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Comparison of pre-operative inflammation parameters of adenomyosis and leiomyoma patients after hysterectomy

Year 2019, Volume: 11 Issue: 4, 555 - 560, 01.12.2019
https://doi.org/10.21601/ortadogutipdergisi.449994

Abstract

Aim: The purpose of the research is evaluation of pre-operative white blood cell, neutrophil, lymphocyte, platelet, neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, platelet distribution width, mean platelet volume and plateletcrit values of patients who diagnosed with adenomyosis or leiomyoma histopathologically.
Material and Method: The research group consist of 640 patients. For gathering data, we review the patients’ files retrospectively and we use patients’ complete blood count (CBC) results.
Results: The mean age of the patients are 54.89±5.11 years. 61.40% (n=393) of them are diagnosed with leiomyoma and 38.60% (n=247) of them are diagnosed with adenomyosis histopathologically. There was no difference between the groups in terms of white cell and platelet count, platelet distribution width, platelet crit, platelet / lymphocyte ratios, and neutrophil / lymphocyte ratios. Mean platelet volume and neutrophil counts in the leiomyoma group were significantly higher than in the adenomyosis group.
Conclusions: The mean platelet volume and neutrophilia percentage values are promising as an adjunctive method in differential diagnosis of leiomyoma and adenomyosis diseases, but these findings should be supported by prospective controlled studies.

References

  • Brosens JJ, Barker FG, de Souza NM. Myometrial zonal differentiation and uterine junctional zone hyperplasia in the non-pregnant uterus. Hum Reprod Update 1998; 4: 496-502.
  • Ferenczy A. Pathophysiology of adenomyosis. Hum Reprod Update 1998; 4: 312-22.
  • Vercellini P, Parazzini F, Oldani S, Panazza S, Bramante T, Crosignani PG. Adenomyosis at Hysterectomy - a Study on Frequency-Distribution and Patient Characteristics. Human Reproduction 1995; 10: 1160-2.
  • Panganamamula UR, Harmanli OH, Isik-Akbay EF, Grotegut CA, Dandolu V, Gaughan JP. Is prior uterine surgery a risk factor for adenomyosis? Obstetr Gynecol 2004; 104: 1034-8.
  • Naftalin J, Hoo W, Pateman K, Mavrelos D, Holland T, Jurkovic D. How common is adenomyosis? A prospective study of prevalence using transvaginal ultrasound in a gynaecology clinic. Human Reproduction 2012; 27: 3432-9.
  • Laughlin SK, Baird DD, Savitz DA, Herring AH, Hartmann KE. Prevalence of uterine leiomyomas in the first trimester of pregnancy: an ultrasound-screening study. Obstet Gynecol 2009; 113: 630-5.
  • Lurie S, Piper I, Woliovitch I, Glezerman M. Age-related prevalence of sonographicaly confirmed uterine myomas. J Obstet Gynaecol 2005; 25: 42-4.
  • Lethaby A, Vollenhoven B. Fibroids (uterine myomatosis, leiomyomas). Am Fam Physician 2005; 71: 1753-6.
  • Khode V, Sindhur J, Kanbur D, Ruikar K, Nallulwar S. Mean platelet volume and other platelet volume indices in patients with stable coronary artery disease and acute myocardial infarction: A case control study. J Cardiovasc Dis Res 2012; 3: 272-5.
  • Ladhani S, Lowe B, Cole AO, Kowuondo K, Newton CR. Changes in white blood cells and platelets in children with falciparum malaria: relationship to disease outcome. Br J Haematol 2002; 119: 839-47.
  • Varma N, Naseem S. Hematologic changes in visceral leishmaniasis/kala azar. Indian J Hematol Blood Transfus 2010; 26: 78-82.
  • Briggs C. Quality counts: new parameters in blood cell counting. Int J Lab Hematol 2009; 31: 277-97.
  • Yang SW, Cho SH, Kwon HS, Sohn IS, Hwang HS. Significance of the platelet distribution width as a severity marker for the development of preeclampsia. Eur J Obstet Gynecol Reprod Biol 2014; 175: 107-11.
  • Koçer A, Yaman A, Niftaliyev E, Dürüyen H, Eryılmaz M, Koçer E. Assessment of platelet indices in patients with neurodegenerative diseases: mean platelet volume was increased in patients with Parkinson’s disease. Curr Gerontol Geriatr Res 2013; 2013: 986254.
  • Liang QC, Jin D, Li Y, Wang RT. Mean platelet volume and platelet distribution width in vascular dementia and Alzheimer’s disease. Platelets 2014; 25: 433-8.
  • Białas AJ, Pedone C, Piotrowski WJ, Antonelli Incalzi R. Platelet distribution width as a prognostic factor in patients with COPD - pilot study. Int J Chron Obstruct Pulmon Dis 2017; 12: 2261-7.
  • Hou J, Liu C, Yao P ve ark. Association of adiposity indices with platelet distribution width and mean platelet volume in chinese adults. PLoS One 2015; 10: 0129677.
  • Aldemir MN, Turkeli M, Simsek M, ve ark. Prognostic value of baseline neutrophil-lymphocyte and platelet-lymphocyte ratios in local and advanced gastric cancer patients. Asian Pac J Cancer Prev 2015; 16: 5933-7.
  • Guthrie GJ, Charles KA, Roxburgh CS, Horgan PG, McMillan DC, Clarke SJ. The systemic inflammation-based neutrophil-lymphocyte ratio: experience in patients with cancer. Crit Rev Oncol Hematol 2013; 88: 218-30.
  • Unal D, Eroglu C, Kurtul N, Oguz A, Tasdemir A. Are neutrophil/lymphocyte and platelet/ lymphocyte rates in patients with non-small cell lung cancer associated with treatment response and prognosis? Asian Pac J Cancer Prev 2013; 14: 5237-42.
  • Yavuzcan A, Cağlar M, Ustün Y. Evaluation of mean platelet volume, neutrophil/lymphocyte ratio and platelet/lymphocyte ratio in advanced stage endometriosis with endometrioma. J Turk Ger Gynecol Assoc 2013; 14: 210-5.
  • Takamizawa S, Minakami H, Usui R, ve ark. Risk of complications and uterine malignancies in women undergoing hysterectomy for presumed benign leiomyomas. Gynecol Obstet Invest 1999; 48: 193-6.
  • Madendağ Y. Şahin E. Aydın E. Madendağ IÇ, Açmaz G, Karaman H. Neutrophil to lymphocyte ratio and platelet to lymphocyte ratio can be useful markers for distinguishing uterine adenomyosis and leiomyoma. Gynecol Obstet Reprod Med 2017; 23: 00-00.
  • Çakmak B, Özsoy Z, Hısım Y, Nacar M. Benign endikasyonlar nedeniyle uygulanan histerektomi materyallerinde adenomyozis sıklığı. J Contemp Med 2012; 2.
  • Şentürk M, Budak M, Çkamak Y, Durukan Ö, Polat M. Histerektomi olgularında adenomyosis prevelansı ve ilişkili faktörler. Zeynep Kamil Tıp Bül 2015; 46: 102-5.
  • Kececioglu M, Tokmak A, Sarikaya E, ve ark. Role of neutrophil lymphocyte ratio at preoperative adenomyosis diagnosis. Medicine Sci 2016; 5: 426-31.
  • Bodur, S., I. Gun, and M. Alpaslan Babayigit. The significance of mean platelet volume on diagnosis and management of adenomyosis. Med Glas (Zenica) 2013; 10: 59-62.

Histerektomi sonrası adenomyozis ve leiomyoma tanıları alan hastaların pre-operatif inflamasyon parametrelerinin karşılaştırılması

Year 2019, Volume: 11 Issue: 4, 555 - 560, 01.12.2019
https://doi.org/10.21601/ortadogutipdergisi.449994

Abstract

Amaç: Bu çalışmada histerektomi sonrası, adenomiyosis ya da leiomyoma histopatolojik tanısı alan hastaların pre-operatif beyaz küre ve platelet sayısı, nötrofili, nötrofil/lenfosit oranı, platelet/lenfosit oranı, platelet dağılım genişliği, ortalama platelet hacmi ve plateletcrit değerlerinin değerlendirilmesi ve iki hastalık arasında bu değerler açısından fark olup olmadığının araştırılması amaçlanmıştır.
Gereç ve Yöntem: Post-operatif histopatolojik tanıları leiomyoma ya da adenomyosis olan 640 hasta çalışmaya dahil edildi. Hastaların demografik özellikleri ve hemogram testi sonuçları retrospektif olarak incelendi.
Bulgular: Toplam 640 hastanın, %61,40’ı (n=393) leiomyoma ve %38,60’ı (n=247) adenomyosis histopatolojik tanısı almıştı. Gruplar arasında beyaz küre ve platelet sayısı, platelet dağılım genişliği, platelet crit, platelet/lenfosit oranları ve nötrofil/lenfosit oranları açısından fark yoktu. Leiomyoma grubunda ortalama platelet hacmi değerleri ve nötrofil yüzdeleri anlamalı olarak adenomiyozis grubuna göre yüksekti.
Sonuçlar: Ortalama platelet hacmi ve nötrofili yüzdesi değerleri leiomyoma ve adenomyozis hastalıkları ayırıcı tanısında yardımcı bir yöntem olarak kullanılabileceği konusunda umut vericidir ancak bu bulguların prospektif kontrollü çalışmalarla desteklenmesi gerekmektedir.

References

  • Brosens JJ, Barker FG, de Souza NM. Myometrial zonal differentiation and uterine junctional zone hyperplasia in the non-pregnant uterus. Hum Reprod Update 1998; 4: 496-502.
  • Ferenczy A. Pathophysiology of adenomyosis. Hum Reprod Update 1998; 4: 312-22.
  • Vercellini P, Parazzini F, Oldani S, Panazza S, Bramante T, Crosignani PG. Adenomyosis at Hysterectomy - a Study on Frequency-Distribution and Patient Characteristics. Human Reproduction 1995; 10: 1160-2.
  • Panganamamula UR, Harmanli OH, Isik-Akbay EF, Grotegut CA, Dandolu V, Gaughan JP. Is prior uterine surgery a risk factor for adenomyosis? Obstetr Gynecol 2004; 104: 1034-8.
  • Naftalin J, Hoo W, Pateman K, Mavrelos D, Holland T, Jurkovic D. How common is adenomyosis? A prospective study of prevalence using transvaginal ultrasound in a gynaecology clinic. Human Reproduction 2012; 27: 3432-9.
  • Laughlin SK, Baird DD, Savitz DA, Herring AH, Hartmann KE. Prevalence of uterine leiomyomas in the first trimester of pregnancy: an ultrasound-screening study. Obstet Gynecol 2009; 113: 630-5.
  • Lurie S, Piper I, Woliovitch I, Glezerman M. Age-related prevalence of sonographicaly confirmed uterine myomas. J Obstet Gynaecol 2005; 25: 42-4.
  • Lethaby A, Vollenhoven B. Fibroids (uterine myomatosis, leiomyomas). Am Fam Physician 2005; 71: 1753-6.
  • Khode V, Sindhur J, Kanbur D, Ruikar K, Nallulwar S. Mean platelet volume and other platelet volume indices in patients with stable coronary artery disease and acute myocardial infarction: A case control study. J Cardiovasc Dis Res 2012; 3: 272-5.
  • Ladhani S, Lowe B, Cole AO, Kowuondo K, Newton CR. Changes in white blood cells and platelets in children with falciparum malaria: relationship to disease outcome. Br J Haematol 2002; 119: 839-47.
  • Varma N, Naseem S. Hematologic changes in visceral leishmaniasis/kala azar. Indian J Hematol Blood Transfus 2010; 26: 78-82.
  • Briggs C. Quality counts: new parameters in blood cell counting. Int J Lab Hematol 2009; 31: 277-97.
  • Yang SW, Cho SH, Kwon HS, Sohn IS, Hwang HS. Significance of the platelet distribution width as a severity marker for the development of preeclampsia. Eur J Obstet Gynecol Reprod Biol 2014; 175: 107-11.
  • Koçer A, Yaman A, Niftaliyev E, Dürüyen H, Eryılmaz M, Koçer E. Assessment of platelet indices in patients with neurodegenerative diseases: mean platelet volume was increased in patients with Parkinson’s disease. Curr Gerontol Geriatr Res 2013; 2013: 986254.
  • Liang QC, Jin D, Li Y, Wang RT. Mean platelet volume and platelet distribution width in vascular dementia and Alzheimer’s disease. Platelets 2014; 25: 433-8.
  • Białas AJ, Pedone C, Piotrowski WJ, Antonelli Incalzi R. Platelet distribution width as a prognostic factor in patients with COPD - pilot study. Int J Chron Obstruct Pulmon Dis 2017; 12: 2261-7.
  • Hou J, Liu C, Yao P ve ark. Association of adiposity indices with platelet distribution width and mean platelet volume in chinese adults. PLoS One 2015; 10: 0129677.
  • Aldemir MN, Turkeli M, Simsek M, ve ark. Prognostic value of baseline neutrophil-lymphocyte and platelet-lymphocyte ratios in local and advanced gastric cancer patients. Asian Pac J Cancer Prev 2015; 16: 5933-7.
  • Guthrie GJ, Charles KA, Roxburgh CS, Horgan PG, McMillan DC, Clarke SJ. The systemic inflammation-based neutrophil-lymphocyte ratio: experience in patients with cancer. Crit Rev Oncol Hematol 2013; 88: 218-30.
  • Unal D, Eroglu C, Kurtul N, Oguz A, Tasdemir A. Are neutrophil/lymphocyte and platelet/ lymphocyte rates in patients with non-small cell lung cancer associated with treatment response and prognosis? Asian Pac J Cancer Prev 2013; 14: 5237-42.
  • Yavuzcan A, Cağlar M, Ustün Y. Evaluation of mean platelet volume, neutrophil/lymphocyte ratio and platelet/lymphocyte ratio in advanced stage endometriosis with endometrioma. J Turk Ger Gynecol Assoc 2013; 14: 210-5.
  • Takamizawa S, Minakami H, Usui R, ve ark. Risk of complications and uterine malignancies in women undergoing hysterectomy for presumed benign leiomyomas. Gynecol Obstet Invest 1999; 48: 193-6.
  • Madendağ Y. Şahin E. Aydın E. Madendağ IÇ, Açmaz G, Karaman H. Neutrophil to lymphocyte ratio and platelet to lymphocyte ratio can be useful markers for distinguishing uterine adenomyosis and leiomyoma. Gynecol Obstet Reprod Med 2017; 23: 00-00.
  • Çakmak B, Özsoy Z, Hısım Y, Nacar M. Benign endikasyonlar nedeniyle uygulanan histerektomi materyallerinde adenomyozis sıklığı. J Contemp Med 2012; 2.
  • Şentürk M, Budak M, Çkamak Y, Durukan Ö, Polat M. Histerektomi olgularında adenomyosis prevelansı ve ilişkili faktörler. Zeynep Kamil Tıp Bül 2015; 46: 102-5.
  • Kececioglu M, Tokmak A, Sarikaya E, ve ark. Role of neutrophil lymphocyte ratio at preoperative adenomyosis diagnosis. Medicine Sci 2016; 5: 426-31.
  • Bodur, S., I. Gun, and M. Alpaslan Babayigit. The significance of mean platelet volume on diagnosis and management of adenomyosis. Med Glas (Zenica) 2013; 10: 59-62.
There are 27 citations in total.

Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Original article
Authors

Funda Erdoğan This is me

Cemile Dayangan Sayan 0000-0002-9220-8903

Mahmut İlkin Yeral 0000-0001-8987-1336

Zehra Sema Özkan 0000-0001-9185-3663

Nevin Sağsöz 0000-0002-9927-5877

Publication Date December 1, 2019
Published in Issue Year 2019 Volume: 11 Issue: 4

Cite

Vancouver Erdoğan F, Dayangan Sayan C, Yeral Mİ, Özkan ZS, Sağsöz N. Histerektomi sonrası adenomyozis ve leiomyoma tanıları alan hastaların pre-operatif inflamasyon parametrelerinin karşılaştırılması. omj. 2019;11(4):555-60.

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