Analysis of Hematological Parameters According to TSH Levels in Thyroid Patients

Mehmet Özdin; Selcuk Yaylacı; Taner Demirci

doi:10.31832/smj.1019576

Research Article

Analysis of Hematological Parameters According to TSH Levels in Thyroid Patients

Year 2023, Volume: 13 Issue: 2, 247 - 254, 30.06.2023

Mehmet Özdin Selcuk Yaylacı Taner Demirci

https://doi.org/10.31832/smj.1019576

Abstract

Objective: In this study, it was aimed to investigate hematological parameters according to thyroid stimulating hormone (TSH) levels in thyroid patients.
Materials and Methods: Thyroid function tests and hemogram data of 5130 thyroid patients admitted to our hospital between January 2019 and August 2021 were analyzed retrospectively.
Results: There was no significant difference between hemoglobin, MCH, leukocyte, basophil and thrombocyte levels according to TSH levels. When compared in terms of MCV, a significant difference was found between group 1 (TSH<0.05) and group 2 (TSH=0.5-4.99) (p<0.001) and group 2 (TSH=0.5-4.99) and group 4 (TSH ≥10). When the neutrophil levels were compared, there were significant differences between group 1 and group 2, group 3 (TSH=5.0-9.99) and group 4. When the lymphocyte levels were compared, there were significant differences between group 1 and group 2 and group 3, and between group 2 and group 3. When monocyte and eosinophil levels were compared, there were significant differences between group 1 and group 4, group 2 and group 3. there were differences. When MPV levels were compared, there were significant differences between group 1 and group 4, and between group 2 and group 3. There were significant differences between the 3rd and 4th groups in terms of MPV levels.
Conclusions: It was determined that there was a significant difference between MCV, neutrophil, lymphocyte, monocytes, eosinophil and MCV values.

Keywords

Hemoglobin, Hematological parameters, Thyroid Stimulating Hormone

Supporting Institution

Herhangi bir kurum tarafından desteklenmemiştir

Project Number

Thanks

References

1. Tiroid Hastalıklarına Güncel Yaklaşım. Metin Özata, 1. Baskı, Epsilon Yayınları, 2005, İstanbul.
2. Tiroid El Kitabı. Prof. Dr. Taylan Kabalak. 1. Basım, Güven Kitabevi, 2009, İzmir.
3. Harrison Endokrinoloji. J Larry Jameson, Çeviri Editörü Abdullah Bereket, Nobel Tıp Kitabevi, 2009, Ankara.
4. Kaya Z. Interpretation of automated blood cell counts. Dicle Medical Journal. 2013; 40 (3): 521-528.
DOI:10.5798/diclemedj.0921.2013.03.0326 5. Sağlam F, Çakır B. Clinical Approach To Thyroid Diseases In Primary Health Care. Ankara Medical Journal, 2012; 12(3): 136-139.
6. Volkan Sinan. Hipotiroidili ve hipertiroidili hastalarda HbA1c düzeyi. Uzmanlık Tezi. İstanbul 2006.
7. Emirzeoğlu M, Sancak R. Tiroit bezi anatomisi, Journal of Experimental and Clinical Medicine, 2012; 29(4S): 273-275. DOI: 10.5835/jecm.omu.29.s4.013
8. Slatosky J, Shipton B, Wahba H, Thyroiditis: differential diagnosisand management. Am. Fam. Physician. 2000;61:1047-1052.
9. Çorapoğlu D, Uysal AR, Çetinarslan B. Haşhimoto tiroiditli olgularımızın klinik ve laboratuvar değerlendirilmesi. Ankara Üniversitesi Tıp Fakültesi mecmuası cilt 49, sayı 1,33-37, 1996.
10. Ferrucci L and Balducci L. “Anemia of aging: the role of chronic inflammation and cancer”. Seminars in Hematology 45.4 (2008): 242-249
11. Çelik B. Tiroid Hormon Disfonksiyonu Olan Hastalarda Trombosit Agregasyon Bozukluğunun İn Vitro Olarak ASPİ/ADP Testleri ile Değerlendirilmesi. Uzmanlık Tezi. Ankara-2014
12. Anand R. “A study of prevalence and pattern of anemia in primary hypothyroidism”. International Journal of Medical Science and Public Health 7.2 (2018):153-160. DOI: 10.5455/ijmsph.2018.1131728122017
13. Szczepanek-Parulska E. “Anemia in thyroid diseases”. Polish Archives of Internal Medicine 127.5(2017): 352-360.
14. Patel RP and Jain A. “Study of anemia in primary hypothyroidism”. Thyroid Research and Practice 14.1(2017):22. DOI: 10.4103/0973-0354.200564
15. Allen Dawson M and W Yarbro J. “Anemia in Hypothyroidism”. Southern Medical Journal 63.8 (1970): 966-970. DOI: 10.1097/00007611-197008000-00018
16. Refaat B. “Prevalence and characteristics of anemia associated with thyroid disorders in non-pregnant Saudi women during the childbearing age: A cross-sectional study”. Biomedical Journal 38.4 (2015): 307-316. DOI: 10.4103/2319-4170.151032.
17. Pekgör S, Eryılmaz MA, Kaya İFK. Evaluation of Neutrophil-Lymphocyte Ratio, Platelet-Lymphocyte Ratio and Mean Platelet Volume in Patients with Hypothyroidism. Euras J Fam Med 2020;9(3):139-46. DOI: 10.33880/ejfm.2020090304
18. Peraka SA, Karre S, Ravuri S, Shanmugam CK. To evaluate prevalence of anemia in hypothyroid patients. IP J Diagn Pathol Oncol 2019; 4(2): 110-113. DOI: 10.18231/j.jdpo.2019.021
19. Özdin M. Atopik Dermatiti Olan Çocuklarda Hematolojik ve Alerjik Değerler Arasındaki İlişki, Balıkesir Medical Journal, 2020; 4(3): 1-6. DOI: 10.33716/bmedj.760653
20. Bilge M, Adas M, Helvaci A. Neutrophil/LymphocyteRatio (NLR) and Platelet/LymphocyteRatio (PLR) in Patients with Hashimoto's Thyroiditis and Their Relationship with Thyroid Autoimmunity. Endocrine Society 2015 https://endo.confex.com/endo/ 2015endo/webprogram/Paper20422.html
21. Kutluturk F, Gul SS, Sahin S, Tasliyurt T. Comparison of Mean Platelet Volume, Platelet Count, Neutrophil/Lymphocyte Ratio and Platelet/Lymphocyte Ratio in the Euthyroid, Overt Hypothyroid and Subclinical Hyperthyroid Phases of Papillary Thyroid Carcinoma. Endocr Metab Immune Disord Drug Targets 2019; 19: 859-65.DOI: 10.2174/1871530319666190206125545.

Tiroid Hastalarında TSH Düzeylerine Göre Hematolojik Parametrelerin Analizi

Year 2023, Volume: 13 Issue: 2, 247 - 254, 30.06.2023

Mehmet Özdin Selcuk Yaylacı Taner Demirci

https://doi.org/10.31832/smj.1019576

Abstract

Amaç: Bu çalışmada tiroid hastalarında tiroid uyarıcı hormon (TSH) düzeylerine göre hematolojik parametrelerin araştırılması amaçlandı.
Gereç ve Yöntemler: Ocak 2019-Ağustos 2021 tarihleri arasında hastanemize başvuran 5130 tiroid hastasının tiroid fonksiyon testleri ve hemogram verileri retrospektif olarak incelendi.
Bulgular: TSH düzeylerine göre hemoglobin, MCH, lökosit, bazofil ve trombosit düzeyleri arasında anlamlı fark yoktu. MCV açısından karşılaştırıldığında, grup 1 (TSH<0.05) ve grup 2 (TSH=0.5-4.99) (p<0.001) ve grup 2 (TSH=0.5-4.99) ve grup 4 (TSH) arasında anlamlı fark bulundu (TSH ≥10). Nötrofil düzeyleri açısından karşılaştırıldığında grup 1 ve grup 2, grup 3 (TSH=5.0-9.99) ile grup 4 ve grup arasında anlamlı farklar vardı. Lenfosit düzeyleri açısından karşılaştırıldığında, grup 1 ile grup 2 arasında, grup 2 ile grup 3 arasında ve grup 1 ile grup 3 ve grup arasında anlamlı farklar vardı. Monosit ve eozinofil düzeyleri karşılaştırıldığında grup 1 ile grup 4, grup 2 ile grup 3 arasında anlamlı farklar vardı. MPV düzeyleri karşılaştırıldığında grup 1 ile grup 4 arasında, grup 2 ile grup 3 arasında anlamlı farklar vardı. MPV seviyeleri açısından 3. ve 4. grup arasında anlamlı farklar vardı.

Sonuç: MCV, nötrofil, lenfosit, monosit, eozinofil ve MCV değerleri arasında anlamlı fark olduğu belirlendi.

Keywords

Hematolojik parametreler;, Tiroid stimülan hormon;, Hemoglobin

Project Number

References

1. Tiroid Hastalıklarına Güncel Yaklaşım. Metin Özata, 1. Baskı, Epsilon Yayınları, 2005, İstanbul.
2. Tiroid El Kitabı. Prof. Dr. Taylan Kabalak. 1. Basım, Güven Kitabevi, 2009, İzmir.
3. Harrison Endokrinoloji. J Larry Jameson, Çeviri Editörü Abdullah Bereket, Nobel Tıp Kitabevi, 2009, Ankara.
4. Kaya Z. Interpretation of automated blood cell counts. Dicle Medical Journal. 2013; 40 (3): 521-528.
DOI:10.5798/diclemedj.0921.2013.03.0326 5. Sağlam F, Çakır B. Clinical Approach To Thyroid Diseases In Primary Health Care. Ankara Medical Journal, 2012; 12(3): 136-139.
6. Volkan Sinan. Hipotiroidili ve hipertiroidili hastalarda HbA1c düzeyi. Uzmanlık Tezi. İstanbul 2006.
7. Emirzeoğlu M, Sancak R. Tiroit bezi anatomisi, Journal of Experimental and Clinical Medicine, 2012; 29(4S): 273-275. DOI: 10.5835/jecm.omu.29.s4.013
8. Slatosky J, Shipton B, Wahba H, Thyroiditis: differential diagnosisand management. Am. Fam. Physician. 2000;61:1047-1052.
9. Çorapoğlu D, Uysal AR, Çetinarslan B. Haşhimoto tiroiditli olgularımızın klinik ve laboratuvar değerlendirilmesi. Ankara Üniversitesi Tıp Fakültesi mecmuası cilt 49, sayı 1,33-37, 1996.
10. Ferrucci L and Balducci L. “Anemia of aging: the role of chronic inflammation and cancer”. Seminars in Hematology 45.4 (2008): 242-249
11. Çelik B. Tiroid Hormon Disfonksiyonu Olan Hastalarda Trombosit Agregasyon Bozukluğunun İn Vitro Olarak ASPİ/ADP Testleri ile Değerlendirilmesi. Uzmanlık Tezi. Ankara-2014
12. Anand R. “A study of prevalence and pattern of anemia in primary hypothyroidism”. International Journal of Medical Science and Public Health 7.2 (2018):153-160. DOI: 10.5455/ijmsph.2018.1131728122017
13. Szczepanek-Parulska E. “Anemia in thyroid diseases”. Polish Archives of Internal Medicine 127.5(2017): 352-360.
14. Patel RP and Jain A. “Study of anemia in primary hypothyroidism”. Thyroid Research and Practice 14.1(2017):22. DOI: 10.4103/0973-0354.200564
15. Allen Dawson M and W Yarbro J. “Anemia in Hypothyroidism”. Southern Medical Journal 63.8 (1970): 966-970. DOI: 10.1097/00007611-197008000-00018
16. Refaat B. “Prevalence and characteristics of anemia associated with thyroid disorders in non-pregnant Saudi women during the childbearing age: A cross-sectional study”. Biomedical Journal 38.4 (2015): 307-316. DOI: 10.4103/2319-4170.151032.
17. Pekgör S, Eryılmaz MA, Kaya İFK. Evaluation of Neutrophil-Lymphocyte Ratio, Platelet-Lymphocyte Ratio and Mean Platelet Volume in Patients with Hypothyroidism. Euras J Fam Med 2020;9(3):139-46. DOI: 10.33880/ejfm.2020090304
18. Peraka SA, Karre S, Ravuri S, Shanmugam CK. To evaluate prevalence of anemia in hypothyroid patients. IP J Diagn Pathol Oncol 2019; 4(2): 110-113. DOI: 10.18231/j.jdpo.2019.021
19. Özdin M. Atopik Dermatiti Olan Çocuklarda Hematolojik ve Alerjik Değerler Arasındaki İlişki, Balıkesir Medical Journal, 2020; 4(3): 1-6. DOI: 10.33716/bmedj.760653
20. Bilge M, Adas M, Helvaci A. Neutrophil/LymphocyteRatio (NLR) and Platelet/LymphocyteRatio (PLR) in Patients with Hashimoto's Thyroiditis and Their Relationship with Thyroid Autoimmunity. Endocrine Society 2015 https://endo.confex.com/endo/ 2015endo/webprogram/Paper20422.html
21. Kutluturk F, Gul SS, Sahin S, Tasliyurt T. Comparison of Mean Platelet Volume, Platelet Count, Neutrophil/Lymphocyte Ratio and Platelet/Lymphocyte Ratio in the Euthyroid, Overt Hypothyroid and Subclinical Hyperthyroid Phases of Papillary Thyroid Carcinoma. Endocr Metab Immune Disord Drug Targets 2019; 19: 859-65.DOI: 10.2174/1871530319666190206125545.

There are 21 citations in total.

Details

Primary Language	English
Subjects	Health Care Administration
Journal Section	Articles
Authors	Mehmet Özdin 0000-0003-3077-7171 Selcuk Yaylacı 0000-0002-6768-7973 Taner Demirci 0000-0002-9579-4530
Project Number	-
Early Pub Date	June 27, 2023
Publication Date	June 30, 2023
Submission Date	November 5, 2021
Published in Issue	Year 2023 Volume: 13 Issue: 2

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AMA	Özdin M, Yaylacı S, Demirci T. Analysis of Hematological Parameters According to TSH Levels in Thyroid Patients. Sakarya Tıp Dergisi. June 2023;13(2):247-254. doi:10.31832/smj.1019576

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