Abstract
References
- Albertin, A., Dedola, E., Bergonzi P.C., 2006. The effect of two target - controlled cocentrations (1-3ng/ml ) of remifentanil on MAC of desflurane. Eur. J. Anest. 23, 510-516.
- Alhashemi, J.A., Daghistani, M.F., 2006. Effects of intraoperative i.v. acetaminophen vs i.m. meperidine on post-tonsillectomy pain in children. British J. Anaesthesia. 96, 790-795.
- Binhas, M., Decailliot, F., Suen, P., 2004. Comparative effect of intraoperative propacetamol versus placebo on morphine consumption after elective reduction mammoplsty under remifentanil-based anestesia: a randomized control trial. BMC Anesthesiol. 4, 6.
- Dejonckheere, M., Desjeux, L., Deneu, S., 2001. Intravenous tramadol compared to propacetamol for postoperative analgesia following thyroidectomy. Acta Anaesthesiol. 52, 29-33.
- Erdine, S., 2000. Ağrı. Nobel Tıp Kitabevleri, İstanbul, S:13-111.
- Glass, P.S.A., Jacobs, J.R., Smith, R.L., 1990. Pharmacokinetic model-driven infusion of fentanyl: Assessment of accuracy. Anesthesiology. 73, 1082-1090.
- Güzeldemir, M.E., 2000. Ağrı tedavisinde Genel Prensipler ve Örnekler. GATA As. Tıp Fakültesi. Anesteziyoloji ders notları.
- Hahn, T.W., Mogensen. T., Lund, C., 2003. Analgesic effect of i.v. paracetamol: possible ceiling effect of paracetamol in postoperative pain. Acta Anaesthesiol. Scand. 47, 138-145.
- Katoh, T., Kobayashi, S., Suzuki, A., 1999. The effect of fentanyl on sevoflurane requirements for somatic and sympathetc responses to surgical incision. Anesthesiology. 90, 2.
- Kayhan, Z., 2004., Klinik Anestezi. Logos Yayıncılık, İstanbul. S: 37-64.
- Lange, S., Boscoe, M.J., Stanley, T.H., 1982. Comparison of sufentannil O2 and fentanyl- O2 for coronary artery surgery. Anesthesiology. 56, 112-118.
- Levy, W. J., Shapiro, H. M., Maruchak, G., Meathe, E., 1980. Automated EEG processing for intraoperative monitoring: Acomparison of techniques. Anesthesiology. 53, 223-236.
- Nishiyama, T., Matsukawa, T., Hanaoka, K., 2004. A comparison of the clinical usefulness of three electroencephalogram monitors: Bispectral index, processed electroencephalogram and auditory evoked potentials. Anesth. Analg. 98, 1341-1345.
- Norholt, S.E., Juhl, G., Tonnesen, E., 2006. Analgesic efficacy and safety of intravenous paracetamol administered as a 2 g starting dose following third molar surgery. Eur. J. Pain. 10, 371-377.
- Palazon, H.J., Tortosa, J.A., Lage, M.J.F., Flores, F.D., 2001. Intravenous administration of propacetamol reduces morphine consumption after spinal fusion surgery. Anesth. Analg. 92, 1473- 1476.
- Peduto, V.A., 1998. Efficacy of propacetamol in the treatment of postoperative pain. Morphine-sparing effect in orthopedic surgery. Acta Anaesthesiol. Scand. 42, 293-298.
- Reynolds, P., Romej, M., Merkel, S., 1996. Effect of preemptive acetaminophen on postoperative pain scores and oral fluid intake in pediatric tonsillectomy patients. J. Am. Ass. Nurs. Anesth. 64, 535-540.
- Schmidt, A., Björkman, S., Akeson, J., 2001. Preoperative rectal diclofenac versus paracetamol for tonsillectomy: effects on pain and blood loss. Acta Anesthesiol. Scand. 45, 48-52.
- Scott, J.C., Cooke, J.E., Stanski, D.R., 1991. Electroencephalographic quantitation of opioid effect:Comparative pharmacodynamics of fentanyl and sufentanil. Anesthesiology. 74, 34.
- Sebel, P. S., Lang, E., Rampil, I.J., 1997. A multicenter study of bispectral electroencephalogram analysis for monitoring anesthetic effect. Anesth. Analg. 84, 891-899.
- Van de Walle, J., Lauwers, P., Ariaensen, H., 1976. Double blind comparison of fentanyl and sufentanil in anaesthesia. Acta Anaesthesiol. Belg. 27, 129-138.
Preoperatif intrevenöz parasetamol uygulamasının intraoperatif volatil ajan tüketimine, derlenme kriterlerine ve postoperatif analjeziye etkisi
Abstract
Bu çalışmada, preemptif uygulanan intravenöz parasetamolün, anestezik gaz tüketimine, postoperatif derlenme kriterlerine ve analjezik gereksinimine etkilerinin değerlendirilmesi amaçladık. Histerektomi planlanmış, 18 - 70 yaş arasındaki 60 hasta rastgele iki gruba ayrıldı. Preoperatif dönemde, intravenöz 1gr parasetamol uygulanan grup; Grup P, intravenöz salin uygulanan kontrol grubu; Grup K olarak adlandırıldı. Hastaların anestezi derinliği indüksiyondan sonra bispektral indeks (BİS) monitörizasyonu (45-55 aralığında) ile standardize edildi. Preoperatif ve intraoperatif dönemdeki kalp hızı, kan basıncı, oksijen satürasyonu, end-tidal karbondioksit değeri, BİS ve minimum alveoler konsantrasyon (MAC) değeri, yan etkiler, postoperatif aldrete skoru, tüketilen volatil ajan miktarı, ekstübasyon zamanı, göz açma zamanı kaydedildi. Hastaların tümüne meperidin ile hasta kontrollü analjezi (HKA) cihazı hazırlandı. Postoperatif dönemde; hastaların HKA cihazı ile yaptıkları analjezik istek sayısı ve giden analjezik miktarı, öksürürken ve istirahatte görsel analog skala (VAS) değerleri kaydedildi. Volatil ajan tüketimi, Grup P’de daha az olmasına karşın istatistiksel olarak anlamlı değildi. Postoperatif dönemde derlenme ünitesindeki analjezik gereksinimi, aldrete skoru ve VAS değerleri arasında da
fark yoktu. Hastaların servis takiplerinde, HKA cihazı uygulama sayısı ve giden analjezik miktarı Grup P’de, Grup K’ya göre istatistiksel olarak anlamlı derecede daha az bulundu
(p< 0,05 ). Preemptif analjezide; yan etkisi az, güvenlik profili geniş, uygulaması kolay olan parasetamolün intravenöz formunun bir alternatif olabileceği kanısına varıldı.
Keywords
Preemptive analgesia intravenous paracetamol intraoperative anesthesic consumption bispectral index patient controlled analgesia postoperative analgesia
References
- Albertin, A., Dedola, E., Bergonzi P.C., 2006. The effect of two target - controlled cocentrations (1-3ng/ml ) of remifentanil on MAC of desflurane. Eur. J. Anest. 23, 510-516.
- Alhashemi, J.A., Daghistani, M.F., 2006. Effects of intraoperative i.v. acetaminophen vs i.m. meperidine on post-tonsillectomy pain in children. British J. Anaesthesia. 96, 790-795.
- Binhas, M., Decailliot, F., Suen, P., 2004. Comparative effect of intraoperative propacetamol versus placebo on morphine consumption after elective reduction mammoplsty under remifentanil-based anestesia: a randomized control trial. BMC Anesthesiol. 4, 6.
- Dejonckheere, M., Desjeux, L., Deneu, S., 2001. Intravenous tramadol compared to propacetamol for postoperative analgesia following thyroidectomy. Acta Anaesthesiol. 52, 29-33.
- Erdine, S., 2000. Ağrı. Nobel Tıp Kitabevleri, İstanbul, S:13-111.
- Glass, P.S.A., Jacobs, J.R., Smith, R.L., 1990. Pharmacokinetic model-driven infusion of fentanyl: Assessment of accuracy. Anesthesiology. 73, 1082-1090.
- Güzeldemir, M.E., 2000. Ağrı tedavisinde Genel Prensipler ve Örnekler. GATA As. Tıp Fakültesi. Anesteziyoloji ders notları.
- Hahn, T.W., Mogensen. T., Lund, C., 2003. Analgesic effect of i.v. paracetamol: possible ceiling effect of paracetamol in postoperative pain. Acta Anaesthesiol. Scand. 47, 138-145.
- Katoh, T., Kobayashi, S., Suzuki, A., 1999. The effect of fentanyl on sevoflurane requirements for somatic and sympathetc responses to surgical incision. Anesthesiology. 90, 2.
- Kayhan, Z., 2004., Klinik Anestezi. Logos Yayıncılık, İstanbul. S: 37-64.
- Lange, S., Boscoe, M.J., Stanley, T.H., 1982. Comparison of sufentannil O2 and fentanyl- O2 for coronary artery surgery. Anesthesiology. 56, 112-118.
- Levy, W. J., Shapiro, H. M., Maruchak, G., Meathe, E., 1980. Automated EEG processing for intraoperative monitoring: Acomparison of techniques. Anesthesiology. 53, 223-236.
- Nishiyama, T., Matsukawa, T., Hanaoka, K., 2004. A comparison of the clinical usefulness of three electroencephalogram monitors: Bispectral index, processed electroencephalogram and auditory evoked potentials. Anesth. Analg. 98, 1341-1345.
- Norholt, S.E., Juhl, G., Tonnesen, E., 2006. Analgesic efficacy and safety of intravenous paracetamol administered as a 2 g starting dose following third molar surgery. Eur. J. Pain. 10, 371-377.
- Palazon, H.J., Tortosa, J.A., Lage, M.J.F., Flores, F.D., 2001. Intravenous administration of propacetamol reduces morphine consumption after spinal fusion surgery. Anesth. Analg. 92, 1473- 1476.
- Peduto, V.A., 1998. Efficacy of propacetamol in the treatment of postoperative pain. Morphine-sparing effect in orthopedic surgery. Acta Anaesthesiol. Scand. 42, 293-298.
- Reynolds, P., Romej, M., Merkel, S., 1996. Effect of preemptive acetaminophen on postoperative pain scores and oral fluid intake in pediatric tonsillectomy patients. J. Am. Ass. Nurs. Anesth. 64, 535-540.
- Schmidt, A., Björkman, S., Akeson, J., 2001. Preoperative rectal diclofenac versus paracetamol for tonsillectomy: effects on pain and blood loss. Acta Anesthesiol. Scand. 45, 48-52.
- Scott, J.C., Cooke, J.E., Stanski, D.R., 1991. Electroencephalographic quantitation of opioid effect:Comparative pharmacodynamics of fentanyl and sufentanil. Anesthesiology. 74, 34.
- Sebel, P. S., Lang, E., Rampil, I.J., 1997. A multicenter study of bispectral electroencephalogram analysis for monitoring anesthetic effect. Anesth. Analg. 84, 891-899.
- Van de Walle, J., Lauwers, P., Ariaensen, H., 1976. Double blind comparison of fentanyl and sufentanil in anaesthesia. Acta Anaesthesiol. Belg. 27, 129-138.
Details
| Primary Language | English |
|---|---|
| Subjects | Health Care Administration |
| Journal Section | Surgery Medical Sciences |
| Authors | |
| Publication Date | January 27, 2012 |
| Submission Date | August 2, 2011 |
| Published in Issue | Year 2011 Volume: 28 Issue: 4 |
Cite
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.