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Gastrointestinal Stromal Tümörlerin Demografik, Histopatolojik, ve İmmünohistokimyasal Karakteristik Bulguları: Tek Merkez Çalışması

Year 2020, Volume: 10 Issue: 3, 381 - 389, 15.09.2020
https://doi.org/10.31832/smj.740190

Abstract

Amaç: Gastrointestinal
stromal tümör (GİST), gastrointestinal sistemin en sık görülen mezenkimal
tümörüdür, interstisyel Cajal hücresinden kaynaklanır veya farklılaşır. Bu
çalışmanın amacı GIST tanılı olguların demografik, histopatolojik ve
immünohistokimyasal özelliklerini literatür ışığında gözden geçirmektir.



Gereç ve Yöntemler:
Çalışmayaxxxxxx Şehir hastanesi patoloji kliniğinde, 2010-2018 yılları arasında
tanı konulan 45 GİST olgusu dahil edildi. Olgular retrospektif olarak
hematoksilen-eozin kesitleri ve immünohistokimyasal boyamaları ile yeniden
değerlendirildi.



Bulgular: Olguların 21'i (%46,66) kadın, 24'ü
(%53,33) erkekti. Yaş ortalaması 64.9 idi. Çalışmaya dahil edilen olguların
4/45'i(%8,88) çok düşük, 20/45'i (%44,44) düşük, 8/45'i (%17,77) orta
derecedeydi ve 13 / 45 olgu (%28.88) yüksek risk grubundaydı.



Sonuç:
GİST'lerde doğru tanı, sınıflandırma, prognoz ve tedavi için histopatoloji ve
immünhistokimyasal çalışmalar önemlidir. Merkezler, rapor formatlarını
uluslararası kabul görmüş rapor örneklerine ve fikir birliği kriterlerine göre
hazırlamalı ve özel makroskobik ve mikroskobik bulgular ile immünohistokimyasal
inceleme sonuçları raporun sonunda liste halinde verilmelidir.

Supporting Institution

Kayseri Şehir Hastanesi

References

  • 1- Miettinen M and Lasota J. Gastrointestinal stromal tumors-definition, clinical, histological, immunohistochemical, and molecular genetic features and differential diagnosis. Virchows Arch 2001;438:1-12.
  • 2- Miettinen M, Sobin LH, Sarloma-Rikala M. Immunohistochemical spectrum of GISTs at different sites and their differential diagnosis with a reference to CD117(KIT). Mod Pathol 2000;13(10):1134-42.
  • 3- Hirota S and Isozaki K. Pathology of gastrointestinal stromal tumors. PatholInt 2006;56:1-9.
  • 4- Park S, Kim M, Kim H, Song BJ, Chi JG. Ultrastructural Studies of Gastrointestinal Stromal tumors. J Korean Med Sci 2004;19:234-44.
  • 5- Christopher DM Fletcher,Jules J Berman,J, Christopher Corless,Fred Gorstein,Jerzy Lasot et al. Diagnosis of Gastrointestinal Stromal Tumors: A Consensus Approach. Hum Pathol 2002 May; 33(5):459-65.
  • 6- Duffaud F, Blay JY. Gastrointestinal Stromal Tumors: Biology and Treatment. Oncology 2003;65:187-197.
  • 7- Miettinen M, Lasota J. Gastrointestinal Stromal Tumors: Review on Morphology, Molecular Pathology, Prognosis, and Differential Diagnosis. Arch Pathol Lab Med 2006;130:1466-1478.
  • 8- Miettinen M, Monihan JM, SarlomoRikala-M. Gastrointestinal stromal tumors/smooth muscle tumors (GISTs) primary in the omentum and mesentery: clinicopathologic and immunohistochemical study of 26 cases. Am J SurgPathol 1999;23(9):1109-1118.
  • 9- Romeo Giuli. Gastrointestinal stromal tumors. Surgical Oncology 2001; 52: 1591-1063.
  • 10- Dei Tos AP. The reappraisal of gastrointestinal stromal tumors: from Stout to the KIT revolution. Virchows Arch 2003;442:421-429.
  • 11- Miettinen M, Lasota J. Gastrointestinal stromal tumors (GISTs): definition, occurrence, pathology, differential diagnosis and molecular genetics. Pol J Pathol 2003;54(1):3-24.
  • 12- Miettinen M, Majidi M, Lasota J. Pathology and diagnostic criteria of gastrointestinal stromal tumors (GISTs): a review. Eur J Cancer 2002;38:39-51.
  • 13- Kisluk J, Zinczuk J, KemonaA,Ustymowicz K,et al. Expression of CD117,DOG1, and IGF-1R in gastrointestinal stromalstumours-an analysis 0f 70 cases from 2004-2010. Gastroenterology Review 2016;11(2):115-122.
  • 14- Saurabh S. Gastrointestinal stromal tumor: an incidental finding during laporoscopic bariatric surgery.ClinicalCaseReports2017;5(11):1905-1906. doi: 10.1002/ccr3.1194
  • 15- Sarlomo-Rikala M, Kovatich A, Barusevicius A, Miettinen M. CD117: a sensitive marker for gastrointestinal stromal tumors that is more specific than CD34. Mod Pathol 1998;11(8):728-734.
  • 16- Hirota S, Isozaki K, Moriyama Y, et al. Gain-of-Function Mutations of c-kit in Human Gastrointestinal Stromal Tumors. Science 1998;279:577-580
  • 17- SaurabhS.Gastrointestinal Stromal Tumor:an incidental finding during laporoscopic bariatric surgery. Clinic Case Report 2017;5(11):1905-1906.
  • 18- Blay JY, Bonvalot S, Casali P, et al. Consensus meeting for the management of gastrointestinal stromal tumors. Report of the GIST Consensus Conference of 20-21 March 2004, under the auspices of ESMO. Annals of Oncology 2005;16:566-578.
  • 19- Sircar K, Hewlett BR, Huizinga JD, Chorneyko K, Berezin I, Riddel RH. Interstitial cells of Cajal as precursors of gastrointestinal stromal tumors. Am J SurgPathol 1999;23:377-389.
  • 20- Strickland L, Letson GD and Muro-Cacho CA. Gastrointestinal Stromal Tumors. Cancer Control 2001;8(3):252-261.
  • 21- Viscido G, Signorini F, Navarro L, Campazzo P, Saleg V, Gorodner V et al. Incidental finding of gastrointestinal stromal tumors during laporoskopic sleeve gastrectomy in obese patients. Obes. Surg. 2017;27(8):2022-2025.
  • 22- Kim KM, Kang DW, Moon WS, et al. Gastrointestinal Stromal Tumors in Koreans: İncidence and the clinical, Pathologic and Immunohistochemical Findings. J Korean Med Sc 2005;20:977-984.
  • 23- Miettinen M, Furlong M, Sarloma-Rikala M, Burke A, Sobin LH, Lasota J. Gastrointestinal stromal tumors, intramural leiomyomas, and leiomyosarcomas in the rectum and anus: a clinicopathologic, immunohistochemical, and molecular genetic study of 144 ceses. Am J SurgPathol 2001; 25(9):1121-1133.
  • 24- Miettinen M, Furlong M, Sarloma-Rikala M, Burke A, Sobin LH, Lasota J. Gastrointestinal stromal tumors, intramural leiomyomas, and leiomyosarcomas in the rectum and anus: a clinicopathologic, immunohistochemical, and molecular genetic study of 144 ceses. Am J SurgPathol 2001; 25(9):1121-1133.
  • 25- Fletcher CD, Berman JJ, Corless C, et al. Diagnosis of Gastrointestinal Stromal Tumors: A Consensus Approach. Hum Pathol 2002;33(5):459-65.
  • 26- Loong HFH. Gastro-intestinal stromal tumours: a review of current management options. Hong Kong Med J 2007;13 (1):61-65.
  • 27- Tasdemir A, Soyuer I, Unal D, Artış T. Prognostic Value of NFkB,CD9,VEGF in gastrointestinal stromal tumors. CotempOncol(Pozn) 2013;17(6):493-8.
  • 28- Swalchick W, Shameckh R, Bui MM. Is DOG1 ImmunoreactivitySpesific to Gastrointestinal Stromal Tumor. Cancer Control 2015;22(4):498-504.
  • 29- Miettinen M, Virolainen M, Sarloma-Rikala M. Gastrointestinal stromal tumors-value of CD34 antigen in their identification and seperation from true leimyomas and schwannomas. Am J SurgPathol 1995;19(2):207-16.
  • 30- Carrillo R, Candia A, Rodrigez-Peralto H, Caz V. Prognostic significance of DNA ploidy and poliferaktive index (MIB-1 index) in gastrointestinal stromal tumors. Hum Pathol 1997;28:160-165.
  • 31- Zhaou Y, HuW,Chen P et al. Ki67 is a biological marker of malignant risk of gastrointestinal stromal tumors:A systematic review and meta-analysis. Medicine(Baltimore) 2017;96(34):e7911.
  • 32. Hinescu M, Ardeleanu C, Gherghiceanu M, Popescu LM. İnterstitial Cajal-like cells in human gallbladder. J MolHist 2007;38(4):275-284.
  • 33. Miettinen M, El-Rıfaı W, Sobin LH and Lasota J. Evaluation of Malignancy and Prognosis of Gastrointestinal Stromal Tumors: A Review. Hum Pathol 2002;33(5):478-483. 34.Eric CH. Lai, Stephanie H.Y.Lau, Wan Yee Lau. Current management of gastrointestinal stromal tumors-A comprehensive rewiew. International Journal of Surgery 2012;10:334-40.
  • 35.Connolly EM, Gaffney E, Reynolds JV. Gastrointestinal stromal tumours. Br J Surg 2003;90:1178-1186.

Demographic, Histopathological and Immunohistochemical Characteristic Findings of Gastrointestinal Stromal Tumors: A Single-Centered Study

Year 2020, Volume: 10 Issue: 3, 381 - 389, 15.09.2020
https://doi.org/10.31832/smj.740190

Abstract

Objective:
Gastrointestinal stromal tumor (GIST) is the most frequent mesenchymal tumor of
the gastrointestinal tract, arises from or is differentiated towards
interstitial cell of Cajal. The aim of this study is to review the demographic,
histopathological and immunohistochemical characteristics of cases diagnosed
with GIST in the light of the literature.



Material and Methods: 

Forty-five GIST cases diagnosed between 2010 and 2018 in xxxxxx
City Hospital's pathology clinic were included in the study.
The
cases were reevaluated retrospectively by hematoxylin-eosin sections and
immunohistochemical staining.



Results: Twenty-one of the cases (46.66%) were
female, and 24 (53.33%) were male. The average age was 64.9 years. 4/45 (8.88%)
of the cases included in the study were in the very low risk, 20/45 (44.44%)
were in the low risk, 8/45 (17.77%) were in the intermediate risk, and 13/45
cases (28.88%) were in the high-risk group.



Conclusion:
Histopathology and immunohistochemical studies are important for the accurate
diagnosis, classification, prognosis, and treatment in GISTs. The centers
should prepare their report formats according to internationally accepted
report samples and consensus criteria, and significant macroscopic and
microscopic findings and immunohistochemical examination results should be
given as a list at the end of the report.

References

  • 1- Miettinen M and Lasota J. Gastrointestinal stromal tumors-definition, clinical, histological, immunohistochemical, and molecular genetic features and differential diagnosis. Virchows Arch 2001;438:1-12.
  • 2- Miettinen M, Sobin LH, Sarloma-Rikala M. Immunohistochemical spectrum of GISTs at different sites and their differential diagnosis with a reference to CD117(KIT). Mod Pathol 2000;13(10):1134-42.
  • 3- Hirota S and Isozaki K. Pathology of gastrointestinal stromal tumors. PatholInt 2006;56:1-9.
  • 4- Park S, Kim M, Kim H, Song BJ, Chi JG. Ultrastructural Studies of Gastrointestinal Stromal tumors. J Korean Med Sci 2004;19:234-44.
  • 5- Christopher DM Fletcher,Jules J Berman,J, Christopher Corless,Fred Gorstein,Jerzy Lasot et al. Diagnosis of Gastrointestinal Stromal Tumors: A Consensus Approach. Hum Pathol 2002 May; 33(5):459-65.
  • 6- Duffaud F, Blay JY. Gastrointestinal Stromal Tumors: Biology and Treatment. Oncology 2003;65:187-197.
  • 7- Miettinen M, Lasota J. Gastrointestinal Stromal Tumors: Review on Morphology, Molecular Pathology, Prognosis, and Differential Diagnosis. Arch Pathol Lab Med 2006;130:1466-1478.
  • 8- Miettinen M, Monihan JM, SarlomoRikala-M. Gastrointestinal stromal tumors/smooth muscle tumors (GISTs) primary in the omentum and mesentery: clinicopathologic and immunohistochemical study of 26 cases. Am J SurgPathol 1999;23(9):1109-1118.
  • 9- Romeo Giuli. Gastrointestinal stromal tumors. Surgical Oncology 2001; 52: 1591-1063.
  • 10- Dei Tos AP. The reappraisal of gastrointestinal stromal tumors: from Stout to the KIT revolution. Virchows Arch 2003;442:421-429.
  • 11- Miettinen M, Lasota J. Gastrointestinal stromal tumors (GISTs): definition, occurrence, pathology, differential diagnosis and molecular genetics. Pol J Pathol 2003;54(1):3-24.
  • 12- Miettinen M, Majidi M, Lasota J. Pathology and diagnostic criteria of gastrointestinal stromal tumors (GISTs): a review. Eur J Cancer 2002;38:39-51.
  • 13- Kisluk J, Zinczuk J, KemonaA,Ustymowicz K,et al. Expression of CD117,DOG1, and IGF-1R in gastrointestinal stromalstumours-an analysis 0f 70 cases from 2004-2010. Gastroenterology Review 2016;11(2):115-122.
  • 14- Saurabh S. Gastrointestinal stromal tumor: an incidental finding during laporoscopic bariatric surgery.ClinicalCaseReports2017;5(11):1905-1906. doi: 10.1002/ccr3.1194
  • 15- Sarlomo-Rikala M, Kovatich A, Barusevicius A, Miettinen M. CD117: a sensitive marker for gastrointestinal stromal tumors that is more specific than CD34. Mod Pathol 1998;11(8):728-734.
  • 16- Hirota S, Isozaki K, Moriyama Y, et al. Gain-of-Function Mutations of c-kit in Human Gastrointestinal Stromal Tumors. Science 1998;279:577-580
  • 17- SaurabhS.Gastrointestinal Stromal Tumor:an incidental finding during laporoscopic bariatric surgery. Clinic Case Report 2017;5(11):1905-1906.
  • 18- Blay JY, Bonvalot S, Casali P, et al. Consensus meeting for the management of gastrointestinal stromal tumors. Report of the GIST Consensus Conference of 20-21 March 2004, under the auspices of ESMO. Annals of Oncology 2005;16:566-578.
  • 19- Sircar K, Hewlett BR, Huizinga JD, Chorneyko K, Berezin I, Riddel RH. Interstitial cells of Cajal as precursors of gastrointestinal stromal tumors. Am J SurgPathol 1999;23:377-389.
  • 20- Strickland L, Letson GD and Muro-Cacho CA. Gastrointestinal Stromal Tumors. Cancer Control 2001;8(3):252-261.
  • 21- Viscido G, Signorini F, Navarro L, Campazzo P, Saleg V, Gorodner V et al. Incidental finding of gastrointestinal stromal tumors during laporoskopic sleeve gastrectomy in obese patients. Obes. Surg. 2017;27(8):2022-2025.
  • 22- Kim KM, Kang DW, Moon WS, et al. Gastrointestinal Stromal Tumors in Koreans: İncidence and the clinical, Pathologic and Immunohistochemical Findings. J Korean Med Sc 2005;20:977-984.
  • 23- Miettinen M, Furlong M, Sarloma-Rikala M, Burke A, Sobin LH, Lasota J. Gastrointestinal stromal tumors, intramural leiomyomas, and leiomyosarcomas in the rectum and anus: a clinicopathologic, immunohistochemical, and molecular genetic study of 144 ceses. Am J SurgPathol 2001; 25(9):1121-1133.
  • 24- Miettinen M, Furlong M, Sarloma-Rikala M, Burke A, Sobin LH, Lasota J. Gastrointestinal stromal tumors, intramural leiomyomas, and leiomyosarcomas in the rectum and anus: a clinicopathologic, immunohistochemical, and molecular genetic study of 144 ceses. Am J SurgPathol 2001; 25(9):1121-1133.
  • 25- Fletcher CD, Berman JJ, Corless C, et al. Diagnosis of Gastrointestinal Stromal Tumors: A Consensus Approach. Hum Pathol 2002;33(5):459-65.
  • 26- Loong HFH. Gastro-intestinal stromal tumours: a review of current management options. Hong Kong Med J 2007;13 (1):61-65.
  • 27- Tasdemir A, Soyuer I, Unal D, Artış T. Prognostic Value of NFkB,CD9,VEGF in gastrointestinal stromal tumors. CotempOncol(Pozn) 2013;17(6):493-8.
  • 28- Swalchick W, Shameckh R, Bui MM. Is DOG1 ImmunoreactivitySpesific to Gastrointestinal Stromal Tumor. Cancer Control 2015;22(4):498-504.
  • 29- Miettinen M, Virolainen M, Sarloma-Rikala M. Gastrointestinal stromal tumors-value of CD34 antigen in their identification and seperation from true leimyomas and schwannomas. Am J SurgPathol 1995;19(2):207-16.
  • 30- Carrillo R, Candia A, Rodrigez-Peralto H, Caz V. Prognostic significance of DNA ploidy and poliferaktive index (MIB-1 index) in gastrointestinal stromal tumors. Hum Pathol 1997;28:160-165.
  • 31- Zhaou Y, HuW,Chen P et al. Ki67 is a biological marker of malignant risk of gastrointestinal stromal tumors:A systematic review and meta-analysis. Medicine(Baltimore) 2017;96(34):e7911.
  • 32. Hinescu M, Ardeleanu C, Gherghiceanu M, Popescu LM. İnterstitial Cajal-like cells in human gallbladder. J MolHist 2007;38(4):275-284.
  • 33. Miettinen M, El-Rıfaı W, Sobin LH and Lasota J. Evaluation of Malignancy and Prognosis of Gastrointestinal Stromal Tumors: A Review. Hum Pathol 2002;33(5):478-483. 34.Eric CH. Lai, Stephanie H.Y.Lau, Wan Yee Lau. Current management of gastrointestinal stromal tumors-A comprehensive rewiew. International Journal of Surgery 2012;10:334-40.
  • 35.Connolly EM, Gaffney E, Reynolds JV. Gastrointestinal stromal tumours. Br J Surg 2003;90:1178-1186.
There are 34 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Articles
Authors

Arzu Tasdemir

Hatice Karaman

Publication Date September 15, 2020
Submission Date May 20, 2020
Published in Issue Year 2020 Volume: 10 Issue: 3

Cite

AMA Tasdemir A, Karaman H. Demographic, Histopathological and Immunohistochemical Characteristic Findings of Gastrointestinal Stromal Tumors: A Single-Centered Study. Sakarya Tıp Dergisi. September 2020;10(3):381-389. doi:10.31832/smj.740190

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