Research Article
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Effect of Transition to Long-acting Injectable Antipsychotic Treatment on Care Burden in Schizophrenia

Year 2021, Volume: 13 Number: Supplement 1 (Research Issue), 361 - 374, 29.12.2021
https://doi.org/10.18863/pgy.991538

Abstract

The main aim of this study is to investigate the difference of transition from oral to long-acting antipsychotic treatments on caregiver burden of patients with schizophrenia. Other factors that may be related to the burden were also discussed. Caregivers (n:138) of patients diagnosed with schizophrenia for at least one year and who received oral paliperidone or aripiprazole were included in the study. The Zarit Caregiver Burden Scale (ZCBS) and The Clinical Global Impression-Disease Severity (CGI-S) were administered at baseline and 1 year after switching to long-acting injectables. Demographic characteristics of caregivers and patients were evaluated to determine other factors associated with the burden. Significant decreases were found in the ZCBS and CGI-S scores after transitioning to long-acting injectable antipsychotics. When the groups using paliperidone and aripiprazole were compared; the decrease in ZCBS scores was not significant, the decrease in CGI-S scores was significant.Caregiver burden was positively correlated with patient's age, CGI-S score, time spent in the same house, duration of illness, and the number of hospitalizations. A significant negative correlation was found among the caregiver’s age, educational level and income. In conclusion, in the present study the importance of switching to long-acting injectable antipsychotics, which is a modifiable factor, to reduce caregiver burden was emphasized.

References

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Şizofrenide Uzun Etkili Enjektabl Antipsikotik Tedaviye Geçişin Bakım Yükü Üzerine Etkisi

Year 2021, Volume: 13 Number: Supplement 1 (Research Issue), 361 - 374, 29.12.2021
https://doi.org/10.18863/pgy.991538

Abstract

Bu çalışmadaki temel amacımız, oral tedaviden uzun etkili antipsikotik tedavilere geçişin şizofreni hastalarında bakım veren yükü üzerinde oluşturduğu farkı araştırmaktır. Yükle ilgili olabilecek diğer faktörler de tartışılmıştır. Çalışmaya en az bir yıldır şizofreni tanısı almış ve oral paliperidon veya aripiprazol alan hastaların bakıcıları (n:138) dahil edildi. Zarit Bakıcı Yükü Ölçeği (ZBYÖ) ve Klinik Global İzlenim-Hastalık Şiddeti (KGİÖ-Ş) ölçeği başlangıçta ve uzun etkili enjektabl antipsikotiklere geçişten 1 yıl sonra uygulandı. Bakım yükü ile ilişkili olabilecek diğer faktörler de ele alındı. Uzun etkili enjekte edilebilir antipsikotiklere geçildikten sonra ZBYÖ ve KGİÖ-Ş puanlarında anlamlı düşüşler bulund. Paliperidon ve aripiprazol kullanan gruplar karşılaştırıldığında; ZBYÖ puanlarındaki düşüş anlamlı değilken, KGİÖ-Ş puanlarındaki düşüş anlamlıydı. Bakım veren yükü, hastanın yaşı, KGİÖ-Ş puanı, aynı evde geçirilen süre, hastalık süresi ve hastaneye yatış sayısı ile pozitif korelasyon gösterdi. Bakım verenin yaşı, eğitim düzeyi ve geliri arasında anlamlı negatif ilişki bulundu. Sonuç olarak bu çalışmada bakım veren yükünün azaltılmasında değiştirilebilir bir faktör olan uzun etkili enjekte edilebilir antipsikotiklere geçilmesinin önemi vurgulanmıştır.

References

  • Referans1 Pereira MAO, Barbieri L, Paula VPd, Franco MdSP. Mental health in the family health program: the conceptions of community agents about mental illness. Revista da Escola de Enfermagem da USP. 2007;41(4):567-72.
  • Referans 2 Schene AH, van Wijngaarden B, Koeter MW. Family caregiving in schizophrenia: domains and distress. Schizophrenia bulletin. 1998;24(4):609-18.
  • Referans 3 Martinez A, Nadal S, Beperet M, Mendióroz P. The schizophrenic patient and his/her relatives: a process of deep change. An Sist Sanit Navarra. 2000;23(1):101-10.
  • Referans 4 Martens L, Addington J. The psychological well-being of family members of individuals with schizophrenia. Social psychiatry and psychiatric epidemiology. 2001;36(3):128-33.
  • Referans 5 Ochoa S, Vilaplana M, Haro JM, Villalta-Gil V, Martínez F, Negredo MC, et al. Do needs, symptoms or disability of outpatients with schizophrenia influence family burden? Social psychiatry and psychiatric epidemiology. 2008;43(8):612-8.
  • Referans 6 Saunders JC. Families living with severe mental illness: A literature review. Issues in mental health nursing. 2003;24(2):175-98.
  • Referans 7 Chan SW-c. Global perspective of burden of family caregivers for persons with schizophrenia. Archives of psychiatric nursing. 2011;25(5):339-49.
  • Referans 8 Atkinson JM, Coia DA. Families coping with schizophrenia: A practitioner's guide to family groups: John Wiley & Sons; 1995.
  • Referans 9 Zhou Y, Ning Y, Rosenheck R, Sun B, Zhang J, Ou Y, et al. Effect of living with patients on caregiver burden of individual with schizophrenia in China. Psychiatry research. 2016;245:230-7.
  • Referans 10 Wolthaus JE, Dingemans PM, Schene AH, Linszen DH, Wiersma D, Van Den Bosch RJ, et al. Caregiver burden in recent-onset schizophrenia and spectrum disorders: the influence of symptoms and personality traits. The Journal of nervous and mental disease. 2002;190(4):241-7.
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  • Referans 12 Reine G, Lancon C, Simeoni M, Duplan S, Auquier P. Caregiver burden in relatives of persons with schizophrenia: an overview of measure instruments. L'encéphale. 2003;29(2):137.
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  • Referans 14 Awad AG, Voruganti LN. The burden of schizophrenia on caregivers. Pharmacoeconomics. 2008;26(2):149-62.
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  • Referans 19 Leucht S, Tardy M, Komossa K, Heres S, Kissling W, Salanti G, et al. Antipsychotic drugs versus placebo for relapse prevention in schizophrenia: a systematic review and meta-analysis. The Lancet. 2012;379(9831):2063-71.
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  • Referans 21 Higashi K, Medic G, Littlewood KJ, Diez T, Granström O, De Hert M. Medication adherence in schizophrenia: factors influencing adherence and consequences of nonadherence, a systematic literature review. Therapeutic advances in psychopharmacology. 2013;3(4):200-18. Referans 22 Lacro JP, Dunn LB, Dolder CR, Jeste DV. Prevalence of and risk factors for medication nonadherence in patients with schizophrenia: a comprehensive review of recent literature. The Journal of clinical psychiatry. 2002;63(10):892-909.
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  • Referans 24 Novick D, Haro JM, Suarez D, Perez V, Dittmann RW, Haddad PM. Predictors and clinical consequences of non-adherence with antipsychotic medication in the outpatient treatment of schizophrenia. Psychiatry research. 2010;176(2-3):109-13.
  • Referans 25 Brissos S, Veguilla MR, Taylor D, Balanzá-Martinez V. The role of long-acting injectable antipsychotics in schizophrenia: a critical appraisal. Therapeutic advances in psychopharmacology. 2014;4(5):198-219.
  • Referans 26 Schooler NR. Relapse and rehospitalization: comparing oral and depot antipsychotics. The Journal of clinical psychiatry. 2003;64:14-7.
  • Referans 27 Lafeuille M-H, Laliberté-Auger F, Lefebvre P, Frois C, Fastenau J, Duh MS. Impact of atypical long-acting injectable versus oral antipsychotics on rehospitalization rates and emergency room visits among relapsed schizophrenia patients: a retrospective database analysis. BMC psychiatry. 2013;13(1):221.
  • Referans 28 Heres S, Lambert M, Vauth R. Treatment of early episode in patients with schizophrenia: the role of long acting antipsychotics. European Psychiatry. 2014;29(S2):1409-13.
  • Referans 29 Markowitz M, Fu D-J, Levitan B, Gopal S, Turkoz I, Alphs L. Long-acting injectable paliperidone palmitate versus oral paliperidone extended release: a comparative analysis from two placebo-controlled relapse prevention studies. Annals of General Psychiatry. 2013;12(1):22.
  • Referans 30 Yoshimura B, Shinkawa I, Konishi A. Hospitalization risk in patients with schizophrenia before and after initiation of risperidone long-acting injection in Japan. Asian journal of psychiatry. 2015;14:67.
  • Referans 31 Castillo EG, Stroup TS. Effectiveness of long-acting injectable antipsychotics: a clinical perspective. Evidence-Based Mental Health. 2015;18(2):36-9.
  • Referans 32 Sreeraj VS, Shivakumar V, Rao NP, Venkatasubramanian G. A critical appraisal of long acting injectable antipsychotics: translating research to clinics. Asian journal of psychiatry. 2017;28:57-64.
  • Referans 33 Ozlu A, Yildiz M, Aker T. A reliability and validity study on the Zarit caregiver burden scale. 2009.
  • Referans 34 Hulya A, Adana F. The Burden of Schizophrenia on Caregivers. Current Approaches in Psychiatry. 2011;3:251-77.
  • Referans 35 Nolan M. Supporting family carers in the UK: overview of issues and challenges. British Journal of Nursing. 2001;10(9):608-13.
  • Referans 36 Cheng L-Y, Chan S. Psychoeducation program for Chinese family carers of members with schizophrenia. Western journal of nursing research. 2005;27(5):583-99.
  • Referans 37 Chan SW-c, Yip B, Tso S, Cheng B-s, Tam W. Evaluation of a psychoeducation program for Chinese clients with schizophrenia and their family caregivers. Patient education and counseling. 2009;75(1):67-76.
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  • Referans 44 Guarnaccia PJ, Parra P. Ethnicity, social status, and families' experiences of caring for a mentally ill family member. Community Mental Health Journal. 1996;32(3):243-60.
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There are 70 citations in total.

Details

Primary Language Turkish
Subjects Psychiatry
Journal Section Research
Authors

Elif Özcan Tozoğlu 0000-0003-2300-2634

Gökhan Özpolat 0000-0003-2623-7236

Publication Date December 29, 2021
Acceptance Date December 12, 2021
Published in Issue Year 2021 Volume: 13 Number: Supplement 1 (Research Issue)

Cite

AMA Özcan Tozoğlu E, Özpolat G. Şizofrenide Uzun Etkili Enjektabl Antipsikotik Tedaviye Geçişin Bakım Yükü Üzerine Etkisi. Psikiyatride Güncel Yaklaşımlar - Current Approaches in Psychiatry. December 2021;13(Ek 1):361-374. doi:10.18863/pgy.991538

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