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Pathology of esophageal carcinomas

Year 2012, Volume: 29 Issue: 4S, 215 - 226, 07.05.2013
https://doi.org/10.5835/jecm.omu.29.s4.005

Abstract

Özofagus kanserleri, geç dönemde bulgu vermeleri ve anatomik özelliklerin kolaylaştırdığı hızlı yayılımları nedeniyle sıklıkla lokal ilerlemiş hastalık olarak karşımıza çıkmaktadır. Tanı ve tedavi yöntemlerinde sağlanan gelişmelere rağmen bu hastalarda çok düşük sağ kalım izlenmektedir.
Bu hastaların premalign hastalık evresinde saptanabilmesi ve doğru takip ve tedavi yaklaşımlarının belirlenmesinde iyi bir klinisyen - patolog korelasyonu gerekmektedir. Burada özofagus kanserleri ve prekanseröz patolojileri histopatolojik, genetik özellikleri ile ele alınacak, hastaların takip ve tedavisinde yönlendirici olabilecek güncel bilgiler sunulmaya çalışılacaktır.

J. Exp. Clin. Med., 2012; 29:S215-S226

Pathology of esophageal carcinomas

Esophageal carcinomas can usually be detected in locally advanced stages, due to asymptomatic course and the anatomic properties of esophagus which facilitate rapid spread. Despite improvements on the diagnostic and therapeutic techniques, these patients show very poor survival rates. Detection of these patiens on the premalignant disease stage and determining the appropriate follow-up and therapy approaches require good correlation of the pathologist and the clinician. Here, esophageal carcinomas and their premalignant diseases will be reviewed with histopathological and genetical properties and current information required for follow up and treatment procedures are going to be presented.

References

  • Abraham, S.C., Krasinskas, A.M., Correa, A.M., Hofstetter, W.L., Ajani, J.A., Swisher, S.G., Wu, T.T., 2007. Duplication of the muscularis mucosae in Barrett esophagus: An underrecognized feature and its implication for staging of adenocarcinoma. Am. J. Surg. Pathol. 31, 1719- 1725.
  • Arnold, G.L., Mardini, H.E., 2002. Barrett’s esophagus-associated polypoid dysplasia: A case report and review of the literature. Dig. Dis. Sci. 47, 1897-1900.
  • Bell-Thomson, J., Haggitt, R.C., Ellis, F.H. Jr., 1980. Mucoepidermoid and adenoid cystic carcinomas of the esophagus. J. Thorac. Cardiov. Sur. 79, 438-446.
  • Berger, A.C., Farma, J., Scott, W.J., Freedman, G., Weiner, L., Cheng, J.D., Wang, H., Goldberg, M., 2005. Complete response to neoadjuvant chemoradiotherapy in esophageal carcinoma is associated with significantly improved survival. J. Clin. Oncol. 23, 4330-4337.
  • Bergmann, M., Charnas, R.M., 1958. Tracheobronchial rests in the esophagus; their relation to some benign strictures and certain types of cancer of the esophagus. J. Thorac. Surg. 35, 97-104.
  • Blot, W.J., McLaughlin, J.K., Fraumeni, J.F., 2006. Esophageal cancer. Cancer Epidemiology and prevention. Oxford University Press, New York. pp. 697-706.
  • Bogomoletz, W.V., Molas, G., Gayet, B., Potet, F., 1989. Superficial squamous cell carcinoma of the esophagus. A report of 76 cases and review of the literature. Am. J. Surg. Pathol. 13, 535-546.
  • Bosman, F., Carneiro, F., Hruban, R., Theise, N., 2010, W.H.O. Classification of tumours of the digestive system. Fourth edition. IARC Press, Lyon, France.
  • Cabrera, E., Fernandes, F., Gomez- Roman, J., Val-Bernal, J.F., 1996. Basaloid squamous carcinoma of the esophagus: Immunohistochemistry and flow cytometric DNA analysis in two cases. Int. J. Surg. Pathol. 3, 267.
  • Chandrasoma, P., Der, R., Dalton, P., 2001. Distribution and significance of epithelial types in columnar-lined esophagus. Am. J. Surg. Pathol. 25, 1188-1193.
  • Chandrasoma, P.T., DeMeester, T.R., 2006. GERD: Reflux to esophageal adenocarcinoma. Elsevier Academic Press, San Diego. 381-437.
  • Chang, F., Deere, H., Mahadeva, U., George, S., 2008. Histopathologic examination and reporting of esophageal carcinomas following preopera- tive neoadjuvant therapy: Practical guidelines and current issues. Am. J. Clin. Pathol. 129, 252-262.
  • Chong, F.K., Graham, J.H., Madoff, I.M., 1979. Mucin-producing carcinoid (“composite tumor”) of upper third of esophagus: A variant of carcinoid tumor. Cancer. 44, 1853-1859.
  • Connor, M.J., Sharma, P., 2004. Chromoendoscopy and magnification endoscopy for diagnosing esophageal cancer and dysplasia. Thorac. Surg. Clin. 14, 87-94.
  • Curado, M.P., Edwards, B., Shin, H.R., Storm, H., Ferlay, J., Heanue, M., 2007, Cancer incidence in five continents. I.A.R.C. Lyon, France.
  • Dawsey, S.M., Lewin, K.J., Wang, G.Q., Liu, F.S., Nieberg, R.K., Yu, Y., Li, J.Y., Blot, W.J., Li, B., Taylor, P.R., 1994. Squamous esophageal histology and subsequent risk of squamous cell carcinoma of the esophagus. A prospective follow-up study from Linxian, China. Cancer. 74, 1686-1692.
  • MANEC’de ise prognozu ekzokrin komponent belirler ve
  • tümör evresi ve histolojik diferansiasyon gibi özellikler
  • önemlidir (Chong ve ark., 1979).

Özofagus kanserleri patolojisi

Year 2012, Volume: 29 Issue: 4S, 215 - 226, 07.05.2013
https://doi.org/10.5835/jecm.omu.29.s4.005

Abstract

Özofagus kanserleri, geç dönemde bulgu vermeleri ve anatomik özelliklerin kolaylaştırdığı hızlı yayılımları nedeniyle sıklıkla lokal ilerlemiş hastalık olarak karşımıza çıkmaktadır. Tanı ve tedavi yöntemlerinde sağlanan gelişmelere rağmen bu hastalarda çok düşük sağ kalım izlenmektedir. Bu hastaların premalign hastalık evresinde saptanabilmesi ve doğru takip ve tedavi yaklaşımlarının belirlenmesinde iyi bir klinisyen - patolog korelasyonu gerekmektedir. Burada özofagus kanserleri ve prekanseröz patolojileri histopatolojik, genetik özellikleri ile ele alınacak, hastaların takip ve tedavisinde yönlendirici olabilecek güncel bilgiler sunulmaya çalışılacaktır.

References

  • Abraham, S.C., Krasinskas, A.M., Correa, A.M., Hofstetter, W.L., Ajani, J.A., Swisher, S.G., Wu, T.T., 2007. Duplication of the muscularis mucosae in Barrett esophagus: An underrecognized feature and its implication for staging of adenocarcinoma. Am. J. Surg. Pathol. 31, 1719- 1725.
  • Arnold, G.L., Mardini, H.E., 2002. Barrett’s esophagus-associated polypoid dysplasia: A case report and review of the literature. Dig. Dis. Sci. 47, 1897-1900.
  • Bell-Thomson, J., Haggitt, R.C., Ellis, F.H. Jr., 1980. Mucoepidermoid and adenoid cystic carcinomas of the esophagus. J. Thorac. Cardiov. Sur. 79, 438-446.
  • Berger, A.C., Farma, J., Scott, W.J., Freedman, G., Weiner, L., Cheng, J.D., Wang, H., Goldberg, M., 2005. Complete response to neoadjuvant chemoradiotherapy in esophageal carcinoma is associated with significantly improved survival. J. Clin. Oncol. 23, 4330-4337.
  • Bergmann, M., Charnas, R.M., 1958. Tracheobronchial rests in the esophagus; their relation to some benign strictures and certain types of cancer of the esophagus. J. Thorac. Surg. 35, 97-104.
  • Blot, W.J., McLaughlin, J.K., Fraumeni, J.F., 2006. Esophageal cancer. Cancer Epidemiology and prevention. Oxford University Press, New York. pp. 697-706.
  • Bogomoletz, W.V., Molas, G., Gayet, B., Potet, F., 1989. Superficial squamous cell carcinoma of the esophagus. A report of 76 cases and review of the literature. Am. J. Surg. Pathol. 13, 535-546.
  • Bosman, F., Carneiro, F., Hruban, R., Theise, N., 2010, W.H.O. Classification of tumours of the digestive system. Fourth edition. IARC Press, Lyon, France.
  • Cabrera, E., Fernandes, F., Gomez- Roman, J., Val-Bernal, J.F., 1996. Basaloid squamous carcinoma of the esophagus: Immunohistochemistry and flow cytometric DNA analysis in two cases. Int. J. Surg. Pathol. 3, 267.
  • Chandrasoma, P., Der, R., Dalton, P., 2001. Distribution and significance of epithelial types in columnar-lined esophagus. Am. J. Surg. Pathol. 25, 1188-1193.
  • Chandrasoma, P.T., DeMeester, T.R., 2006. GERD: Reflux to esophageal adenocarcinoma. Elsevier Academic Press, San Diego. 381-437.
  • Chang, F., Deere, H., Mahadeva, U., George, S., 2008. Histopathologic examination and reporting of esophageal carcinomas following preopera- tive neoadjuvant therapy: Practical guidelines and current issues. Am. J. Clin. Pathol. 129, 252-262.
  • Chong, F.K., Graham, J.H., Madoff, I.M., 1979. Mucin-producing carcinoid (“composite tumor”) of upper third of esophagus: A variant of carcinoid tumor. Cancer. 44, 1853-1859.
  • Connor, M.J., Sharma, P., 2004. Chromoendoscopy and magnification endoscopy for diagnosing esophageal cancer and dysplasia. Thorac. Surg. Clin. 14, 87-94.
  • Curado, M.P., Edwards, B., Shin, H.R., Storm, H., Ferlay, J., Heanue, M., 2007, Cancer incidence in five continents. I.A.R.C. Lyon, France.
  • Dawsey, S.M., Lewin, K.J., Wang, G.Q., Liu, F.S., Nieberg, R.K., Yu, Y., Li, J.Y., Blot, W.J., Li, B., Taylor, P.R., 1994. Squamous esophageal histology and subsequent risk of squamous cell carcinoma of the esophagus. A prospective follow-up study from Linxian, China. Cancer. 74, 1686-1692.
  • MANEC’de ise prognozu ekzokrin komponent belirler ve
  • tümör evresi ve histolojik diferansiasyon gibi özellikler
  • önemlidir (Chong ve ark., 1979).
There are 19 citations in total.

Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Surgery Medical Sciences
Authors

Duygu Kankaya

Işınsu Kuzu This is me

Publication Date May 7, 2013
Submission Date April 11, 2012
Published in Issue Year 2012 Volume: 29 Issue: 4S

Cite

APA Kankaya, D., & Kuzu, I. (2013). Özofagus kanserleri patolojisi. Journal of Experimental and Clinical Medicine, 29(4S), 215-226. https://doi.org/10.5835/jecm.omu.29.s4.005
AMA Kankaya D, Kuzu I. Özofagus kanserleri patolojisi. J. Exp. Clin. Med. May 2013;29(4S):215-226. doi:10.5835/jecm.omu.29.s4.005
Chicago Kankaya, Duygu, and Işınsu Kuzu. “Özofagus Kanserleri Patolojisi”. Journal of Experimental and Clinical Medicine 29, no. 4S (May 2013): 215-26. https://doi.org/10.5835/jecm.omu.29.s4.005.
EndNote Kankaya D, Kuzu I (May 1, 2013) Özofagus kanserleri patolojisi. Journal of Experimental and Clinical Medicine 29 4S 215–226.
IEEE D. Kankaya and I. Kuzu, “Özofagus kanserleri patolojisi”, J. Exp. Clin. Med., vol. 29, no. 4S, pp. 215–226, 2013, doi: 10.5835/jecm.omu.29.s4.005.
ISNAD Kankaya, Duygu - Kuzu, Işınsu. “Özofagus Kanserleri Patolojisi”. Journal of Experimental and Clinical Medicine 29/4S (May 2013), 215-226. https://doi.org/10.5835/jecm.omu.29.s4.005.
JAMA Kankaya D, Kuzu I. Özofagus kanserleri patolojisi. J. Exp. Clin. Med. 2013;29:215–226.
MLA Kankaya, Duygu and Işınsu Kuzu. “Özofagus Kanserleri Patolojisi”. Journal of Experimental and Clinical Medicine, vol. 29, no. 4S, 2013, pp. 215-26, doi:10.5835/jecm.omu.29.s4.005.
Vancouver Kankaya D, Kuzu I. Özofagus kanserleri patolojisi. J. Exp. Clin. Med. 2013;29(4S):215-26.