The Anticancer Effect of Cannabinoid 2 Agonist L-759,633 on C6 and SH-SY5Y Cell Lines

Zıad Joha; Fatih Yulak; Ayşegül Öztürk; Bilal Şahin; Şahin Yıldırım

doi:10.51972/tfsd.929180

Research Article

Year 2021, Volume: 2 Issue: 3, 6 - 13, 30.09.2021

Zıad Joha Fatih Yulak Ayşegül Öztürk Bilal Şahin Şahin Yıldırım

https://doi.org/10.51972/tfsd.929180

Cited By: 2

Abstract

References

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The Anticancer Effect of Cannabinoid 2 Agonist L-759,633 on C6 and SH-SY5Y Cell Lines

Year 2021, Volume: 2 Issue: 3, 6 - 13, 30.09.2021

Zıad Joha Fatih Yulak Ayşegül Öztürk Bilal Şahin Şahin Yıldırım

https://doi.org/10.51972/tfsd.929180

Cited By: 2

Abstract

Purpose: Previous studies have shown that cannabinoid 2 agonists have anticancer effects on different cancer cell lines. However, the effect of L-759,633 on the C6 and SH-SY5Y cell lines is still unclear. The current study was designed to investigate the potential cytotoxic effects of a cannabinoid 2 agonist L-759,633 on the C6 and SH-SY5Y cell lines.
Material and Methods: In this study, the C6 and SH-SY5Y cell lines were used. For each cell line two cell groups were prepared to examine the effect of L-759,633 on C6 glioma and SH-SY5Y cell death. It was not applied any treatment to the cells in the control groups. Various concentrations (5, 10, 20, 40 and 80 μM) of L-759,633 was applied to the cells in the L-759,633 groups. After 24 hours the cell viability was examined using XTT assay. Total oxidant status (TOS) and Total antioxidant status (TAS) in the cells were measured by commercial kits.
Results: L-759,633 at the concentrations of 5, 10, 20, 40 and 80 μM significantly decreased the cell viability in C6 cells (p < 0.001). It also significantly increased the TOS levels (p < 0.001) whereas didn’t alter the TAS levels (p > 0.05). On the other hand this agent did not reduce SH-SY5Y cell viability.
Conclusion: L-759,633 has antiproliferative effect on C6 cells. Additionally, one of the potential mechanisms involved in this effect is activation the oxidant generation. However this drug didn’t show antiproliferative effect on SH-SY5Y cell.
Keywords: L-759,633, Oxidative Stress, cell viability, C6 Glioma, SH-SY5Y cell.

Keywords

L-759,633, Oxidative Stress, C6 Glioma, SH-SY5Y cell

References

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Blázquez, C., Salazar, M., Carracedo, A., Lorente, M., Egia, A., González-Feria, L., Haro, A., Velasco, G., & Guzmán, M. (2008). Cannabinoids inhibit glioma cell invasion by down-regulating matrix metalloproteinase-2 expression. Cancer Research, 68(6), 1945–1952. https://doi.org/10.1158/0008-5472.CAN-07-5176
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Choi, M., Kim, W., Cheon, M. G., Lee, C. W., & Kim, J. E. (2015). Polo-like kinase 1 inhibitor BI2536 causes mitotic catastrophe following activation of the spindle assembly checkpoint in non-small cell lung cancer cells. Cancer Letters, 357(2), 591–601. https://doi.org/10.1016/j.canlet.2014.12.023
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Cioni, C., Tassi, M., Marotta, G., Mugnaini, C., Corelli, F., & Annunziata, P. (2019). A Novel Highly Selective Cannabinoid CB2 Agonist Reduces in vitro Growth and TGF-beta Release of Human Glial Cell Tumors. Central Nervous System Agents in Medicinal Chemistry, 19(3), 206–214. https://doi.org/10.2174/1871524919666190923154351
Den Boon, F. S., Chameau, P., Schaafsma-Zhao, Q., Van Aken, W., Bari, M., Oddi, S., Kruse, C. G., Maccarrone, M., Wadman, W. J., & Werkmana, T. R. (2012). Excitability of prefrontal cortical pyramidal neurons is modulated by activation of intracellular type-2 cannabinoid receptors. Proceedings of the National Academy of Sciences of the United States of America, 109(9), 3534–3539. https://doi.org/10.1073/pnas.1118167109
Ellert-Miklaszewska, A., Grajkowska, W., Gabrusiewicz, K., Kaminska, B., & Konarska, L. (2007). Distinctive pattern of cannabinoid receptor type II (CB2) expression in adult and pediatric brain tumors. Brain Research, 1137(1), 161–169. https://doi.org/10.1016/j.brainres.2006.12.060
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Erel, O. (2004b). A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation. Clinical Biochemistry, 37(4), 277–285. https://doi.org/10.1016/j.clinbiochem.2003.11.015
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Ergul, M., & Bakar-Ates, F. (2020). A specific inhibitor of polo-like kinase 1, GSK461364A, suppresses proliferation of Raji Burkitt’s lymphoma cells through mediating cell cycle arrest, DNA damage, and apoptosis. Chemico-Biological Interactions, 332. https://doi.org/10.1016/j.cbi.2020.109288
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García, M. C., Cinquina, V., Palomo-Garo, C., Rábano, A., & Fernández-Ruiz, J. (2015). Identification of CB2 receptors in human nigral neurons that degenerate in Parkinson’s disease. Neuroscience Letters, 587, 1–4. https://doi.org/10.1016/j.neulet.2014.12.003
Held-Feindt, J., Dorner, L., Sahan, G., Mehdorn, H. M., & Mentlein, R. (2006). Cannabinoid receptors in human astroglial tumors. Journal of Neurochemistry, 98(3), 886–893. https://doi.org/10.1111/j.1471-4159.2006.03911.x
Jacobsson, S. O. P., Rongård, E., Stridh, M., Tiger, G., & Fowler, C. J. (2000). Serum-dependent effects of tamoxifen and cannabinoids upon C6 glioma cell viability. Biochemical Pharmacology, 60(12), 1807–1813. https://doi.org/10.1016/S0006-2952(00)00492-5
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Details

Primary Language	English
Subjects	Pharmacology and Pharmaceutical Sciences
Journal Section	Articles
Authors	Zıad Joha Fatih Yulak 0000-0003-3708-6752 Ayşegül Öztürk 0000-0001-8130-7968 Bilal Şahin 0000-0002-4419-1385 Şahin Yıldırım 0000-0003-1312-7273
Publication Date	September 30, 2021
Submission Date	April 29, 2021
Acceptance Date	August 19, 2021
Published in Issue	Year 2021 Volume: 2 Issue: 3

Cite

APA	Joha, Z., Yulak, F., Öztürk, A., Şahin, B., et al. (2021). The Anticancer Effect of Cannabinoid 2 Agonist L-759,633 on C6 and SH-SY5Y Cell Lines. Turkish Journal of Science and Health, 2(3), 6-13. https://doi.org/10.51972/tfsd.929180