Clinical Research
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The relationship between Thiol/disulfide homeostasis and endometrial hyperplasia in patients with abnormal uterine bleeding/

Year 2022, Volume: 7 Issue: 2, 340 - 351, 01.08.2022

Sezin Ertürk Aksakal Elif Gülşah Diktaş Ramazan Erda Pay Ömer Lütfi Tapısız Burcu Timur Vakkas Korkmaz Özcan Erel Yaprak Üstün

https://doi.org/10.25279/sak.1101029

Abstract

Introduction: The role of oxidative stress and antioxidant capacity in the development of endometrial hyperplasia (EH) is controversial. Aim: The study aimed to evaluate Thiol/disulfide Homeostasis and ischemia modified albumin (IMA) levels in patients with EH without atypia. Materials and Methods: In this prospective case-control study, patients with EH without atypia (HP group) (n=28), patients with nonhyperplasia (proliferative/secretory/irregular proliferative/irregular secretory endometrium) (non-HP group) (n=28), and 28 healthy women (control group) were included. The patient's clinical characteristics, serum Thiol/disulfide parameters, and IMA levels were compared between groups. Results: A total of 84 patients were included in the study. Patients’ mean age, BMI, and mean native thiol (-SH-), total thiol (-SH-+-SS-), disulfide (-SS-), and IMA levels were similar among the three groups. The -SS- /-SH- ratio was higher in the HP group than the non-HP group. -SS- /-SH-+-SS- ratio was higher in the HP group vs. the other two groups. The -SS- /-SH-+-SS ratio was higher in the HP group vs. the non-HP group. -SH-/ -SH-+-SS- ratio was lower in the HP group than in the non-HP group. ET was greater in the HP group than in the non-HP and control groups. ET was also significantly greater in the non-HP group vs. in the control group. -SS-/-SH- ratio was found to be predictive with 64% sensitivity and 68% specificity for EH (area under curve = 0.672, p = 0.01). Conclusion and Suggestions: The dynamic thiol/disulfide balance shifted to the disulfide side in women with endometrial hyperplasia.

Keywords

Thiol/disulfide homeostasis Oxidative stress Endometrial hyperplasia without atypia Ischemia modified albumin.

References

  • Alcázar, J. L., Bonilla, L., Marucco, J., Padilla, A. I., Chacón, E., Manzour, N. et al. (2018). Risk of endometrial cancer and endometrial hyperplasia with atypia in asymptomatic postmenopausal women with endometrial thickness≥ 11 mm: A systematic review and meta‐analysis. Journal of Clinical Ultrasound, 46(9), 565-570. https://doi.org/10.1002/jcu.22631.
  • Arioz, D. T., Camuzcuoglu, H., Toy, H., Kurt, S., Celik, H. and Erel, O. (2009). Assessment of serum paraoxonase and arylesterase activity in patients with endometrial cancer. European Journal of Gynaecologic Oncology, 30(6), 679-682.
  • Baba, S. P. and Bhatnagar, A. (2018). Role of thiols in oxidative stress. Current Opinion in Toxicology, 7, 133-139. https://doi.org/10.1016/j.cotox.2018.03.005
  • Bar-Or, D., Rael, L.T., Bar-Or, R., Slone, D.S., Mains, C.W., Rao, N.K.R. and Curtis, C.G. (2008). The cobalt–albumin binding assay: insights into its mode of action. Clinica Chimica Acta, 387(1-2), 120-127. https://doi.org/10.1016/j.cca.2007.09.018.
  • Cremers, C. M. and Jakob, U. (2013). Oxidant sensing by reversible disulfide bond formation. Journal of Bioogical Chemistry, 288(37), 26489-26496. https://doi.org/10.1074/jbc.R113. 462929.
  • Emons, G., Beckmann, M. W., Schmidt, D. and Mallmann, P. (2015). Uterus commission of the Gynecological Oncology Working Group (A. G. O). New WHO Classification of Endometrial Hyperplasias. Geburtshilfe Frauenheilkd, 75(2), 135-136. https://doi.org/10.1055/s-0034-1396256.6), 563-570.
  • Erel, O. and Neselioglu, S. (2014). A novel and automated assay for thiol/disulphide homeostasis. Clinical Biochemistry, 47(18), 326–332. https://doi.org/10.1016/j.clinbiochem.2014.09.026.
  • Eroglu, S., Haskul, İ., Aziz, V., Yurtcu, E., Karatas, F., Neselioglu, S. and Erel, O. (2017). Dynamic thiol/disulphide homeostasis in patients with Uterine Myoma. European Journal of Obstetrics & Gynecology and Reproductive Biology, 216, 24-26. https://doi.org/10.1016/j.ejogrb.2017. 06.045.
  • Eryilmaz, M. A., Kozanhan, B., Solak, I., Çetinkaya, Ç. D., Neselioglu, S. and Erel, Ö. (2019). Thiol-disulfide homeostasis in breast cancer patients. Journal of Cancer Research and Therapeutics, 15(5), 1062. https://doi.org/10.4103/jcrt.JCRT_553_17.
  • Getpook, C. and Wattanakumtornkul, S. (2006). Endometrial thickness screening in premenopausal women with abnormal uterine bleeding. Journal of Obstetrics and Gynaecology Research, 32(6), 588-592. https://doi.org/10.1111/j.1447-0756.2006.00455.x.
  • Giannella, L., Mfuta, K., Setti, T., Boselli, F., Bergamini, E. and Cerami, L. B. (2014). Diagnostic accuracy of endometrial thickness for the detection of intra-uterine pathologies and appropriateness of performed hysteroscopies among asymptomatic postmenopausal women. European Journal of Obstetrics & Gynecology and Reproductive Biology, 177, 29-33. https://doi.org/10.1016/j.ejogrb.2014.03.025.
  • Giannella, L., Cerami, L. B., Setti, T., Bergamini, E. and Boselli, F. (2019). Prediction of endometrial hyperplasia and cancer among premenopausal women with abnormal uterine bleeding. BioMed research international, 8598152. https://doi.org/10.1155/2019/8598152.
  • Gómez-Zubeldia, M. A., Bazo, A. P., Gabarre, J. J. A., Nogales, A. G. and Palomino, J. C. M. (2008). Oxidative stress in endometrial hyperplasia. Menopause, 15(2), 363-368. https://doi.org/ 10.1097/gme.0b013e318093e646
  • Goncharenko, V. M., Beniuk, V. A., Kalenska, O. V., Demchenko, O. M., Spivak M. Y. and Bubnov, R.V. (2013). Predictive diagnosis of endometrial hyperplasia and personalized therapeutic strategy in women of fertile age. EPMA Journal, 4(1), 1-20. https://doi.org/10.1186/1878-5085-4-24,
  • Henderson, B. E. and Feigelson, H. S. (2000). Hormonal carcinogenesis. Carci¬nogenesis, 21, 427-433. Jones, D. P. and Liang, Y. (2009). Measuring the poise of thiol/disulfide couples in vivo. Free Radical Biology and Medicine, 47(10), 1329-1338. https://doi.org/10.1016/j.freeradbiomed.2009. 08.021
  • Kubyshkin, A. V., Aliev, L. L., Fomochkina, I. I., Kovalenko, Y. P., Litvinova, S. V., Filonenko, T. G. et al. (2016). Endometrial hyperplasia-related inflammation: its role in the development and progression of endometrial hyperplasia. Inflammation Research, 65(10), 785-794. https://doi.org/10.1007/s00011-016-0960-z,
  • Lecanda, J., Parekh, T.V., Gama, P, Lin, K., Liarski, V., Uretsky, S., Mittal, K. and Gold, L. I. (2007). Transforming growth factor-b, estrogen, and progesterone converge on the regulation of p27Kip1 in the normal and malignant endometrium. Cancer Reserach. 67(3), 1007-1018. https://doi.org/10.1158/0008-5472.CAN-06-0235
  • Louie, M., Canavan, T. P. and Mansuria, S. (2016). Threshold for endometrial sampling among postmenopausal patients without vaginal bleeding. International Journal of Gynecology & Obstetrics, 132(3), 314-317. https://doi.org/10.1016/j.ijgo.2015.07.023
  • Matsuo, K., Ramzan, A. A., Gualtieri, M. R., Mhawech-Fauceglia, P., Machida, H., Moeini, A. et al. (2015). Prediction of concurrent endometrial carcinoma in women with endometrial hyperplasia. Gynecologic Oncology, 139(2), 261-267. https://doi.org/10.1016/j.ygyno.2015. 07.108
  • No, G. T. G. (2016). Management of Endometrial Hyperplasia. RCOG BSGE Joint Guideline, 67, 30. Ozaksit, G., Tokmak, A., Kosem, A., Kuru-Pekcan, M. and Ozcan, E. (2019). Could there be any role of thiol-disulfide homeostasis and ischemia-modified albumin in the pathogenesis of endometrial polyps?. Journal of Experimental Therapeutics & Oncology, 13(2), 125-129.
  • Özdemir, S., Çelik, Ç., Gezginç, K., Kıreşi, D. and Esen, H. (2010). Evaluation of endometrial thickness with transvaginal ultrasonography and histopathology in premenopausal women with abnormal vaginal bleeding. Archives of Gynecology and Obstetrics, 282(4), 395-399. https://doi.org/10.1007/s00404-009-1290-y
  • Özkaya, E., Korkmaz, V., Özkaya, Y., Tosun, A., Küçükozkan, T. and Bostan, H. (2013). Ultrasonographic endometrial thickness measurement is predictive for treatment response in simple endometrial hyperplasia without atypia. Journal of the Turkish German Gynecological Association, 14(1), 19. https://doi.org/10.5152/jtgga.2013.05
  • Pejić, S., Todorović, A., Stojiljković, V., Kasapović, J. and Pajović, S. B. (2009). Antioxidant enzymes and lipid peroxidation in endometrium of patients with polyps, myoma, hyperplasia and adenocarcinoma. Reproductive Biology and Endocrinology, 7(1), 1-9. https://doi.org/10.1186/1477-7827-7-149
  • Pejić, S., Todorović, A., Stojiljković, V., Pavlović, I., Gavrilović, L., Popović, N. and Pajović, S. B. (2016). Antioxidant status and sex hormones in women with complex endometrial hyperplasia. Cellular and Molecular Biology, 62(11), 51-56. https://doi.org/10.14715/cmb/ 2016.62.11.9
  • Rizk, B., Badr, M. and Talerico, C. (2013). Oxidative stress and the endometrium. In studies on women's health. Humana Press, Totowa, 1, 61-74. https://doi.org/10.1007/978-1-62703-041-0_3
  • Saatli, B., Yildirim, N., Olgan, S., Koyuncuoglu, M., Emekci, O. and Saygılı, U. (2014). The role of endometrial thickness for detecting endometrial pathologies in asymptomatic postmenopausal women. Australian and New Zealand Journal of Obstetrics and Gynaecology, 54(1), 36-40. https://doi.org/10.1111/ajo.12174
  • Sezgin, B., Kinci, M.F., Pirinççi, F., Camzuoglu, A., Erel, O., Neselioglu, S. and Camzuoglu, H. (2020). Thiol‐disulfide status of patients with cervical cancer. Journal of Obstetrics and Gynaecology Research, 46, 2423-2429. https://doi.org/10.1111/jog.14480
  • Sherman, M. E. (2000). Theories of endometrial carcinogenesis: a multidisciplinary approach. Modern Pathology, 13(3), 295-308. https://doi.org/10.1038/modpathol.3880051
  • Sugino, N., Shimamura, K., Takiguchi, S., Tamura, H., Nakata, M., Nakamura, Y., Ogino, K., Uda, T. and Kato, H. (1996). Changes in activity of superoxide dismutase in the human endometrium throughout the menstrual cycle and early pregnancy. Human Reproduction, 11(5), 1073–1078. https://doi.org/10.1093/oxfordjournals.humrep.a019299
  • Sugino, N., Nakata, M., Kashida, S., Karube, A., Takiguchi, S. and Kato, H. (2000). Decreased superoxide dismutase expression and increased concentrations of lipid peroxide and prostaglandin F2-a in the decidua of failed pregnancy. Molecular Human Reproduction, 6(7), 642–647. https://doi.org/10.1093/molehr/6.7.642
  • Sugino, N., Karube-Harada, A., Kashida, S., Takiguchi, S. and Kato, H. (2001). Reactive oxygen species stimulate prostaglandin F2a production in human endometrial stromal cells in vitro. Human reproduction, 16(9), 1797-1801. https://doi.org/10.1093/humrep/16.9.1797,
  • Todorović, A., Stojiljković, V., Cvetković, D., Lučić, N., Radojičić, R. M. and Saičić, Z. S. (2008). Superoxide dismutase and lipid hydroperoxides in blood and endometrial tissue of patients with benign, hyperplastic and malignant endometrium. Anais da Academia Brasileira de Ciências, 80(3), 515-522. https://doi.org/10.1590/S0001-37652008000300011
  • Todorović, A., Pejić, S., Gavrilović, L., Pavlović, I., Stojiljković, V., Popović, N. and Pajović, S. B. (2019). Expression of antioxidant enzymes in patients with uterine polyp, myoma, hyperplasia, and adenocarcinoma. Antioxidants, 8(4), 97. https://doi.org/10.3390/antiox8040097
  • Turell, L., Radi, R. and Alvarez, B. (2013). The thiol pool in human plasma: the central contribution of albumin to redox processes. Free Radical Biology and Medicine, 65, 244-253. https://doi.org/10.1016/j.freeradbiomed.2013.05.050

Anormal uterin kanamalı kadınlarda endometrial hiperplazi ve thiol disülfat homeostazis ilişkisi

Year 2022, Volume: 7 Issue: 2, 340 - 351, 01.08.2022

Sezin Ertürk Aksakal Elif Gülşah Diktaş Ramazan Erda Pay Ömer Lütfi Tapısız Burcu Timur Vakkas Korkmaz Özcan Erel Yaprak Üstün

https://doi.org/10.25279/sak.1101029

Abstract

Giriş: Endometrial hiperplazi gelişimde oksidatif stres ve antioksidan kapasitenin rolü tartışmalıdır.
Giriş: Endometrial hiperplazi gelişimde oksidatif stres ve antioksidan kapasitenin rolü tartışmalıdır. Amaç: Çalışma, Basit atipisiz endometrial hiperplazili hastalarda thiol-disulfat homeostazis ve iskemi-modifiye albumin (IMA) seviyelerini değerlendirmeyi amaçlamıştır. Gereç ve Yöntemler: Prospektif vaka kontrol dizaynlı çalışmada, atipisiz endometrial hiperplazili (HP grup) (n=28) hastalar, nonhiperplazi (proliferatif/sekretuar/düzensiz proliferatif/düzensiz sekretuar endometrium) saptanan hastalar (non-HP grup) (n=28) ve 28 sağlıklı kadın (kontrol grubu) çalışmaya dahil edildi. Hastaların klinik özellikleri, Thiol-disulfat parametreleri ve IMA seviyeleri gruplar arasında karşılaştırıldı. Bulgular: Çalışmaya toplam 84 hasta dahil edildi. Hastaların ortalama yaş, BMI, mean native thiol (-SH-), total thiol (-SH-+-SS-), disulfide (-SS-) ve IMA seviyeleri 3 grup arasında benzerdi. -SS-/-SH- ve -SS-/-SH-+-SS oranı HP grubunda non-HP grubundan anlamlı yüksekti. -SS-/-SH-+-SS- oranı HP grubunda diğer iki gruptan anlamlı yüksekti. -SH-/-SH-+-SS- oranı Hp grubunda non-HP grubuna göre anlamlı düşüktü. Endometrial kalınlık (ET), HP grubunda, non-HP ve kontrol grubuna göre daha kalındı. ET non-HP grubunda, kontrol grubundan anlamlı kalındı. -SS-/-SH- oranı %64 sensitivite, %68 spesifite ile endometrial hiperplaziyi öngörmektedir. Sonuç ve Öneriler: Endometrial hiperplazili kadınlarda Dinamik thiol-disülfat dengesi disülfat tarafına kaymıştır.

Keywords

Thiol-Disülfat homeostazis Oksidatif stres Atipisiz endometrial hiperplazi İskemi-modifiye albumin

References

  • Alcázar, J. L., Bonilla, L., Marucco, J., Padilla, A. I., Chacón, E., Manzour, N. et al. (2018). Risk of endometrial cancer and endometrial hyperplasia with atypia in asymptomatic postmenopausal women with endometrial thickness≥ 11 mm: A systematic review and meta‐analysis. Journal of Clinical Ultrasound, 46(9), 565-570. https://doi.org/10.1002/jcu.22631.
  • Arioz, D. T., Camuzcuoglu, H., Toy, H., Kurt, S., Celik, H. and Erel, O. (2009). Assessment of serum paraoxonase and arylesterase activity in patients with endometrial cancer. European Journal of Gynaecologic Oncology, 30(6), 679-682.
  • Baba, S. P. and Bhatnagar, A. (2018). Role of thiols in oxidative stress. Current Opinion in Toxicology, 7, 133-139. https://doi.org/10.1016/j.cotox.2018.03.005
  • Bar-Or, D., Rael, L.T., Bar-Or, R., Slone, D.S., Mains, C.W., Rao, N.K.R. and Curtis, C.G. (2008). The cobalt–albumin binding assay: insights into its mode of action. Clinica Chimica Acta, 387(1-2), 120-127. https://doi.org/10.1016/j.cca.2007.09.018.
  • Cremers, C. M. and Jakob, U. (2013). Oxidant sensing by reversible disulfide bond formation. Journal of Bioogical Chemistry, 288(37), 26489-26496. https://doi.org/10.1074/jbc.R113. 462929.
  • Emons, G., Beckmann, M. W., Schmidt, D. and Mallmann, P. (2015). Uterus commission of the Gynecological Oncology Working Group (A. G. O). New WHO Classification of Endometrial Hyperplasias. Geburtshilfe Frauenheilkd, 75(2), 135-136. https://doi.org/10.1055/s-0034-1396256.6), 563-570.
  • Erel, O. and Neselioglu, S. (2014). A novel and automated assay for thiol/disulphide homeostasis. Clinical Biochemistry, 47(18), 326–332. https://doi.org/10.1016/j.clinbiochem.2014.09.026.
  • Eroglu, S., Haskul, İ., Aziz, V., Yurtcu, E., Karatas, F., Neselioglu, S. and Erel, O. (2017). Dynamic thiol/disulphide homeostasis in patients with Uterine Myoma. European Journal of Obstetrics & Gynecology and Reproductive Biology, 216, 24-26. https://doi.org/10.1016/j.ejogrb.2017. 06.045.
  • Eryilmaz, M. A., Kozanhan, B., Solak, I., Çetinkaya, Ç. D., Neselioglu, S. and Erel, Ö. (2019). Thiol-disulfide homeostasis in breast cancer patients. Journal of Cancer Research and Therapeutics, 15(5), 1062. https://doi.org/10.4103/jcrt.JCRT_553_17.
  • Getpook, C. and Wattanakumtornkul, S. (2006). Endometrial thickness screening in premenopausal women with abnormal uterine bleeding. Journal of Obstetrics and Gynaecology Research, 32(6), 588-592. https://doi.org/10.1111/j.1447-0756.2006.00455.x.
  • Giannella, L., Mfuta, K., Setti, T., Boselli, F., Bergamini, E. and Cerami, L. B. (2014). Diagnostic accuracy of endometrial thickness for the detection of intra-uterine pathologies and appropriateness of performed hysteroscopies among asymptomatic postmenopausal women. European Journal of Obstetrics & Gynecology and Reproductive Biology, 177, 29-33. https://doi.org/10.1016/j.ejogrb.2014.03.025.
  • Giannella, L., Cerami, L. B., Setti, T., Bergamini, E. and Boselli, F. (2019). Prediction of endometrial hyperplasia and cancer among premenopausal women with abnormal uterine bleeding. BioMed research international, 8598152. https://doi.org/10.1155/2019/8598152.
  • Gómez-Zubeldia, M. A., Bazo, A. P., Gabarre, J. J. A., Nogales, A. G. and Palomino, J. C. M. (2008). Oxidative stress in endometrial hyperplasia. Menopause, 15(2), 363-368. https://doi.org/ 10.1097/gme.0b013e318093e646
  • Goncharenko, V. M., Beniuk, V. A., Kalenska, O. V., Demchenko, O. M., Spivak M. Y. and Bubnov, R.V. (2013). Predictive diagnosis of endometrial hyperplasia and personalized therapeutic strategy in women of fertile age. EPMA Journal, 4(1), 1-20. https://doi.org/10.1186/1878-5085-4-24,
  • Henderson, B. E. and Feigelson, H. S. (2000). Hormonal carcinogenesis. Carci¬nogenesis, 21, 427-433. Jones, D. P. and Liang, Y. (2009). Measuring the poise of thiol/disulfide couples in vivo. Free Radical Biology and Medicine, 47(10), 1329-1338. https://doi.org/10.1016/j.freeradbiomed.2009. 08.021
  • Kubyshkin, A. V., Aliev, L. L., Fomochkina, I. I., Kovalenko, Y. P., Litvinova, S. V., Filonenko, T. G. et al. (2016). Endometrial hyperplasia-related inflammation: its role in the development and progression of endometrial hyperplasia. Inflammation Research, 65(10), 785-794. https://doi.org/10.1007/s00011-016-0960-z,
  • Lecanda, J., Parekh, T.V., Gama, P, Lin, K., Liarski, V., Uretsky, S., Mittal, K. and Gold, L. I. (2007). Transforming growth factor-b, estrogen, and progesterone converge on the regulation of p27Kip1 in the normal and malignant endometrium. Cancer Reserach. 67(3), 1007-1018. https://doi.org/10.1158/0008-5472.CAN-06-0235
  • Louie, M., Canavan, T. P. and Mansuria, S. (2016). Threshold for endometrial sampling among postmenopausal patients without vaginal bleeding. International Journal of Gynecology & Obstetrics, 132(3), 314-317. https://doi.org/10.1016/j.ijgo.2015.07.023
  • Matsuo, K., Ramzan, A. A., Gualtieri, M. R., Mhawech-Fauceglia, P., Machida, H., Moeini, A. et al. (2015). Prediction of concurrent endometrial carcinoma in women with endometrial hyperplasia. Gynecologic Oncology, 139(2), 261-267. https://doi.org/10.1016/j.ygyno.2015. 07.108
  • No, G. T. G. (2016). Management of Endometrial Hyperplasia. RCOG BSGE Joint Guideline, 67, 30. Ozaksit, G., Tokmak, A., Kosem, A., Kuru-Pekcan, M. and Ozcan, E. (2019). Could there be any role of thiol-disulfide homeostasis and ischemia-modified albumin in the pathogenesis of endometrial polyps?. Journal of Experimental Therapeutics & Oncology, 13(2), 125-129.
  • Özdemir, S., Çelik, Ç., Gezginç, K., Kıreşi, D. and Esen, H. (2010). Evaluation of endometrial thickness with transvaginal ultrasonography and histopathology in premenopausal women with abnormal vaginal bleeding. Archives of Gynecology and Obstetrics, 282(4), 395-399. https://doi.org/10.1007/s00404-009-1290-y
  • Özkaya, E., Korkmaz, V., Özkaya, Y., Tosun, A., Küçükozkan, T. and Bostan, H. (2013). Ultrasonographic endometrial thickness measurement is predictive for treatment response in simple endometrial hyperplasia without atypia. Journal of the Turkish German Gynecological Association, 14(1), 19. https://doi.org/10.5152/jtgga.2013.05
  • Pejić, S., Todorović, A., Stojiljković, V., Kasapović, J. and Pajović, S. B. (2009). Antioxidant enzymes and lipid peroxidation in endometrium of patients with polyps, myoma, hyperplasia and adenocarcinoma. Reproductive Biology and Endocrinology, 7(1), 1-9. https://doi.org/10.1186/1477-7827-7-149
  • Pejić, S., Todorović, A., Stojiljković, V., Pavlović, I., Gavrilović, L., Popović, N. and Pajović, S. B. (2016). Antioxidant status and sex hormones in women with complex endometrial hyperplasia. Cellular and Molecular Biology, 62(11), 51-56. https://doi.org/10.14715/cmb/ 2016.62.11.9
  • Rizk, B., Badr, M. and Talerico, C. (2013). Oxidative stress and the endometrium. In studies on women's health. Humana Press, Totowa, 1, 61-74. https://doi.org/10.1007/978-1-62703-041-0_3
  • Saatli, B., Yildirim, N., Olgan, S., Koyuncuoglu, M., Emekci, O. and Saygılı, U. (2014). The role of endometrial thickness for detecting endometrial pathologies in asymptomatic postmenopausal women. Australian and New Zealand Journal of Obstetrics and Gynaecology, 54(1), 36-40. https://doi.org/10.1111/ajo.12174
  • Sezgin, B., Kinci, M.F., Pirinççi, F., Camzuoglu, A., Erel, O., Neselioglu, S. and Camzuoglu, H. (2020). Thiol‐disulfide status of patients with cervical cancer. Journal of Obstetrics and Gynaecology Research, 46, 2423-2429. https://doi.org/10.1111/jog.14480
  • Sherman, M. E. (2000). Theories of endometrial carcinogenesis: a multidisciplinary approach. Modern Pathology, 13(3), 295-308. https://doi.org/10.1038/modpathol.3880051
  • Sugino, N., Shimamura, K., Takiguchi, S., Tamura, H., Nakata, M., Nakamura, Y., Ogino, K., Uda, T. and Kato, H. (1996). Changes in activity of superoxide dismutase in the human endometrium throughout the menstrual cycle and early pregnancy. Human Reproduction, 11(5), 1073–1078. https://doi.org/10.1093/oxfordjournals.humrep.a019299
  • Sugino, N., Nakata, M., Kashida, S., Karube, A., Takiguchi, S. and Kato, H. (2000). Decreased superoxide dismutase expression and increased concentrations of lipid peroxide and prostaglandin F2-a in the decidua of failed pregnancy. Molecular Human Reproduction, 6(7), 642–647. https://doi.org/10.1093/molehr/6.7.642
  • Sugino, N., Karube-Harada, A., Kashida, S., Takiguchi, S. and Kato, H. (2001). Reactive oxygen species stimulate prostaglandin F2a production in human endometrial stromal cells in vitro. Human reproduction, 16(9), 1797-1801. https://doi.org/10.1093/humrep/16.9.1797,
  • Todorović, A., Stojiljković, V., Cvetković, D., Lučić, N., Radojičić, R. M. and Saičić, Z. S. (2008). Superoxide dismutase and lipid hydroperoxides in blood and endometrial tissue of patients with benign, hyperplastic and malignant endometrium. Anais da Academia Brasileira de Ciências, 80(3), 515-522. https://doi.org/10.1590/S0001-37652008000300011
  • Todorović, A., Pejić, S., Gavrilović, L., Pavlović, I., Stojiljković, V., Popović, N. and Pajović, S. B. (2019). Expression of antioxidant enzymes in patients with uterine polyp, myoma, hyperplasia, and adenocarcinoma. Antioxidants, 8(4), 97. https://doi.org/10.3390/antiox8040097
  • Turell, L., Radi, R. and Alvarez, B. (2013). The thiol pool in human plasma: the central contribution of albumin to redox processes. Free Radical Biology and Medicine, 65, 244-253. https://doi.org/10.1016/j.freeradbiomed.2013.05.050
There are 34 citations in total.

Details

Primary Language English
Subjects Obstetrics and Gynaecology
Journal Section Original research articles
Authors

Sezin Ertürk Aksakal 0000-0002-4418-7319

Elif Gülşah Diktaş This is me 0000-0002-2869-6914

Ramazan Erda Pay 0000-0001-7183-4246

Ömer Lütfi Tapısız 0000-0002-7128-8086

Burcu Timur 0000-0001-8769-5949

Vakkas Korkmaz 0000-0001-8895-6864

Özcan Erel 0000-0002-2996-3236

Yaprak Üstün 0000-0002-1011-3848

Early Pub Date August 30, 2022
Publication Date August 1, 2022
Submission Date April 9, 2022
Acceptance Date April 21, 2022
Published in Issue Year 2022 Volume: 7 Issue: 2

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APA Ertürk Aksakal, S., Diktaş, E. G., Pay, R. E., Tapısız, Ö. L., et al. (2022). The relationship between Thiol/disulfide homeostasis and endometrial hyperplasia in patients with abnormal uterine bleeding/. Sağlık Akademisi Kastamonu, 7(2), 340-351. https://doi.org/10.25279/sak.1101029
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Health Academy Kastamonu is included in the class of 1-b journals (journals scanned in international indexes other than SCI, SSCI, SCI-expanded, ESCI) according to UAK associate professorship criteria. HEALTH ACADEMY KASTAMONU Journal cover is registered by the Turkish Patent Institute.