Kinolon ilişkili nadir bir komplikasyon: Uzun QT sendromu

Tayfun Arslan; Rıdvan Erdin; Hüseyin Kandemir; Aydın Çifci; Aşkın Güngüneş; Selim Yalçın; Taner Sarak; Mehmet Kabalcı

doi:10.18663/tjcl.298035

Review

Kinolon ilişkili nadir bir komplikasyon: Uzun QT sendromu

Year 2019, Volume: 10 Issue: 1, 125 - 127, 21.03.2019

Tayfun Arslan Rıdvan Erdin Hüseyin Kandemir Aydın Çifci Aşkın Güngüneş Selim Yalçın Taner Sarak Mehmet Kabalcı

https://doi.org/10.18663/tjcl.298035

Abstract

Enfekte diyabetik ayak ülserlerinin tedavisinde
antibiyotikler sık kullanılan tedavi ajanları arasında yer almaktadır. Ancak
antibiyotiklere bağlı bazen hayatı tehdit edebilecek boyutta ciddi yan etkiler
görülebilir. Bu yazıda enfekte diyabetik ayak ülseri nedeniyle kinolon grubu
antibiyotik tedavisi başlanan bir hastada bu tedaviyi takiben gelişen uzun QT
sendromu ve devamında kardiyopulmoner arrest gelişen ve defibrilasyon tedavisi
ile reanimasyonu sağlanan oldukça nadir bir vaka tartışılarak nadir görülen komplikasyon
üzerine dikkat çekmeyi amaçladık.

Keywords

uzun QT sendromu, antibiyotik, kinolon

References

1. Moss AJ. Long QT syndrome. JAMA 2003; 289: 2041-44.
2. Vincet GM. Themoleculargenetic of thelong QT syndrome: Genes causing fainting and sudden death. Annu Rev Med 1998; 49: 263-74.
3. Vincent GM. Long QT syndrome. Cardiology Clinics 2000; 18: 309-25.
4. Roden DM. Takingthe ‘idio’ out of ‘idiosyncratic’. Predicting torsades de pointes. Pacing Clin Electrophysiol 1998; 21: 1029-34.
5. Donger C, Denjoy I, Berthet M et al. KVLQT1 C terminal missense mutation causes a forme fruste long QT syndrome. Circulation 1997; 96: 2778-81.
6. Wang WX, Ebert SN, Liu XK et al. "Conventional" antihistamines slow cardiac repolarization in isolated perfused (Langendorff) feline hearts. J Cardiovasc Pharmacol 1998; 32: 123-28.
7. Reardon M, Malik M. QT interval change with age in an overtly healthy older population. Clin Cardiol1996; 19: 94952.
8. Fogarty C, Grossman C, Williams J et al. Efficacy and safety of moxifloxacin vs. clarithromycin for community-acquiredpneumonia. Infect Med 1999; 16: 748 – 63.
9. Korvick J. QT and quinolones: recent regulatory actions. Office of Drug Evaluation IV. Division of Special Pathogens FDA 5/23/01.
10. Noel GJ, Natarajan J, Chien S et al. Effects of three fluoroquinolones on QT interval in healthy adults after single doses. Clin Pharmacol Ther 2003; 73: 292 – 303.
11. Stahlmann R, Schwabe R. Safetyprofile of grepafloxacin compared with other fluoroquinolones. J Antimicrob Chemother 1997; 40: 83 – 92.
12. Owens RC Jr, Ambrose PG. Clinical use of the fluoroquinolones. Med Clin North Am 2000; 84: 1447 – 96.
13. Appelbaum PC, Hunter PA. The fluoroquinolone antibacterials: Past, present and future perspectives. Int J Antimicrob Agents 2000; 16: 5 – 15.
14. Stahlman R, Lode H. Toxicity of quinolones. Drugs 1999; 58: 37 – 42.
15. Bertino J, Fish D The safety profile of the fluoroquinolones Clin Ther 2000; 22: 798 – 817.
16. Ball P. Future of the quinolones. Semin Respir Infect 2001; 16: 215 – 24.

Quinolone-associated a rare complication: Long QT syndrome

Year 2019, Volume: 10 Issue: 1, 125 - 127, 21.03.2019

Tayfun Arslan Rıdvan Erdin Hüseyin Kandemir Aydın Çifci Aşkın Güngüneş Selim Yalçın Taner Sarak Mehmet Kabalcı

https://doi.org/10.18663/tjcl.298035

Abstract

In the treatment of infected diabetic
foot ulcers, antibiotics are frequently used as treatment agents. However,
serious adverse effects may be seen on antibiotics, which can sometimes be
life-threatening. In this article, we aimed to draw attention to a
rare complication in a patientwhowastreatedwithquinoloneantibioticsduetoinfecteddiabeticfootulcer,
a rare long QT syndrome following this treatment, subsequent cardiopulmonary arrest and reanimation with defibrillation therapy.

Keywords

Long QT syndrome, antibiotic, quinolone

References

1. Moss AJ. Long QT syndrome. JAMA 2003; 289: 2041-44.
2. Vincet GM. Themoleculargenetic of thelong QT syndrome: Genes causing fainting and sudden death. Annu Rev Med 1998; 49: 263-74.
3. Vincent GM. Long QT syndrome. Cardiology Clinics 2000; 18: 309-25.
4. Roden DM. Takingthe ‘idio’ out of ‘idiosyncratic’. Predicting torsades de pointes. Pacing Clin Electrophysiol 1998; 21: 1029-34.
5. Donger C, Denjoy I, Berthet M et al. KVLQT1 C terminal missense mutation causes a forme fruste long QT syndrome. Circulation 1997; 96: 2778-81.
6. Wang WX, Ebert SN, Liu XK et al. "Conventional" antihistamines slow cardiac repolarization in isolated perfused (Langendorff) feline hearts. J Cardiovasc Pharmacol 1998; 32: 123-28.
7. Reardon M, Malik M. QT interval change with age in an overtly healthy older population. Clin Cardiol1996; 19: 94952.
8. Fogarty C, Grossman C, Williams J et al. Efficacy and safety of moxifloxacin vs. clarithromycin for community-acquiredpneumonia. Infect Med 1999; 16: 748 – 63.
9. Korvick J. QT and quinolones: recent regulatory actions. Office of Drug Evaluation IV. Division of Special Pathogens FDA 5/23/01.
10. Noel GJ, Natarajan J, Chien S et al. Effects of three fluoroquinolones on QT interval in healthy adults after single doses. Clin Pharmacol Ther 2003; 73: 292 – 303.
11. Stahlmann R, Schwabe R. Safetyprofile of grepafloxacin compared with other fluoroquinolones. J Antimicrob Chemother 1997; 40: 83 – 92.
12. Owens RC Jr, Ambrose PG. Clinical use of the fluoroquinolones. Med Clin North Am 2000; 84: 1447 – 96.
13. Appelbaum PC, Hunter PA. The fluoroquinolone antibacterials: Past, present and future perspectives. Int J Antimicrob Agents 2000; 16: 5 – 15.
14. Stahlman R, Lode H. Toxicity of quinolones. Drugs 1999; 58: 37 – 42.
15. Bertino J, Fish D The safety profile of the fluoroquinolones Clin Ther 2000; 22: 798 – 817.
16. Ball P. Future of the quinolones. Semin Respir Infect 2001; 16: 215 – 24.

There are 16 citations in total.

Details

Primary Language	Turkish
Subjects	Health Care Administration
Journal Section	Case Report
Authors	Tayfun Arslan This is me Rıdvan Erdin This is me Hüseyin Kandemir This is me Aydın Çifci Aşkın Güngüneş This is me Selim Yalçın This is me Taner Sarak This is me Mehmet Kabalcı
Publication Date	March 21, 2019
Published in Issue	Year 2019 Volume: 10 Issue: 1

Cite

APA	Arslan, T., Erdin, R., Kandemir, H., Çifci, A., et al. (2019). Kinolon ilişkili nadir bir komplikasyon: Uzun QT sendromu. Turkish Journal of Clinics and Laboratory, 10(1), 125-127. https://doi.org/10.18663/tjcl.298035
AMA	Arslan T, Erdin R, Kandemir H, Çifci A, Güngüneş A, Yalçın S, Sarak T, Kabalcı M. Kinolon ilişkili nadir bir komplikasyon: Uzun QT sendromu. TJCL. March 2019;10(1):125-127. doi:10.18663/tjcl.298035
Chicago	Arslan, Tayfun, Rıdvan Erdin, Hüseyin Kandemir, Aydın Çifci, Aşkın Güngüneş, Selim Yalçın, Taner Sarak, and Mehmet Kabalcı. “Kinolon ilişkili Nadir Bir Komplikasyon: Uzun QT Sendromu”. Turkish Journal of Clinics and Laboratory 10, no. 1 (March 2019): 125-27. https://doi.org/10.18663/tjcl.298035.
EndNote	Arslan T, Erdin R, Kandemir H, Çifci A, Güngüneş A, Yalçın S, Sarak T, Kabalcı M (March 1, 2019) Kinolon ilişkili nadir bir komplikasyon: Uzun QT sendromu. Turkish Journal of Clinics and Laboratory 10 1 125–127.
IEEE	T. Arslan, “Kinolon ilişkili nadir bir komplikasyon: Uzun QT sendromu”, TJCL, vol. 10, no. 1, pp. 125–127, 2019, doi: 10.18663/tjcl.298035.
ISNAD	Arslan, Tayfun et al. “Kinolon ilişkili Nadir Bir Komplikasyon: Uzun QT Sendromu”. Turkish Journal of Clinics and Laboratory 10/1 (March 2019), 125-127. https://doi.org/10.18663/tjcl.298035.
JAMA	Arslan T, Erdin R, Kandemir H, Çifci A, Güngüneş A, Yalçın S, Sarak T, Kabalcı M. Kinolon ilişkili nadir bir komplikasyon: Uzun QT sendromu. TJCL. 2019;10:125–127.
MLA	Arslan, Tayfun et al. “Kinolon ilişkili Nadir Bir Komplikasyon: Uzun QT Sendromu”. Turkish Journal of Clinics and Laboratory, vol. 10, no. 1, 2019, pp. 125-7, doi:10.18663/tjcl.298035.
Vancouver	Arslan T, Erdin R, Kandemir H, Çifci A, Güngüneş A, Yalçın S, Sarak T, Kabalcı M. Kinolon ilişkili nadir bir komplikasyon: Uzun QT sendromu. TJCL. 2019;10(1):125-7.