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Comparison of maternal serum and umbilical cord concentrations of nitric oxide and asymmetric-dimethyl-arginine in pre-eclamptic and uncomplicated pregnancies

Year 2013, Volume: 30 Issue: 2, 125 - 128, 31.07.2013

Mustafa Albayrak Mahmut Öncül Seyfettin Uludağ Hafize Uzun Ali Benian Onur Güralp Rıza Madazlı

Abstract

The aim of this study was to compare maternal serum and umbilical cord levels of asymmetric-dimethyl-arginine (ADMA) and nitric oxide (NO) in pre-eclamptic and non-pre-eclamptic women and the possible effects of ADMA and NO on fetal outcome. Mean umbilical cord and maternal serum NO and ADMA levels of 29 women with preeclampsia (PE) and 24 randomly selected healthy pregnant women were compared. Maternal venous blood samples were collected before delivery and umbilical cord venous blood samples were obtained after delivery. Birth weight, apgar score, cord blood pH, duration of stay in the neonatal intensive care unit (NICU), and maternal and neonatal complications were recorded. Umbilical cord ADMA and maternal NO levels were significantly higher in women with pre-eclampsia compared to women without pre-eclampsia. There were no significant differences between means of maternal serum ADMA levels and cord blood NO levels in women with and without pre-eclampsia. Maternal and cord serum NO and ADMA levels in the pre-eclampsia group did not show a significant correlation with cord blood pH, umbilical artery pulsatility index (PI). In conclusion, umbilical cord ADMA and maternal NO levels were significantly higher in
women with pre-eclampsia compared to women without pre-eclampsia.

Keywords

Asymmetric dimethyl arginine; cord blood; maternal serum; nitric oxide; pre-eclampsia

References

  • Ahmad, S., Ahmed, A,. 2004. Elevated placental soluble vascular endothelial growth factor receptor-1 inhibits angiogenesis in preeclampsia. Circ. Res. 95, 884-891.
  • Cunningham, F.G., Gant, N.F., Leveno, K.J., Gilstrap, L.C., Hauth, J.C., Wenstrom, K.D., 2001. Hypertensive Disorders in Pregnancy. Williams Obstetrics. 21st ED, McGraw-Hill., New York. 568-573.
  • Egerman, R.S., Andersen, R.N., Manejwala, F.M., Sibai, B.M., 1999. Neuropeptide Y and nitrite levels in preeclamptic and normotensive gravid women. Am. J. Obstet. Gynecol. 181, 921-923.
  • Garcia, R.G.,Celedón, J., Sierra-Laguado, J., Alarcón, M.A., Luengas, C., Silva, F., Arenas-Mantilla, M., López-Jaramillo, P., 2007. Raised Creactive protein and impaired flow-mediated vasodilation precede the development of preeclampsia. Am. J. Hypertens. 20, 98-103.
  • Gude, N.M., King, R.G., Brennecke, S.P., 1990. Role of endothelium-derived nitric oxide in maintenance of low fetal vascular resistance in placenta. Lancet. 336, 1589-1590.
  • Holden, D.P., Fickling, S.A., Whitley, G.S., Nussey, S.S., 1998. Plasma concentrations of asymmetric dimethylarginine, a natural inhibitor of nitric oxide synthase, in normal pregnancy and preeclampsia. Am J Obstet Gynecol. 178, 551-556.
  • Laresgoiti-Servitje, E., Gómez-López, N., Olson, D.M., 2010. An immunological insight into the origins of pre-eclampsia. Hum. Reprod. Update.16, 510-524.
  • Maeda, T., Yoshimura, T., Okamura, H., 2003. Asymmetric dimethylarginine, an endogenous inhibitor of nitric oxide synthase, in maternal and fetal circulation. J. Soc. Gynecol. Investig. 10, 2-4.
  • Moncada, S., Palmer, R.M., Higgs, E.A., 1991. Nitric oxide: Physiology, pathophysiology, and pharmacology. Pharmacol. Rev. 43, 109-142. Mutlu-Türkoglu, U., Aykaç-Toker, G., Ibrahimoglu, L., Ademoglu, E., Uysal, M., 1999. Plasma nitric oxide metabolites and lipid peroxide levels in preeclamptic pregnant women before and after delivery. Gynecol. Obstet. Invest. 48, 247-250.
  • Myatt, L., Brewer, A., Brockman, D.E. 1991. The action of nitric oxide the perfused human fetal-placental circulation. Am. J. Obstet. Gynecol. 164, 687-92.
  • Myatt, L., Brockman, D.E., Eis, A.L., Pollock, J.S., 1993. Immunohistochemical localization of nitric oxide synthase in the human placenta. Placenta. 14, 487-495.
  • Myatt, L.,Webster, R.P., 2009. Webster Vascular biology of preeclampsia. J. Thromb. Haemost. 375-384.
  • Pinheiro, M.B., Gomes, K.B., Dusse, L.M., 2013. Fibrinolyticsysteminpreeclampsia. Clin. Chim. Acta. 1, 416, 67-71.
  • Roberts, J.M., Taylor, R.N., Musci, T.J., Rodgers, G.M., Hubel, C.A., McLaughlin, M.K.,1989. Preeclampsia: An endothelial cell disorder. Am.J.Obstet. Gynecol. 161, 1200-1204.
  • Rudherford, R.A., McCarty, A., Sullvian, M.H., Elder, M.G., Polak, J.M., Warton, J., 1995. Nitric oxide synthase in human placenta and umbilical cord from normal, intrauterine growth-retarded and pre-eclamptic pregnancies. Br. J. Pharmacol. 116, 3099-3109.
  • Savvidou, D.M., Hingorani, A.D., Tsikas, D., Frölich, J.C., Vallance, P., Nicolaides, K.H., 2003. Endothelial dysfunction and raised plasma concantrations of asymmetric dimethyl arginine (ADMA) in pregnant woman who subsequently developed pre-eclampsia. Lancet. 361, 1511-1517.
  • Seligman, S.P., Buyon, J.P., Clancy, R.M., Young, B.K., Abramson, S.B., 1994. The role of nitric oxide in the pathogenesis of preeclampsia. Am. J. Obstet. Gynecol. 171, 944-948.
  • Shaamash, A.H., Elsonosy, E.D., Zakhari, M.M., Radwan, S.H., El-Dien, H.M., 2001. Placental nitric oxide synthase (NOS) activity and nitric oxide (NO) production in normal pregnancy, pre-eclampsia and eclampsia. Int. J. Gynaecol. Obstet. 72, 127-133.
  • Sibai, B., Dekker, G., Kupferminc, M., 2005. Pre-eclampsia. Lancet. 365, 785-799.
  • Sladek, S.M., Magness, R.R., Conrad, K.P., 1997. Nitric oxide and pregnancy. Am. J. Physiol. 272, 441-463.
  • Slaghekke, F., Dekker, G., Jeffries, B., 2006. Endogenous inhibitors of nitric oxide and preeclampsia: A review. J. Matern. Fetal. Neonatal Med. 19, 447-452.

Year 2013, Volume: 30 Issue: 2, 125 - 128, 31.07.2013

Mustafa Albayrak Mahmut Öncül Seyfettin Uludağ Hafize Uzun Ali Benian Onur Güralp Rıza Madazlı

Abstract

References

  • Ahmad, S., Ahmed, A,. 2004. Elevated placental soluble vascular endothelial growth factor receptor-1 inhibits angiogenesis in preeclampsia. Circ. Res. 95, 884-891.
  • Cunningham, F.G., Gant, N.F., Leveno, K.J., Gilstrap, L.C., Hauth, J.C., Wenstrom, K.D., 2001. Hypertensive Disorders in Pregnancy. Williams Obstetrics. 21st ED, McGraw-Hill., New York. 568-573.
  • Egerman, R.S., Andersen, R.N., Manejwala, F.M., Sibai, B.M., 1999. Neuropeptide Y and nitrite levels in preeclamptic and normotensive gravid women. Am. J. Obstet. Gynecol. 181, 921-923.
  • Garcia, R.G.,Celedón, J., Sierra-Laguado, J., Alarcón, M.A., Luengas, C., Silva, F., Arenas-Mantilla, M., López-Jaramillo, P., 2007. Raised Creactive protein and impaired flow-mediated vasodilation precede the development of preeclampsia. Am. J. Hypertens. 20, 98-103.
  • Gude, N.M., King, R.G., Brennecke, S.P., 1990. Role of endothelium-derived nitric oxide in maintenance of low fetal vascular resistance in placenta. Lancet. 336, 1589-1590.
  • Holden, D.P., Fickling, S.A., Whitley, G.S., Nussey, S.S., 1998. Plasma concentrations of asymmetric dimethylarginine, a natural inhibitor of nitric oxide synthase, in normal pregnancy and preeclampsia. Am J Obstet Gynecol. 178, 551-556.
  • Laresgoiti-Servitje, E., Gómez-López, N., Olson, D.M., 2010. An immunological insight into the origins of pre-eclampsia. Hum. Reprod. Update.16, 510-524.
  • Maeda, T., Yoshimura, T., Okamura, H., 2003. Asymmetric dimethylarginine, an endogenous inhibitor of nitric oxide synthase, in maternal and fetal circulation. J. Soc. Gynecol. Investig. 10, 2-4.
  • Moncada, S., Palmer, R.M., Higgs, E.A., 1991. Nitric oxide: Physiology, pathophysiology, and pharmacology. Pharmacol. Rev. 43, 109-142. Mutlu-Türkoglu, U., Aykaç-Toker, G., Ibrahimoglu, L., Ademoglu, E., Uysal, M., 1999. Plasma nitric oxide metabolites and lipid peroxide levels in preeclamptic pregnant women before and after delivery. Gynecol. Obstet. Invest. 48, 247-250.
  • Myatt, L., Brewer, A., Brockman, D.E. 1991. The action of nitric oxide the perfused human fetal-placental circulation. Am. J. Obstet. Gynecol. 164, 687-92.
  • Myatt, L., Brockman, D.E., Eis, A.L., Pollock, J.S., 1993. Immunohistochemical localization of nitric oxide synthase in the human placenta. Placenta. 14, 487-495.
  • Myatt, L.,Webster, R.P., 2009. Webster Vascular biology of preeclampsia. J. Thromb. Haemost. 375-384.
  • Pinheiro, M.B., Gomes, K.B., Dusse, L.M., 2013. Fibrinolyticsysteminpreeclampsia. Clin. Chim. Acta. 1, 416, 67-71.
  • Roberts, J.M., Taylor, R.N., Musci, T.J., Rodgers, G.M., Hubel, C.A., McLaughlin, M.K.,1989. Preeclampsia: An endothelial cell disorder. Am.J.Obstet. Gynecol. 161, 1200-1204.
  • Rudherford, R.A., McCarty, A., Sullvian, M.H., Elder, M.G., Polak, J.M., Warton, J., 1995. Nitric oxide synthase in human placenta and umbilical cord from normal, intrauterine growth-retarded and pre-eclamptic pregnancies. Br. J. Pharmacol. 116, 3099-3109.
  • Savvidou, D.M., Hingorani, A.D., Tsikas, D., Frölich, J.C., Vallance, P., Nicolaides, K.H., 2003. Endothelial dysfunction and raised plasma concantrations of asymmetric dimethyl arginine (ADMA) in pregnant woman who subsequently developed pre-eclampsia. Lancet. 361, 1511-1517.
  • Seligman, S.P., Buyon, J.P., Clancy, R.M., Young, B.K., Abramson, S.B., 1994. The role of nitric oxide in the pathogenesis of preeclampsia. Am. J. Obstet. Gynecol. 171, 944-948.
  • Shaamash, A.H., Elsonosy, E.D., Zakhari, M.M., Radwan, S.H., El-Dien, H.M., 2001. Placental nitric oxide synthase (NOS) activity and nitric oxide (NO) production in normal pregnancy, pre-eclampsia and eclampsia. Int. J. Gynaecol. Obstet. 72, 127-133.
  • Sibai, B., Dekker, G., Kupferminc, M., 2005. Pre-eclampsia. Lancet. 365, 785-799.
  • Sladek, S.M., Magness, R.R., Conrad, K.P., 1997. Nitric oxide and pregnancy. Am. J. Physiol. 272, 441-463.
  • Slaghekke, F., Dekker, G., Jeffries, B., 2006. Endogenous inhibitors of nitric oxide and preeclampsia: A review. J. Matern. Fetal. Neonatal Med. 19, 447-452.
There are 21 citations in total.

Details

Primary Language English
Journal Section Basic Medical Sciences
Authors

Mustafa Albayrak This is me

Mahmut Öncül

Seyfettin Uludağ This is me

Hafize Uzun

Ali Benian This is me

Onur Güralp

Rıza Madazlı This is me

Publication Date July 31, 2013
Submission Date December 2, 2012
Published in Issue Year 2013 Volume: 30 Issue: 2

Cite

APA Albayrak, M., Öncül, M., Uludağ, S., Uzun, H., et al. (2013). Comparison of maternal serum and umbilical cord concentrations of nitric oxide and asymmetric-dimethyl-arginine in pre-eclamptic and uncomplicated pregnancies. Journal of Experimental and Clinical Medicine, 30(2), 125-128. https://doi.org/10.5835/jecm.omu.30.02.007
AMA Albayrak M, Öncül M, Uludağ S, Uzun H, Benian A, Güralp O, Madazlı R. Comparison of maternal serum and umbilical cord concentrations of nitric oxide and asymmetric-dimethyl-arginine in pre-eclamptic and uncomplicated pregnancies. J. Exp. Clin. Med. July 2013;30(2):125-128. doi:10.5835/jecm.omu.30.02.007
Chicago Albayrak, Mustafa, Mahmut Öncül, Seyfettin Uludağ, Hafize Uzun, Ali Benian, Onur Güralp, and Rıza Madazlı. “Comparison of Maternal Serum and Umbilical Cord Concentrations of Nitric Oxide and Asymmetric-Dimethyl-Arginine in Pre-Eclamptic and Uncomplicated Pregnancies”. Journal of Experimental and Clinical Medicine 30, no. 2 (July 2013): 125-28. https://doi.org/10.5835/jecm.omu.30.02.007.
EndNote Albayrak M, Öncül M, Uludağ S, Uzun H, Benian A, Güralp O, Madazlı R (July 1, 2013) Comparison of maternal serum and umbilical cord concentrations of nitric oxide and asymmetric-dimethyl-arginine in pre-eclamptic and uncomplicated pregnancies. Journal of Experimental and Clinical Medicine 30 2 125–128.
IEEE M. Albayrak, “Comparison of maternal serum and umbilical cord concentrations of nitric oxide and asymmetric-dimethyl-arginine in pre-eclamptic and uncomplicated pregnancies”, J. Exp. Clin. Med., vol. 30, no. 2, pp. 125–128, 2013, doi: 10.5835/jecm.omu.30.02.007.
ISNAD Albayrak, Mustafa et al. “Comparison of Maternal Serum and Umbilical Cord Concentrations of Nitric Oxide and Asymmetric-Dimethyl-Arginine in Pre-Eclamptic and Uncomplicated Pregnancies”. Journal of Experimental and Clinical Medicine 30/2 (July 2013), 125-128. https://doi.org/10.5835/jecm.omu.30.02.007.
JAMA Albayrak M, Öncül M, Uludağ S, Uzun H, Benian A, Güralp O, Madazlı R. Comparison of maternal serum and umbilical cord concentrations of nitric oxide and asymmetric-dimethyl-arginine in pre-eclamptic and uncomplicated pregnancies. J. Exp. Clin. Med. 2013;30:125–128.
MLA Albayrak, Mustafa et al. “Comparison of Maternal Serum and Umbilical Cord Concentrations of Nitric Oxide and Asymmetric-Dimethyl-Arginine in Pre-Eclamptic and Uncomplicated Pregnancies”. Journal of Experimental and Clinical Medicine, vol. 30, no. 2, 2013, pp. 125-8, doi:10.5835/jecm.omu.30.02.007.
Vancouver Albayrak M, Öncül M, Uludağ S, Uzun H, Benian A, Güralp O, Madazlı R. Comparison of maternal serum and umbilical cord concentrations of nitric oxide and asymmetric-dimethyl-arginine in pre-eclamptic and uncomplicated pregnancies. J. Exp. Clin. Med. 2013;30(2):125-8.
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