Research Article
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Comparison of Brain Natriuretic Peptide and Other Laboratory Parameters of Those Who Died From Coronavirus Disease and Those Who Were Discharged

Year 2023, Volume: 8 Issue: 4, 441 - 447, 18.12.2023

Mehmet Özdin Mehmet Köroğlu Selcuk Yaylacı Erdem Çokluk İbrahim Kocayiğit Aziz Öğütlü

https://doi.org/10.26453/otjhs.1242798

Abstract

Objectıve: In this study, we aim to compare the brain natriuretic peptide (BNP) of patients who were diagnosed with COVID-19 infection, who were hospitalized and discharged, and those who died.
Materials and Methods: The study was conducted on 474 patients diagnosed with COVID-19 disease. Information of 56 patients who died and 418 patients with COVID-19 who were discharged were obtained from the hospital information management system (HIMS) and analyzed retrospectively. The relationship between BNP, white blood cell (WBC), neutrophil (NEU), lymphocyte (LYM), platelet (PLT), Procalcitonin (PCT), High Sensitive Troponin I (hs Tn I), D-dimer and C-Reactive Protein (CRP) levels in deceased patients and discharged patients researched.
Results: There was no statistically significant difference in mortality between women and men (p=0.385). There was no statistically significant difference in BNP, WBC, NEU, LYM, platelet, PCT and hs Tn I values between those who died and those who were discharged. D-dimer and CRP values of those who died and discharged were statistically significant (p< 0.031 and 0.020, respectively).
Conclusions: Increased levels of CRP and D-dimer were found to be associated with mortality. More comprehensive studies are needed on this subject.

Keywords

Brain natriüretik peptide C-reactive protein coronavirus infections D-dimer

Supporting Institution

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Project Number

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Thanks

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References

  • Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: A retrospective cohort study. Lancet. 2020;395(10229):1054–1062. doi:10.1016/S0140-6736(20)30566-3
  • Gandhi RT, Lynch JB, Del Rio C. Mild or moderate Covid-19. N Engl J Med. 2020;383(18):1757-1766. doi:10.1056/NEJMcp2009249
  • Guo T, Fan Y, Chen M, Wu X, Zhang L, He T. Cardiovascular implications of fatal outcomes of patients with Coronavirus Disease 2019 (COVID-19). JAMA Cardiol. 2020;5(7):811–818. doi:10.1001/jamacardio.2020.1017
  • Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395(10223):497–506. doi:10.1016/S0140-6736(20)30183-5
  • Özdin M. Atopik Dermatiti Olan Çocuklarda Hematolojik ve Alerjik Değerler Arasındaki İlişki, Balıkesir Medical Journal. 2020;4(3):1-6. doi:10.33716 bmedj.734178
  • Yazar H, Kayacan Y, Özdin M. Investigation of C-reactive Protein and D-dimer Findings in Patients with COVID-19. Bezmialem Science. 2021;9 (Supplement 1):4-8. doi:10.14235/bas.galenos.2020.4884
  • Halaby R, Popma CJ, Cohen A, et al. D-dimer elevation and adverse outcomes. J Thromb Thrombolysis. 2015;39(1):55-59. doi:10.1007/s11239-014-1101-6
  • Braithwaite S. Procalcitonin: new insights on regulation and origin. Crit Care Med. 2000;28(2):586–588.
  • Avcıküçük M, Bakır F, Topçuoğlu C, Güçtekin A. Akut koroner sendromda troponin T ve troponin I. Turk Hij Den Biyol Derg. 2011;68(3):127-134. doi:10.5505/ TurkHijyen.2011.85047
  • Dede H, Sametoğlu F, İnal BB, Şahin M, Güvenen G. Evaluation of serum pro-BNP and hs-CRP levels with echocardiography Data in Patients with Heart Failure. Istanbul Med J. 2010;11(3):97-103.
  • Bajwa EK, Januzzi JL, Gong MN, Thompson BT, Christiani DC. Prognostic value of plasma N-terminal probrain natriuretic peptide levels in the acute respiratory distress syndrome. Crit Care Med. 2008;36(8):2322-2327. doi:10.1097/CCM. 0b013e318181040d
  • Yang J, Yang Y, Liu Q. Study on the levels of main inflammatory factors in septic shock and their clinical significance. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2019;31(6):680–683. doi:10.3760/cma.j.issn.2095-4352.2019.06.004
  • Tao G, Yongzhen F, Ming C, Xiaoyan W, Lin Z, Tao H. Cardiovascular implications of fatal outcomes of patients with Coronavirus Disease 2019. JAMA Cardiol. 2020;5(7):1–8. doi:10.1001/jamacardio. 2020.1017
  • Xu Z, Shi L, Wang Y, Zhang J, Huang L, Zhang C, Pathological findings of COVID-19 associated with acute respiratory distress syndrome. The Lancet Respiratory Medicine. 2020;8(4):420-422. doi:10.1016/S2213-2600(20)30076-X
  • Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395(10223):497-506. doi:10.1016/S0140-6736(20)30183-5
  • Bonetti G, Manelli F, Patroni A, Bettinardi A, Borrelli G, Fiordalisi G. Laboratory predictors of death from coronavirus disease 2019 (COVID-19) in the area of Valcamonica, Italy. Clin Chem Lab Med. 2020;58(7):1100-1105. doi:10.1515/cclm-2020-0459
  • Bonetti G, Manelli F, Patroni A, et al. Laboratory predictors of death from coronavirus disease 2019 (COVID-19) in the area of Valcamonica, Italy. Clin Chem Lab Med. 2020;58(7):1100-1105. doi:10.1515/cclm-2020-0459
  • Tan W, Zhao X, Ma X, et al. A Novel Coronavirus Genome Identified in a Cluster of Pneumonia Cases - Wuhan, China 2019-2020. China CDC Wkly. 2020;2(4):61-62. doi:10.46234/ccdcw2020.017
  • Guan W. Clinical Characteristics of Coronavirus Disease 2019 in China. NEJM. 2020;382(18):1708-1720. doi:10.1056/NEJMoa2002032
  • Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395(10223):497-506. doi:10.1016/S0140-6736(20)30183-5
  • Wu Z, McGoogan JM. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention. JAMA. 2020;323(13):1239–1242. doi:10.1001/jama.2020.2648
  • Kilbas I, Kahraman Kilbas EP, Ciftci IH. The relationship of procalcitonin level with the severity of COVID-19 infection. Phnx Med J. 2021;3(3):97-100. doi:10.38175/phnx.899465
  • Komaru Y, Doi K. Does a slight change in serum creatinine matter in coronavirus disease 2019 (COVID-19) patients? Kidney Res Clin Pract. 2021;40(2):177-179.
  • Terpos E, Stathopoulos IN, Elalamy I, Kastritis E, Sergentanis TN, Politou M. Hematological findings and complications of COVID-19. Am J Hematol. 2020;95(7):834-847.
  • Pan F, Yang L, Li Y, et al. Factors associated with death outcome in patients with severe coronavirus disease-19 (COVID-19): a case-control study. Int J Med Sci. 2020;17(9):1281-1292. doi:10.7150/ijms.46614
  • Liao D, Zhou F, Luo L. Haematological characteristics and risk factors in the classification and prognosis evaluation of COVID-19: a retrospective cohort study. Lancet Haematol. 2020;7(9):671-678. doi:10.1016/S2352-3026(20)30217-9
  • Ozdin M, Kaya H, Gulacti U, et al. The diagnostic value of neutrophil to lymphocyte ratio in determining the severity of COVID-19. IMC J Med Sci. 2022;16(1):1-7. doi:10.55010/imcjms.16.001
  • Shi S, Qin M, Shen B, et al. Association of cardiac injury with mortality in hospitalized patients with COVID-19 in Wuhan, China. JAMA Cardiol. 2020;5(7):802-810. doi:10.1001/jamacardio.2020.0950
  • Terpos E, Stathopoulos IN, Elalamy I, Kastritis E, Sergentanis TN, Politou M. Hematological findings and complications of COVID-19. Am J Hematol. 2020;95(7):834-847. doi:10.1002/ajh.25829
  • Connors JM, Levy JH. COVID-19 and its implications for thrombosis and anticoagulation. Blood. 2020;135(23):2033-2040. doi:10.1182/blood.2020006000

Koronavirüs Hastalığı Nedeniyle Ölenlerle Taburcu Olanların Beyin Natriüretik Peptit ve Diğer Laboratuvar Parametrelerinin Karşılaştırılması

Year 2023, Volume: 8 Issue: 4, 441 - 447, 18.12.2023

Mehmet Özdin Mehmet Köroğlu Selcuk Yaylacı Erdem Çokluk İbrahim Kocayiğit Aziz Öğütlü

https://doi.org/10.26453/otjhs.1242798

Abstract

Amaç: Bu çalışmada amacımız, COVID-19 enfeksiyonu teşhisi alıp hastanede yatıp taburcu olanlar ile ölen hastaların beyin natriüretik peptidini (BNP) karşılaştırmaktır.
Materyal ve Metot: Çalışma COVID-19 hastalığı teşhisi konan 474 hasta üzerinde gerçekleştirildi. Ölen 56 hasta ile taburcu olan 418 COVID-19 hastasının bilgileri hastane bilgi yönetim sisteminden (HBYS) alındı ve geriye dönük olarak analiz edildi. Ölen hastalar ile taburcu olan hastalarda BNP, beyaz küre hücresi (WBC) , nötrofil (NEU), lenfosit (LYM), trombosit (PLT), Procalsitonin (PCT), Yüksek Duyarlı Troponin I (hs Tn I), D-dimer ve C-Reaktif Protein (CRP) düzeyleri arasındaki ilişki araştırıldı.
Bulgular: Kadınlar ile erkekler arasında mortalite açısından istatistiksel olarak anlamlı bir fark yoktu (p=0,385). Ölenler ile taburcu olanlar arasında BNP, WBC, NEU, LYM, trombosit, PCT ve hs Tn I değerlerinde istatistiksel olarak anlamlı fark yoktu. Ölenler ile taburcu olanların D-dimer (p<0,031) ve CRP (p<0,020) değerleri istatistiksel olarak anlamlı bulundu.
Sonuç: Artan CRP ve D-dimer düzeylerinin mortalite ile ilişkili olduğu bulundu. Bu konuda daha kapsamlı çalışmalara ihtiyaç vardır.

Keywords

Beyin natriüretik peptid C-reactive protein D-dimer koronavirus enfeksiyonları

Project Number

-

References

  • Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: A retrospective cohort study. Lancet. 2020;395(10229):1054–1062. doi:10.1016/S0140-6736(20)30566-3
  • Gandhi RT, Lynch JB, Del Rio C. Mild or moderate Covid-19. N Engl J Med. 2020;383(18):1757-1766. doi:10.1056/NEJMcp2009249
  • Guo T, Fan Y, Chen M, Wu X, Zhang L, He T. Cardiovascular implications of fatal outcomes of patients with Coronavirus Disease 2019 (COVID-19). JAMA Cardiol. 2020;5(7):811–818. doi:10.1001/jamacardio.2020.1017
  • Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395(10223):497–506. doi:10.1016/S0140-6736(20)30183-5
  • Özdin M. Atopik Dermatiti Olan Çocuklarda Hematolojik ve Alerjik Değerler Arasındaki İlişki, Balıkesir Medical Journal. 2020;4(3):1-6. doi:10.33716 bmedj.734178
  • Yazar H, Kayacan Y, Özdin M. Investigation of C-reactive Protein and D-dimer Findings in Patients with COVID-19. Bezmialem Science. 2021;9 (Supplement 1):4-8. doi:10.14235/bas.galenos.2020.4884
  • Halaby R, Popma CJ, Cohen A, et al. D-dimer elevation and adverse outcomes. J Thromb Thrombolysis. 2015;39(1):55-59. doi:10.1007/s11239-014-1101-6
  • Braithwaite S. Procalcitonin: new insights on regulation and origin. Crit Care Med. 2000;28(2):586–588.
  • Avcıküçük M, Bakır F, Topçuoğlu C, Güçtekin A. Akut koroner sendromda troponin T ve troponin I. Turk Hij Den Biyol Derg. 2011;68(3):127-134. doi:10.5505/ TurkHijyen.2011.85047
  • Dede H, Sametoğlu F, İnal BB, Şahin M, Güvenen G. Evaluation of serum pro-BNP and hs-CRP levels with echocardiography Data in Patients with Heart Failure. Istanbul Med J. 2010;11(3):97-103.
  • Bajwa EK, Januzzi JL, Gong MN, Thompson BT, Christiani DC. Prognostic value of plasma N-terminal probrain natriuretic peptide levels in the acute respiratory distress syndrome. Crit Care Med. 2008;36(8):2322-2327. doi:10.1097/CCM. 0b013e318181040d
  • Yang J, Yang Y, Liu Q. Study on the levels of main inflammatory factors in septic shock and their clinical significance. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2019;31(6):680–683. doi:10.3760/cma.j.issn.2095-4352.2019.06.004
  • Tao G, Yongzhen F, Ming C, Xiaoyan W, Lin Z, Tao H. Cardiovascular implications of fatal outcomes of patients with Coronavirus Disease 2019. JAMA Cardiol. 2020;5(7):1–8. doi:10.1001/jamacardio. 2020.1017
  • Xu Z, Shi L, Wang Y, Zhang J, Huang L, Zhang C, Pathological findings of COVID-19 associated with acute respiratory distress syndrome. The Lancet Respiratory Medicine. 2020;8(4):420-422. doi:10.1016/S2213-2600(20)30076-X
  • Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395(10223):497-506. doi:10.1016/S0140-6736(20)30183-5
  • Bonetti G, Manelli F, Patroni A, Bettinardi A, Borrelli G, Fiordalisi G. Laboratory predictors of death from coronavirus disease 2019 (COVID-19) in the area of Valcamonica, Italy. Clin Chem Lab Med. 2020;58(7):1100-1105. doi:10.1515/cclm-2020-0459
  • Bonetti G, Manelli F, Patroni A, et al. Laboratory predictors of death from coronavirus disease 2019 (COVID-19) in the area of Valcamonica, Italy. Clin Chem Lab Med. 2020;58(7):1100-1105. doi:10.1515/cclm-2020-0459
  • Tan W, Zhao X, Ma X, et al. A Novel Coronavirus Genome Identified in a Cluster of Pneumonia Cases - Wuhan, China 2019-2020. China CDC Wkly. 2020;2(4):61-62. doi:10.46234/ccdcw2020.017
  • Guan W. Clinical Characteristics of Coronavirus Disease 2019 in China. NEJM. 2020;382(18):1708-1720. doi:10.1056/NEJMoa2002032
  • Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395(10223):497-506. doi:10.1016/S0140-6736(20)30183-5
  • Wu Z, McGoogan JM. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention. JAMA. 2020;323(13):1239–1242. doi:10.1001/jama.2020.2648
  • Kilbas I, Kahraman Kilbas EP, Ciftci IH. The relationship of procalcitonin level with the severity of COVID-19 infection. Phnx Med J. 2021;3(3):97-100. doi:10.38175/phnx.899465
  • Komaru Y, Doi K. Does a slight change in serum creatinine matter in coronavirus disease 2019 (COVID-19) patients? Kidney Res Clin Pract. 2021;40(2):177-179.
  • Terpos E, Stathopoulos IN, Elalamy I, Kastritis E, Sergentanis TN, Politou M. Hematological findings and complications of COVID-19. Am J Hematol. 2020;95(7):834-847.
  • Pan F, Yang L, Li Y, et al. Factors associated with death outcome in patients with severe coronavirus disease-19 (COVID-19): a case-control study. Int J Med Sci. 2020;17(9):1281-1292. doi:10.7150/ijms.46614
  • Liao D, Zhou F, Luo L. Haematological characteristics and risk factors in the classification and prognosis evaluation of COVID-19: a retrospective cohort study. Lancet Haematol. 2020;7(9):671-678. doi:10.1016/S2352-3026(20)30217-9
  • Ozdin M, Kaya H, Gulacti U, et al. The diagnostic value of neutrophil to lymphocyte ratio in determining the severity of COVID-19. IMC J Med Sci. 2022;16(1):1-7. doi:10.55010/imcjms.16.001
  • Shi S, Qin M, Shen B, et al. Association of cardiac injury with mortality in hospitalized patients with COVID-19 in Wuhan, China. JAMA Cardiol. 2020;5(7):802-810. doi:10.1001/jamacardio.2020.0950
  • Terpos E, Stathopoulos IN, Elalamy I, Kastritis E, Sergentanis TN, Politou M. Hematological findings and complications of COVID-19. Am J Hematol. 2020;95(7):834-847. doi:10.1002/ajh.25829
  • Connors JM, Levy JH. COVID-19 and its implications for thrombosis and anticoagulation. Blood. 2020;135(23):2033-2040. doi:10.1182/blood.2020006000
There are 30 citations in total.

Details

Primary Language English
Subjects Medical Biochemistry - Proteins, Peptides and Proteomics
Journal Section Research article
Authors

Mehmet Özdin 0000-0003-3077-7171

Mehmet Köroğlu 0000-0001-8101-1104

Selcuk Yaylacı 0000-0002-6768-7973

Erdem Çokluk 0000-0002-6205-5109

İbrahim Kocayiğit 0000-0001-8295-9837

Aziz Öğütlü 0000-0003-3840-4038

Project Number -
Early Pub Date December 13, 2023
Publication Date December 18, 2023
Submission Date January 26, 2023
Acceptance Date October 5, 2023
Published in Issue Year 2023 Volume: 8 Issue: 4

Cite

AMA Özdin M, Köroğlu M, Yaylacı S, Çokluk E, Kocayiğit İ, Öğütlü A. Comparison of Brain Natriuretic Peptide and Other Laboratory Parameters of Those Who Died From Coronavirus Disease and Those Who Were Discharged. OTJHS. December 2023;8(4):441-447. doi:10.26453/otjhs.1242798
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