Research Article
Year 2013,
Volume: 30 Issue: 4, 301 - 304, 04.02.2014
Abstract
The mortality and morbidity of ischemic stroke (IS) can be decreased by early diagnosis and proper treatment of these patients in the emergency department. The levels of trace elements in the human body are important in maintaining the balance in the various biological components. In this study, we examined the impact of imbalance in levels of trace elements in patients with acute IS. In this prospective study, serum copper (Cu), lead (Pb), cadmium (Cd), zinc (Zn), cobalt (Co), manganese (Mn), and magnesium (Mg) levels were investigated in 25 healthy participants (control group) and 24 IS patients. The Cd, Pb, Co, and Cu levels were significantly higher in the patients compared to control groups (P<0.05), while the levels of Zn, Mg, Mn were lower. The results of our study show that an increase in the levels of Cd, Pb, Co and Cu may be important in the occurrence of IS.
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- Larsen, N.A., Pakkenberg, H., Damsgard, E., Deydorm, K., Wold, S., 1981. Distribution of arsenic, manganese, and selenium in the human brain in chronic renal insufficiency, Parkinson’s disease, and amyotrophic lateral sclerosis. J. Neurol. Sci. 51, 437-446.
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Year 2013,
Volume: 30 Issue: 4, 301 - 304, 04.02.2014
Abstract
References
- Akarachkova, E.S., Vershinina, S.V., Kotova, O.V., 2012. Magnesium in the treatment and prevention of cerebrovascular disease. Kardiologiia. 52, 80-86.
- Altamura, C., Squitti, R., Pasqualetti, P., Gaudino, C., Palazzo, P., Tibuzzi, F., Lupoi, D., Cortesi, M., Rossini, P.M., Vernieri, F., 2009. Ceruloplasmin/Transferrin system is related to clinical status in acute stroke. Stroke. 40, 1282-1288.
- Atasoy, N., Mercan, U., Alacabey, İ., Kul, A.R., 2011. Levels of heavy metals and certain macro elements in potable and tap water at Van city center. Hacettepe J. Biol. & Chem. 39, 391-396.
- Bradbury, M.W., 1992. An approach to study of transport of trace metals at the blood-brain barrier. Prog. Brain Res. 91, 133-138.
- Burnet, F.M., 1981. A possible role of zinc in the pathology of dementia. Lancet. 24, 186-188.
- Cebi, A., Kaya, Y., Gungor, H., Demir, H., Yoruk, I.H., Soylemez, N., Gunes, Y., Tuncer, M., 2011. Trace elements, heavy metals and vitamin levels in patients with coronary artery disease. Int. J. Med. Sci. 8, 456-460.
- Cocco, P., Dosemeci, M., Heineman, E.F., 1988. Brain cancer and occupational exposure to lead. J. Occup. Environ. Med. 40, 937-942.
- Dexter, D.T., Wells, F.R., Lees, A.J., Agid, F., Agid, Y., Jenner, P., Marsden, C.D., 1989. Increased nigral iron content and alterations in other metal ions occurring in brain in Parkinson’s disease. J. Neurochem. 52, 1830-1836.
- Donma, O., Donma, M.M., 2002. Association of headaches and the metals. Biol. Trace. Elem. Res. 90, 1-14.
- Emre, U., Durukan, A., Tatlısumak, T., 2007. Emergency management of acute ischemıc stroke. Turkiye Klinikleri, J. Surg. Med. Sci. 3, 6-12. Goldman, R.S., Finkbeiner, S.M., 1988. Therapeutic use of magnesium sulfate in selected cases of cerebral ischemia and seizure. N. Engl. J. Med. 319, 1224-1225.
- Hankey, G.J., 2006. Potential new risk factors for ischemic stroke: What is their potential?. Stroke. 37, 2181-2188.
- Herrmann, M., Vos, P., Wunderlich, M.T., de Bruijn, C.H., Lamers, K.J., 2000. Release of glial tissue-specific proteins after acute stroke: A comparative analysis of serum concentrations of protein S-100b and glial fibrillary acidic protein. Stroke. 31, 2670-2677.
- Imai, N., Okabe, T., 2011. Kinetics differ between copper-zinc and manganese superoxide dismutase activity with acute ischemic stroke. J. Stroke Cerebrovasc. Dis. 20, 75-78.
- Larsen, N.A., Pakkenberg, H., Damsgard, E., Deydorm, K., Wold, S., 1981. Distribution of arsenic, manganese, and selenium in the human brain in chronic renal insufficiency, Parkinson’s disease, and amyotrophic lateral sclerosis. J. Neurol. Sci. 51, 437-446.
- Messner, B., Knoflach, M., Seubert, A., Ritsch, A., Pfaller, K., Henderson, B., Shen, Y.H., Zeller, I., Willeit, J., Laufer, G., Wick, G., Kiechl, S., Bernhard, D., 2009. Cadmium is a novel and independent risk factor for early atherosclerosis mechanisms and in vivo relevance. Arterioscler. Thromb. Vasc. Biol. 29, 1392-1398.
- Munshi, A., Babu, S., Kaul, S., Shafi, G., Rajeshwar, K., Alladi, S., Jyothy, A., 2010. Depletion of serum zinc in ischemic stroke patients. Methods Find Exp. Clin. Pharmacol. 32, 433-436.
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Details
| Primary Language | English |
|---|---|
| Subjects | Health Care Administration |
| Journal Section | Internal Medical Sciences |
| Authors | |
| Publication Date | February 4, 2014 |
| Submission Date | August 14, 2013 |
| Published in Issue | Year 2013 Volume: 30 Issue: 4 |
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