Pleksiform Miksoid Gastrointestinal Stromal Tümör, İnce Barsak Yerleşimli Nadir Bir Histolojik Patern: Olgu Sunumu

Leymune Parlak; Rabia Altunbaş; Erdem Özdemir; Emine Zeynep Tarini; Buket Gedik

doi:10.20515/otd.913177

Case Report

Plexiform Myxoid Gastrointestinal Stromal Tumor, A Rare Histological Pattern Located in the Small Intestine: A Case Report

Year 2022, Volume: 44 Issue: 1, 129 - 133, 14.01.2022

Leymune Parlak Rabia Altunbaş Erdem Özdemir Emine Zeynep Tarini Buket Gedik

https://doi.org/10.20515/otd.913177

Abstract

Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor of the gastrointestinal system originating from kajal cells. It is frequently seen after the age of 50 and 60% in the stomach, the second most frequently in the jejunum and ileum (30%). Small bowel residents have 40-50% more malignant prognosis than those in the stomach. In addition, small intestine GISTs do not constitute distinctive histological subtypes like gastric GISTs. They are mostly spindle cell. Epithelioids, on the other hand, constitute a very small part. In our case, in addition to epithelioid and spindle cell features, there is a plexiform growth pattern and myxoid stroma in the ground.

Keywords

GIST, Small bowel, Plexiform, Myxoid

References

1.Barsouk A, Rawla P, Barsouk A, Thandra KC. Epidemiology of Cancers of the Small Intestine: Trends, Risk Factors, and Prevention. Med Sci. 2019;7(3):46. doi:10.3390/medsci7030046
2. Jumniensuk C, Charoenpitakchai M. Gastrointestinal stromal tumor: Clinicopathological characteristics and pathologic prognostic analysis. World J Surg Oncol. 2018;16(1):1-9. doi:10.1186/s12957-018-1532-1
3. Peng F, Liu Y. Gastrointestinal stromal tumors of the small intestine: Progress in diagnosis and treatment research. Cancer Manag Res. 2020;12:3877-3889. doi:10.2147/CMAR.S238227
4. Miettinen M, Lasota J. Gastrointestinal stromal tumors: Review on morphology, molecular pathology, prognosis, and differential diagnosis. Arch Pathol Lab Med. 2006;130(10):1466-1478. doi:10.5858/2006-130-1466-gstrom
5. Miettinen M, Lasota J. Gastrointestinal stromal tumors: Pathology and prognosis at different sites. Semin Diagn Pathol. 2006;23(2):70-83. doi:10.1053/j.semdp.2006.09.001
6. Bulu H, Aydin A, Yavuz A, Tanto U, Kuru S, Co A. RevieGastroi̇ntesti̇nal Stromal Tümörler : Derleme Gastrointestinal Stromal Tumours : a. 2012;6(3):101-107.
7. Tornillo L. Gastrointestinal stromal tumor - an evolving concept. Front Med. 2014;1(NOV). doi:10.3389/fmed.2014.00043
8. Wu CE, Tzen CY, Wang SY, Yeh CN. Clinical diagnosis of gastrointestinal stromal tumor (Gist): From the molecular genetic point of view. Cancers (Basel). 2019;11(5):1-15. doi:10.3390/cancers11050679
9. Giustiniani MC, Papa V, Martini M, et al. Plexiform architecture in gastrointestinal stromal tumors is not restricted to succinate dehydrogenase-deficient cases. Hum Pathol Case Reports. 2018;13(April):69-72. doi:10.1016/j.ehpc.2018.05.009
10. Li B, Zhang QF, Han YN, Ouyang L. Plexiform myxoid gastrointestinal stromal tumor: A potential diagnostic pitfall in pathological findings. Int J Clin Exp Pathol. 2015;8(10):13613-13618.
11. Setsu N, Miyake M, Wakai S, et al. Primary Retroperitoneal Myxoid Liposarcomas. Am J Surg Pathol. 2016;40(9):1286-1290. doi:10.1097/PAS.0000000000000657
12. Prakash S, Antonescu CR. Deep-Seated Plexiform Schwannoma. 2005;10021:1042-1048.
13. Shannalee R. Martinez, Maresha S. Gay and LZ. 乳鼠心肌提取 HHS Public Access. Physiol Behav. 2016;176(1):139-148. doi:10.1007/s00256-018-3050-1.Plexiform