The value of preoperative inflammatory markers in patients through total laryngectomy for advanced stage larynx carcinoma
Abstract
The aim of this study is to evaluate the difference between neutrophil, lymphocyte, platelet and RDW (red cell distribution width) counts and NLR (neutrophil/lymphocyte ratio) and PLR (platelet/lymphocyte ratio) between patients who underwent total laryngectomy for advanced stage laryngeal squamous cell carcinoma and healthy control group. The study group consisted of 37 patients (36 male, 1 female) who underwent total laryngectomy and bilateral neck dissection for advanced stage laryngeal squamous cell carcinoma between January 2017 and December 2019. As a control group, complete blood count records of 35 healthy individuals who were routinely examined in 2019 within the scope of occupational health and safety were compiled. Blood was collected preoperatively from the patient in the study group. The data obtained from the whole blood counts of the two groups were analyzed statistically by comparing neutrophil, lymphocyte, platelet, RDW, NLR and PLR values. The age difference between the study and control groups was not significant (p>0.05). Neutrophil, platelet and RDW counts were higher in the study group compared to the control group and this difference was statistically significant (p=0.001, p=0.035, p=0.001, respectively). Although the lymphocyte count was high in the study group, the difference was not significant (p=0.061). The difference between NLR and PLR between the two groups was high in the study group and this difference was statistically significant (p=0.001, p=0.007, respectively). Neutrophil, platelet, RDW, NLR, PLR values were significantly higher in patients with advanced stage laryngeal cancer than in the control group. NLR, PLR and RDW values, which can be obtained cheap, simple and rapidly at the diagnosis stage of laryngeal cancers, may be biomarkers in determining prognosis. For this, multicenter, prospective studies are needed.
Keywords
Laryngeal carcinoma neutrophil lymphocyte ratio platelet lymphocyte ratio red cell distribution width
References
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- 6. Choi WJ, Cleghorn MC, Jiang H, Jackson TD, Okrainec A, Quereshy FA. Preoperative neutrophil-to-lymphocyte ratio is a better prognostic serum biomarker than platelet-to-lymphocyte ratio in patients undergoing resection for nonmetastatic colorectal Cancer. Ann Surg Oncol. Ann Surg Oncol. 2015;22(Suppl 3):S603–S613.
- 7. Koma Y, Onishi A, Matsuoka H, Oda N, Yokota N, Matsumoto Y,et al. Increased red blood cell distribution width associates withcancer stage and prognosis in patients with lung cancer. PLoSONE. 2013;8(11):e80240.
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- 9. Woodard TD, Oplatek A and Petruzzelli GJ: Life after total laryngectomy: A measure of long-term survival, function, and quality of life. Arch Otolaryngol Head Neck Surg. 2007;133:526–532.
- 10. Kara M, Uysal S, Altinişik U, Cevizci S, Güçlü O, Dereköy FS. The pre-treatment neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and red cell distribution width predict prognosis in patients with laryngeal carcinoma. Eur Arch Otorhinolaryngol. 2017; 274: 535-542.
- 11. Pillay J, Kamp VM, van Hoffen E, Visser T, Tak T, Lammers JW et al. A subset of neutrophils in human systemic inflammation inhibits T cell responses through Mac-1. J Clin Invest. 2012;122:327–36.
- 12. Teng MW, Swann JB, Koebel CM, Schreiber RD, Smyth MJ. Immune-mediated dormancy: an equilibrium with cancer. J Leukoc Biol. 2008;84(4): 988–93.
- 13. Mantovani A, Allavena P, Sica A, Ballkwill F. Cancer-related inflammation. Nature. 2008;454(7203):436-44.
- 14. Brown KM, Domin C, Aranha GV, Yong S, Shoup M. Increased preoperative platelet count is associated with decreased survival after resection for adenocarcinoma of the pancreas. Am J Surg. 2005;189:278-82.
- 15. Zhao Z, Liu T, Li J, Yang W, Liu E, Li G. Elevated red cell distribution width level is associated with oxidative stress and inflammation in a canine model of rapid atrial pacing. Int J Cardiol. 2014; 174:174–6.
- 16. Tham T, Bardash Y, Teegala S, Herman WS, Costantino PD. The red cell distribution width as a prognostic indicator in upper aerodigestive tract (UADT) cancer: a systematic review and meta-analysis. Am J Otolaryngol. 2018; 39:453–8.
- 17. Bozkurt G, Korkut AY, Soytaş P, Dizdar SK, Erol ZN. The role of red cell distribution width in the locoregional recurrence of laryngeal cancer. Braz J Otorhinolaryngol.2019;85(3):357-64.
- 18. Hsueh CY, Lau HC, Li S, Tao L, Zhang M, Gong H, Zhou L. Pretreatment Level of Red Cell Distribution Width as a Prognostic Indicator for Survival in a Large Cohort Study of Male Laryngeal Squamous Carcinoma. Front Onkol. 2019;9:271.
- 19. Rassouli A, Saliba J, Castano R, Hier M and Zeitouni AG: Systemic inflammatory markers as independent prognosticators of head and neck squamous cell carcinoma. Head Neck. 37:103–110. 2015.
- 20. Tu XP, Tian T, Liang-Si Chen LS, Luo XN, Lu ZM, Zhang SY, Chen SH. Prognostic values of p reoperative NLR and PLR in patients with laryngeal squamous cell carcinoma. Transl Cancer Res 2018;7(2):301-309.
Abstract
Keywords
Laryngeal carcinoma neutrophil lymphocyte ratio platelet lymphocyte ratio red cell distribution width
References
- 1. Ballenger JJ, Snow JB. Otorhinolaryngology: head and neck surgery. 15th ed. Media, Williams & Wilkins, PA, USA. 1996.
- 2. Kim S, Smith BD, Haffty BG. Prognostic factors in patients with head and neck cancer. In: Head and Neck Cancer: A Multidisciplinary Approach. Harrison LB, Sessions RB, Kies MS, editors. Philadelphia, U.S.A: Wolters Kluwer; 2013. p. 87-111.
- 3. Chen L, Zeng H, Yang J, Lu Y, Zhang D, Wang J, Kuang C, Zhu S, Wang M, Ma X. Survival and prognostic analysis of preoperative inflammatory markers in patients undergoing surgical resection for laryngeal squamous cell carcinoma. BMC Cancer. 2018;18(1):816.
- 4. Schreiber RD, Old LJ, Smyth MJ. Cancer immunoediting: integrating immunity’s roles in cancer suppression and promotion. Science. 2011;331:1565-70 .
- 5. Dunn GP, Old LJ, Schreiber RD. The immunobiology of cancer immunosurveillance and immunoediting. Immunity. 2004;21:137–48.
- 6. Choi WJ, Cleghorn MC, Jiang H, Jackson TD, Okrainec A, Quereshy FA. Preoperative neutrophil-to-lymphocyte ratio is a better prognostic serum biomarker than platelet-to-lymphocyte ratio in patients undergoing resection for nonmetastatic colorectal Cancer. Ann Surg Oncol. Ann Surg Oncol. 2015;22(Suppl 3):S603–S613.
- 7. Koma Y, Onishi A, Matsuoka H, Oda N, Yokota N, Matsumoto Y,et al. Increased red blood cell distribution width associates withcancer stage and prognosis in patients with lung cancer. PLoSONE. 2013;8(11):e80240.
- 8. Ji W, Guan C and Pan Z: Analysis of curative effects on laryngeal carcinoma patients in the northeast region of China. Acta Otolaryngol. 2008;128:574–577.
- 9. Woodard TD, Oplatek A and Petruzzelli GJ: Life after total laryngectomy: A measure of long-term survival, function, and quality of life. Arch Otolaryngol Head Neck Surg. 2007;133:526–532.
- 10. Kara M, Uysal S, Altinişik U, Cevizci S, Güçlü O, Dereköy FS. The pre-treatment neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and red cell distribution width predict prognosis in patients with laryngeal carcinoma. Eur Arch Otorhinolaryngol. 2017; 274: 535-542.
- 11. Pillay J, Kamp VM, van Hoffen E, Visser T, Tak T, Lammers JW et al. A subset of neutrophils in human systemic inflammation inhibits T cell responses through Mac-1. J Clin Invest. 2012;122:327–36.
- 12. Teng MW, Swann JB, Koebel CM, Schreiber RD, Smyth MJ. Immune-mediated dormancy: an equilibrium with cancer. J Leukoc Biol. 2008;84(4): 988–93.
- 13. Mantovani A, Allavena P, Sica A, Ballkwill F. Cancer-related inflammation. Nature. 2008;454(7203):436-44.
- 14. Brown KM, Domin C, Aranha GV, Yong S, Shoup M. Increased preoperative platelet count is associated with decreased survival after resection for adenocarcinoma of the pancreas. Am J Surg. 2005;189:278-82.
- 15. Zhao Z, Liu T, Li J, Yang W, Liu E, Li G. Elevated red cell distribution width level is associated with oxidative stress and inflammation in a canine model of rapid atrial pacing. Int J Cardiol. 2014; 174:174–6.
- 16. Tham T, Bardash Y, Teegala S, Herman WS, Costantino PD. The red cell distribution width as a prognostic indicator in upper aerodigestive tract (UADT) cancer: a systematic review and meta-analysis. Am J Otolaryngol. 2018; 39:453–8.
- 17. Bozkurt G, Korkut AY, Soytaş P, Dizdar SK, Erol ZN. The role of red cell distribution width in the locoregional recurrence of laryngeal cancer. Braz J Otorhinolaryngol.2019;85(3):357-64.
- 18. Hsueh CY, Lau HC, Li S, Tao L, Zhang M, Gong H, Zhou L. Pretreatment Level of Red Cell Distribution Width as a Prognostic Indicator for Survival in a Large Cohort Study of Male Laryngeal Squamous Carcinoma. Front Onkol. 2019;9:271.
- 19. Rassouli A, Saliba J, Castano R, Hier M and Zeitouni AG: Systemic inflammatory markers as independent prognosticators of head and neck squamous cell carcinoma. Head Neck. 37:103–110. 2015.
- 20. Tu XP, Tian T, Liang-Si Chen LS, Luo XN, Lu ZM, Zhang SY, Chen SH. Prognostic values of p reoperative NLR and PLR in patients with laryngeal squamous cell carcinoma. Transl Cancer Res 2018;7(2):301-309.
Details
| Primary Language | English |
|---|---|
| Subjects | Health Care Administration |
| Journal Section | Research Article |
| Authors | |
| Early Pub Date | March 18, 2023 |
| Publication Date | March 18, 2023 |
| Submission Date | January 13, 2023 |
| Acceptance Date | March 15, 2023 |
| Published in Issue | Year 2023 Volume: 40 Issue: 1 |
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