Year 2013,
Volume: 35 Issue: 3 - OSMANGAZİ TIP DERGİSİ / Osmangazi Journal of Medicine, - , 18.06.2015
Abstract
SUMMARY: Leser-Trélat sign is characterized by the abrupt appearance of multiple seborrheic keratoses, which are often pruritic, usually it is associated with an underlying malignant disease. Here we report a case of 72-year-old healthy woman with Leser-Trélat. She is consulted to dermatology for her rapidly growing lesions over her lower abdominal and suprapubic regions for seven months. She oriented to our clinic for malignity scanning. We were followed for 1 year and not detected any internal cancer. To date, almost all cases of Leser-Trélat sign have been reported in association with an underlying malignancy. It is less known that Leser-Trélat sign can also occur in healthy individuals in the absence of internal malignancy. Leser-Trélat sign of the patients are evaluated for malignancy and the screening of suspect cases is important. A new and rapidly growing seborrheic keratoses; Leser-Trelat sign is important and suspected cases should be screened for malignancy.
KEY WORDS: Leser- Trelat Sign, internal malignancy, seborrheic keratosis.
ÖZET: Leser- Trelat işareti kaşıntılı çoklu seboreik keratotik lezyonlar olarak tanımlanır ve sıklıkla altında yatan malignitelerle ilşkilidir. Burada 72 yaşında Leser-Trelat işareti olan bir bayan sunduk. Dermatoloji kliniğinden 7 ayda karın alt kadranda ve suprapubik alanda hızla büyüyen lezyonlarla konsülte edildi. Kliniğimizde malignite tarandı. Bir yıllık takibimizde herhangi bir malignite tespit edilemedi. Bugüne kadar, Leser-Trélat işareti hemen hemen tüm durumlarda altta yatan bir malignite ile birlikte bildirilmiştir. Daha az bilinen ise Leser Trelat işaretinin malignite olmadan da görülebileceğidir. Yeni ve hızla çoğalan seboreik keratoz; Leser-Trelat işareti önemlidir ve şüpheli vakalar malignite açısından taranmalıdır.
ANAHTAR KELİMELER: Leser-Trelat Sign, malignite, seboreik keratoz
References
- Sneddon, I. B. Roberts, J. B. (1962). An incomplete from of acanthosis nigricans. Gut. 3, 269-72.
- Hollander, E. V. (1900). Beitrage zur Fruhdiagnose des Darmcarcinomas (Hereditatsverhaltnisse Hautveranderungen) Wochenschr. 26, 483-85. und Med Dtsch
- Schwartz, R.A. (1996). Sign of Leser- Trélat. J Am Acad Dermatol.35, 88-95.
- Ponti, G. Luppi, G. Losi, L. Giannetti, A. Seidenari S. (2010). Leser-Trélat syndrome in patients affected by six multiple cancers. J Hematol Oncol. 3,2. primitive
- Baron, L. A. Prendiville, J. S. (1992). The sign of Leser- Trelat in a young woman with osteogenic sarcoma. J Am Acad Dermatol. 26, 344-47
- Heaphy, M. R. Jr, Millns, J. L. Schroeter, A. L. (2000). The sign of Leser-Trélat adenocarcinoma of the lung. J Am Acad Dermatol. 43, 386-390. of
- Ellis, D. L. Kafka, S. P. Chow, J. C. Nanney, L. B. Inman, W. H. Mc Cadden, M. E. King, L. E. (1987). Jr. Melanoma, growth factors, acanthosis nigricans, the sign of Leser-Trelat, and multipl acrochordons: a possible role of alpha-transforming growth factor in cutaneous paraneoplastic syndromes. N Engl J Med.317,1582- 87.
- Hafner, C. Vogt, T. (2008). Seborrheic keratosis. J Dtsch Dermatol Ges. 6, 664-77.
- Gallagher, E. J. LeRoith, D. (2010). The proliferating role of insülin and insülin- like growth factors in cancer. Trends Endocrinol Metab. 21, 610-18.
- İnamadar, A. C. Palit, A. (2003). Eruptive seborrkoeic keratosis in human infection: a coinsidence or ‘the sign of Leser Trelat’ Br J Dermatol. 149, 435- 36. virus
Year 2013,
Volume: 35 Issue: 3 - OSMANGAZİ TIP DERGİSİ / Osmangazi Journal of Medicine, - , 18.06.2015
Abstract
References
- Sneddon, I. B. Roberts, J. B. (1962). An incomplete from of acanthosis nigricans. Gut. 3, 269-72.
- Hollander, E. V. (1900). Beitrage zur Fruhdiagnose des Darmcarcinomas (Hereditatsverhaltnisse Hautveranderungen) Wochenschr. 26, 483-85. und Med Dtsch
- Schwartz, R.A. (1996). Sign of Leser- Trélat. J Am Acad Dermatol.35, 88-95.
- Ponti, G. Luppi, G. Losi, L. Giannetti, A. Seidenari S. (2010). Leser-Trélat syndrome in patients affected by six multiple cancers. J Hematol Oncol. 3,2. primitive
- Baron, L. A. Prendiville, J. S. (1992). The sign of Leser- Trelat in a young woman with osteogenic sarcoma. J Am Acad Dermatol. 26, 344-47
- Heaphy, M. R. Jr, Millns, J. L. Schroeter, A. L. (2000). The sign of Leser-Trélat adenocarcinoma of the lung. J Am Acad Dermatol. 43, 386-390. of
- Ellis, D. L. Kafka, S. P. Chow, J. C. Nanney, L. B. Inman, W. H. Mc Cadden, M. E. King, L. E. (1987). Jr. Melanoma, growth factors, acanthosis nigricans, the sign of Leser-Trelat, and multipl acrochordons: a possible role of alpha-transforming growth factor in cutaneous paraneoplastic syndromes. N Engl J Med.317,1582- 87.
- Hafner, C. Vogt, T. (2008). Seborrheic keratosis. J Dtsch Dermatol Ges. 6, 664-77.
- Gallagher, E. J. LeRoith, D. (2010). The proliferating role of insülin and insülin- like growth factors in cancer. Trends Endocrinol Metab. 21, 610-18.
- İnamadar, A. C. Palit, A. (2003). Eruptive seborrkoeic keratosis in human infection: a coinsidence or ‘the sign of Leser Trelat’ Br J Dermatol. 149, 435- 36. virus
There are 10 citations in total.
Details
| Primary Language | Turkish |
|---|---|
| Journal Section | OLGU SUNUMU |
| Authors | |
| Publication Date | June 18, 2015 |
| Published in Issue | Year 2013 Volume: 35 Issue: 3 - OSMANGAZİ TIP DERGİSİ / Osmangazi Journal of Medicine |