BibTex RIS Cite

Recurrent abortions and postnatal loses in two cases including G-negative band within Chromosome 1qh region

Year 2011, Volume: 28 Issue: 3, 117 - 119, 09.02.2012

Nurten Kara Gülsen Ökten Şengül Tural Nevin Karakuş İdris Koçak

Abstract

ABSTRACT
Morphological variations due to heterochromatic DNA of the secondary constriction re¬gion (qh) of human chromosome 1 are considered normal. The presence of a G-negative band within the qh region of chromosome 1 has been considered as a rare or unusual variant. The aim of the present study was investigated the role of G-negative band that embedded within the secondary constriction region of chromosome 1 in two cases. Both cases were unrelated and two different family. First family history was three postna¬tal loses-one stillborn and second family had three recurrent abortions. There were no risk factors for fetal losses. Clinical assessment and cytogenetic studies were evaluated. Chromosomal analysis was performed with conventional methods from lymphocytes and karyotyped using G and C banding techniques. Male in the first family (case I) was 46,XY,1qh G-negative band in all metaphases and his wife was normal 46, XX chromo¬some structure. Female in the second family (case II) was 46,XX,1qh G-negative band and her husband was normal 46, XY chromosome. Both cases were phenotypicaly nor¬mal and they have one healthy child. We presented that those families for interesting although clinical consequences of heterochromatic variants remain obscure. Our study is important by virtue a rare study to investigate relationship between fetal loses and G-negative band in chromosome1qh.
J. Exp. Clin. Med., 2011; 28:117-119

Keywords

-

References

  • Ashley, T., 1988. G-band position effects on meiotic synapses and crossing over. Genetics, 118, 307-317.
  • Bernardi, G., Bernardi, G., 1986. Compositional constraints and genomic evolution. J. Molec. Evol. 24, 1-11.
  • Imai, A., Misao, R., Tamaya, T., 1995. Recurrent abortion associated with 1qh+. J. Med. 26, 343-345.
  • Knight, L.A., Soon, G.M., Tan, M., 1993. Extra G positive band on the long arm of chromosome 9. J. Med. Genet. 30, 613.
  • Luke, S., Verma, R.S., Conte, R.A., Mathews, T., 1992. Molecular characterization of secondary constriction region (qh) of human chromosome with pericentric inversion. J. Cell. Sci. 103, 919-923.

Year 2011, Volume: 28 Issue: 3, 117 - 119, 09.02.2012

Nurten Kara Gülsen Ökten Şengül Tural Nevin Karakuş İdris Koçak

Abstract

References

  • Ashley, T., 1988. G-band position effects on meiotic synapses and crossing over. Genetics, 118, 307-317.
  • Bernardi, G., Bernardi, G., 1986. Compositional constraints and genomic evolution. J. Molec. Evol. 24, 1-11.
  • Imai, A., Misao, R., Tamaya, T., 1995. Recurrent abortion associated with 1qh+. J. Med. 26, 343-345.
  • Knight, L.A., Soon, G.M., Tan, M., 1993. Extra G positive band on the long arm of chromosome 9. J. Med. Genet. 30, 613.
  • Luke, S., Verma, R.S., Conte, R.A., Mathews, T., 1992. Molecular characterization of secondary constriction region (qh) of human chromosome with pericentric inversion. J. Cell. Sci. 103, 919-923.
There are 5 citations in total.

Details

Primary Language English
Journal Section Basic Medical Sciences
Authors

Nurten Kara

Gülsen Ökten This is me

Şengül Tural This is me

Nevin Karakuş This is me

İdris Koçak This is me

Publication Date February 9, 2012
Submission Date October 20, 2011
Published in Issue Year 2011 Volume: 28 Issue: 3

Cite

APA Kara, N., Ökten, G., Tural, Ş., Karakuş, N., et al. (2012). Recurrent abortions and postnatal loses in two cases including G-negative band within Chromosome 1qh region. Journal of Experimental and Clinical Medicine, 28(3), 117-119. https://doi.org/10.5835/jecm.omu.28.03.004
AMA Kara N, Ökten G, Tural Ş, Karakuş N, Koçak İ. Recurrent abortions and postnatal loses in two cases including G-negative band within Chromosome 1qh region. J. Exp. Clin. Med. February 2012;28(3):117-119. doi:10.5835/jecm.omu.28.03.004
Chicago Kara, Nurten, Gülsen Ökten, Şengül Tural, Nevin Karakuş, and İdris Koçak. “Recurrent Abortions and Postnatal Loses in Two Cases Including G-Negative Band Within Chromosome 1qh Region”. Journal of Experimental and Clinical Medicine 28, no. 3 (February 2012): 117-19. https://doi.org/10.5835/jecm.omu.28.03.004.
EndNote Kara N, Ökten G, Tural Ş, Karakuş N, Koçak İ (February 1, 2012) Recurrent abortions and postnatal loses in two cases including G-negative band within Chromosome 1qh region. Journal of Experimental and Clinical Medicine 28 3 117–119.
IEEE N. Kara, G. Ökten, Ş. Tural, N. Karakuş, and İ. Koçak, “Recurrent abortions and postnatal loses in two cases including G-negative band within Chromosome 1qh region”, J. Exp. Clin. Med., vol. 28, no. 3, pp. 117–119, 2012, doi: 10.5835/jecm.omu.28.03.004.
ISNAD Kara, Nurten et al. “Recurrent Abortions and Postnatal Loses in Two Cases Including G-Negative Band Within Chromosome 1qh Region”. Journal of Experimental and Clinical Medicine 28/3 (February 2012), 117-119. https://doi.org/10.5835/jecm.omu.28.03.004.
JAMA Kara N, Ökten G, Tural Ş, Karakuş N, Koçak İ. Recurrent abortions and postnatal loses in two cases including G-negative band within Chromosome 1qh region. J. Exp. Clin. Med. 2012;28:117–119.
MLA Kara, Nurten et al. “Recurrent Abortions and Postnatal Loses in Two Cases Including G-Negative Band Within Chromosome 1qh Region”. Journal of Experimental and Clinical Medicine, vol. 28, no. 3, 2012, pp. 117-9, doi:10.5835/jecm.omu.28.03.004.
Vancouver Kara N, Ökten G, Tural Ş, Karakuş N, Koçak İ. Recurrent abortions and postnatal loses in two cases including G-negative band within Chromosome 1qh region. J. Exp. Clin. Med. 2012;28(3):117-9.
 Download Cover Image

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.