Abstract
Amaç:
Jinekolojik kanserler arasında en sık görüleni endometrium
kanseridir. Tüm kanserlerde olduğu gibi, endometrium kanserinde de kronik
inflamasyon etyolojik faktör olarak rol oynamaktadır.
Gereç
ve Yöntem: Çalışmamıza her grupta 35 olmak üzere üç
grup ve toplam 105 hasta dahil edildi. Endometrial örnekleme sonuçlarına göre
gruplar; benign grup, hiperplazi grubu ve malign grup olarak isimlendirildi.
Gruplar arasında hematolojik parametrelerde anlamlı fark olup olmadığı
araştırıldı.
Bulgular:
Nötrofil sayısı, lenfosit sayısı, platelet sayısı, nötrofil/lenfosit
oranı ve platelet/lenfosit oranı bakımından gruplar arasında istatistiksel
olarak anlamlı bir fark saptanmadı (p>0,05). Hemoglobin, ortalama platelet
volümü ve Platelet dağılım genişliği değerleri malign grupta istatistiksel
olarak anlamlı derecede yüksek saptandı (p<0,05).
Sonuç: Çalışmamızda elde ettiğimiz sonuçlar bize; inflamasyonun,
platelet aktivitesini arttırarak endometrium kanserine zemin hazırlayabileceğini
düşündürdü.
References
- Referans1. Elit LM, Pond G, Seow H. Time interval between endometrial biopsy and surgical staging for type I endometrial cancer: association between tumor characteristics and survival outcome. Obstet Gynecol. 2015;125:1497-1498.
- Referans2. Kim MK, Seong SJ, Kim JW ve ark. Management of Endometrial Hyperplasia: A Survey of Members of the Korean Gynecologic Oncology Group. Int J Gynecol Cancer. 2015;25:1277-1284.
- Referans3. Kim DK, Oh SY, Kwon HC ve ark. Clinical significances of preoperative serum interleukin-6 and C-reactive protein level inoperable gastric cancer. BMC Cancer. 2009;9:155.
- Referans4. Mangalpally KK, Siqueiros-Garcia A, Vaduganathan M, Dong JF, Kleiman NS, Guthikonda S. Platelet activation patterns in platelet size sub-populations: differential responses to aspirin in vitro. Journal of Thrombosis and Thrombolysis. 2010;30:251–262.
- Referans5. Talhouk A, McConechy MK, Leung S ve ark. A clinically applicable molecular-based classification for endometrial cancers. Br J Cancer. 2015;113:299-310.
- Referans6. D. W. Kamp, E. Shacter, and S. A. Weitzman, Chronic inflammation and cancer: the role of the mitochondria. Oncology. 2011;400–413.
- Referans7. Arango HA, Icely S, Roberts WS, Cavanagh D, Becker JL. Aspirin effects on endometrial cancer cell growth. Obstet Gynecol 2001;423–427.
- Referans8. L. Dossus, S. Rinaldi, S. Becker ve ark. Obesity, inflammatory markers, and endometrial cancer risk: a prospective Case-Control Study. Endocrine-Related Cancer. 2010;1007–1019.
- Referans9. Vagdatli E, Gounari E, Lazaridou E, Katsibourlia E, Tsikopoulou F, Labrianou I. Platelet distribution width: a simple, practical and specific marker of activation of coagulation. Hippokratia. 2010;14:28-32.
- Referans10. Tuszynski GP, Nicosia RF. The role of thrombospondin-1 in tumor progression and angiogenesis. Bioessays, 1996; 71-76.
- Referans11. Oge T, Yalcin OT, Ozalp SS, Isikci T. Platelet volume as a parameter for platelet activation in patients with endometrial cancer. J Obstet Gynaecol. 2013;33:301-304.
- Referans12. Ercan Yılmaz, Ebru İnci Coşkun, Nurhan Şahin, Tamer Elkıran, Barış Cıplak, Yavuz Şimşek. The sıgnıfıcance of MPV and N/L value ın dıagnosıs of endometrıal cancer. Türk Jinekolojik Onkoloji Dergisi. 2015;33-36.
- Referans13. Karateke A, Kaplanoglu M, Baloglu A. Relations of Platelet Indices with Endometrial Hyperplasia and Endometrial Cancer. Asian Pac J Cancer Prev. 2015;16:4905-4908.
- Referans14. Yıldırım MA, Seckin KD, Togrul C ve ark. Roles of neutrophil/lymphocyte and platelet/lymphocyte ratios in the early diagnosis of malignant ovarian masses. Asian Pac J Cancer Prev. 2014;15:6881-6885.
- Referans15. Kokcu A, Kurtoglu E, Celik H, Tosun M, Malatyalıoglu E, Ozdemir AZ. May the platelet to lymphocyte ratio be a prognostic factor for epithelial ovarian cancer? Asian Pac J Cancer Prev. 2014;15:9781-9784.
Abstract
Aim:
Endometrium cancer is the most commonly seen
gynecologic cancer. As in all the cancer processes,
chronic inflammation plays an etiological role.
Material
and Method: The study included a total of 105 patients. Three
groups each
consisting 35 patients are formed. Based
on the results of endometrial sampling, the patients are groped as benign,
hyperplasia and malignant. Differences of
hematologic parameters between the groups were
investigated.
Results: There
was no statistically significant difference between the groups
in terms of neutrophil, lymphocyte, and platelet count,
neutrophil/lymphocyte ratio and
platelet/lymphocyte ratio (p>0.05).
Hemoglobin, mean platelet volume and platelet distribution width values were
found statistically significantly higher in the malignant group (p<0.05).
Conclusion: As a result; inflammation may increase platelet
activity and provide a basis for endometrial cancer.
Keywords
Endometrium cancer neutrophil/lymphocyte ratio mean platelet volume platelet distribution width
References
- Referans1. Elit LM, Pond G, Seow H. Time interval between endometrial biopsy and surgical staging for type I endometrial cancer: association between tumor characteristics and survival outcome. Obstet Gynecol. 2015;125:1497-1498.
- Referans2. Kim MK, Seong SJ, Kim JW ve ark. Management of Endometrial Hyperplasia: A Survey of Members of the Korean Gynecologic Oncology Group. Int J Gynecol Cancer. 2015;25:1277-1284.
- Referans3. Kim DK, Oh SY, Kwon HC ve ark. Clinical significances of preoperative serum interleukin-6 and C-reactive protein level inoperable gastric cancer. BMC Cancer. 2009;9:155.
- Referans4. Mangalpally KK, Siqueiros-Garcia A, Vaduganathan M, Dong JF, Kleiman NS, Guthikonda S. Platelet activation patterns in platelet size sub-populations: differential responses to aspirin in vitro. Journal of Thrombosis and Thrombolysis. 2010;30:251–262.
- Referans5. Talhouk A, McConechy MK, Leung S ve ark. A clinically applicable molecular-based classification for endometrial cancers. Br J Cancer. 2015;113:299-310.
- Referans6. D. W. Kamp, E. Shacter, and S. A. Weitzman, Chronic inflammation and cancer: the role of the mitochondria. Oncology. 2011;400–413.
- Referans7. Arango HA, Icely S, Roberts WS, Cavanagh D, Becker JL. Aspirin effects on endometrial cancer cell growth. Obstet Gynecol 2001;423–427.
- Referans8. L. Dossus, S. Rinaldi, S. Becker ve ark. Obesity, inflammatory markers, and endometrial cancer risk: a prospective Case-Control Study. Endocrine-Related Cancer. 2010;1007–1019.
- Referans9. Vagdatli E, Gounari E, Lazaridou E, Katsibourlia E, Tsikopoulou F, Labrianou I. Platelet distribution width: a simple, practical and specific marker of activation of coagulation. Hippokratia. 2010;14:28-32.
- Referans10. Tuszynski GP, Nicosia RF. The role of thrombospondin-1 in tumor progression and angiogenesis. Bioessays, 1996; 71-76.
- Referans11. Oge T, Yalcin OT, Ozalp SS, Isikci T. Platelet volume as a parameter for platelet activation in patients with endometrial cancer. J Obstet Gynaecol. 2013;33:301-304.
- Referans12. Ercan Yılmaz, Ebru İnci Coşkun, Nurhan Şahin, Tamer Elkıran, Barış Cıplak, Yavuz Şimşek. The sıgnıfıcance of MPV and N/L value ın dıagnosıs of endometrıal cancer. Türk Jinekolojik Onkoloji Dergisi. 2015;33-36.
- Referans13. Karateke A, Kaplanoglu M, Baloglu A. Relations of Platelet Indices with Endometrial Hyperplasia and Endometrial Cancer. Asian Pac J Cancer Prev. 2015;16:4905-4908.
- Referans14. Yıldırım MA, Seckin KD, Togrul C ve ark. Roles of neutrophil/lymphocyte and platelet/lymphocyte ratios in the early diagnosis of malignant ovarian masses. Asian Pac J Cancer Prev. 2014;15:6881-6885.
- Referans15. Kokcu A, Kurtoglu E, Celik H, Tosun M, Malatyalıoglu E, Ozdemir AZ. May the platelet to lymphocyte ratio be a prognostic factor for epithelial ovarian cancer? Asian Pac J Cancer Prev. 2014;15:9781-9784.
Details
| Primary Language | Turkish |
|---|---|
| Subjects | Health Care Administration |
| Journal Section | Original article |
| Authors | |
| Publication Date | September 30, 2018 |
| Published in Issue | Year 2018 Volume: 10 Issue: 3 |
e-ISSN: 2548-0251
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