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Evaluation of laboratory parameters in inflammatory myositis

Year 2021, Volume: 12 Issue: 3, 255 - 259, 29.09.2021

Melih Pamukcu Tuğba İzci Duran

https://doi.org/10.18663/tjcl.947989

Abstract

Aim: Polymyositis (PM) and dermatomyositis (DM) are the two most common forms of idiopathic inflammatory myositis (IIM) and they are generally rare diseases. We evaluate the relationship of C-reactive protein (CRP)/albumin ratio (CAR), neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio and other inflammatory markers with IIM.
Material and Methods: 30 patients and 30 healthy volunteers aged >18 years were included. Demographic data such as age, gender were recorded. CRP, erythrocyte sedimentation rate (ESR), albumin values, leukocyte, neutrophil, lymphocyte, platelet counts were determined.
Results: The median (IQR) age of the patients and healthy volunteers were 46 (38-60) years and 45 (42-52) years, respectively. 50% of the patients had a diagnosis of DM and 50% of them had a diagnosis of PM, and the median (IQR) duration of disease was 4 (0.5-13) years. The median value of CAR was 3.6 (1.0-5.1) in the patient group and 0.3 (0.1-0.6) in the control group; the NLR was 3.4 (2.3-4.4) in the patient group, 1.8 (1.6-2.1) in the control group; PLR was 223 (157-249) in the patient group, 107 (100-125) in the control group and CAR, NLR, and PLR values between the groups were significantly different (p<0.001, p=0.002 and p=0.040, respectively).
Conclusion: CAR can be considered as a helpful assessment tool to show inflammation in patients with IIM.

Keywords

Idiopathic inflammatory myopathies C-Reactive Protein / analysis* Inflammation / immunology Lymphocytes / metabolism* Neutrophils / immunology

References

  • 1. Furst D.E., et al., Epidemiology of adult idiopathic inflammatory myopathies in a U.S. managed care plan. Muscle Nerve, 2012; 45: 676-83.
  • 2. Ha Y.J., et al., Baseline peripheral blood neutrophil-to-lymphocyte ratio could predict survival in patients with adult polymyositis and dermatomyositis: A retrospective observational study. PLoS One, 2018; 1: 0190411.
  • 3. Marie I., et al., Polymyositis and dermatomyositis: short term and longterm outcome, and predictive factors of prognosis. J Rheumatol, 2001; 28: 2230-7.
  • 4. Airio A, H. Kautiainen, and M. Hakala, Prognosis and mortality of polymyositis and dermatomyositis patients. Clin Rheumatol, 2006; 25: 234-9.
  • 5. Benbassat, J., et al. Prognostic factors in polymyositis/dermatomyositis. A computer-assisted analysis of ninety-two cases. Arthritis Rheum, 1985; 28: 249-55.
  • 6. BOHAN, A., et al., A COMPUTER-ASSISTED ANALYSIS OF 153 PATIENTS WITH POLYMYOSITIS AND DERMATOMYOSITIS. Medicine, 1977; 56: 255-86.
  • 7. Carpenter, J.R., et al., Survival in polymyositis: corticosteroids and risk factors. J Rheumatol, 1977; 4: 207-14.
  • 8. DeVere, R. and W.G. Bradley. Polymyositis: its presentation, morbidity and mortality. Brain, 1975; 98: 637-66.
  • 9. Dankó, K., et al. Long-Term Survival of Patients With Idiopathic Inflammatory Myopathies According to Clinical Features: A Longitudinal Study of 162 Cases. Medicine, 2004; 83: 35-42.
  • 10. Henriksson, K.G. and P. Sandstedt .Polymyositis--treatment and prognosis. A study of 107 patients. Acta Neurol Scand, 1982; 65: 280-300.
  • 11. Hochberg, M.C., D. Lopez-Acuna, and A.M. Gittelsohn, Mortality from polymyositis and dermatomyositis in the United States, 1968-1978. Arthritis Rheum, 1983; 26: 1465-71.
  • 12. Lynn, S.J., et al., Adult-onset inflammatory myopathy: North Canterbury experience 1989–2001. Internal Medicine Journal, 2005; 35: 170-3.
  • 13. Mustafa, K.N. and S.S. Dahbour, Clinical characteristics and outcomes of patients with idiopathic inflammatory myopathies from Jordan 1996-2009. Clin Rheumatol, 2010; 29: 1381-5.
  • 14. Schiopu, E., et al., Predictors of survival in a cohort of patients with polymyositis and dermatomyositis: effect of corticosteroids, methotrexate and azathioprine. Arthritis Research & Therapy, 2012; 14: 22.
  • 15. Torres, C., et al., Survival, mortality and causes of death in inflammatory myopathies. Autoimmunity, 2006; 39: 205-15.
  • 16. Yamasaki, Y., et al., Longterm survival and associated risk factors in patients with adult-onset idiopathic inflammatory myopathies and amyopathic dermatomyositis: experience in a single institute in Japan. J Rheumatol, 2011; 38: 1636-43.
  • 17. Yu, K.H., et al., Survival analysis of patients with dermatomyositis and polymyositis: analysis of 192 Chinese cases. Clin Rheumatol, 2011; 30: 1595-601.
  • 18. Uthman, I., D. Vázquez-Abad, and J.L. Senécal, Distinctive features of idiopathic inflammatory myopathies in French Canadians. Semin Arthritis Rheum, 1996; 26: 447-58.
  • 19. Maugars, Y.M., et al., Long-term prognosis of 69 patients with dermatomyositis or polymyositis. Clin Exp Rheumatol, 1996; 14: 263-74.
  • 20. Marie, I., Morbidity and mortality in adult polymyositis and dermatomyositis. Curr Rheumatol Rep, 2012; 14: 275-85.
  • 21. Dalakas, M.C., Inflammatory muscle diseases. N Engl J Med, 2015; 372: 1734-47.
  • 22. Salvador, F.B. and D.A. Isenberg, Outcome predictors in patients with idiopathic inflammatory myopathies. Clin Exp Rheumatol, 2012; 30: 980.
  • 23. Lu, X., Q. Peng, and G. Wang, Discovery of new biomarkers of idiopathic inflammatory myopathy. Clin Chim Acta, 2015; 444: 117-25.
  • 24. Templeton, A.J., et al., Prognostic role of neutrophil-to-lymphocyte ratio in solid tumors: a systematic review and meta-analysis. J Natl Cancer Inst, 2014; 106: 124.
  • 25. Xu, X.L., et al., A Novel Inflammation-Based Prognostic Score, the C-Reactive Protein/Albumin Ratio Predicts the Prognosis of Patients with Operable Esophageal Squamous Cell Carcinoma. PLoS One, 2015; 10: 0138657.
  • 26. Ishizuka, M., et al., Clinical Significance of the C-Reactive Protein to Albumin Ratio for Survival After Surgery for Colorectal Cancer. Ann Surg Oncol, 2016; 23: 900-7.
  • 27. Rifaioglu, E.N., et al., Neutrophil to lymphocyte ratio in Behçet's disease as a marker of disease activity. Acta Dermatovenerol Alp Pannonica Adriat, 2014; 23: 65-7.
  • 28. Uslu, A.U., et al., Two new inflammatory markers associated with Disease Activity Score-28 in patients with rheumatoid arthritis: neutrophil-lymphocyte ratio and platelet-lymphocyte ratio. Int J Rheum Dis, 2015; 18: 731-5.
  • 29. Qin, B., et al., Neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) were useful markers in assessment of inflammatory response and disease activity in SLE patients. Mod Rheumatol, 2016; 26: 372-6.
  • 30. Peng, Y.F., et al., Platelet to Lymphocyte Ratio in Polymyositis as a Marker of Disease Activity. Clin Lab, 2016; 62; 915-9.
  • 31. Gao, M.Z., et al., Red blood cell distribution width and neutrophil to lymphocyte ratio are correlated with disease activity of dermatomyositis and polymyositis. J Clin Lab Anal, 2018; 32.
  • 32. Yang, W., et al., Neutrophil-lymphocyte ratio and platelet-lymphocyte ratio are 2 new inflammatory markers associated with pulmonary involvement and disease activity in patients with dermatomyositis. Clin Chim Acta, 2017; 465: 11-6.
  • 33. Medsger, T.A., Jr., H. Robinson, and A.T. Masi, Factors affecting survivorship in polymyositis. A life-table study of 124 patients. Arthritis Rheum, 1971; 14: 249-58.
  • 34. Limaye, V., et al., Mortality and its predominant causes in a large cohort of patients with biopsy-determined inflammatory myositis. Intern Med J, 2012; 42: 191-8.
  • 35. Sunar, İ. and Ş. Ataman, Serum C-Reactive Protein/Albumin Ratio in Rheumatoid Arthritis and its Relationship With Disease Activity, Physical Function, and Quality of Life. 2020; 35: 247-53.
  • 36. Absenger, G., et al., A derived neutrophil to lymphocyte ratio predicts clinical outcome in stage II and III colon cancer patients. Br J Cancer, 2013; 109: 395-400.
  • 37. Seringec Akkececi, N., et al., The C-Reactive Protein/Albumin Ratio and Complete Blood Count Parameters as Indicators of Disease Activity in Patients with Takayasu Arteritis. Med Sci Monit, 2019; 25: 1401- 09.
  • 38. Moon, J.S., et al., C-Reactive Protein to Serum Albumin Ratio Is an Independent Predictor of All-Cause Mortality in Patients with ANCA-Associated Vasculitis. 2018; 59: 865-71.

İnflamatuar miyozitte laboratuvar parametrelerinin değerlendirilmesi

Year 2021, Volume: 12 Issue: 3, 255 - 259, 29.09.2021

Melih Pamukcu Tuğba İzci Duran

https://doi.org/10.18663/tjcl.947989

Abstract

Amaç: Polimiyozit (PM) ve dermatomiyozit (DM), idiyopatik inflamatuar miyozitin (İİM) en sık görülen iki formudur ve genellikle nadir görülen hastalıklardır. C-reaktif protein (CRP)/albümin oranı (CAR), nötrofil/lenfosit oranı (NLR), trombosit/lenfosit oranı ve diğer inflamatuar belirteçlerin İİM ile ilişkisini değerlendirmeyi amaçladık.
Gereç ve Yöntemler: 18 yaş üstü, 30 hasta ve 30 sağlıklı gönüllü dahil edildi. Yaş, cinsiyet gibi demografik veriler kaydedildi. CRP, eritrosit sedimantasyon hızı (ESR), albümin değerleri, lökosit, nötrofil, lenfosit, trombosit sayıları belirlendi.
Bulgular: Hastaların ve sağlıklı gönüllülerin medyan (IQR) yaşı sırasıyla 46 (38-60) yıl ve 45 (42-52) yıl idi. Hastaların %50'sine DM, %50'sine PM tanısı konuldu ve ortanca (IQR) hastalık süresi 4 (0,5-13) yıldı. CAR medyan değeri hasta grubunda 3,6 (1,0-5,1) ve kontrol grubunda 0,3 (0,1-0,6); NLR hasta grubunda 3,4 (2,3-4,4), kontrol grubunda 1,8 (1,6-2,1) idi; Hasta grubunda PLR 223 (157-249), kontrol grubunda 107 (100-125) ve gruplar arasında CAR, NLR ve PLR değerleri anlamlı olarak farklıydı (sırasıyla, p<0,001, p=0,002 ve p=0,040).
Sonuç: CRP/albumin oranı, IIM'li hastalarda inflamasyonu göstermek için yararlı bir değerlendirme aracı olarak düşünülebilir.

Keywords

İdiyopatik inflamatuar miyopatiler C-Reaktif Protein İnflamasyon Lenfositler Nötrofiller

References

  • 1. Furst D.E., et al., Epidemiology of adult idiopathic inflammatory myopathies in a U.S. managed care plan. Muscle Nerve, 2012; 45: 676-83.
  • 2. Ha Y.J., et al., Baseline peripheral blood neutrophil-to-lymphocyte ratio could predict survival in patients with adult polymyositis and dermatomyositis: A retrospective observational study. PLoS One, 2018; 1: 0190411.
  • 3. Marie I., et al., Polymyositis and dermatomyositis: short term and longterm outcome, and predictive factors of prognosis. J Rheumatol, 2001; 28: 2230-7.
  • 4. Airio A, H. Kautiainen, and M. Hakala, Prognosis and mortality of polymyositis and dermatomyositis patients. Clin Rheumatol, 2006; 25: 234-9.
  • 5. Benbassat, J., et al. Prognostic factors in polymyositis/dermatomyositis. A computer-assisted analysis of ninety-two cases. Arthritis Rheum, 1985; 28: 249-55.
  • 6. BOHAN, A., et al., A COMPUTER-ASSISTED ANALYSIS OF 153 PATIENTS WITH POLYMYOSITIS AND DERMATOMYOSITIS. Medicine, 1977; 56: 255-86.
  • 7. Carpenter, J.R., et al., Survival in polymyositis: corticosteroids and risk factors. J Rheumatol, 1977; 4: 207-14.
  • 8. DeVere, R. and W.G. Bradley. Polymyositis: its presentation, morbidity and mortality. Brain, 1975; 98: 637-66.
  • 9. Dankó, K., et al. Long-Term Survival of Patients With Idiopathic Inflammatory Myopathies According to Clinical Features: A Longitudinal Study of 162 Cases. Medicine, 2004; 83: 35-42.
  • 10. Henriksson, K.G. and P. Sandstedt .Polymyositis--treatment and prognosis. A study of 107 patients. Acta Neurol Scand, 1982; 65: 280-300.
  • 11. Hochberg, M.C., D. Lopez-Acuna, and A.M. Gittelsohn, Mortality from polymyositis and dermatomyositis in the United States, 1968-1978. Arthritis Rheum, 1983; 26: 1465-71.
  • 12. Lynn, S.J., et al., Adult-onset inflammatory myopathy: North Canterbury experience 1989–2001. Internal Medicine Journal, 2005; 35: 170-3.
  • 13. Mustafa, K.N. and S.S. Dahbour, Clinical characteristics and outcomes of patients with idiopathic inflammatory myopathies from Jordan 1996-2009. Clin Rheumatol, 2010; 29: 1381-5.
  • 14. Schiopu, E., et al., Predictors of survival in a cohort of patients with polymyositis and dermatomyositis: effect of corticosteroids, methotrexate and azathioprine. Arthritis Research & Therapy, 2012; 14: 22.
  • 15. Torres, C., et al., Survival, mortality and causes of death in inflammatory myopathies. Autoimmunity, 2006; 39: 205-15.
  • 16. Yamasaki, Y., et al., Longterm survival and associated risk factors in patients with adult-onset idiopathic inflammatory myopathies and amyopathic dermatomyositis: experience in a single institute in Japan. J Rheumatol, 2011; 38: 1636-43.
  • 17. Yu, K.H., et al., Survival analysis of patients with dermatomyositis and polymyositis: analysis of 192 Chinese cases. Clin Rheumatol, 2011; 30: 1595-601.
  • 18. Uthman, I., D. Vázquez-Abad, and J.L. Senécal, Distinctive features of idiopathic inflammatory myopathies in French Canadians. Semin Arthritis Rheum, 1996; 26: 447-58.
  • 19. Maugars, Y.M., et al., Long-term prognosis of 69 patients with dermatomyositis or polymyositis. Clin Exp Rheumatol, 1996; 14: 263-74.
  • 20. Marie, I., Morbidity and mortality in adult polymyositis and dermatomyositis. Curr Rheumatol Rep, 2012; 14: 275-85.
  • 21. Dalakas, M.C., Inflammatory muscle diseases. N Engl J Med, 2015; 372: 1734-47.
  • 22. Salvador, F.B. and D.A. Isenberg, Outcome predictors in patients with idiopathic inflammatory myopathies. Clin Exp Rheumatol, 2012; 30: 980.
  • 23. Lu, X., Q. Peng, and G. Wang, Discovery of new biomarkers of idiopathic inflammatory myopathy. Clin Chim Acta, 2015; 444: 117-25.
  • 24. Templeton, A.J., et al., Prognostic role of neutrophil-to-lymphocyte ratio in solid tumors: a systematic review and meta-analysis. J Natl Cancer Inst, 2014; 106: 124.
  • 25. Xu, X.L., et al., A Novel Inflammation-Based Prognostic Score, the C-Reactive Protein/Albumin Ratio Predicts the Prognosis of Patients with Operable Esophageal Squamous Cell Carcinoma. PLoS One, 2015; 10: 0138657.
  • 26. Ishizuka, M., et al., Clinical Significance of the C-Reactive Protein to Albumin Ratio for Survival After Surgery for Colorectal Cancer. Ann Surg Oncol, 2016; 23: 900-7.
  • 27. Rifaioglu, E.N., et al., Neutrophil to lymphocyte ratio in Behçet's disease as a marker of disease activity. Acta Dermatovenerol Alp Pannonica Adriat, 2014; 23: 65-7.
  • 28. Uslu, A.U., et al., Two new inflammatory markers associated with Disease Activity Score-28 in patients with rheumatoid arthritis: neutrophil-lymphocyte ratio and platelet-lymphocyte ratio. Int J Rheum Dis, 2015; 18: 731-5.
  • 29. Qin, B., et al., Neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) were useful markers in assessment of inflammatory response and disease activity in SLE patients. Mod Rheumatol, 2016; 26: 372-6.
  • 30. Peng, Y.F., et al., Platelet to Lymphocyte Ratio in Polymyositis as a Marker of Disease Activity. Clin Lab, 2016; 62; 915-9.
  • 31. Gao, M.Z., et al., Red blood cell distribution width and neutrophil to lymphocyte ratio are correlated with disease activity of dermatomyositis and polymyositis. J Clin Lab Anal, 2018; 32.
  • 32. Yang, W., et al., Neutrophil-lymphocyte ratio and platelet-lymphocyte ratio are 2 new inflammatory markers associated with pulmonary involvement and disease activity in patients with dermatomyositis. Clin Chim Acta, 2017; 465: 11-6.
  • 33. Medsger, T.A., Jr., H. Robinson, and A.T. Masi, Factors affecting survivorship in polymyositis. A life-table study of 124 patients. Arthritis Rheum, 1971; 14: 249-58.
  • 34. Limaye, V., et al., Mortality and its predominant causes in a large cohort of patients with biopsy-determined inflammatory myositis. Intern Med J, 2012; 42: 191-8.
  • 35. Sunar, İ. and Ş. Ataman, Serum C-Reactive Protein/Albumin Ratio in Rheumatoid Arthritis and its Relationship With Disease Activity, Physical Function, and Quality of Life. 2020; 35: 247-53.
  • 36. Absenger, G., et al., A derived neutrophil to lymphocyte ratio predicts clinical outcome in stage II and III colon cancer patients. Br J Cancer, 2013; 109: 395-400.
  • 37. Seringec Akkececi, N., et al., The C-Reactive Protein/Albumin Ratio and Complete Blood Count Parameters as Indicators of Disease Activity in Patients with Takayasu Arteritis. Med Sci Monit, 2019; 25: 1401- 09.
  • 38. Moon, J.S., et al., C-Reactive Protein to Serum Albumin Ratio Is an Independent Predictor of All-Cause Mortality in Patients with ANCA-Associated Vasculitis. 2018; 59: 865-71.
There are 38 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Orıgınal Artıcle
Authors

Melih Pamukcu 0000-0002-9129-0503

Tuğba İzci Duran 0000-0003-4428-9873

Publication Date September 29, 2021
Published in Issue Year 2021 Volume: 12 Issue: 3

Cite

APA Pamukcu, M., & İzci Duran, T. (2021). Evaluation of laboratory parameters in inflammatory myositis. Turkish Journal of Clinics and Laboratory, 12(3), 255-259. https://doi.org/10.18663/tjcl.947989
AMA Pamukcu M, İzci Duran T. Evaluation of laboratory parameters in inflammatory myositis. TJCL. September 2021;12(3):255-259. doi:10.18663/tjcl.947989
Chicago Pamukcu, Melih, and Tuğba İzci Duran. “Evaluation of Laboratory Parameters in Inflammatory Myositis”. Turkish Journal of Clinics and Laboratory 12, no. 3 (September 2021): 255-59. https://doi.org/10.18663/tjcl.947989.
EndNote Pamukcu M, İzci Duran T (September 1, 2021) Evaluation of laboratory parameters in inflammatory myositis. Turkish Journal of Clinics and Laboratory 12 3 255–259.
IEEE M. Pamukcu and T. İzci Duran, “Evaluation of laboratory parameters in inflammatory myositis”, TJCL, vol. 12, no. 3, pp. 255–259, 2021, doi: 10.18663/tjcl.947989.
ISNAD Pamukcu, Melih - İzci Duran, Tuğba. “Evaluation of Laboratory Parameters in Inflammatory Myositis”. Turkish Journal of Clinics and Laboratory 12/3 (September 2021), 255-259. https://doi.org/10.18663/tjcl.947989.
JAMA Pamukcu M, İzci Duran T. Evaluation of laboratory parameters in inflammatory myositis. TJCL. 2021;12:255–259.
MLA Pamukcu, Melih and Tuğba İzci Duran. “Evaluation of Laboratory Parameters in Inflammatory Myositis”. Turkish Journal of Clinics and Laboratory, vol. 12, no. 3, 2021, pp. 255-9, doi:10.18663/tjcl.947989.
Vancouver Pamukcu M, İzci Duran T. Evaluation of laboratory parameters in inflammatory myositis. TJCL. 2021;12(3):255-9.


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