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Year 2022, Volume: 39 Issue: 1, 7 - 11, 01.01.2022

Özlem Akdoğan Derya Yapar Kazım Çebi Sertaç Arslan Hilal Boyacı Yasemin Arı Yılmaz Pınar Tunçel Öztürk Ünsal Savcı Hüseyin Kayadibi Ayşe Yılmaz Meral Gülhan Aysel Kocagül Çelikbaş Nurcan Baykam

Abstract

Supporting Institution

Yok

Project Number

12.05.2020 tarih ve 240 nolu etik kurul onayı , Sağlık Bakanlığı izni ve kurum izni alınmıştır

Thanks

2019 yılı biterken Çin'den tüm dünyaya yayılarak SARS COV-2'nin neden olduğu COVID-19 pandemisi süresinde olağanüstü bir şekilde görev yapan tüm sağlık çalışanlarına teşekkür ederim.

References

  • 1. https://www.worldometers.info/coronavirus/.
  • 2. https://www.who.int/emergencies/diseases/novelcoronavirus-2019.
  • 3. Acter T, Uddin N, Das J, Akhter A, Choudhury TR, Kim S. Evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as coronavirus disease 2019 (COVID-19) pandemic: A global health emergency. Sci Total Environ. 2020; 15;730:138996.
  • 4. Li Q, Guan X, Wu P, Wang X, Zhou L, Tong Y, et al. Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus-Infected Pneumonia. N Engl J Med, 2020; 382(13): 1199-1207.
  • 5. WHO. Clinical management of severe acute respiratory infection (SARI) when COVID-19 disease is suspected. Interim guidance. 2020 Mar 13.
  • 6. Li X, Geng M, Peng Y, Meng L, Lu S. Molecular immune pathogenesis and diagnosis of COVID-19. J Pharm Anal. 2020;10(2):102-108. doi: 10.1016/j.jpha.2020.03.001
  • 7. Müdürlüğü, T.C.S.B.H.S.G., COVID-19 (SARS-CoV-2 Enfeksiyonu) Rehberi. 2020.
  • 8. Pascarella G, Strumia A, Piliego C, Bruno F, Del Buono R, Costa F, et al. COVID‐19 diagnosis and management: a comprehensive review. J Intern Med. 2020; 288(2): 192-206.
  • 9. Xie J, Ding C, Li J, Wang Y, Guo H, Lu Z, Wang J, et al. Characteristics of patients with coronavirus disease (COVID-19) confirmed using an IgM-IgG antibody test. J Med Virol, 2020; 92(10): 2004-2010.
  • 10. Goudouris, E.S., Laboratory diagnosis of COVID-19. J Pediatr (Rio J), 2021; 97(1): 7-12.
  • 11. Ai T, Yang Z, Hou H, Zhan C, Chen C, Lv W, et al. Correlation of Chest CT and RT-PCR Testing for Coronavirus Disease 2019 (COVID-19) in China: A Report of 1014 Cases. Radiology, 2020; 296(2): E32-e40.
  • 12. Kostakoglu U, Kant A, Atalar S, Ertunc B, Erensoy S, Dalmanoglu E, et al. Diagnostic value of Chest CT and Initial Real-Time RT-PCR in COVID-19 Infection. Pak J Med Sci. 2021; 37(1): 234.
  • 13. Li, Y. and L.J.A.J.o.R. Xia. Coronavirus disease 2019 (COVID-19): role of chest CT in diagnosis and management. 2020; 214(6): 1280-1286.
  • 14. Zainol Rashid Z, Othman SN, Abdul Samat MN, Ali UK, Wong KK. Diagnostic performance of COVID-19 serology assays. Malays J Pathol. 2020; 42(1): 13-21.
  • 15. Li Z, Yi Y, Luo X, Xiong N, Liu Y, Li S, et al. Development and clinical application of a rapid IgM-IgG combined antibody test for SARS-CoV-2 infection diagnosis. J Med Virol, 2020; 92(9): 1518-1524.
  • 16. Chaimayo C, Kaewnaphan B, Tanlieng N, Athipanyasilp N, Sirijatuphat R, Chayakulkeeree M, et al. Rapid SARS-CoV-2 antigen detection assay in comparison with real-time RT-PCR assay for laboratory diagnosis of COVID-19 in Thailand. Virol J, 2020; 17(1): 177.
  • 17. Baloch S, Baloch MA, Zheng T, Pei X. The Coronavirus Disease 2019 (COVID-19) Pandemic. Tohoku J Exp Med, 2020; 250(4): 271-278.
  • 18. Jin JM, Bai P, He W, Wu F, Liu XF, Han DM, et al. Gender Differences in Patients With COVID-19: Focus on Severity and Mortality. Front Public Health, 2020; 8: 152.
  • 19. Nikpouraghdam M, Jalali Farahani A, Alishiri G, Heydari S, Ebrahimnia M, Samadinia H, et al., Epidemiological characteristics of coronavirus disease 2019 (COVID-19) patients in IRAN: A single center study. J Clin Virol. 2020; 127: 104378.
  • 20. Wan S, Xiang Y, Fang W, Zheng Y, Li B, Hu Y, et al., Clinical features and treatment of COVID‐19 patients in northeast Chongqing. J Med Virol. 2020; 92(7): 797-806.
  • 21. WHO, Clinical management of severe acute respiratory infection (SARI) when COVID-19 disease is suspected. 2020; Mar 13.
  • 22. Wang M, Cao R, Zhang L, Yang X, Liu J, Xu M, et al. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 2020; 30(3): 269-271

Evaluation of Covid-19 cases that applied to the hospital at the first peak of the pandemic

Year 2022, Volume: 39 Issue: 1, 7 - 11, 01.01.2022

Özlem Akdoğan Derya Yapar Kazım Çebi Sertaç Arslan Hilal Boyacı Yasemin Arı Yılmaz Pınar Tunçel Öztürk Ünsal Savcı Hüseyin Kayadibi Ayşe Yılmaz Meral Gülhan Aysel Kocagül Çelikbaş Nurcan Baykam

Abstract

Early diagnosis in COVID-19 is essential in terms of treatment and prevention of contagiousness. In this study, we aimed to find an alternative diagnosis method by using fewer laboratory parameters in the early diagnosis of COVID-19 disease by creating a fast, easily accessible, cost-effective index and has a diagnostic accuracy rate of over 90%. All patients over the age of 18 who applied to Hitit University Erol Olçok Training and Research Hospital Emergency COVID Outpatient Clinic with a pre-diagnosis of COVID-19 between March and April 2020 were evaluated retrospectively. Patients were divided into two groups as COVID-19 positive and COVID-19 negative. It was aimed to create a HITIT-19 index by evaluating the cases according to the clinical and laboratory results. Between March and April 2020 (in the first peak of the pandemic), 1586 patients were applied to the Emergency COVID-19 outpatient clinic with a pre-diagnosis of COVID-19. According to COVID-19 RT-PCR, card test, and CT involvement, 285 (13%) patients were diagnosed with COVID-19. PCR was positive in 285 (18%) of 1586 patients, and PCR was negative in 1301 (82%). While 153 (53.7%) of the patients diagnosed with COVID-19 were male and the median age was 45 (28-62.75), 883 (55.7%) of the patients not diagnosed with COVID-19 were male, and the median age was 43 (31-65). Hypertension (HT) was the most common underlying disease in 10.5% of patients applied to the emergency room with a diagnosis of COVID-19, while 38.9% dyspnea and 35.1% fever were the most common symptoms. While 76% of Plaquenil and 58% azithromycin were the most frequently started treatments, 31.4% (28.4% of them were hospitalized in the service, 3% in the intensive care unit) of them hospitalized. It was to create a HITIT-19 index that is fast, easily accessible, cost-effective, and has a diagnostic accuracy rate of over 90% by using laboratory tests. However, we could not achieve this goal due to the low accuracy of the diagnostic tests and the lack of significant change in the laboratory levels of the patients at admission. Considering that the pandemic is continuing rapidly, there is still a need to develop practical diagnostic methods that are easier and cheaper in diagnosis. In this sense, we believe that our study will be a guiding study for other studies that will be designed for diagnostic index studies.

Keywords

Covid-19 early diagnosis Covid-19 early diagnosis RT-PCR HITIT-19 index

Project Number

12.05.2020 tarih ve 240 nolu etik kurul onayı , Sağlık Bakanlığı izni ve kurum izni alınmıştır

References

  • 1. https://www.worldometers.info/coronavirus/.
  • 2. https://www.who.int/emergencies/diseases/novelcoronavirus-2019.
  • 3. Acter T, Uddin N, Das J, Akhter A, Choudhury TR, Kim S. Evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as coronavirus disease 2019 (COVID-19) pandemic: A global health emergency. Sci Total Environ. 2020; 15;730:138996.
  • 4. Li Q, Guan X, Wu P, Wang X, Zhou L, Tong Y, et al. Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus-Infected Pneumonia. N Engl J Med, 2020; 382(13): 1199-1207.
  • 5. WHO. Clinical management of severe acute respiratory infection (SARI) when COVID-19 disease is suspected. Interim guidance. 2020 Mar 13.
  • 6. Li X, Geng M, Peng Y, Meng L, Lu S. Molecular immune pathogenesis and diagnosis of COVID-19. J Pharm Anal. 2020;10(2):102-108. doi: 10.1016/j.jpha.2020.03.001
  • 7. Müdürlüğü, T.C.S.B.H.S.G., COVID-19 (SARS-CoV-2 Enfeksiyonu) Rehberi. 2020.
  • 8. Pascarella G, Strumia A, Piliego C, Bruno F, Del Buono R, Costa F, et al. COVID‐19 diagnosis and management: a comprehensive review. J Intern Med. 2020; 288(2): 192-206.
  • 9. Xie J, Ding C, Li J, Wang Y, Guo H, Lu Z, Wang J, et al. Characteristics of patients with coronavirus disease (COVID-19) confirmed using an IgM-IgG antibody test. J Med Virol, 2020; 92(10): 2004-2010.
  • 10. Goudouris, E.S., Laboratory diagnosis of COVID-19. J Pediatr (Rio J), 2021; 97(1): 7-12.
  • 11. Ai T, Yang Z, Hou H, Zhan C, Chen C, Lv W, et al. Correlation of Chest CT and RT-PCR Testing for Coronavirus Disease 2019 (COVID-19) in China: A Report of 1014 Cases. Radiology, 2020; 296(2): E32-e40.
  • 12. Kostakoglu U, Kant A, Atalar S, Ertunc B, Erensoy S, Dalmanoglu E, et al. Diagnostic value of Chest CT and Initial Real-Time RT-PCR in COVID-19 Infection. Pak J Med Sci. 2021; 37(1): 234.
  • 13. Li, Y. and L.J.A.J.o.R. Xia. Coronavirus disease 2019 (COVID-19): role of chest CT in diagnosis and management. 2020; 214(6): 1280-1286.
  • 14. Zainol Rashid Z, Othman SN, Abdul Samat MN, Ali UK, Wong KK. Diagnostic performance of COVID-19 serology assays. Malays J Pathol. 2020; 42(1): 13-21.
  • 15. Li Z, Yi Y, Luo X, Xiong N, Liu Y, Li S, et al. Development and clinical application of a rapid IgM-IgG combined antibody test for SARS-CoV-2 infection diagnosis. J Med Virol, 2020; 92(9): 1518-1524.
  • 16. Chaimayo C, Kaewnaphan B, Tanlieng N, Athipanyasilp N, Sirijatuphat R, Chayakulkeeree M, et al. Rapid SARS-CoV-2 antigen detection assay in comparison with real-time RT-PCR assay for laboratory diagnosis of COVID-19 in Thailand. Virol J, 2020; 17(1): 177.
  • 17. Baloch S, Baloch MA, Zheng T, Pei X. The Coronavirus Disease 2019 (COVID-19) Pandemic. Tohoku J Exp Med, 2020; 250(4): 271-278.
  • 18. Jin JM, Bai P, He W, Wu F, Liu XF, Han DM, et al. Gender Differences in Patients With COVID-19: Focus on Severity and Mortality. Front Public Health, 2020; 8: 152.
  • 19. Nikpouraghdam M, Jalali Farahani A, Alishiri G, Heydari S, Ebrahimnia M, Samadinia H, et al., Epidemiological characteristics of coronavirus disease 2019 (COVID-19) patients in IRAN: A single center study. J Clin Virol. 2020; 127: 104378.
  • 20. Wan S, Xiang Y, Fang W, Zheng Y, Li B, Hu Y, et al., Clinical features and treatment of COVID‐19 patients in northeast Chongqing. J Med Virol. 2020; 92(7): 797-806.
  • 21. WHO, Clinical management of severe acute respiratory infection (SARI) when COVID-19 disease is suspected. 2020; Mar 13.
  • 22. Wang M, Cao R, Zhang L, Yang X, Liu J, Xu M, et al. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 2020; 30(3): 269-271
There are 22 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Clinical Research
Authors

Özlem Akdoğan 0000-0003-2969-474X

Derya Yapar 0000-0003-3566-9751

Kazım Çebi This is me 0000-0002-2214-2945

Sertaç Arslan 0000-0002-9198-8274

Hilal Boyacı 0000-0003-4331-3552

Yasemin Arı Yılmaz 0000-0002-8674-8911

Pınar Tunçel Öztürk 0000-0003-1106-0546

Ünsal Savcı 0000-0003-2319-8171

Hüseyin Kayadibi 0000-0002-3922-4517

Ayşe Yılmaz 0000-0001-6235-6617

Meral Gülhan This is me 0000-0002-8169-570X

Aysel Kocagül Çelikbaş 0000-0002-7448-5210

Nurcan Baykam 0000-0002-2398-8686

Project Number 12.05.2020 tarih ve 240 nolu etik kurul onayı , Sağlık Bakanlığı izni ve kurum izni alınmıştır
Early Pub Date January 3, 2022
Publication Date January 1, 2022
Submission Date April 19, 2021
Acceptance Date May 31, 2021
Published in Issue Year 2022 Volume: 39 Issue: 1

Cite

APA Akdoğan, Ö., Yapar, D., Çebi, K., Arslan, S., et al. (2022). Evaluation of Covid-19 cases that applied to the hospital at the first peak of the pandemic. Journal of Experimental and Clinical Medicine, 39(1), 7-11.
AMA Akdoğan Ö, Yapar D, Çebi K, Arslan S, Boyacı H, Arı Yılmaz Y, Tunçel Öztürk P, Savcı Ü, Kayadibi H, Yılmaz A, Gülhan M, Kocagül Çelikbaş A, Baykam N. Evaluation of Covid-19 cases that applied to the hospital at the first peak of the pandemic. J. Exp. Clin. Med. January 2022;39(1):7-11.
Chicago Akdoğan, Özlem, Derya Yapar, Kazım Çebi, Sertaç Arslan, Hilal Boyacı, Yasemin Arı Yılmaz, Pınar Tunçel Öztürk, Ünsal Savcı, Hüseyin Kayadibi, Ayşe Yılmaz, Meral Gülhan, Aysel Kocagül Çelikbaş, and Nurcan Baykam. “Evaluation of Covid-19 Cases That Applied to the Hospital at the First Peak of the Pandemic”. Journal of Experimental and Clinical Medicine 39, no. 1 (January 2022): 7-11.
EndNote Akdoğan Ö, Yapar D, Çebi K, Arslan S, Boyacı H, Arı Yılmaz Y, Tunçel Öztürk P, Savcı Ü, Kayadibi H, Yılmaz A, Gülhan M, Kocagül Çelikbaş A, Baykam N (January 1, 2022) Evaluation of Covid-19 cases that applied to the hospital at the first peak of the pandemic. Journal of Experimental and Clinical Medicine 39 1 7–11.
IEEE Ö. Akdoğan, “Evaluation of Covid-19 cases that applied to the hospital at the first peak of the pandemic”, J. Exp. Clin. Med., vol. 39, no. 1, pp. 7–11, 2022.
ISNAD Akdoğan, Özlem et al. “Evaluation of Covid-19 Cases That Applied to the Hospital at the First Peak of the Pandemic”. Journal of Experimental and Clinical Medicine 39/1 (January 2022), 7-11.
JAMA Akdoğan Ö, Yapar D, Çebi K, Arslan S, Boyacı H, Arı Yılmaz Y, Tunçel Öztürk P, Savcı Ü, Kayadibi H, Yılmaz A, Gülhan M, Kocagül Çelikbaş A, Baykam N. Evaluation of Covid-19 cases that applied to the hospital at the first peak of the pandemic. J. Exp. Clin. Med. 2022;39:7–11.
MLA Akdoğan, Özlem et al. “Evaluation of Covid-19 Cases That Applied to the Hospital at the First Peak of the Pandemic”. Journal of Experimental and Clinical Medicine, vol. 39, no. 1, 2022, pp. 7-11.
Vancouver Akdoğan Ö, Yapar D, Çebi K, Arslan S, Boyacı H, Arı Yılmaz Y, Tunçel Öztürk P, Savcı Ü, Kayadibi H, Yılmaz A, Gülhan M, Kocagül Çelikbaş A, Baykam N. Evaluation of Covid-19 cases that applied to the hospital at the first peak of the pandemic. J. Exp. Clin. Med. 2022;39(1):7-11.
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