Abstract
Objective: Atrial fibrillation is a common cardiac arrhythmia and is an important risk factor for ischemic stroke and heart failure. Thyroid hormones have important effects on the cardiovascular system. In this study, we aimed to evaluate the relationship between atrial fibrillation (AF) and thyroid disorders.
Materials and Methods: 587 newly diagnosed AF patients who applied to the Cardiology Clinic between January and December 2022 were included in this study. Thyroid function tests of the patients were examined.
Results: The mean age of the patients included in the study was 62.2 ± 9.8 years. 62% of the patients were female, and 38% were male. Euthyroid in 539 patients (91.7%), hypothyroidism in 2 patients (0.3%), subclinical hypothyroidism in 11 patients (2%), hyperthyroidism in 23 patients (3.9%), and subclinical hyperthyroidism in 12 patients (2.1%).
Conclusion: Atrial Fibrillation is associated with both hyperthyroidism and hypothyroidism. Thyroid dysfunctions are more common in patients with AF than in the normal population. Patients with AF should be screened for thyroid disorders.
Project Number
YOK
References
- Sagris M, Vardas EP, Theofilis P, et al. Atrial fibrillation: Pathogenesis, predisposing factors, and genetics. International Journal of Molecular Sciences. 2021;23(1):6. doi:10.3390/ijms23010006
- Kornej J, Börschel CS, Benjamin EJ, et al. Epidemiology of atrial fibrillation in the 21st century: novel methods and new insights. Circulation Research. 2020;127(1):4-20. doi:10.1161/CIRCRESAHA.120.316340
- Sepehri Shamloo A, Dagres N, Hindricks G, et al. 2020 ESC guidelines on atrial fibrillation: Summary of the most relevant recommendations and innovations. Each Z. 2021;46:28-37. doi:10.1007/s00059-020-05005-y
- Kuś A, Teumer A, Medici M, et al. A deeper understanding of the causal relationships between thyroid function and atrial fibrillation. The Journal of Clinical Endocrinology & Metabolism. 2022;107(1):e429-e431. doi:10.1210/clinem/dgab525
- Al-Makhamreh H, Al-Ani A, Alkhulaifat D, et al. Impact of thyroid disease in patients with atrial fibrillation: Analysis from the JoFib registry. Annals of Medicine and Surgery. 2022;74:103325. doi:10.1016/j.amsu.2022.103325
- Huang M, Yang S, Ge G, et al. Effects of thyroid dysfunction and thyroid stimulating hormone levels on the Atrial fibrillation risks: a systematic review and dose-response meta-analysis from cohort studies. Endocrine Practice. 2022. doi:10.1016/j.eprac.2022.05.008
- Thyroid Diseases Diagnosis and Treatment Guide 2020. Turkish Society of Endocrinology and Metabolism https://file.temd.org.tr/Uploads/publications/guides/documents/20200929134733-2020tbl_kilavuzf527c34496.pdf?a=1. Accessed January 08, 2023.
- Cooper DS, Biondi B. Subclinical thyroid disease. The Lancet. 2012;379(9821): 1142-1154. doi:10.1016/S0140-6736(11)60276-6
- Barbesino G. Thyroid function changes in the elderly and their relationship to cardiovascular health: a mini-review. Gerontology. 2019;65(1):1-8. doi:10.1159/000490911
- Collet TH, Gussekloo J, Bauer DC, et al. Subclinical hyperthyroidism and the risk of coronary heart disease and mortality. Archives of Internal Medicine. 2012;172(10):799-809. doi:10.1001/archinternmed.2012.402
- Bekiaridou A, Kartas A, Moysidis, DV, et al. The bidirectional relationship of thyroid disease and atrial fibrillation: Established knowledge and future considerations. Reviews in Endocrine and Metabolic Disorders. 2022;23(3):621-630. doi:10.1007/s11154-022-09713-0
- Kowalewski C. Mapping atrial fibrillation: An overview of potential mechanisms underlying atrial fibrillation. Each Z. 2021;46(4):305-311. doi:10.1161/CIRCRESAHA.120.316340
Abstract
Amaç: Atriyal fibrilasyon yaygın bir kardiyak aritmidir ve iskemik inme ve kalp yetmezliği için önemli bir risk faktörüdür. Tiroid hormonlarının kardiyovasküler sistem üzerinde önemli etkileri vardır. Bu çalışmada atrial fibrilasyon (AF) ile tiroid bozuklukları arasındaki ilişkiyi değerlendirmek amaçlandı.
Materyal ve Metot: Bu çalışmaya Ocak – Aralık 2022 arasında Kardiyoloji Kliniğine başvuran yeni tanı almış 587 AF’li hasta alındı. Hastaların tiroid fonksiyon testleri incelendi.
Bulgular: Çalışmaya alınan hastaların yaş ortalaması 62.2 ± 9.8 idi. Hastaların %62’si kadın %38’i erkekti. 539 hasta ötiroid (%91,7), 2 hastada hipotiroidi (%0,3), 11 hastada subklinik hipotiroidi (%2), 23 hastada hipertiroidi (%3,9) ve 12 hastada subklinik hipertiroidi (%2,1) tespit edildi.
Sonuç: Atrial Fibrilasyon hem hipertiroidi ve hem hipotiroidi ile ilişkilidir. Tiroid fonksiyon bozuklukları AF’li hastalarda normal popülasyona göre daha sık görülür. AF’li hastalar tiroid bozuklukları açısından taranmalıdır.
Keywords
Supporting Institution
YOK
Project Number
YOK
Thanks
YOK
References
- Sagris M, Vardas EP, Theofilis P, et al. Atrial fibrillation: Pathogenesis, predisposing factors, and genetics. International Journal of Molecular Sciences. 2021;23(1):6. doi:10.3390/ijms23010006
- Kornej J, Börschel CS, Benjamin EJ, et al. Epidemiology of atrial fibrillation in the 21st century: novel methods and new insights. Circulation Research. 2020;127(1):4-20. doi:10.1161/CIRCRESAHA.120.316340
- Sepehri Shamloo A, Dagres N, Hindricks G, et al. 2020 ESC guidelines on atrial fibrillation: Summary of the most relevant recommendations and innovations. Each Z. 2021;46:28-37. doi:10.1007/s00059-020-05005-y
- Kuś A, Teumer A, Medici M, et al. A deeper understanding of the causal relationships between thyroid function and atrial fibrillation. The Journal of Clinical Endocrinology & Metabolism. 2022;107(1):e429-e431. doi:10.1210/clinem/dgab525
- Al-Makhamreh H, Al-Ani A, Alkhulaifat D, et al. Impact of thyroid disease in patients with atrial fibrillation: Analysis from the JoFib registry. Annals of Medicine and Surgery. 2022;74:103325. doi:10.1016/j.amsu.2022.103325
- Huang M, Yang S, Ge G, et al. Effects of thyroid dysfunction and thyroid stimulating hormone levels on the Atrial fibrillation risks: a systematic review and dose-response meta-analysis from cohort studies. Endocrine Practice. 2022. doi:10.1016/j.eprac.2022.05.008
- Thyroid Diseases Diagnosis and Treatment Guide 2020. Turkish Society of Endocrinology and Metabolism https://file.temd.org.tr/Uploads/publications/guides/documents/20200929134733-2020tbl_kilavuzf527c34496.pdf?a=1. Accessed January 08, 2023.
- Cooper DS, Biondi B. Subclinical thyroid disease. The Lancet. 2012;379(9821): 1142-1154. doi:10.1016/S0140-6736(11)60276-6
- Barbesino G. Thyroid function changes in the elderly and their relationship to cardiovascular health: a mini-review. Gerontology. 2019;65(1):1-8. doi:10.1159/000490911
- Collet TH, Gussekloo J, Bauer DC, et al. Subclinical hyperthyroidism and the risk of coronary heart disease and mortality. Archives of Internal Medicine. 2012;172(10):799-809. doi:10.1001/archinternmed.2012.402
- Bekiaridou A, Kartas A, Moysidis, DV, et al. The bidirectional relationship of thyroid disease and atrial fibrillation: Established knowledge and future considerations. Reviews in Endocrine and Metabolic Disorders. 2022;23(3):621-630. doi:10.1007/s11154-022-09713-0
- Kowalewski C. Mapping atrial fibrillation: An overview of potential mechanisms underlying atrial fibrillation. Each Z. 2021;46(4):305-311. doi:10.1161/CIRCRESAHA.120.316340
Details
| Primary Language | English |
|---|---|
| Subjects | Endocrinology |
| Journal Section | Research article |
| Authors | |
| Project Number | YOK |
| Early Pub Date | August 30, 2023 |
| Publication Date | September 6, 2023 |
| Submission Date | March 24, 2023 |
| Acceptance Date | June 17, 2023 |
| Published in Issue | Year 2023 Volume: 8 Issue: 3 |
