Relationship between gestational diabetes mellitus, vitamin D level and maternal age

Ayşe Şeyma Küçükakça

Research Article

Year 2023, Volume: 40 Issue: 2, 273 - 277, 19.07.2023

Ayşe Şeyma Küçükakça

Abstract

Keywords

Gestational diabetes mellitus, vitamin D, pregnancy, advanced maternal age.

References

1. Sweeting A, Wong J, Murphy HR, Ross GP. A Clinical Update on Gestational Diabetes Mellitus. Endocr Rev. 2022 Sep 26;43(5):763-793.
2. Çetin C, Güngör ND, Yavuz M. First trimester glycosylated hemoglobin for gestational diabetes mellitus screening. Taiwan J Obstet Gynecol. 2021 Sep;60(5):899-902.
3. Pillay J, Donovan L, Guitard S, Zakher B, Korownyk C, Gates M, et al. Screening for Gestational Diabetes Mellitus: A Systematic Review to Update the 2014 U.S. Preventive Services Task Force Recommendation [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2021 Aug. Report No.: 21-05273-EF-1.
4. Law KP, Zhang H. The pathogenesis and pathophysiology of gestational diabetes mellitus: Deductions from a three-part longitudinal metabolomics study in China. Clin Chim Acta. 2017 May;468:60-70.
5. Kulie T, Groff A, Redmer J, Hounshell J, Schrager S. Vitamin D: an evidence-based review. J Am Board Fam Med. 2009;22(6):698-706.
6. Gürbüz T, GÜNGÖR ND. Hiperemezis gravidarum etiyopatogenezinde vitamin D eksikliğinin rolü var mı? Adıyaman Üniversitesi Sağlık Bilimleri Dergisi. 2018;4(2):761-71.
7. Gürbüz T, Güngör ND, Yurci A. Does intracytoplasmic sperm injection increase the risk of gestational diabetes in patients with polycystic over? Anatolian Curr Med J 2021;(1); 53-58.
8. Mosavat M, Arabiat D, Smyth A, Newnham J, Whitehead L. Second-trimester maternal serum vitamin D and pregnancy outcome: The Western Australian Raine cohort study. Diabetes Res Clin Pract. 2021;175:108779.
9. LeRoith D, Holly JM, Forbes BE. Insulin-like growth factors: Ligands, binding proteins, and receptors. Mol Metab. 2021;52:101245.
10. Glick I, Kadish E, Rottenstreich M. Management of pregnancy in women of advanced maternal age: Improving outcomes for mother and baby Int J Womens Health. 2021;13:751.
11. Cefalu WT, Berg EG, Saraco M, Petersen MP, Uelmen S, Robinson S. Classification and diagnosis of diabetes: standards of medical care in diabetes-2019. Diabetes Care. 2019;42:S13-S28.
12. Giustina A, Adler RA, Binkley N, Bouillon R, Ebeling PR, Lazaretti-Castro M, et al. Controversies in vitamin D: summary statement from an international conference. J Clin Endocrinol Metab. 2019;104(2):234-40.
13. Sempos CT, Heijboer AC, Bikle DD, Bollerslev J, Bouillon R, Brannon PM, et al. Vitamin D assays and the definition of hypovitaminosis D: results from the First International Conference on Controversies in Vitamin D. Br J Clin Pharmacol. 2018;84(10):2194-207.
14. Munns CF, Shaw N, Kiely M, Specker BL, Thacher TD, Ozono K, et al. Global consensus recommendations on prevention and management of nutritional rickets. Horm Res Paediatr. 2016;85(2):83-106.
15. Faul F, Erdfelder E, Buchner A, Lang A-G. Statistical power analyses using G* Power 3.1: Tests for correlation and regression analyses. Behav Res Methods. 2009;41(4):1149-60.
16. El Lithy A, Abdella RM, El-Faissal YM, Sayed AM, Samie RMA. The relationship between low maternal serum vitamin D levels and glycemic control in gestational diabetes assessed by HbA1c levels: an observational cross-sectional study. BMC Pregnancy Childbirth. 2014;14(1):1-6.
17. Agarwal S, Kovilam O, Agrawal DK. Vitamin D and its impact on maternal-fetal outcomes in pregnancy: A critical review. Crit Rev Food Sci Nutr. 2018;58(5):755-69.
18. Muthukrishnan J, Dhruv G. Vitamin D status and gestational diabetes mellitus. Indian J Endocrinol Metab. 2015;19(5):616.
19. Rajput R, Vohra S, Nanda S, Rajput M. Severe 25(OH)vitamin-D deficiency: A risk factor for development of gestational diabetes mellitus. Diabetes Metab Syndr. 2019 Mar-Apr;13(2):985-987.
20. Zhang Y, Gong Y, Xue H, Xiong J, Cheng G. Vitamin D and gestational diabetes mellitus: a systematic review based on data free of Hawthorne effect. BJOG. 2018 Jun;125(7):784-793.
21. Jafarzadeh L, Motamedi A, Behradmanesh M, Hashemi R. A comparison of serum levels of 25-hydroxy vitamin d in pregnant women at risk for gestational diabetes mellitus and women without risk factors. Mater Sociomed. 2015 Oct;27(5):318-22.
22. Ismail NA, Mohamed Ismail NA, Bador KM. Vitamin D in gestational diabetes mellitus and its association with hyperglycaemia, insulin sensitivity and other factors. J Obstet Gynaecol. 2021 Aug;41(6):899-903.
23. Makgoba M, Nelson SM, Savvidou M, Messow C-M, Nicolaides K, Sattar N. First-trimester circulating 25-hydroxyvitamin D levels and development of gestational diabetes mellitus. Diabetes Care. 2011 May;34(5):1091-3.
24. Luo C, Li Z, Lu Y, Wei F, Suo D, Lan S, et al. Association of serum vitamin D status with gestational diabetes mellitus and other laboratory parameters in early pregnant women. BMC Pregnancy Childbirth. 2022 May 11;22(1):400.
25. Keller A, Stougård M, Frederiksen P, Thorsteinsdottir F, Vaag A, Damm P, et al. In utero exposure to extra vitamin D from food fortification and the risk of subsequent development of gestational diabetes: the D-tect study. Nutr J. 2018 Nov 2;17(1):100.
26. Farrant HJ, Krishnaveni GV, Hill JC, Boucher BJ, Fisher DJ, Noonan K, et al. Vitamin D insufficiency is common in Indian mothers but is not associated with gestational diabetes or variation in newborn size. Eur J Clin Nutr. 2009;63(5):646-52.
27. Park S, Yoon H-K, Ryu H-M, Han YJ, Lee SW, Park BK, et al. Maternal vitamin D deficiency in early pregnancy is not associated with gestational diabetes mellitus development or pregnancy outcomes in Korean pregnant women in a prospective study. J Nutr Sci Vitaminol (Tokyo). 2014;60(4):269-75.
28. Baker AM, Haeri S, Camargo Jr CA, Stuebe AM, Boggess KA. First‐trimester maternal vitamin D status and risk for gestational diabetes (GDM) a nested case‐control study. Diabetes Metab Res Rev. 2012;28(2):164-8.
29. Milajerdi A, Abbasi F, Mousavi SM, Esmaillzadeh A. Maternal vitamin D status and risk of gestational diabetes mellitus: A systematic review and meta-analysis of prospective cohort studies. Clin Nutr. 2021;40(5):2576-86.
30. Wang L, Zhang C, Song Y, Zhang Z. Serum vitamin D deficiency and risk of gestational diabetes mellitus: a meta-analysis. Arch Med Sci. 2020 Apr 15;16(4):742-751.
31. Krishnaveni GV, Veena SR, Winder NR, Hill JC, Noonan K, Boucher BJ, et al. Maternal vitamin D status during pregnancy and body composition and cardiovascular risk markers in Indian children: the Mysore Parthenon Study. Am J Clin Nutr. 2011 Mar;93(3):628-35.

Relationship between gestational diabetes mellitus, vitamin D level and maternal age

Year 2023, Volume: 40 Issue: 2, 273 - 277, 19.07.2023

Ayşe Şeyma Küçükakça

Abstract

Our study aimed to determine the vitamin D level of pregnant women was associated with gestational diabetes mellitus (GDM) and whether maternal age affects this. This cohort study retrospectively examined the electronic records of 200 pregnant women. The patients were divided into two groups: the GDM group (n: 35) as the case group and the healthy group (n: 165) as the control group. Pregnant women aged 19-44 years were included in the study. Vitamin D levels are deficient <12 ng/mL, insufficient 12-20 ng/mL, and sufficient >20 ng/mL. Results found a statistically significant association between vitamin D level and GDM in women (p <0.05). The vitamin D level in the GDM group (M=16.19; SD=5.59) was lower than vitamin D level in controls (M=25.48; SD=10.01). The percentage of women whose vitamin D was within the sufficient range in GDM was 11% compared to 63% of healthy pregnant women. There was no statistically significant association between age and GDM (p>0.05). Results showed that the vitamin D levels in the GDM group was significantly lower than in the control group.

Keywords

Gestational diabetes mellitus, vitamin D, pregnancy, advanced maternal age.

References

1. Sweeting A, Wong J, Murphy HR, Ross GP. A Clinical Update on Gestational Diabetes Mellitus. Endocr Rev. 2022 Sep 26;43(5):763-793.
2. Çetin C, Güngör ND, Yavuz M. First trimester glycosylated hemoglobin for gestational diabetes mellitus screening. Taiwan J Obstet Gynecol. 2021 Sep;60(5):899-902.
3. Pillay J, Donovan L, Guitard S, Zakher B, Korownyk C, Gates M, et al. Screening for Gestational Diabetes Mellitus: A Systematic Review to Update the 2014 U.S. Preventive Services Task Force Recommendation [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2021 Aug. Report No.: 21-05273-EF-1.
4. Law KP, Zhang H. The pathogenesis and pathophysiology of gestational diabetes mellitus: Deductions from a three-part longitudinal metabolomics study in China. Clin Chim Acta. 2017 May;468:60-70.
5. Kulie T, Groff A, Redmer J, Hounshell J, Schrager S. Vitamin D: an evidence-based review. J Am Board Fam Med. 2009;22(6):698-706.
6. Gürbüz T, GÜNGÖR ND. Hiperemezis gravidarum etiyopatogenezinde vitamin D eksikliğinin rolü var mı? Adıyaman Üniversitesi Sağlık Bilimleri Dergisi. 2018;4(2):761-71.
7. Gürbüz T, Güngör ND, Yurci A. Does intracytoplasmic sperm injection increase the risk of gestational diabetes in patients with polycystic over? Anatolian Curr Med J 2021;(1); 53-58.
8. Mosavat M, Arabiat D, Smyth A, Newnham J, Whitehead L. Second-trimester maternal serum vitamin D and pregnancy outcome: The Western Australian Raine cohort study. Diabetes Res Clin Pract. 2021;175:108779.
9. LeRoith D, Holly JM, Forbes BE. Insulin-like growth factors: Ligands, binding proteins, and receptors. Mol Metab. 2021;52:101245.
10. Glick I, Kadish E, Rottenstreich M. Management of pregnancy in women of advanced maternal age: Improving outcomes for mother and baby Int J Womens Health. 2021;13:751.
11. Cefalu WT, Berg EG, Saraco M, Petersen MP, Uelmen S, Robinson S. Classification and diagnosis of diabetes: standards of medical care in diabetes-2019. Diabetes Care. 2019;42:S13-S28.
12. Giustina A, Adler RA, Binkley N, Bouillon R, Ebeling PR, Lazaretti-Castro M, et al. Controversies in vitamin D: summary statement from an international conference. J Clin Endocrinol Metab. 2019;104(2):234-40.
13. Sempos CT, Heijboer AC, Bikle DD, Bollerslev J, Bouillon R, Brannon PM, et al. Vitamin D assays and the definition of hypovitaminosis D: results from the First International Conference on Controversies in Vitamin D. Br J Clin Pharmacol. 2018;84(10):2194-207.
14. Munns CF, Shaw N, Kiely M, Specker BL, Thacher TD, Ozono K, et al. Global consensus recommendations on prevention and management of nutritional rickets. Horm Res Paediatr. 2016;85(2):83-106.
15. Faul F, Erdfelder E, Buchner A, Lang A-G. Statistical power analyses using G* Power 3.1: Tests for correlation and regression analyses. Behav Res Methods. 2009;41(4):1149-60.
16. El Lithy A, Abdella RM, El-Faissal YM, Sayed AM, Samie RMA. The relationship between low maternal serum vitamin D levels and glycemic control in gestational diabetes assessed by HbA1c levels: an observational cross-sectional study. BMC Pregnancy Childbirth. 2014;14(1):1-6.
17. Agarwal S, Kovilam O, Agrawal DK. Vitamin D and its impact on maternal-fetal outcomes in pregnancy: A critical review. Crit Rev Food Sci Nutr. 2018;58(5):755-69.
18. Muthukrishnan J, Dhruv G. Vitamin D status and gestational diabetes mellitus. Indian J Endocrinol Metab. 2015;19(5):616.
19. Rajput R, Vohra S, Nanda S, Rajput M. Severe 25(OH)vitamin-D deficiency: A risk factor for development of gestational diabetes mellitus. Diabetes Metab Syndr. 2019 Mar-Apr;13(2):985-987.
20. Zhang Y, Gong Y, Xue H, Xiong J, Cheng G. Vitamin D and gestational diabetes mellitus: a systematic review based on data free of Hawthorne effect. BJOG. 2018 Jun;125(7):784-793.
21. Jafarzadeh L, Motamedi A, Behradmanesh M, Hashemi R. A comparison of serum levels of 25-hydroxy vitamin d in pregnant women at risk for gestational diabetes mellitus and women without risk factors. Mater Sociomed. 2015 Oct;27(5):318-22.
22. Ismail NA, Mohamed Ismail NA, Bador KM. Vitamin D in gestational diabetes mellitus and its association with hyperglycaemia, insulin sensitivity and other factors. J Obstet Gynaecol. 2021 Aug;41(6):899-903.
23. Makgoba M, Nelson SM, Savvidou M, Messow C-M, Nicolaides K, Sattar N. First-trimester circulating 25-hydroxyvitamin D levels and development of gestational diabetes mellitus. Diabetes Care. 2011 May;34(5):1091-3.
24. Luo C, Li Z, Lu Y, Wei F, Suo D, Lan S, et al. Association of serum vitamin D status with gestational diabetes mellitus and other laboratory parameters in early pregnant women. BMC Pregnancy Childbirth. 2022 May 11;22(1):400.
25. Keller A, Stougård M, Frederiksen P, Thorsteinsdottir F, Vaag A, Damm P, et al. In utero exposure to extra vitamin D from food fortification and the risk of subsequent development of gestational diabetes: the D-tect study. Nutr J. 2018 Nov 2;17(1):100.
26. Farrant HJ, Krishnaveni GV, Hill JC, Boucher BJ, Fisher DJ, Noonan K, et al. Vitamin D insufficiency is common in Indian mothers but is not associated with gestational diabetes or variation in newborn size. Eur J Clin Nutr. 2009;63(5):646-52.
27. Park S, Yoon H-K, Ryu H-M, Han YJ, Lee SW, Park BK, et al. Maternal vitamin D deficiency in early pregnancy is not associated with gestational diabetes mellitus development or pregnancy outcomes in Korean pregnant women in a prospective study. J Nutr Sci Vitaminol (Tokyo). 2014;60(4):269-75.
28. Baker AM, Haeri S, Camargo Jr CA, Stuebe AM, Boggess KA. First‐trimester maternal vitamin D status and risk for gestational diabetes (GDM) a nested case‐control study. Diabetes Metab Res Rev. 2012;28(2):164-8.
29. Milajerdi A, Abbasi F, Mousavi SM, Esmaillzadeh A. Maternal vitamin D status and risk of gestational diabetes mellitus: A systematic review and meta-analysis of prospective cohort studies. Clin Nutr. 2021;40(5):2576-86.
30. Wang L, Zhang C, Song Y, Zhang Z. Serum vitamin D deficiency and risk of gestational diabetes mellitus: a meta-analysis. Arch Med Sci. 2020 Apr 15;16(4):742-751.
31. Krishnaveni GV, Veena SR, Winder NR, Hill JC, Noonan K, Boucher BJ, et al. Maternal vitamin D status during pregnancy and body composition and cardiovascular risk markers in Indian children: the Mysore Parthenon Study. Am J Clin Nutr. 2011 Mar;93(3):628-35.

There are 31 citations in total.

Details

Primary Language	English
Subjects	Health Care Administration
Journal Section	Research Article
Authors	Ayşe Şeyma Küçükakça 0000-0003-4432-3824
Early Pub Date	August 1, 2023
Publication Date	July 19, 2023
Submission Date	January 7, 2023
Acceptance Date	January 18, 2023
Published in Issue	Year 2023 Volume: 40 Issue: 2

Cite

APA	Küçükakça, A. Ş. (2023). Relationship between gestational diabetes mellitus, vitamin D level and maternal age. Journal of Experimental and Clinical Medicine, 40(2), 273-277.
AMA	Küçükakça AŞ. Relationship between gestational diabetes mellitus, vitamin D level and maternal age. J. Exp. Clin. Med. July 2023;40(2):273-277.
Chicago	Küçükakça, Ayşe Şeyma. “Relationship Between Gestational Diabetes Mellitus, Vitamin D Level and Maternal Age”. Journal of Experimental and Clinical Medicine 40, no. 2 (July 2023): 273-77.
EndNote	Küçükakça AŞ (July 1, 2023) Relationship between gestational diabetes mellitus, vitamin D level and maternal age. Journal of Experimental and Clinical Medicine 40 2 273–277.
IEEE	A. Ş. Küçükakça, “Relationship between gestational diabetes mellitus, vitamin D level and maternal age”, J. Exp. Clin. Med., vol. 40, no. 2, pp. 273–277, 2023.
ISNAD	Küçükakça, Ayşe Şeyma. “Relationship Between Gestational Diabetes Mellitus, Vitamin D Level and Maternal Age”. Journal of Experimental and Clinical Medicine 40/2 (July 2023), 273-277.
JAMA	Küçükakça AŞ. Relationship between gestational diabetes mellitus, vitamin D level and maternal age. J. Exp. Clin. Med. 2023;40:273–277.
MLA	Küçükakça, Ayşe Şeyma. “Relationship Between Gestational Diabetes Mellitus, Vitamin D Level and Maternal Age”. Journal of Experimental and Clinical Medicine, vol. 40, no. 2, 2023, pp. 273-7.
Vancouver	Küçükakça AŞ. Relationship between gestational diabetes mellitus, vitamin D level and maternal age. J. Exp. Clin. Med. 2023;40(2):273-7.

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