Research Article
Respiratuar Distres Sendromlu Bronkopulmoner Displazi Gelişen Hastalarımızda Klinik ve Demografik Bulgularımız ve Literatürün Gözden Geçirilmesi
Abstract
Amaç: Bu
çalışmanın amacı ünitemizde RDS tanısı ile takip ve tedavi ettiğimiz preterm
bebeklerdeki BPD görülme oranı, bu bebeklerin klinik ve demografik verileri ve
risk faktörleri paylaşılarak gelişen yenidoğan yoğun bakım tekniklerine rağmen
hastalığın süreçten nasıl etkilendiğinin belirlemesidir.
Gereç ve Yöntemler: Meram
Tıp Fakültesi Yenidoğan Yoğun Bakım Ünitesi'nde 2017 Ocak ile 2018 Mart ayları
arasında, prematürelik nedeniyle yatırılarak RDS tanısı ile sürfaktan verilen
ve izlemlerinde BPD tanısı alarak, tedavi verdiğimiz 10 olgunun dosyalarından
verileri kaydedildi.
Bulgular: Ocak
2017- Mart 2018 arasında 10 (%13,3) hasta BPD tanısı aldı. Ortalama doğum
haftası 26,5 ±1,64 (25-29), ortalama doğum
kilosu 821,8 ± 236,9 gr (1378-490) idi.
Olguların 7 (%70) tanesi 28 haftanın altında ve 9 (%90) tanesi 1000 gr’ın
altında idi. Olguların 8 (%80) tanesi erkek, 2 (%20) tanesi kızdı. Olgular
ortalama 19,35± 19,52 (1,5-41) gün invaziv, 25,6± 11,76 (4-43) gün non-invaziv
mekanik ventilasyon ile solunum desteği aldı. Serbest oksijen ihtiyaçları eve
oksijen ile taburcu olan ağır BPD’li 1 hasta hariç ortalama 39,5±17,19 (69-14) gün sürdü.
Sonuç: Sonuç olarak yenidoğan bakım uygulamalarındaki tüm gelişmelere
rağmen BPD ciddi bir sorun olmaya devam etmektedir. Çalışmamızda da
prematürite, düşük doğum ağırlığı, invaziv mekanik ventilasyon uygulama süresi,
yoğun ve uzun süreli oksijen desteği BPD’nin zemin hazırlayan risk faktörleri
olarak öne çıkmaktadır.
Keywords
References
- 1. Northway WH Jr, Rosan RC, Porter DY. Pulmonary disease following respirator therapy of hyaline-membrane disease.2. Bronchopulmonary dysplasia. Engl J Med 1967; 276: 357-68.Jobe AH, Bancalari E. Bronchopulmonary dysplasia. Am J Respir Crit Care Med 2001; 163:1723.3. Fanaroff AA, Stoll BJ, Wright LL et al. Trends in neonatal morbidity and mortality for very low birth weight infants. Am J Obstet Gynecol 2007;196:1-8.4. Jensen EA, Schmidt B. Epidemiology of bronchopulmonary dysplasia. Birth Defects Res A Clin Mol Teratol 2014; 100:145.5. Birenbaum HJ, Dentry A, Cirelli J, Helou S, Pane MA, Star K, Melick CF, Updegraff L, Arnold C, Tamayo A, Torres V, Gungon N, Liverman S (2009) Reduction in the incidence of chronic lung disease in very low birth weight infants: results of a quality improvement process in a tertiary level neonatal intensive care unit. Pediatrics 123(1):44–506. Özkan H, Köksal N, Ç etinkaya M et al. Risk factors for broncho-pulmonary dysplasia. Güncel Pediatri 2008;6:66-717. Zeitlin J, Draper ES, Kollee I et al. Differences in rates and short term outcome of the births before 32 weeks of gestation in Europe in 2003: results from the MOSAIC cohort. Pediatrics 2008;121:936-44.8. Payne NR, LaCorte M, Karna P, Chen S, Finkelstein M, Goldsmith JP, Carpenter JH; Breathsavers Group, Vermont Oxford Network Neonatal Intensive Care Quality Improvement Collaborative. Reduction of bronchopulmonary dysplasia after participation in the Breathsavers Group of the Vermont Oxford Network Neonatal Intensive Care Quality Improvement Collaborative. Pediatrics. 2006 Nov;118 Suppl 2:S73-79. Bhandari V, Bizzarro MJ, Shetty A, Zhong X, Page GP, Zhang H, Ment LR, Gruen JR Familial and genetic susceptibility to major neonatal morbidities in preterm twins. Pediatrics 2006;117(6):1901–190610. Chorioamnionitis alters the response to surfactant in preterm infants Been JV, Rours IG, Kornelisse RF, Jonkers F, de Krijger RR, Zimmermann L J Pediatr. 2010;156(1):10.11. Hartling L, Liang Y, Lacaze-Masmonteil T. Chorioamnionitis as a risk factor for bronchopulmonary dysplasia: a systematic review and meta-analysis. Arch Dis Child Fetal Neonatal Ed. 2012 Jan;97(1):F8-F17.12. Coalson JJ. Pathology of new bronchopulmonary dysplasia. Semin Neonatol. 2003;8(1):73–81.13. Klingenberg C, Wheeler K, McCallion N, Morley CJ, Davis PG. Volume-targeted versus pressure-limited ventilation in the neonate. Cochrane Database of Systematic Reviews 201714. Jobe AH, Bancalari E. Bronchopulmonary Dysplasia. Am J Respir Crit Care Med 2001;163:1723-915. Askie LM, Darlow BA, Davis PG et al. Effects of targeting lower versus higher arterial oxygen saturations on death or disability in preterm infants. Cochrane Database of Systematic Reviews 2017, CD011190. 16. Gursoy T, Hayran M, Derin H, Ovali F. A clinical scoring system to predict the development of bronchopulmonary dysplasia. Am J Perinatol. 2015 Jun;32(7):659-66.17. Slaughter J, Reagan PB, Newman TB, Klebanof MA. Comparative Effectiveness of Nonsteroidal Anti-inflammatory Drug Treatment vs No Treatment for Patent Ductus Arteriosus in Preterm Infants. JAMA Pediatr 2017; 171: e16435418. Cunningham CK, McMillan JA, Gross SJ. Rehospitalization for respiratory illness in infants of less than 32 weeks' gestation. Pediatrics. 1991 Sep;88(3):527-32.
Year 2018,
Volume: 8 Issue: 2, 388 - 394, 29.06.2018
Abstract
References
- 1. Northway WH Jr, Rosan RC, Porter DY. Pulmonary disease following respirator therapy of hyaline-membrane disease.2. Bronchopulmonary dysplasia. Engl J Med 1967; 276: 357-68.Jobe AH, Bancalari E. Bronchopulmonary dysplasia. Am J Respir Crit Care Med 2001; 163:1723.3. Fanaroff AA, Stoll BJ, Wright LL et al. Trends in neonatal morbidity and mortality for very low birth weight infants. Am J Obstet Gynecol 2007;196:1-8.4. Jensen EA, Schmidt B. Epidemiology of bronchopulmonary dysplasia. Birth Defects Res A Clin Mol Teratol 2014; 100:145.5. Birenbaum HJ, Dentry A, Cirelli J, Helou S, Pane MA, Star K, Melick CF, Updegraff L, Arnold C, Tamayo A, Torres V, Gungon N, Liverman S (2009) Reduction in the incidence of chronic lung disease in very low birth weight infants: results of a quality improvement process in a tertiary level neonatal intensive care unit. Pediatrics 123(1):44–506. Özkan H, Köksal N, Ç etinkaya M et al. Risk factors for broncho-pulmonary dysplasia. Güncel Pediatri 2008;6:66-717. Zeitlin J, Draper ES, Kollee I et al. Differences in rates and short term outcome of the births before 32 weeks of gestation in Europe in 2003: results from the MOSAIC cohort. Pediatrics 2008;121:936-44.8. Payne NR, LaCorte M, Karna P, Chen S, Finkelstein M, Goldsmith JP, Carpenter JH; Breathsavers Group, Vermont Oxford Network Neonatal Intensive Care Quality Improvement Collaborative. Reduction of bronchopulmonary dysplasia after participation in the Breathsavers Group of the Vermont Oxford Network Neonatal Intensive Care Quality Improvement Collaborative. Pediatrics. 2006 Nov;118 Suppl 2:S73-79. Bhandari V, Bizzarro MJ, Shetty A, Zhong X, Page GP, Zhang H, Ment LR, Gruen JR Familial and genetic susceptibility to major neonatal morbidities in preterm twins. Pediatrics 2006;117(6):1901–190610. Chorioamnionitis alters the response to surfactant in preterm infants Been JV, Rours IG, Kornelisse RF, Jonkers F, de Krijger RR, Zimmermann L J Pediatr. 2010;156(1):10.11. Hartling L, Liang Y, Lacaze-Masmonteil T. Chorioamnionitis as a risk factor for bronchopulmonary dysplasia: a systematic review and meta-analysis. Arch Dis Child Fetal Neonatal Ed. 2012 Jan;97(1):F8-F17.12. Coalson JJ. Pathology of new bronchopulmonary dysplasia. Semin Neonatol. 2003;8(1):73–81.13. Klingenberg C, Wheeler K, McCallion N, Morley CJ, Davis PG. Volume-targeted versus pressure-limited ventilation in the neonate. Cochrane Database of Systematic Reviews 201714. Jobe AH, Bancalari E. Bronchopulmonary Dysplasia. Am J Respir Crit Care Med 2001;163:1723-915. Askie LM, Darlow BA, Davis PG et al. Effects of targeting lower versus higher arterial oxygen saturations on death or disability in preterm infants. Cochrane Database of Systematic Reviews 2017, CD011190. 16. Gursoy T, Hayran M, Derin H, Ovali F. A clinical scoring system to predict the development of bronchopulmonary dysplasia. Am J Perinatol. 2015 Jun;32(7):659-66.17. Slaughter J, Reagan PB, Newman TB, Klebanof MA. Comparative Effectiveness of Nonsteroidal Anti-inflammatory Drug Treatment vs No Treatment for Patent Ductus Arteriosus in Preterm Infants. JAMA Pediatr 2017; 171: e16435418. Cunningham CK, McMillan JA, Gross SJ. Rehospitalization for respiratory illness in infants of less than 32 weeks' gestation. Pediatrics. 1991 Sep;88(3):527-32.
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Details
| Primary Language | Turkish |
|---|---|
| Subjects | Health Care Administration |
| Journal Section | Articles |
| Authors | |
| Publication Date | June 29, 2018 |
| Submission Date | April 24, 2018 |
| Published in Issue | Year 2018 Volume: 8 Issue: 2 |
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