Research Article
Year 2021,
Volume: 38 Issue: 4, 622 - 628, 09.10.2021
Abstract
Supporting Institution
Erciyes University
Project Number
2018-7917
Thanks
Yok
References
- Asgharpour, F., Moghadamnia, A.A., Motallebnejad, M., Nouri, H.R., 2019. Propolis attenuates lipopolysaccharide-induced inflammatory responses through intracellular ROS and NO levels along with downregulation of IL-1β and IL-6 expressions in murine RAW 264.7 macrophages. J Food Biochem 43: e12926.
- Bhargava, P., Kumari, A., Putri, J.F., Ishida, Y., Terao, K., Kaul, S.C., Sundar, D., Wadhwa, R., 2018. Caffeic acid phenethyl ester (CAPE) possesses pro-hypoxia and anti-stress activities: bioinformatics and experimental evidences. Cell Stress Chaperones. 23: 1055-68.
- Carvalho, A., Finger, D., Machado, C.S., Schmidt, E., 2011. In vivo antitumoral activity and composition of an oil extract of Brazilian propolis. Food Chem. 126:1239-45.
- Ceylan, T., Kaymak, E., Cantürk Tan, F., Yakan, B., 2020. Researches on the protective effect of caffeic acid phenethyl ester on testicular damage caused by cisplatin. Turk J Med Sci. Jul 6. doi: 10.3906/sag-2002-58.
- Dantas Silva, R.P., Machado, B.A., Barreto, G.A., Costa, S.S., Andrade, L.N., Amaral, R.G., Carvalho, A.A., Padilha, F.F., Barbosa, J.D., Umsza-Guez, M.A., 2017. Antioxidant, antimicrobial, antiparasitic, and cytotoxic properties of various Brazilian propolis extracts. PLoS One. 12: e0172585.
- Dasari, S., Tchounwou, P.B., 2014. Cisplatin in cancer therapy: molecular mechanisms of action. Eur J Pharmacol. 740:364-78. Duan, J., Xiaokaiti, Y., Fan, S., Pan, Y., Li, X., 2017. Direct interaction between caffeic acid phenethyl ester and human neutrophil elastase inhibits the growth and migration of PANC-1 cells. Oncol Rep 37: 3019-25.
- Dufour, P., Bergerat, J.P., Eber, M., Renaud, P., Karcher, V., Giron, C., Leroy, M.J., Oberling, F., 1990. Cisplatin-induced anemia: a potential interference with iron metabolism at erythroid progenitors level. Colloq Inse 1:49-54.
- Ibrahim, N.A., 2013. The possible protective effect of bee propolis on experimentally mediated cisplatin reproductive toxicity: a histological and immunohistochemical study. Egypt J Histology 36:78-86.
- Johnsen, S.G., 1970. Testicular biopsy score count–a method for registration of spermatogenesis in human testes: normal values and results in 335 hypogonadal males. Horm Res Paediat. 1:2-25.
- Kart, A., Cigremis, Y., Karaman, M., Ozen, H., 2010. Caffeic acid phenethyl ester (CAPE) ameliorates cisplatin-induced hepatotoxicity in rabbit. Exp Toxicol Pathol 62:45-52.
- Kizilay, A., Kalcioglu, M.T., Ozerol, E., Iraz, M., Gulec, M., Akyol, O., Ozturan, O., 2004. Caffeic acid phenethyl ester ameliorated ototoxicity induced by cisplatin in rats. Journal of chemotherapy 16:381-7. Manohar, S., Leung, N., 2018. Cisplatin nephrotoxicity: a review of the literature. J Nephrol. 31:15-25.
- Olas, B., Wachowicz, B., Majsterek, I., Blasiak, J., 2005. Resveratrol may reduce oxidative stress induced by platinum compounds in human plasma, blood platelets and lymphocytes. Colloq Inse 16:659-65.
- Oun, R., Moussa, Y.E., Wheate, N.J., 2018. The side effects of platinum-based chemotherapy drugs: a review for chemists. Dalton Trans. 47(19):6645-53. Ozen, S., Akyol, O., Iraz, M., Söğüt, S., Ozuğurlu, F., Ozyurt, H., Odaci, E., Yildirim, Z., 2004. Role of caffeic acid phenethyl ester, an active component of propolis, against cisplatin-induced nephrotoxicity in rats. J Appl Toxicol 24:27-35.
- Pujirahayu, N., Ritonga, H., Uslinawaty, Z., 2014. Properties and flavonoids content in propolis of some extraction method of raw propolis. Int J Pharm Pharm Sci. 6:338-40.
- Quintanilha, J.C.F., Saavedra, K.F., Visacri, M.B., Moriel, P., Salazar, L.A., 2019. Role of epigenetic mechanisms in cisplatin-induced toxicity. Crit Rev Oncol Hematol. 137:131-42.
- Ramanauskienė, K., Inkėnienė, A.M., 2011. Propolis oil extract: quality analysis and evaluation of its antimicrobial activity. Nat Prod Res. 25: 1463-8. Reis, J.S., Oliveira, G.B., Monteiro, M.C., Machado, C.S., Torres, Y.R., Prediger, R.D., Maia, C.S., 2014. Antidepressant- and anxiolytic like activities of an oil extract of propolis in rats. Phytomedicine 21:1466-72.
- Sawhney, P., Giammona, J., Meistrich, M., Richburg, J., 2005. Cisplatin-induced long-term failure of spermatogenesis in adult C57/Bl/6 J mice. J Androl 26:136–45.
- Shirwaikar, A., Deepti Issac, D., Malini, S., 2004. Effect of Aerva lanata on cisplatin and gentamicin models of acute renal failure. J Ethnopharmacol 90:81–6. Silici, S., Koç, N.A., Ayangil, D., Cankaya, S., 2005. Antifungal activities of propolis collected by different races of honeybees against yeasts isolated from patients with superficial mycoses. J Pharmacol Sci. 99: 39-44.
- Sonmez, M., Türk, G., Yüce, A., 2005. The effect of ascorbic acid supplementation on sperm quality, lipid peroxidation and testosterone levels of male Wistar rats. Theriogenology. 63:2063-72.
- Thongnuanjan, P., Soodvilai, S., Chatsudthipong, V., Soodvilai, S., 2016. Fenofibrate reduces cisplatin-induced apoptosis of renal proximal tubular cells via inhibition of JNK and p38 pathways. J Toxicol Sci. 41:339-49.
- Tohamy, A.A., Abdella, E.M., Ahmed, R.R., Ahmed, Y.K., 2014. Assessment of anti-mutagenic, anti-histopathologic and antioxidant capacities of Egyptian bee pollen and propolis extracts. Cytotechnology 66:283-97. Turan, I., Demir, S., Misir, S., Kılınc, K., Mentese, A., Aliyaıcıoglu, Y., Deger, O., 2015. Cytotoxic effect of Turkish propolis on liver, colon, breast, cervix and prostate cancer cell lines. Trop J Pharm Res 14:777-82.
- Yilmaz, H.R., Uz, E., Yucel, N., Altuntas, I., Ozcelik, N., 2014. Protective effect of caffeic acid phenethyl ester (CAPE) on lipid peroxidation and antioxidant enzymes in diabetic rat liver. J Biochem Mol Toxic 18:234-8.
- Yilmaz, H.R., Sogut, S., Ozyurt, B., Ozugurlu, F., Sahin, S., Isik, B., Uz, E., Ozyurt, H., 2005. The activities of liver adenosine deaminase, xanthine oxidase, catalase, superoxide dismutase enzymes and the levels of malondialdehyde and nitric oxide after cisplatin toxicity in rats: protective effect of caffeic acid phenethyl ester. Toxicol Ind Health 21:67-73.
- Yılmaz, H.R., Uz, E., Altunbaşak, A., Sakallı, E., Özçelik, N., 2010. Anticlastogenic effect of caffeic acid phenethyl ester on cisplatin-induced chromosome aberrations in rat bone marrow cells. Toxicol Ind Health 26:33-7.
Poplar-Type Propolis Provides Protection of Blood Cells, Testosterone Levels and Sperm Motility in Cisplatin-Induced Toxicity
Abstract
Cisplatin is a frequently used chemotherapeutic in many types of cancer, especially urological cancers. Despite its efficacy in the treatment of cancer, it causes various toxic side effects such as nephrotoxicity, neurotoxicity and ototoxicity. The aim of this study was to determine the protective role of olive oile extract of propolis (OEP) with biochemical and histopathological approaches to cisplatin induced toxicity. Sixty-four adult male Wistar rats were divided into eight groups, control, propolis (100 and 200 mg/kg, orally daily for 10 days) and combined therapy (propolis 10 days before and after CP injection). Haematological (Wbc, Rbc, Mpv, Hgb, Htc, Mcv, Mch, Mchc, Lym, Neu), biochemical (triglyceride, total cholesteol, HDL and LDL-cholesterol, glucose, BUN, uric acid and testosterone level), epididymal sperm concentration, sperm motility, and histological studies. According to the results, cisplatin has negative effects on hematological, biochemical parameters, and sperm motility compared to control group. Administration of pre-cisplatin propolis ameliorated wbc, hct, mcv, mchc, neu levels. The administration of OEP prior to CP normalized the increased BUN and uric acid levels induced by CP. Interestingly it was also revealed that the testosterone levels increased in the OEP groups compared to the control group. Additionally, the combined administration of CP with OEP normalized the decreased testosterone levels induced by CP, particularly pre-treatment OEP. As a results, propolis, a natural product with numerous useful biological effects, was shown to a have protective as well as amelioration and normalizing effect on CP-induced damage.
Project Number
2018-7917
References
- Asgharpour, F., Moghadamnia, A.A., Motallebnejad, M., Nouri, H.R., 2019. Propolis attenuates lipopolysaccharide-induced inflammatory responses through intracellular ROS and NO levels along with downregulation of IL-1β and IL-6 expressions in murine RAW 264.7 macrophages. J Food Biochem 43: e12926.
- Bhargava, P., Kumari, A., Putri, J.F., Ishida, Y., Terao, K., Kaul, S.C., Sundar, D., Wadhwa, R., 2018. Caffeic acid phenethyl ester (CAPE) possesses pro-hypoxia and anti-stress activities: bioinformatics and experimental evidences. Cell Stress Chaperones. 23: 1055-68.
- Carvalho, A., Finger, D., Machado, C.S., Schmidt, E., 2011. In vivo antitumoral activity and composition of an oil extract of Brazilian propolis. Food Chem. 126:1239-45.
- Ceylan, T., Kaymak, E., Cantürk Tan, F., Yakan, B., 2020. Researches on the protective effect of caffeic acid phenethyl ester on testicular damage caused by cisplatin. Turk J Med Sci. Jul 6. doi: 10.3906/sag-2002-58.
- Dantas Silva, R.P., Machado, B.A., Barreto, G.A., Costa, S.S., Andrade, L.N., Amaral, R.G., Carvalho, A.A., Padilha, F.F., Barbosa, J.D., Umsza-Guez, M.A., 2017. Antioxidant, antimicrobial, antiparasitic, and cytotoxic properties of various Brazilian propolis extracts. PLoS One. 12: e0172585.
- Dasari, S., Tchounwou, P.B., 2014. Cisplatin in cancer therapy: molecular mechanisms of action. Eur J Pharmacol. 740:364-78. Duan, J., Xiaokaiti, Y., Fan, S., Pan, Y., Li, X., 2017. Direct interaction between caffeic acid phenethyl ester and human neutrophil elastase inhibits the growth and migration of PANC-1 cells. Oncol Rep 37: 3019-25.
- Dufour, P., Bergerat, J.P., Eber, M., Renaud, P., Karcher, V., Giron, C., Leroy, M.J., Oberling, F., 1990. Cisplatin-induced anemia: a potential interference with iron metabolism at erythroid progenitors level. Colloq Inse 1:49-54.
- Ibrahim, N.A., 2013. The possible protective effect of bee propolis on experimentally mediated cisplatin reproductive toxicity: a histological and immunohistochemical study. Egypt J Histology 36:78-86.
- Johnsen, S.G., 1970. Testicular biopsy score count–a method for registration of spermatogenesis in human testes: normal values and results in 335 hypogonadal males. Horm Res Paediat. 1:2-25.
- Kart, A., Cigremis, Y., Karaman, M., Ozen, H., 2010. Caffeic acid phenethyl ester (CAPE) ameliorates cisplatin-induced hepatotoxicity in rabbit. Exp Toxicol Pathol 62:45-52.
- Kizilay, A., Kalcioglu, M.T., Ozerol, E., Iraz, M., Gulec, M., Akyol, O., Ozturan, O., 2004. Caffeic acid phenethyl ester ameliorated ototoxicity induced by cisplatin in rats. Journal of chemotherapy 16:381-7. Manohar, S., Leung, N., 2018. Cisplatin nephrotoxicity: a review of the literature. J Nephrol. 31:15-25.
- Olas, B., Wachowicz, B., Majsterek, I., Blasiak, J., 2005. Resveratrol may reduce oxidative stress induced by platinum compounds in human plasma, blood platelets and lymphocytes. Colloq Inse 16:659-65.
- Oun, R., Moussa, Y.E., Wheate, N.J., 2018. The side effects of platinum-based chemotherapy drugs: a review for chemists. Dalton Trans. 47(19):6645-53. Ozen, S., Akyol, O., Iraz, M., Söğüt, S., Ozuğurlu, F., Ozyurt, H., Odaci, E., Yildirim, Z., 2004. Role of caffeic acid phenethyl ester, an active component of propolis, against cisplatin-induced nephrotoxicity in rats. J Appl Toxicol 24:27-35.
- Pujirahayu, N., Ritonga, H., Uslinawaty, Z., 2014. Properties and flavonoids content in propolis of some extraction method of raw propolis. Int J Pharm Pharm Sci. 6:338-40.
- Quintanilha, J.C.F., Saavedra, K.F., Visacri, M.B., Moriel, P., Salazar, L.A., 2019. Role of epigenetic mechanisms in cisplatin-induced toxicity. Crit Rev Oncol Hematol. 137:131-42.
- Ramanauskienė, K., Inkėnienė, A.M., 2011. Propolis oil extract: quality analysis and evaluation of its antimicrobial activity. Nat Prod Res. 25: 1463-8. Reis, J.S., Oliveira, G.B., Monteiro, M.C., Machado, C.S., Torres, Y.R., Prediger, R.D., Maia, C.S., 2014. Antidepressant- and anxiolytic like activities of an oil extract of propolis in rats. Phytomedicine 21:1466-72.
- Sawhney, P., Giammona, J., Meistrich, M., Richburg, J., 2005. Cisplatin-induced long-term failure of spermatogenesis in adult C57/Bl/6 J mice. J Androl 26:136–45.
- Shirwaikar, A., Deepti Issac, D., Malini, S., 2004. Effect of Aerva lanata on cisplatin and gentamicin models of acute renal failure. J Ethnopharmacol 90:81–6. Silici, S., Koç, N.A., Ayangil, D., Cankaya, S., 2005. Antifungal activities of propolis collected by different races of honeybees against yeasts isolated from patients with superficial mycoses. J Pharmacol Sci. 99: 39-44.
- Sonmez, M., Türk, G., Yüce, A., 2005. The effect of ascorbic acid supplementation on sperm quality, lipid peroxidation and testosterone levels of male Wistar rats. Theriogenology. 63:2063-72.
- Thongnuanjan, P., Soodvilai, S., Chatsudthipong, V., Soodvilai, S., 2016. Fenofibrate reduces cisplatin-induced apoptosis of renal proximal tubular cells via inhibition of JNK and p38 pathways. J Toxicol Sci. 41:339-49.
- Tohamy, A.A., Abdella, E.M., Ahmed, R.R., Ahmed, Y.K., 2014. Assessment of anti-mutagenic, anti-histopathologic and antioxidant capacities of Egyptian bee pollen and propolis extracts. Cytotechnology 66:283-97. Turan, I., Demir, S., Misir, S., Kılınc, K., Mentese, A., Aliyaıcıoglu, Y., Deger, O., 2015. Cytotoxic effect of Turkish propolis on liver, colon, breast, cervix and prostate cancer cell lines. Trop J Pharm Res 14:777-82.
- Yilmaz, H.R., Uz, E., Yucel, N., Altuntas, I., Ozcelik, N., 2014. Protective effect of caffeic acid phenethyl ester (CAPE) on lipid peroxidation and antioxidant enzymes in diabetic rat liver. J Biochem Mol Toxic 18:234-8.
- Yilmaz, H.R., Sogut, S., Ozyurt, B., Ozugurlu, F., Sahin, S., Isik, B., Uz, E., Ozyurt, H., 2005. The activities of liver adenosine deaminase, xanthine oxidase, catalase, superoxide dismutase enzymes and the levels of malondialdehyde and nitric oxide after cisplatin toxicity in rats: protective effect of caffeic acid phenethyl ester. Toxicol Ind Health 21:67-73.
- Yılmaz, H.R., Uz, E., Altunbaşak, A., Sakallı, E., Özçelik, N., 2010. Anticlastogenic effect of caffeic acid phenethyl ester on cisplatin-induced chromosome aberrations in rat bone marrow cells. Toxicol Ind Health 26:33-7.
There are 24 citations in total.
Details
| Primary Language | English |
|---|---|
| Subjects | Health Care Administration |
| Journal Section | Clinical Research |
| Authors | |
| Project Number | 2018-7917 |
| Publication Date | October 9, 2021 |
| Submission Date | March 4, 2021 |
| Acceptance Date | March 7, 2021 |
| Published in Issue | Year 2021 Volume: 38 Issue: 4 |
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