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Solid Pseudopapillary Neoplasm of the Pancreas: Radiological, Clinical, Histopathological and Prognostic Features of 5 Patients

Year 2023, Volume: 5 Issue: 3, 233 - 238, 01.11.2023

Nuray Çolapkulu Nesrin Gündüz Humeyra Gunel Mehmet Sait Özsoy Orhan Alimoğlu

https://doi.org/10.38175/phnx.1300358

Abstract

Solid pseudopapillary neoplasms of the pancreas are rare lesions, classified as borderline malignant tumors. They predominantly affect younger females and have more favorable outcomes compared to other pancreatic tumors. While patients may present with non-specific symptoms, the use of imaging modalities has led to an increase in incidental cases. These neoplasms are typically diagnosed using radiological imaging methods due to their characteristic features. Unlike pancreatic adenocarcinomas, surgical treatment results in lower morbidity rates and disease-free survival rates above ninety percent. This study aims to report the clinical, histopathological, and prognostic features of five cases of solid pseudopapillary neoplasms of the pancreas and review the current literature.

Keywords

Pseudopapillary tumor pancreas incidental tumors

References

  • Yu P, Hu Z, Wang X. Solid pseudopapillary tumor of the pancreas: a review of 553 cases in Chinese literature. World J Gastroenterol. 2010;16(10):1209-1214.
  • Law JK, Ahmed A, Singh VK, Akshintala VS, Olson MT, Raman SP, et al. A systematic review of solid-pseudopapillary neoplasms: are these rare lesions? Pancreas. 2014;43(3):331-7. doi: 10.1097/MPA.0000000000000061.
  • Uğuz A, Ünalp ÖV, Akpınar G, Karaca CA, Oruç N, Nart D, et al. Solid pseudopapillary neoplasms of the pancreas: Case series with a review of the literature. Turk J Gastroenterol. 2020;31(12):930-935. doi: 10.5152/tjg.2020.19227.
  • Antoniou E, Damaskos C, Garmpis N. Solid Pseudopapillary Tumor of the Pancreas: A Single-center Experience and Review of the Literature. In Vivo (Brooklyn) 2017;31(4):501–510.
  • Machado MCC, Machado MAC, Bacchella T, Jukemura J, Almeida JL, Cunha JEM. Solid pseudopapillary neoplasm of the pancreas: distinct patterns of onset, diagnosis, and prognosis for male versus female patients. Surgery 2008;143(1):29–34.
  • Hosokawa I, Shimizu H, Ohtsuka M, Kato A, Yoshitomi H, Furukawa K. Preoperative diagnosis and surgical management for solid pseudopapillary neoplasm of the pancreas. J Hepatobiliary Pancreat Sci. 2014;21(8):573-578.
  • Song H, Dong M, Zhou J, Sheng W, Zhong B, Gao W. Solid Pseudopapillary Neoplasm of the Pancreas: Clinicopathologic Feature, Risk Factors of Malignancy, and Survival Analysis of 53 Cases from a Single Center. Biomed Res Int. 2017;2017:1–7.
  • Hansen CP, Kristensen TS, Storkholm JH, Federspiel BH. Solid pseudopapillary neoplasm of the pancreas: Clinical-pathological features and management, a single-center experience. Rare Tumors. 2019;11:203636131987851.
  • Mao C, Guvendi M, Domenico DR, Kim K, Thomford NR, Howard JM. Papillary cystic and solid tumors of the pancreas: A pancreatic embryonic tumor? Studies of three cases and cumulative review of the world’s literature. Surgery. 1995;118(5):821–828.
  • Frantz V. No Title. In: Atlas of Tumour Pathology. Washington DC: Armed Forces Institute of Pathology; 1959. p. First Series, Fasc, 27 and 28.
  • Paredes O, Kawaguchi Y, Ruiz E, Payet E, Berrospi F. Surgery of pancreas tumors in pediatric and adolescent patients: a single institution experience in South America. Pediatr Surg Int. 2021;37(8):1041-1047.
  • Meriam S, Ines B, Fatma BF, et al. Atypical solid pseudopapillary tumor of the pancreas in a 14‐year‐old. Clin Case Reports 2021;9(3):1716–1720
  • Yee AM, Kelly BG, Gonzalez-Velez JM, Nakakura EK. Solid pseudopapillary neoplasm of the pancreas head in a pregnant woman: safe pancreaticoduodenectomy postpartum. J Surg Case Reports. 2015;2015(8):rjv108
  • Huang SC, Wu TH, Chen CC, Chen TC. Spontaneous rupture of solid pseudopapillary neoplasm of the pancreas during pregnancy. Obstet Gynecol. 2013;121(2 Pt 2 Suppl 1):486–488.
  • Papavramidis T, Papavramidis S. Solid pseudopapillary tumors of the pancreas: review of 718 patients reported in English literature. J Am Coll Surg. 2005;200(6):965–972.
  • Reddy S, Cameron JL, Scudiere J, Hruban RH, Fishman EK, Ahuja N, et al. Surgical management of solid-pseudopapillary neoplasms of the pancreas (Franz or Hamoudi tumors): a large single-institutional series. J Am Coll Surg. 2009;208(5):950-7; discussion 957-9. doi: 10.1016/j.jamcollsurg.2009.01.044.
  • Yu MH, Lee JY, Kim MA, et al. MR Imaging Features of Small Solid Pseudopapillary Tumors: Retrospective Differentiation From Other Small Solid Pancreatic Tumors. Am J Roentgenol. 2010;195(6):1324–1332.
  • Pelosi G, Iannucci A, Zamboni G, Bresaola E, Iacono C, Serio G. Solid and cystic papillary neoplasm of the pancreas: A clinico-cytopathologic and immunocytochemical study of five new cases diagnosed by fine-needle aspiration cytology and a review of the literature. Diagn Cytopathol. 1995;13(3):233–246.
  • Vargas-Serrano B, Domínguez-Ferreras E, Chinchón-Espino D. Four cases of solid pseudopapillary tumors of pancreas: Imaging findings and pathological correlations. Eur J Radiol. 2006;58(1):132–139.
  • Kehagias D, Smyrniotis V, Gouliamos A, Vlahos L. Cystic Pancreatic Neoplasms: Computed Tomography and Magnetic Resonance Imaging Findings. Int J Gastrointest Cancer. 2000;28(3):223–230.
  • Dong A, Wang Y, Dong H, Zhang J, Cheng C, Zuo C. FDG PET/CT Findings of Solid Pseudopapillary Tumor of the Pancreas With CT and MRI Correlation. Clin Nucl Med. 2013;38(3):e118–124.
  • Tanaka Y, Kato K, Notohara K, Hojo H, Ijiri R, Miyake T, et al. Frequent beta-catenin mutation and cytoplasmic/nuclear accumulation in pancreatic solid-pseudopapillary neoplasm. Cancer Res. 2001;61(23):8401-4.
  • Abraham SC, Klimstra DS, Wilentz RE, Yeo CJ, Conlon K, Brennan M, et al. Solid-pseudopapillary tumors of the pancreas are genetically distinct from pancreatic ductal adenocarcinomas and almost always harbor beta-catenin mutations. Am J Patho 2002;160(4):1361–1369.
  • Ohara Y, Oda T, Hashimoto S, Akashi Y, Miyamoto R, Enomoto T, et al. Pancreatic neuroendocrine tumor and solid-pseudopapillary neoplasm: Key immunohistochemical profiles for differential diagnosis. World J Gastroenterol. 2016;22(38):8596-8604. doi: 10.3748/wjg.v22.i38.8596.
  • Kloppel G, Solcia E, Longnecker DS, Capella C, Sobin LH. Histological typing of tumours of the exocrine pancreas. In: Kloppel G, Solcia E LD, editor. World Health Organization international histological classification of tumours. 2nd ed. New Yor: Springer-Verlag; 1996. p. 1–68.
  • Marchegiani G, Andrianello S, Massignani M, Malleo G, Maggino L, Paiella S,et al. Solid pseudopapillary tumors of the pancreas: Specific pathological features predict the likelihood of postoperative recurrence. J Surg Oncol. 2016;114(5):597-601. doi: 10.1002/jso.24380.
  • Lee JS, Han HJ, Choi SB, Jung CW, Song TJ, Choi SY. Surgical outcomes of solid pseudopapillary neoplasm of the pancreas: a single institution’s experience for the last ten years. Am Surg. 2012;78(2):216–219.
  • Yang F, Jin C, Long J, Yu XJ, Xu J, Di Y, et al. Solid pseudopapillary tumor of the pancreas: a case series of 26 consecutive patients. Am J Surg. 2009;198(2):210-5. doi: 10.1016/j.amjsurg.2008.07.062.
  • Patil TB, Shrikhande SV, Kanhere HA, Saoji RR, Ramadwar MR, Shukla PJ. Solid pseudopapillary neoplasm of the pancreas: a single institution experience of 14 cases. HPB. 2006;8(2):148–150.
  • Vassos N, Agaimy A, Klein P, Hohenberger W, Croner RS. Solid-pseudopapillary neoplasm (SPN) of the pancreas: case series and literature review on an enigmatic entity. Int J Clin Exp Pathol. 2013;6(6):1051–1059.

Pankreasın Solid Psödopapiller Neoplazmı: 5 Hastanın Radyolojik, Klinik, Histopatolojik ve Prognostik Özellikleri

Year 2023, Volume: 5 Issue: 3, 233 - 238, 01.11.2023

Nuray Çolapkulu Nesrin Gündüz Humeyra Gunel Mehmet Sait Özsoy Orhan Alimoğlu

https://doi.org/10.38175/phnx.1300358

Abstract

Pankreasın solid psödopapiller neoplazmaları nadir lezyonlardır ve borderline malign tümor olarak sınıflandırılır. Daha çok genç yaştaki kadınlarda görülürler ve pankreasın diğer tümörlerine kıyasla daha iyi prognoza sahiptirler. Hastalar spesifik olmayan semptomlarla başvurabilir, ancak insidental vakaların sayısı son yıllarda görüntüleme yöntemlerinin yoğun kullanımının bir sonucu olarak artmıştır. Tümörlerin karakteristik özellikleri ile çoğunlukla radyolojik görüntüleme yöntemleri ile teşhis edilirler. Pankreas adenokarsinomlarından farklı olarak cerrahi ile morbidite oranları daha düşüktür ve hastalıksız sağ kalım oranları yüzde doksanın üzerindedir. Bu çalışmada beş pankreas solid psödopapiller neoplazi olgusunun klinik, histopatolojik ve prognostik özelliklerini sunmayı ve literatürün güncel durumunu gözden geçirmeyi amaçladık.

Keywords

Psödopapiller tümör Pankreas

References

  • Yu P, Hu Z, Wang X. Solid pseudopapillary tumor of the pancreas: a review of 553 cases in Chinese literature. World J Gastroenterol. 2010;16(10):1209-1214.
  • Law JK, Ahmed A, Singh VK, Akshintala VS, Olson MT, Raman SP, et al. A systematic review of solid-pseudopapillary neoplasms: are these rare lesions? Pancreas. 2014;43(3):331-7. doi: 10.1097/MPA.0000000000000061.
  • Uğuz A, Ünalp ÖV, Akpınar G, Karaca CA, Oruç N, Nart D, et al. Solid pseudopapillary neoplasms of the pancreas: Case series with a review of the literature. Turk J Gastroenterol. 2020;31(12):930-935. doi: 10.5152/tjg.2020.19227.
  • Antoniou E, Damaskos C, Garmpis N. Solid Pseudopapillary Tumor of the Pancreas: A Single-center Experience and Review of the Literature. In Vivo (Brooklyn) 2017;31(4):501–510.
  • Machado MCC, Machado MAC, Bacchella T, Jukemura J, Almeida JL, Cunha JEM. Solid pseudopapillary neoplasm of the pancreas: distinct patterns of onset, diagnosis, and prognosis for male versus female patients. Surgery 2008;143(1):29–34.
  • Hosokawa I, Shimizu H, Ohtsuka M, Kato A, Yoshitomi H, Furukawa K. Preoperative diagnosis and surgical management for solid pseudopapillary neoplasm of the pancreas. J Hepatobiliary Pancreat Sci. 2014;21(8):573-578.
  • Song H, Dong M, Zhou J, Sheng W, Zhong B, Gao W. Solid Pseudopapillary Neoplasm of the Pancreas: Clinicopathologic Feature, Risk Factors of Malignancy, and Survival Analysis of 53 Cases from a Single Center. Biomed Res Int. 2017;2017:1–7.
  • Hansen CP, Kristensen TS, Storkholm JH, Federspiel BH. Solid pseudopapillary neoplasm of the pancreas: Clinical-pathological features and management, a single-center experience. Rare Tumors. 2019;11:203636131987851.
  • Mao C, Guvendi M, Domenico DR, Kim K, Thomford NR, Howard JM. Papillary cystic and solid tumors of the pancreas: A pancreatic embryonic tumor? Studies of three cases and cumulative review of the world’s literature. Surgery. 1995;118(5):821–828.
  • Frantz V. No Title. In: Atlas of Tumour Pathology. Washington DC: Armed Forces Institute of Pathology; 1959. p. First Series, Fasc, 27 and 28.
  • Paredes O, Kawaguchi Y, Ruiz E, Payet E, Berrospi F. Surgery of pancreas tumors in pediatric and adolescent patients: a single institution experience in South America. Pediatr Surg Int. 2021;37(8):1041-1047.
  • Meriam S, Ines B, Fatma BF, et al. Atypical solid pseudopapillary tumor of the pancreas in a 14‐year‐old. Clin Case Reports 2021;9(3):1716–1720
  • Yee AM, Kelly BG, Gonzalez-Velez JM, Nakakura EK. Solid pseudopapillary neoplasm of the pancreas head in a pregnant woman: safe pancreaticoduodenectomy postpartum. J Surg Case Reports. 2015;2015(8):rjv108
  • Huang SC, Wu TH, Chen CC, Chen TC. Spontaneous rupture of solid pseudopapillary neoplasm of the pancreas during pregnancy. Obstet Gynecol. 2013;121(2 Pt 2 Suppl 1):486–488.
  • Papavramidis T, Papavramidis S. Solid pseudopapillary tumors of the pancreas: review of 718 patients reported in English literature. J Am Coll Surg. 2005;200(6):965–972.
  • Reddy S, Cameron JL, Scudiere J, Hruban RH, Fishman EK, Ahuja N, et al. Surgical management of solid-pseudopapillary neoplasms of the pancreas (Franz or Hamoudi tumors): a large single-institutional series. J Am Coll Surg. 2009;208(5):950-7; discussion 957-9. doi: 10.1016/j.jamcollsurg.2009.01.044.
  • Yu MH, Lee JY, Kim MA, et al. MR Imaging Features of Small Solid Pseudopapillary Tumors: Retrospective Differentiation From Other Small Solid Pancreatic Tumors. Am J Roentgenol. 2010;195(6):1324–1332.
  • Pelosi G, Iannucci A, Zamboni G, Bresaola E, Iacono C, Serio G. Solid and cystic papillary neoplasm of the pancreas: A clinico-cytopathologic and immunocytochemical study of five new cases diagnosed by fine-needle aspiration cytology and a review of the literature. Diagn Cytopathol. 1995;13(3):233–246.
  • Vargas-Serrano B, Domínguez-Ferreras E, Chinchón-Espino D. Four cases of solid pseudopapillary tumors of pancreas: Imaging findings and pathological correlations. Eur J Radiol. 2006;58(1):132–139.
  • Kehagias D, Smyrniotis V, Gouliamos A, Vlahos L. Cystic Pancreatic Neoplasms: Computed Tomography and Magnetic Resonance Imaging Findings. Int J Gastrointest Cancer. 2000;28(3):223–230.
  • Dong A, Wang Y, Dong H, Zhang J, Cheng C, Zuo C. FDG PET/CT Findings of Solid Pseudopapillary Tumor of the Pancreas With CT and MRI Correlation. Clin Nucl Med. 2013;38(3):e118–124.
  • Tanaka Y, Kato K, Notohara K, Hojo H, Ijiri R, Miyake T, et al. Frequent beta-catenin mutation and cytoplasmic/nuclear accumulation in pancreatic solid-pseudopapillary neoplasm. Cancer Res. 2001;61(23):8401-4.
  • Abraham SC, Klimstra DS, Wilentz RE, Yeo CJ, Conlon K, Brennan M, et al. Solid-pseudopapillary tumors of the pancreas are genetically distinct from pancreatic ductal adenocarcinomas and almost always harbor beta-catenin mutations. Am J Patho 2002;160(4):1361–1369.
  • Ohara Y, Oda T, Hashimoto S, Akashi Y, Miyamoto R, Enomoto T, et al. Pancreatic neuroendocrine tumor and solid-pseudopapillary neoplasm: Key immunohistochemical profiles for differential diagnosis. World J Gastroenterol. 2016;22(38):8596-8604. doi: 10.3748/wjg.v22.i38.8596.
  • Kloppel G, Solcia E, Longnecker DS, Capella C, Sobin LH. Histological typing of tumours of the exocrine pancreas. In: Kloppel G, Solcia E LD, editor. World Health Organization international histological classification of tumours. 2nd ed. New Yor: Springer-Verlag; 1996. p. 1–68.
  • Marchegiani G, Andrianello S, Massignani M, Malleo G, Maggino L, Paiella S,et al. Solid pseudopapillary tumors of the pancreas: Specific pathological features predict the likelihood of postoperative recurrence. J Surg Oncol. 2016;114(5):597-601. doi: 10.1002/jso.24380.
  • Lee JS, Han HJ, Choi SB, Jung CW, Song TJ, Choi SY. Surgical outcomes of solid pseudopapillary neoplasm of the pancreas: a single institution’s experience for the last ten years. Am Surg. 2012;78(2):216–219.
  • Yang F, Jin C, Long J, Yu XJ, Xu J, Di Y, et al. Solid pseudopapillary tumor of the pancreas: a case series of 26 consecutive patients. Am J Surg. 2009;198(2):210-5. doi: 10.1016/j.amjsurg.2008.07.062.
  • Patil TB, Shrikhande SV, Kanhere HA, Saoji RR, Ramadwar MR, Shukla PJ. Solid pseudopapillary neoplasm of the pancreas: a single institution experience of 14 cases. HPB. 2006;8(2):148–150.
  • Vassos N, Agaimy A, Klein P, Hohenberger W, Croner RS. Solid-pseudopapillary neoplasm (SPN) of the pancreas: case series and literature review on an enigmatic entity. Int J Clin Exp Pathol. 2013;6(6):1051–1059.
There are 30 citations in total.

Details

Primary Language English
Subjects Surgery
Journal Section Case Reports
Authors

Nuray Çolapkulu 0000-0002-3033-8702

Nesrin Gündüz 0000-0001-8754-5676

Humeyra Gunel 0000-0003-3987-4314

Mehmet Sait Özsoy 0000-0003-2935-8463

Orhan Alimoğlu 0000-0003-2130-2529

Early Pub Date October 24, 2023
Publication Date November 1, 2023
Submission Date May 22, 2023
Acceptance Date August 11, 2023
Published in Issue Year 2023 Volume: 5 Issue: 3

Cite

Vancouver Çolapkulu N, Gündüz N, Gunel H, Özsoy MS, Alimoğlu O. Solid Pseudopapillary Neoplasm of the Pancreas: Radiological, Clinical, Histopathological and Prognostic Features of 5 Patients. Phnx Med J. 2023;5(3):233-8.
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