Review
Bone-minerale metabolism disorders (renal osteodystrophy) in chronic kidney disease and treatment approach
Abstract
When renal functions decrease with
the ongoing parenchymal loss in chronic renal disease impairement of bone-
mineral metabolism occurs. Secondary hyperparathyroidism is there all cause
of this situation, and this case is
called renal osteodystrophia. In this disease there are vitamin D deficiency,
phosphate retension, hypocalcemia,
mineral metabolism impairement
due to secondary hyperparathyroidism, disturbance in the bone structure and
vascular and/or soft tissue
calcification, metastatic calcifications. Renal osteodystrophia is important in
chronic kidney disease patients as it
not only disturbs the quality of life
of the patients but also decreases the survey of
the patients.
References
- Pickenpack A, Lang B, Palitzsch KD, Schölmerich J, Straub RH. A 63 year-old patient with worsening general condition, bone demineralization, hypocalcemia and excess parathyroid hormone: late manifestations of pseudo hyperparathyroidism. Dtsch Med Wochenschr. 1999 7;124(18):551-5.
- Gokal R. Renal osteodystrophy and aluminum bone disease in CAPD patients. Clin Nephrol. 1988;(30)1: 64-7.
- Peneva M, Anadoliiska A, Apostolova D. Dental caries with chronic renal insufficiency. Stomatologiia (Soffia). 1989;71(3):6-10.
- Solak Y, Biyik Z, Ozbek O, Demircioğlu S, Turk S. Spontaneous bilateral humeral shaft fracture due to several renal osteodystrophia. Am J Med Sci. 2011:342(1):55.
- Kiss D, Brunner FP. Management of renal osteopathy in patients with chronic dialysis. Schweiz Med Wochenschr. 1996;126(42):1792-8.
- Ghitu S, Oprisiu R, Benamar L, Said S, Tataru Albu A, Arsenescu I, el Esper N, Moriniere P, Fournier A. Renal osteodystrophy (3); its treatment in dialysis patients. Nephrologie. 2000;21(8):413-24.
- Coburn JW. Mineral metabolism and renal bone disease: effects of CAPD versus hemodialysis. Kidney Int Suppl. 1993;40:S92-100.
- Cushner HM, Adams ND. Rena losteodystrophy-pathogenesis and treatment. Am J Med Sci.1985;290(6):234-45.
- Nakanishi S, Fukagawa M. Role of vitamin D in the pathogenesis of renal osteodystophy. ClinCalcium. 2004;14(9):15-20.
- Honda H, Sanada D, Akizwa T. Vitamin D metabolism and chronic kidney disease. ClinCalcium 2006;16(7):1143-46.
- Hamada Y, Fukagawa M. Chronic kidney disease (CKD) and bone. The mechanisms of chronic kidney disease-mineral and bone disorder (CKD-MBD). ClinCalcium. 2009;19(4).486-92.
- Moe SM, Drüeke T, Lameirre N, Eknoyan G. Chronic Kidney Disease-mineral bone disorder: a new paradigm. Adv Chronic Kidney Dis. 2007;14(1):3-12.
- Gal-Moscovici A, Sprague SM. Bone health in chronic kidney disease -mineral and bone disease. Adv Chronic Kidney Dis. 2007;14(1):27-36.
- Suchowierska E, Myswiliec M. Mineral and bone disturbances associated with chronic kidney disease. Pol Merkur Lekarski. 2010;28(164):138-43.
- Kidney Disease: Improving Global Outcomes (KDIGO) CKD-MBD Work Group. KDIGO Clinical Practice Guideline for the Diagnosis, Evaluation, Prevention, and Treatment of Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD). Kidney Int Suppl. 2009 Aug;(113):S1-130. doi: 10.1038/ki.2009.188.
- Reichel H. Current treatment options in secondary renal hyperparathyroidism. Nephrol Dial Transplant. 2006 Jan ;21(1):23-8. Epub 2005 Sep 6. Review.
- National Kidney Foundation. K/DOQI Cllinical Practice Guidelines for Bone Metabolism and Disease in Chronic Kidney Disease. Am J Kidney Dis. 2003;42(3): 1-202.
- Moe S, Drüeke T, Cunningham J, Goodman W, Martin K, Olgaard K, et al. Definition, evaluation, and classification of rena losteodystrohy: A position statement from KidneyDisease: Improving Global Outcomes (KDIGO). Kidney International. 2006 Jun;69(11):1945-53.
- Tomic-Brzac H, Pavlovic D. Ultrasonography methods in the diagnosis and renal osteodystrohy. ActaMed Croatica.2004;58(1):43-9.
- 20.Lorenzo Sallares V, Torregrosa V. Changes in mineral matabolism in stage 3, 4, 5 chronic kidney disease (not on dialysis). Nefrologia. 2008;(28)3:67-78.
Kronik böbrek hastalığında kemik-mineral metabolizması bozuklukları (renal osteodistrofi) ve tedavi yaklaşımı
Abstract
Kronik böbrek hastalığında devam
eden parankim kaybı nedeniyle böbrek fonksiyonları azaldıkça kemik-mineral
metabolizmasında bozulmalar olmaktadır. Bu durumu oluşturan temel neden sekonder
hiperparatiroididir ve bu tabloya da renal osteodistrofi denilmektedir. Bu
tabloda vitamin D eksikliği, fosfat retansiyonu, hipokalsemi, sekonder
hiperparatiroidinin oluşturduğu mineral metabolizması bozukluğu, kemik
yapısında bozulma ile beraber vasküler ve/veya yumuşak doku kalsifikasyonları,
metastatik kalsifikasyonlar söz konusudur. Renal osteodistrofi kronik böbrek
hastalarında hem yaşam kalitesini düşürmesi
hem de yaşam süresini kısaltıyor olması nedeniyle önem arz etmektedir.
References
- Pickenpack A, Lang B, Palitzsch KD, Schölmerich J, Straub RH. A 63 year-old patient with worsening general condition, bone demineralization, hypocalcemia and excess parathyroid hormone: late manifestations of pseudo hyperparathyroidism. Dtsch Med Wochenschr. 1999 7;124(18):551-5.
- Gokal R. Renal osteodystrophy and aluminum bone disease in CAPD patients. Clin Nephrol. 1988;(30)1: 64-7.
- Peneva M, Anadoliiska A, Apostolova D. Dental caries with chronic renal insufficiency. Stomatologiia (Soffia). 1989;71(3):6-10.
- Solak Y, Biyik Z, Ozbek O, Demircioğlu S, Turk S. Spontaneous bilateral humeral shaft fracture due to several renal osteodystrophia. Am J Med Sci. 2011:342(1):55.
- Kiss D, Brunner FP. Management of renal osteopathy in patients with chronic dialysis. Schweiz Med Wochenschr. 1996;126(42):1792-8.
- Ghitu S, Oprisiu R, Benamar L, Said S, Tataru Albu A, Arsenescu I, el Esper N, Moriniere P, Fournier A. Renal osteodystrophy (3); its treatment in dialysis patients. Nephrologie. 2000;21(8):413-24.
- Coburn JW. Mineral metabolism and renal bone disease: effects of CAPD versus hemodialysis. Kidney Int Suppl. 1993;40:S92-100.
- Cushner HM, Adams ND. Rena losteodystrophy-pathogenesis and treatment. Am J Med Sci.1985;290(6):234-45.
- Nakanishi S, Fukagawa M. Role of vitamin D in the pathogenesis of renal osteodystophy. ClinCalcium. 2004;14(9):15-20.
- Honda H, Sanada D, Akizwa T. Vitamin D metabolism and chronic kidney disease. ClinCalcium 2006;16(7):1143-46.
- Hamada Y, Fukagawa M. Chronic kidney disease (CKD) and bone. The mechanisms of chronic kidney disease-mineral and bone disorder (CKD-MBD). ClinCalcium. 2009;19(4).486-92.
- Moe SM, Drüeke T, Lameirre N, Eknoyan G. Chronic Kidney Disease-mineral bone disorder: a new paradigm. Adv Chronic Kidney Dis. 2007;14(1):3-12.
- Gal-Moscovici A, Sprague SM. Bone health in chronic kidney disease -mineral and bone disease. Adv Chronic Kidney Dis. 2007;14(1):27-36.
- Suchowierska E, Myswiliec M. Mineral and bone disturbances associated with chronic kidney disease. Pol Merkur Lekarski. 2010;28(164):138-43.
- Kidney Disease: Improving Global Outcomes (KDIGO) CKD-MBD Work Group. KDIGO Clinical Practice Guideline for the Diagnosis, Evaluation, Prevention, and Treatment of Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD). Kidney Int Suppl. 2009 Aug;(113):S1-130. doi: 10.1038/ki.2009.188.
- Reichel H. Current treatment options in secondary renal hyperparathyroidism. Nephrol Dial Transplant. 2006 Jan ;21(1):23-8. Epub 2005 Sep 6. Review.
- National Kidney Foundation. K/DOQI Cllinical Practice Guidelines for Bone Metabolism and Disease in Chronic Kidney Disease. Am J Kidney Dis. 2003;42(3): 1-202.
- Moe S, Drüeke T, Cunningham J, Goodman W, Martin K, Olgaard K, et al. Definition, evaluation, and classification of rena losteodystrohy: A position statement from KidneyDisease: Improving Global Outcomes (KDIGO). Kidney International. 2006 Jun;69(11):1945-53.
- Tomic-Brzac H, Pavlovic D. Ultrasonography methods in the diagnosis and renal osteodystrohy. ActaMed Croatica.2004;58(1):43-9.
- 20.Lorenzo Sallares V, Torregrosa V. Changes in mineral matabolism in stage 3, 4, 5 chronic kidney disease (not on dialysis). Nefrologia. 2008;(28)3:67-78.
There are 20 citations in total.
Details
| Subjects | Health Care Administration |
|---|---|
| Journal Section | Review |
| Authors | |
| Publication Date | December 1, 2016 |
| Published in Issue | Year 2016 Volume: 8 Issue: 4 |
e-ISSN: 2548-0251
The content of this site is intended for health care professionals. All the published articles are distributed under the terms of
Creative Commons Attribution Licence,
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.