir değişikliğe sebep olmakla birlikte bu teknolojinin önünde yatan birçok potansiyel avantaj ve olağanüstü zorluklar tartışılmaktadır. Bu derlemede, PROTAC’ın geleneksel ve modern tedavi yöntemleri ile karşılaştırılarak, kanser tedavisine ve ilaç keşif çalışmalarına katkı sağlayacak avantaj ve zorluklarına yönelik bilgilere yer verilmektedir.

Keywords

PROTAC UPS İlaç keşfi Kanser tedavisi

Supporting Institution

Bingöl Üniversitesi

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Proteolysis Targeted Chimera “PROTAC”

Year 2023, Volume: 6 Issue: 2, 1611 - 1640, 05.07.2023

Seher Saruhan Can Ali Agca

Abstract

As an emerging therapeutic strategy, Proteolysis Targeted Chimera (PROTAC) is a bifunctional molecule that leads to degradation rather than inhibition of the activity of a specific target protein. PROTAC molecules consist of three parts, a target protein ligand, E3 ligase, and a linker, and use the ubiquitin proteosome system in the cell to cleave different target proteins. PROTAC technology has advanced significantly in the last two decades and has become a breakthrough in cancer treatment by attracting attention today. While the PROTAC approach is also causing a devastating change in drug discovery studies, the many potential advantages and extraordinary challenges that lie ahead of this technology are discussed. In this review, information on the advantages and challenges of PROTAC that will contribute to cancer treatment and drug discovery studies is given by comparing it with traditional and modern treatment methods.

Keywords

PROTAC UPS Drug discovery Cancer treatment

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Details

Primary Language Turkish
Journal Section REVIEWS
Authors

Seher Saruhan

Can Ali Agca

Publication Date July 5, 2023
Submission Date June 16, 2022
Acceptance Date October 20, 2022
Published in Issue Year 2023 Volume: 6 Issue: 2

Cite

APA Saruhan, S., & Agca, C. A. (2023). Kanser Tedavisinde Yeni Bir Yaklaşım “Proteoliz Hedefli Kimera”. Osmaniye Korkut Ata Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 6(2), 1611-1640.
AMA Saruhan S, Agca CA.Kanser Tedavisinde Yeni Bir Yaklaşım “Proteoliz Hedefli Kimera.” Osmaniye Korkut Ata University Journal of Natural and Applied Sciences. July 2023;6(2):1611-1640.
Chicago Saruhan, Seher, and Can Ali Agca. “Kanser Tedavisinde Yeni Bir Yaklaşım ‘Proteoliz Hedefli Kimera’”. Osmaniye Korkut Ata Üniversitesi Fen Bilimleri Enstitüsü Dergisi 6, no. 2 (July 2023): 1611-40.
EndNote Saruhan S, Agca CA (July 1, 2023) Kanser Tedavisinde Yeni Bir Yaklaşım “Proteoliz Hedefli Kimera”. Osmaniye Korkut Ata Üniversitesi Fen Bilimleri Enstitüsü Dergisi 6 2 1611–1640.
IEEE S. Saruhan and C. A. Agca, “Kanser Tedavisinde Yeni Bir Yaklaşım ‘Proteoliz Hedefli Kimera’”, Osmaniye Korkut Ata University Journal of Natural and Applied Sciences, vol. 6, no. 2, pp. 1611–1640, 2023.
ISNAD Saruhan, Seher - Agca, Can Ali. “Kanser Tedavisinde Yeni Bir Yaklaşım ‘Proteoliz Hedefli Kimera’”. Osmaniye Korkut Ata Üniversitesi Fen Bilimleri Enstitüsü Dergisi 6/2 (July 2023), 1611-1640.
JAMA Saruhan S, Agca CA. Kanser Tedavisinde Yeni Bir Yaklaşım “Proteoliz Hedefli Kimera”. Osmaniye Korkut Ata University Journal of Natural and Applied Sciences. 2023;6:1611–1640.
MLA Saruhan, Seher and Can Ali Agca. “Kanser Tedavisinde Yeni Bir Yaklaşım ‘Proteoliz Hedefli Kimera’”. Osmaniye Korkut Ata Üniversitesi Fen Bilimleri Enstitüsü Dergisi, vol. 6, no. 2, 2023, pp. 1611-40.
Vancouver Saruhan S, Agca CA. Kanser Tedavisinde Yeni Bir Yaklaşım “Proteoliz Hedefli Kimera”. Osmaniye Korkut Ata University Journal of Natural and Applied Sciences. 2023;6(2):1611-40.

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